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Autophagy, ISSN 1554-8627, 04/2019, Volume 15, Issue 4, pp. 742 - 743
WIPI2 contributes to autophagy by recruiting the ATG12-ATG5-ATG16L1 complex to PtdIns3P-rich membranes, which enables the growth and elongation of phagophores.... 
HUWE1 | MTORC1 | WIPI2 | ubiquitination | Autophagy | CELL BIOLOGY
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2019, Volume 148, pp. 358 - 365
Glycine receptors (GlyRs) are pentameric proteins that consist of α (α1-α4) subunits and/or β subunit. In the spinal cord of adult animals, the majority of... 
Disinhibition | HUWE1 | Ubiquitination | Inflammatory pain | Glycine receptors | LIGASE HUWE1 | PHOSPHORYLATION | MULE | TRAFFICKING | PROLIFERATION | NEUROSCIENCES | GATES | E3 LIGASE | NEURONS | PHARMACOLOGY & PHARMACY | Ubiquitin | Glycine | Ligases
Journal Article
by Liu, F and Cao, L and Zhang, T and Chang, F and Xu, YJ and Li, Q and Deng, JC and Li, L and Shao, GZ
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ISSN 0006-291X, 06/2018, Volume 501, Issue 2, pp. 440 - 447
The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in diverse biological processes including DNA damage repair and apoptosis. Our previous... 
Proteasomal degradation | APOPTOSIS | CELLS | ACTIVATION | LIGASE HUWE1 | MULE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | HUWE1 | BRCA1 | RBAP46 | Ubiquitination | REPAIR | BIOPHYSICS | INTERACTS | RBBP7 | CUL4B
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 501, Issue 2, pp. 440 - 447
The E3 ubiquitin ligase HUWE1/Mule/ARF-BP1 plays an important role in diverse biological processes including DNA damage repair and apoptosis. Our previous... 
Proteasomal degradation | HUWE1 | Ubiquitination | RBBP7 | CUL4B
Journal Article
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 05/2012, Volume 14, Issue 5, pp. 477 - U80
Stem-cell functions require activation of stem-cell-intrinsic transcriptional programs and extracellular interaction with a niche microenvironment. How the... 
ADHESION | IN-VIVO | SELF-RENEWAL | VASCULAR NICHE | NEUROGENESIS | PROLIFERATION | BETA-GAMMA-SUBUNITS | UBIQUITIN LIGASE HUWE1 | CEREBRAL-CORTEX | BRAIN | CELL BIOLOGY
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2017, Volume 68, Issue 1, pp. 233 - 246.e5
Several ubiquitin chain types have remained unstudied, mainly because tools and techniques to detect these posttranslational modifications are scarce.... 
X-ray crystallography | mitophagy | HUWE1 | microscale thermophoresis | Mfn2 | Lys6-linked ubiquitin chains | affimer | Parkin | PARKIN | POLYUBIQUITIN | PROTEIN | RECOGNITION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPLACEMENT STRATEGY | CHAINS | DEUBIQUITINASE | LIGASE | CELL BIOLOGY | Humans | Ubiquitin - metabolism | Substrate Specificity | Crystallography, X-Ray | Mitochondrial Proteins - genetics | GTP Phosphohydrolases - chemistry | Ubiquitination | Mitochondrial Proteins - metabolism | Cloning, Molecular | Escherichia coli - metabolism | HEK293 Cells | Carrier Proteins - chemistry | Lysine - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Recombinant Proteins - metabolism | Gene Expression | Protein Structure, Secondary | Signal Transduction | Ubiquitin - chemistry | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Ubiquitin - genetics | Ubiquitin-Protein Ligases - chemistry | Amino Acid Motifs | Carrier Proteins - genetics | Molecular Probes - chemistry | Carrier Proteins - metabolism | GTP Phosphohydrolases - metabolism | Escherichia coli - genetics | GTP Phosphohydrolases - genetics | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Protein Binding | Protein Processing, Post-Translational | HeLa Cells | Kinetics | Lysine - chemistry | Ubiquitin-Protein Ligases - genetics | Tumor Suppressor Proteins | Ubiquitin | Structure | Ligases | Fluorescence microscopy | Crystals | Viral antibodies | Chemical tests and reagents | Fluorescence | Antibodies | Nucleic acids | Molecular biology
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 4625 - 13
The proneural transcription factor Ascl1 is a master regulator of neurogenesis, coordinating proliferation and differentiation in the central nervous system.... 
PRONEURAL PROTEINS | REGULATES NEUROGENESIS | STEM-CELLS | STABILITY | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | NEURONAL DIFFERENTIATION | BHLH PROTEINS | MECHANISMS | UBIQUITIN LIGASE HUWE1 | MULTIPOTENCY | ASCL1 protein | Ubiquitin | Translation | Chromatin | Central nervous system | Post-translation | Helix-loop-helix proteins | Neurogenesis | Ubiquitin-protein ligase | Cytoplasm | Huwe1 protein
Journal Article
Genes and Development, ISSN 0890-9369, 05/2013, Volume 27, Issue 10, pp. 1101 - 1114
Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or... 
Huwe1 | c-Myc | Mule | Ras | p21 | Miz1 | DNA-DAMAGE | KERATINOCYTE GROWTH | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | BASE EXCISION-REPAIR | HUWE1 UBIQUITIN LIGASE | NEGATIVE REGULATION | GENETICS & HEREDITY | ARF TUMOR-SUPPRESSOR | DIFFERENTIATION | MIZ-1 | HUMAN CANCER | Protein Inhibitors of Activated STAT - deficiency | Tetradecanoylphorbol Acetate - pharmacology | 9,10-Dimethyl-1,2-benzanthracene - pharmacology | Male | Protein Inhibitors of Activated STAT - metabolism | Cyclin-Dependent Kinase Inhibitor p15 - biosynthesis | Oncogene Protein p21(ras) - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Oncogene Protein p21(ras) - antagonists & inhibitors | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cell Transformation, Neoplastic - genetics | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Nuclear Proteins - deficiency | Protein Inhibitors of Activated STAT - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Nuclear Proteins - genetics | Protein Inhibitors of Activated STAT - antagonists & inhibitors | Skin Neoplasms - pathology | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | Signal Transduction | Down-Regulation | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Skin Neoplasms - chemically induced | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Skin Neoplasms - metabolism | Keratinocytes - pathology | Animals | Tumor Suppressor Protein p53 | Keratinocytes - drug effects | Keratinocytes - metabolism | Nuclear Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-myc - deficiency | Skin Neoplasms - genetics | Proto-Oncogene Proteins c-myc - antagonists & inhibitors | Ubiquitin-Protein Ligases - deficiency | Mice | Proto-Oncogene Proteins c-myc - genetics | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Genes, ras | Ubiquitin-Protein Ligases - genetics | Oncogene Protein p21(ras) - genetics | Carcinogenesis | Ras genes | Analysis | Research Paper
Journal Article
Scientific reports, ISSN 2045-2322, 04/2018, Volume 8, Issue 1, pp. 6010 - 1
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. 
Oxidative stress | Intellectual disabilities | Huwe1 protein
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 01/2018, Volume 26, Issue 1, pp. 64 - 74
Journal Article
Journal Article