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The Lancet (British edition), ISSN 0140-6736, 2015, Volume 386, Issue 10008, pp. 2078 - 2088
...Introduction In 2008, one in six new cancer diagnoses worldwide was attributable to an infectious pathogen. Human papillomavirus (HPV) causes one-third... 
Internal Medicine | REGRESSION | MEDICINE, GENERAL & INTERNAL | ELECTROPORATION | METHYLATION | INTEGRATION | IMMUNOTHERAPY | E2 BINDING-SITES | NATURAL-HISTORY | CANCER | BURDEN | EXPRESSION | Human papillomavirus 18 - immunology | Humans | Papillomavirus E7 Proteins - immunology | Vaccines, DNA - immunology | Cervical Intraepithelial Neoplasia - drug therapy | Human papillomavirus 16 - immunology | Papillomavirus E7 Proteins - genetics | Young Adult | Cancer Vaccines - therapeutic use | Adult | Female | Oncogene Proteins, Viral - genetics | Papillomavirus Infections - virology | Human papillomavirus 18 - genetics | DNA-Binding Proteins - immunology | Papillomavirus Vaccines - therapeutic use | Double-Blind Method | Repressor Proteins - genetics | Treatment Outcome | Uterine Cervical Neoplasms - drug therapy | Vaccines, DNA - therapeutic use | DNA-Binding Proteins - genetics | Cervical Intraepithelial Neoplasia - virology | Cancer Vaccines - immunology | Repressor Proteins - immunology | Papillomavirus Infections - drug therapy | Uterine Cervical Neoplasms - virology | Papillomavirus Vaccines - immunology | Oncogene Proteins, Viral - immunology | Human papillomavirus 16 - genetics | Proteins | Cervix dysplasia | DNA | Clinical trials | Product development | Vaccines | Health aspects | Papillomavirus infections | Medical research | Analysis | Medicine, Experimental | Human papillomavirus | Immunization | Womens health | Immunotherapy | Genomes | Cervical cancer | Deoxyribonucleic acid--DNA
Journal Article
Virology, ISSN 0042-6822, 2016, Volume 500, pp. 218 - 225
Abstract Human Papillomavirus E6 and E7 play critical roles in cancer development, although not all isolates of the viral oncoproteins are identical... 
Infectious Disease | pRb | CKII phosphorylation | TBP | HPV | ONCOPROTEIN | PROTEIN | HUMAN-PAPILLOMAVIRUS TYPE-16 | SEQUENCE VARIATION | PHOSPHORYLATION | RETINOBLASTOMA TUMOR-SUPPRESSOR | 16 E6 | E7 | COMPLEX-FORMATION | VIROLOGY | ADENOVIRUS E1A | DEGRADATION | Phosphorylation | Human papillomavirus 16 - physiology | Humans | Retinoblastoma Protein - metabolism | Amino Acid Motifs | Papillomavirus E7 Proteins - genetics | Papillomavirus Infections - genetics | TATA-Box Binding Protein - metabolism | Papillomavirus E7 Proteins - metabolism | TATA-Box Binding Protein - genetics | Papillomavirus Infections - metabolism | Retinoblastoma Protein - genetics | Protein Binding | Papillomavirus E7 Proteins - chemistry | Papillomavirus Infections - virology | Human papillomavirus 16 - chemistry | Binding Sites | Human papillomavirus 16 - genetics | Cell Transformation, Viral | Papillomavirus infections | Human papillomavirus 16/physiology | Papillomavirus Infections/virology | Papillomavirus Infections/metabolism | Papillomavirus E7 Proteins/metabolism | TATA-Box Binding Protein/metabolism | Retinoblastoma Protein/genetics | Virology | Life Sciences | Microbiology and Parasitology | Human health and pathology | TATA-Box Binding Protein/genetics | Papillomavirus E7 Proteins/chemistry | Human papillomavirus 16/chemistry | Papillomavirus E7 Proteins/genetics | Human papillomavirus 16/genetics | Retinoblastoma Protein/metabolism | Papillomavirus Infections/genetics | Cancer
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2013, Volume 8, Issue 4, p. e61473
Background: The E7 protein of the Human Papillomavirus (HPV) type 16, being involved in malignant cellular transformation, represents a key antigen for developing therapeutic vaccines against HPV-related lesions and cancers... 
