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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2009, Volume 106, Issue 22, pp. 8923 - 8928
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 108 - 111
Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and... 
PATHOGENESIS | CELLS | PROTEIN | MULTIDISCIPLINARY SCIENCES | MACHADO-JOSEPH-DISEASE | MUTANT HUNTINGTIN | ATAXIN-3 | INTRANUCLEAR INCLUSIONS | LC3 | MOUSE MODELS | AGGREGATION | Humans | Ubiquitin - metabolism | Male | Neurons - cytology | Autophagy | Brain - metabolism | Peptides - metabolism | Protein Domains | Ataxin-3 - chemistry | Female | Food Deprivation | Neurons - metabolism | Protein Stability | Ataxin-3 - metabolism | Disease Models, Animal | Binding, Competitive | Cell Line | Ataxin-3 - deficiency | Huntingtin Protein - metabolism | Mice, Inbred C57BL | Phagosomes - metabolism | Cells, Cultured | Mutant Proteins - genetics | Exons - genetics | Mutant Proteins - metabolism | Huntington Disease - metabolism | Huntingtin Protein - chemistry | Animals | Mutant Proteins - chemistry | Brain - pathology | Huntington Disease - genetics | Protein Binding | Mice | Huntingtin Protein - genetics | Mutation | Proteasome Endopeptidase Complex - metabolism | Beclin-1 - metabolism | Ataxin-3 - genetics | Physiological aspects | Autophagy (Cytology) | Neural circuitry | Observations | Huntingtons disease | Competition | Biotechnology | Huntingtin | Toxicity | Pathogenesis | Impairment | Biosynthesis | Kinases | Experiments | Degradation | Proteins | Scholarships & fellowships | Ataxin | Rodents | Spinocerebellar ataxia | Ataxia | Biocompatibility | Trinucleotide repeat diseases | Medical research | Starvation | Neurodegenerative diseases | Polyglutamine diseases | Huntington's disease | Neurological diseases | Machado-Joseph disease | Cell lines | Scientific imaging | Mass spectrometry | Phagocytosis | Index Medicus
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 08/2012, Volume 37, Issue 2, pp. 223 - 234
Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous... 
IMMUNITY | MYCOBACTERIUM-TUBERCULOSIS INFECTION | MUTANT HUNTINGTIN | P62/SQSTM1 | ADAPTER | INNATE | KAPPA-B | IMMUNOLOGY | PROTEINS | HUNTINGTONS-DISEASE | CELL | Green Fluorescent Proteins | Phosphorylation | Mycobacterium bovis - immunology | Microtubule-Associated Proteins - genetics | Sequestosome-1 Protein | Humans | rab GTP-Binding Proteins - genetics | Serine - immunology | Autophagy - immunology | Phagosomes - immunology | Interleukin-1beta - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - immunology | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Phagosomes - drug effects | Heat-Shock Proteins - metabolism | Phagosomes - metabolism | Interleukin-1beta - immunology | Microtubule-Associated Proteins - antagonists & inhibitors | Serine - metabolism | Heat-Shock Proteins - immunology | Tuberculosis - immunology | Microscopy, Confocal | Autophagy-Related Protein 7 | Macrophages - metabolism | Animals | rab GTP-Binding Proteins - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Mice | RNA, Small Interfering | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Research | Universities and colleges | Macrophages | Oncology, Experimental | Cancer | Proteins | Antimicrobial agents | Microscopy | Kinases | Autophagy | Rodents | Index Medicus | Pathogens | BCG | Interleukin 1 | Phagosomes | Inflammation | Immunity | Organelles | Phagocytosis | membrane trafficking
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6768 - 6768
The brain has a limited capacity to self-protect against protein aggregate-associated pathology, and mounting evidence supports a role for phagocytic glia in... 
MOTOR-NEURONS | CELLS | IN-VITRO | ACTIVATION | ENGULFMENT | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | DISEASE | TAU | PATHOLOGY | PROPAGATION | Protein Aggregates | Neurons - pathology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Neuroglia - pathology | Humans | Huntington Disease - pathology | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Brain - metabolism | Drosophila melanogaster - metabolism | Molecular Mimicry | Membrane Proteins - metabolism | Neurons - metabolism | Protein Aggregation, Pathological - genetics | Genes, Reporter | Disease Models, Animal | Neuroglia - chemistry | Prions - metabolism | Neurons - chemistry | Signal Transduction | Membrane Proteins - genetics | Bacterial Proteins - genetics | Gene Expression Regulation | Prions - chemistry | Huntington Disease - metabolism | Disease Progression | Huntingtin Protein | Animals | Brain - pathology | Huntington Disease - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Neuroglia - metabolism | Drosophila Proteins - genetics | Mutation | Phagocytosis | Protein Aggregation, Pathological - metabolism | Luminescent Proteins - metabolism | Draper protein | Neuroprotection | Brain | Huntingtin | Neurodegenerative diseases | Pathogenesis | Drosophila | Conversion | Neuronal-glial interactions | Proteins | Neurological diseases | Phagocytes | Signal transduction | Aggregates | Insects | Cytoplasm | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 07/2011, Volume 43, Issue 1, pp. 19 - 32
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 11/2015, Volume 88, Issue 4, pp. 667 - 677
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2015, Volume 17, Issue 3, pp. 262 - 275
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2016, Volume 63, Issue 6, pp. 951 - 964
Huntington’s disease is one of several neurodegenerative disorders characterized by the aggregation of polyglutamine (polyQ)-expanded mutant protein. How polyQ... 
POLYGLUTAMINE | PROTEIN | FUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUTANT HUNTINGTIN | PHASE-TRANSITION | DISEASE | MUTATIONS | INCLUSION-BODY FORMATION | AGGREGATION | PROTEOSTASIS | CELL BIOLOGY | Protein Aggregates | Neurons - pathology | Humans | Protein Multimerization | Peptides - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Ribosomal Proteins - metabolism | Peptides - metabolism | Neurons - metabolism | Gene Ontology | Green Fluorescent Proteins - metabolism | Gene Expression | HSP40 Heat-Shock Proteins - metabolism | HSP40 Heat-Shock Proteins - genetics | Peptides - chemistry | Ribosomal Proteins - genetics | Huntingtin Protein - metabolism | Molecular Sequence Annotation | Bacterial Proteins - genetics | Solubility | Spectrometry, Fluorescence | Single Molecule Imaging - methods | Protein Interaction Mapping | Animals | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | HeLa Cells | Huntingtin Protein - genetics | Mutation | Luminescent Proteins - metabolism | Ubiquitin | Fluorescence spectroscopy | Nervous system diseases | RNA | Heat shock proteins | Fluorescence | Biosynthesis | Genetic transcription | Oligomers | Analysis | Cellular signal transduction | Research institutes | Binding proteins | Protein binding | Index Medicus
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 02/2010, Volume 17, Issue 2, pp. 268 - 277
Apoptotic cell death is mediated by caspase activation. Autophagy involves the sequestration of cytoplasmic contents into autophagosomes for traffic to... 
Caspase | Cleavage | Autophagy |