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Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 01/2019, Volume 843, pp. 190 - 198
Interleukin (IL)-23 is thought to be critical in the pathogenesis of psoriasis, and anti-IL-23 monoclonal antibodies (mAbs) have been approved for the... 
Interleukin-23 receptor monoclonal antibody | Psoriatic human skin xenograft model | Psoriasis | Th17 | Pharmacodynamic marker | STAT3 phosphorylation | RISANKIZUMAB | STAT3 | MARKERS | THERAPY | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | EXPRESSION | Index Medicus
Journal Article
Clinical Immunology, ISSN 1521-6616, 2018
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molecular interactions that dictate its... 
Human monoclonal IL-23 antibodies | IL-23/IL-23R pathways | Skin and joint inflammation | Cytokines | Therapeutics | Psoriatic arthritis
Journal Article
Journal Article
Journal of Crohn's & colitis, ISSN 1873-9946, 2018, Volume 12, Issue 10, pp. 1170 - 1179
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 04/2017, Volume 376, Issue 16, pp. 1551 - 1560
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 10/2010, Volume 402, Issue 5, pp. 797 - 812
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0141550 - e0141550
Interleukin (IL)-23 and IL-12 are closely related in structure, and these cytokines regulate both innate and adaptive immunity. However, the precise signaling... 
IMMUNE-RESPONSE | ACTIVATION | PROTEIN | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | RESISTANCE | INNATE | INFECTION | CYTOKINE | MICE | EXPRESSION | Up-Regulation | Humans | Enzyme Inhibitors - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | MAP Kinase Signaling System | Toxoplasma | Toxoplasmosis - pathology | Toxoplasmosis - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Line, Tumor | Interleukin-23 - biosynthesis | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Interleukin-12 - biosynthesis | Care and treatment | Interleukins | Patient outcomes | Physiological aspects | Monoclonal antibodies | Development and progression | Genetic aspects | Research | Health aspects | Networks | Adaptive structures | Phosphorylation | Interleukin | Intracellular signalling | AKT protein | Interleukin 23 | Biology | Infections | Activation | Tachyzoites | Parasites | Kinases | Immunity | Proteins | Signal transduction | Transfection | Pathways | Cascades | Gastroenterology | Toll-like receptors | Inhibition | Pretreatment | Immunoglobulins | Cytokines | Dendritic cells | Secretion | Neutrophils | Extracellular signal-regulated kinase | MAP kinase | Interleukin 12 | JNK protein | siRNA | Adaptive immunity | TLR4 protein | Gene expression | 1-Phosphatidylinositol 3-kinase | Medicine | Monocytes | Hospitals | Inhibitors | TLR2 protein | Wortmannin | Ligands | Intracellular | Index Medicus
Journal Article
Gut, ISSN 0017-5749, 04/2014, Volume 63, Issue 4, pp. 567 - 577
Background We analysed incidence, predictors, histological features and specific treatment options of anti-tumour necrosis factor α (TNF-α) antibody-induced... 
RHEUMATOID-ARTHRITIS | ULCERATIVE-COLITIS | DOUBLE-BLIND | PROINFLAMMATORY GENE-EXPRESSION | ACTIVE CROHNS-DISEASE | NECROSIS FACTOR THERAPY | GASTROENTEROLOGY & HEPATOLOGY | MAINTENANCE THERAPY | HUMAN KERATINOCYTES | INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY | GENOME-WIDE ASSOCIATION | Th1 Cells - physiology | Prospective Studies | Humans | Inflammatory Bowel Diseases - immunology | Interleukin-12 - physiology | Interleukin-17 - immunology | Interleukin-17 - physiology | Psoriasis - etiology | Ustekinumab | Inflammatory Bowel Diseases - physiopathology | Male | Th1 Cells - immunology | Interleukins - physiology | Inflammatory Bowel Diseases - pathology | Interleukins - immunology | Tumor Necrosis Factor-alpha - immunology | Antibodies - immunology | Adult | Female | Inflammatory Bowel Diseases - complications | Interleukin-23 - physiology | Skin - pathology | Skin - immunology | Psoriasis - immunology | Antibodies - therapeutic use | Antibodies, Monoclonal, Humanized - therapeutic use | Interferon-gamma - physiology | Interleukin-23 - immunology | Psoriasis - physiopathology | Interferon-gamma - immunology | Interleukin-12 - immunology | Tumor Necrosis Factor-alpha - physiology | Skin - physiopathology | Antibodies, Monoclonal, Humanized - immunology | Complications and side effects | Inflammatory bowel diseases | Care and treatment | Psoriasis | Tumor necrosis factor | Influence | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article