TRANSFORMATION | ANTICANCER ACTIVITY | PLANT | ONCOPROTEIN | PROTEIN | MULTIDISCIPLINARY SCIENCES | PURIFICATION | CHLOROPLAST | CERVICAL-CANCER | REINHARDTII | EXPRESSION | Recombinant Fusion Proteins - immunology | Papillomavirus Vaccines - genetics | Humans | Papillomavirus E7 Proteins - immunology | Human papillomavirus 16 - immunology | Antibodies, Viral - blood | Papillomavirus E7 Proteins - genetics | Chlamydomonas reinhardtii - genetics | Papillomavirus Infections - immunology | Female | 3' Untranslated Regions | Papillomavirus Vaccines - administration & dosage | Chloroplasts - genetics | Recombinant Fusion Proteins - administration & dosage | Uterine Cervical Neoplasms - mortality | Antibodies, Viral - biosynthesis | Vaccines, Subunit | Mice, Inbred C57BL | Uterine Cervical Neoplasms - prevention & control | Uterine Cervical Neoplasms - immunology | Papillomavirus Infections - mortality | Animals | Papillomavirus E7 Proteins - administration & dosage | 5' Untranslated Regions | Papillomavirus Infections - prevention & control | Survival Analysis | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Antibodies, Viral - immunology | Papillomavirus Vaccines - immunology | Mice | Human papillomavirus 16 - genetics | Antigens | Vaccination | Genomics | Development and progression | Biological products industry | T cells | Cancer vaccines | Proteins | Papillomaviruses | Analysis | Health aspects | Papillomavirus infections | Tumors | Cell proliferation | Transformation | Animal models | Protein purification | Homologous recombination | Clinical trials | Cytotoxicity | Homology | Genomes | Lymphocytes T | Vaccines | E7 protein | Human papillomavirus | Chloroplasts | Lesions | Good Manufacturing Practice | Algae | Plant protection | Regression analysis | Gene expression | Economic development | Virology | Immunogenicity | 3' Untranslated regions | Affinity | Cervical cancer
Journal Article
Journal Article
Oncogene, ISSN 1476-5594, 2007, Volume 27, Issue 18, pp. 2575 - 2582
Human papillomaviruses (HPVs) are involved in the pathogenesis of cancer of the cervix (CaCx). MicroRNA (miRNA) expression analysis using Ambion (Austin, TX,... 
microRNA | HPVs | Oncogene | Cervical cancer | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | oncogene | cervical cancer | CANCER | P53 | HPV | CELL BIOLOGY | GENOMIC INSTABILITY | ONCOLOGY | LAMININ-5 | GENETICS & HEREDITY | GENE-EXPRESSION | TUMOR-SUPPRESSOR | Cell Adhesion Molecules - genetics | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Regulation, Neoplastic | Human papillomavirus 6 - genetics | Papillomavirus E7 Proteins | Gene Expression Profiling | Repressor Proteins - antagonists & inhibitors | Oncogene Proteins, Viral - antagonists & inhibitors | Uterine Cervical Neoplasms - metabolism | Cell Transformation, Viral - genetics | Female | Oncogene Proteins, Viral - genetics | Cell Adhesion Molecules - biosynthesis | Repressor Proteins - genetics | MicroRNAs - biosynthesis | Uterine Cervical Neoplasms - genetics | Oncogene Proteins, Viral - biosynthesis | Human papillomavirus 16 - metabolism | Human papillomavirus 6 - metabolism | Papillomavirus Infections - genetics | RNA, Neoplasm - biosynthesis | Repressor Proteins - biosynthesis | Papillomavirus Infections - metabolism | RNA, Neoplasm - genetics | Uterine Cervical Neoplasms - virology | Biomarkers, Tumor - genetics | MicroRNAs - genetics | HeLa Cells | Human papillomavirus 16 - genetics | Biomarkers, Tumor - biosynthesis | Papillomaviruses | Complications and side effects | RNA | Physiological aspects | Genetic aspects | Research | Health aspects | Papillomavirus infections | Risk factors | Cell culture | Oncology | Genetics | Human papillomavirus | Ribonucleic acid--RNA
Journal Article
JNCI : Journal of the National Cancer Institute, ISSN 1460-2105, 2008, Volume 100, Issue 6, pp. 407 - 420
Journal Article
The Lancet (British edition), ISSN 0140-6736, 2013, Volume 382, Issue 9895, pp. 889 - 899
Summary Cervical cancer is caused by human papillomavirus infection. Most human papillomavirus infection is harmless and clears spontaneously but persistent infection with high-risk human papillomavirus (especially type 16... 
