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Cell Metabolism, ISSN 1550-4131, 2010, Volume 12, Issue 1, pp. 65 - 77
Obesity-induced inflammation is critical for the development of insulin resistance. Here, we show that genetic inactivation of PKCζ in vivo leads to a... 
HUMDISEASE
Journal Article
Neuron, ISSN 0896-6273, 06/2007, Volume 54, Issue 5, pp. 713 - 720
The apolipoprotein E (APOE) ε4 allele is the best established genetic risk factor for late-onset Alzheimer's disease (LOAD). We conducted genome-wide surveys... 
HUMDISEASE | MOLNEURO
Journal Article
Cell Metabolism, ISSN 1550-4131, 2010, Volume 11, Issue 4, pp. 320 - 330
G α, the G protein that mediates receptor-stimulated cAMP generation, has been implicated as a regulator of adipogenesis and adipose tissue function.... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 2010, Volume 11, Issue 3, pp. 194 - 205
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triacylglycerol (TAG) hydrolysis in adipocytes. The precise mechanisms whereby ATGL is... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 12/2009, Volume 10, Issue 6, pp. 455 - 465
Long-term (72 hr) exposure of pancreatic islets to palmitate inhibited glucose-induced insulin secretion by >50% with first- and second-phase secretion being... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 2008, Volume 7, Issue 3, pp. 227 - 235
Alcohol-induced fatty liver, a major cause of morbidity, has been attributed to enhanced hepatic lipogenesis and decreased fat clearance of unknown mechanism.... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 2008, Volume 7, Issue 5, pp. 456 - 465
Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2 diabetes. Moreover, obesity and... 
HUMDISEASE
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 53, Issue 3, pp. 439 - 452
Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of... 
HUMDISEASE | MOLNEURO | SIGNALING
Journal Article
Cell Metabolism, ISSN 1550-4131, 2007, Volume 5, Issue 5, pp. 331 - 344
and mutations have been reported to cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder characterized by hyperkalemia and... 
HUMDISEASE
Journal Article
Cell, ISSN 0092-8674, 05/2008, Volume 133, Issue 4, pp. 727 - 741
and are tumor suppressors frequently mutated in human tumors. In a high-throughput screen in mice for mutations collaborating with either or deficiency, we... 
SYSBIO | HUMDISEASE | SIGNALING | Resource
Journal Article
Cell Metabolism, ISSN 1550-4131, 03/2010, Volume 11, Issue 3, pp. 194 - 205
Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme for triacylglycerol (TAG) hydrolysis in adipocytes. The precise mechanisms whereby ATGL is... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 2009, Volume 10, Issue 1, pp. 13 - 26
Accumulation of unfolded protein within the endoplasmic reticulum (ER) attenuates mRNA translation through PERK-mediated phosphorylation of eukaryotic... 
HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2007, Volume 5, Issue 5, pp. 331 - 344
WNK1 and WNK4 mutations have been reported to cause pseudohypoaldosteronism type II (PHAII), an autosomal-dominant disorder characterized by hyperkalemia and... 
HUMDISEASE
Journal Article
Cell, ISSN 0092-8674, 02/2010, Volume 140, Issue 4, pp. 477 - 490
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor NF2, inhibits mitogenic signaling at or near the plasma membrane.... 
HUMDISEASE | SIGNALING
Journal Article
Neuron, ISSN 0896-6273, 11/2006, Volume 52, Issue 4, pp. 679 - 690
Zn is thought to modulate neurotransmission by affecting currents mediated by ligand-gated ion channels and transmitter reuptake by Na -dependent transporter... 
HUMDISEASE | MOLNEURO | SIGNALING
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 140, Issue 4, pp. 477 - 490
Current models imply that the FERM domain protein Merlin, encoded by the tumor suppressor , inhibits mitogenic signaling at or near the plasma membrane. Here,... 
HUMDISEASE | SIGNALING
Journal Article
Molecular Cell, ISSN 1097-2765, 2010, Volume 37, Issue 3, pp. 333 - 343
WEE1 (Swe1), the only “true” tyrosine kinase in budding yeast, is an Hsp90 client protein. Here we show that Swe1 phosphorylates a conserved tyrosine residue... 
HUMDISEASE | PROTEINS
Journal Article
Cell Metabolism, ISSN 1550-4131, 2010, Volume 11, Issue 4, pp. 273 - 285
The endocannabinoid system (ECS) plays a critical role in obesity development. The pharmacological blockade of cannabinoid receptor type 1 (CB ) has been shown... 
MOLNEURO | HUMDISEASE
Journal Article
Cell Metabolism, ISSN 1550-4131, 2007, Volume 6, Issue 2, pp. 137 - 143
Th1 cytokines promote monocyte differentiation into proatherogenic M1 macrophages, while Th2 cytokines lead to an “alternative” anti-inflammatory M2 macrophage... 
HUMDISEASE | DIFFERENTIATION | RECEPTORS | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | CELL BIOLOGY
Journal Article
20.