Internal Medicine | WOMEN | POPULATION | MEDICINE, GENERAL & INTERNAL | PERSISTENCE | DNA | VACCINE | HPV INFECTION | FOLLOW-UP | RISK | CYTOLOGY | INTRAEPITHELIAL NEOPLASIA | Human papillomavirus 18 - immunology | Human papillomavirus 6 - immunology | Humans | Uterine Cervical Neoplasms - epidemiology | Human papillomavirus 11 - ultrastructure | Uterine Cervical Neoplasms - pathology | Human papillomavirus 16 - immunology | Human papillomavirus 6 - ultrastructure | Papillomavirus Infections - pathology | Papillomavirus Infections - immunology | Female | Papillomavirus Infections - virology | Human papillomavirus 11 - immunology | Human papillomavirus 16 - ultrastructure | Human papillomavirus 11 - pathogenicity | Papillomavirus Vaccines - administration & dosage | Human papillomavirus 6 - pathogenicity | Human papillomavirus 16 - pathogenicity | Cross-Sectional Studies | Papillomavirus Infections - epidemiology | Uterine Cervical Neoplasms - prevention & control | Uterine Cervical Neoplasms - immunology | Vaginal Smears | Mass Screening | Virus Replication | Human papillomavirus 18 - pathogenicity | Papillomavirus Infections - prevention & control | Uterine Cervical Neoplasms - virology | Human papillomavirus 18 - ultrastructure | Papillomavirus Vaccines - immunology | Developing Countries | Cell Transformation, Neoplastic - pathology | Cell Transformation, Viral | Prevention | Papillomaviruses | Usage | Vaccines | Properties | Papillomavirus infections | Risk factors | Cervical cancer | Studies | Human papillomavirus | Immunization | Cellular biology | Womens health | Medical screening | Epidemiology | Age
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, p. e0183177
High-risk human papillomaviruses (hr-HPVs) cause cervical cancer, the fourth most common cancer in women worldwide. A HPV-16 candidate therapeutic vaccine,... 
PHARMACEUTICAL PROTEINS | ANTICANCER ACTIVITY | LOCALIZATION | MULTIDISCIPLINARY SCIENCES | PURIFICATION | VIRUS-LIKE PARTICLES | PLANTS | INFECTION | MONOCLONAL-ANTIBODIES | IDENTIFICATION | YOUNG-WOMEN | Papillomavirus Vaccines - genetics | Humans | Papillomavirus E7 Proteins - immunology | Peptides - genetics | Papillomavirus Vaccines - biosynthesis | Human papillomavirus 16 - immunology | Recombinant Proteins - biosynthesis | Papillomavirus E7 Proteins - genetics | Peptides - metabolism | Escherichia coli - metabolism | Agrobacterium - metabolism | Papillomavirus Infections - immunology | Female | Papillomavirus Infections - virology | Papillomavirus E7 Proteins - biosynthesis | Human papillomavirus 16 - chemistry | Chloroplasts - genetics | Gene Expression | Genetic Vectors - chemistry | Tobacco - metabolism | Peptides - immunology | Uterine Cervical Neoplasms - prevention & control | Genetic Vectors - metabolism | Uterine Cervical Neoplasms - immunology | Gene Silencing - immunology | Recombinant Proteins - genetics | Chloroplasts - metabolism | Recombinant Proteins - immunology | Escherichia coli - genetics | Papillomavirus Infections - prevention & control | Tobacco - genetics | Agrobacterium - genetics | Uterine Cervical Neoplasms - virology | Papillomavirus Vaccines - immunology | Care and treatment | Dosage and administration | Cell membranes | Vaccines | Research | Tobacco (Plant) | Papillomavirus infections | Risk factors | Cancer | Peptides | Laboratories | Infections | Biology | E7 protein | Optimization | Developing countries--LDCs | Proteins | Leaves | Human papillomavirus | Replicating | Chloroplasts | Affinity chromatography | Bacteria | Localization | Expression vectors | Immunization | Health risks | Cervix | Gene expression | Suppressors | Chromatography | Studies | Gene silencing | Observatories | Genetic engineering | Cervical cancer | Tumors | Costs | Developing countries | LDCs
Journal Article