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The Journal of biological chemistry, ISSN 1083-351X, 06/2004, Volume 279, Issue 26, pp. 26991 - 27007
Journal Article
Gut, ISSN 0017-5749, 01/2013, Volume 62, Issue 1, pp. 112 - 120
Objective Pancreatic ductal adenocarcinoma (PDA) is characterised by stromal desmoplasia and vascular dysfunction, which critically impair drug delivery. This... 
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Immunohistochemistry | Cell Adhesion Molecules - administration & dosage | Tissue Array Analysis | Pancreatic Neoplasms - blood supply | Antineoplastic Agents - administration & dosage | Hyaluronic Acid - physiology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Delivery Systems | Pancreatic Neoplasms - drug therapy | Hyaluronoglucosaminidase - administration & dosage | Carcinoma, Pancreatic Ductal - mortality | Cell Adhesion Molecules - pharmacology | Pancreatic Neoplasms - mortality | Doxorubicin - administration & dosage | Deoxycytidine - administration & dosage | Kaplan-Meier Estimate | Mice, Transgenic | Treatment Outcome | Biomarkers, Tumor - physiology | Recombinant Proteins - pharmacology | Recombinant Proteins - administration & dosage | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Pancreatic Ductal - physiopathology | Mice | Carcinoma, Pancreatic Ductal - blood supply | Pancreatic Neoplasms - physiopathology | Drug Resistance, Neoplasm - physiology | Deoxycytidine - analogs & derivatives | Drug Resistance, Neoplasm - drug effects | Care and treatment | Blood-vessels | Pancreatic cancer | Patient outcomes | Physiological aspects | Models | Research | Hyaluronic acid | Tumors | Studies | Angiogenesis | Medical research | Medical prognosis | Cytotoxicity | Extracellular matrix | Permeability | Kinases | Vascular endothelial growth factor | Index Medicus | Abridged Index Medicus | stem cells | cell death | cancer vaccines | hyaluronan | epithelial cell growth | cancer immunobiology | drug delivery | matrix | epithelial cell adhesion | cancer genetics | carcinogenesis | pancreatic fibrosis | pharmacology | pharmacokinetics | tumour microenvironment | cancer | fibrosis | pancreatic disease | Original | 1506 | pancreatic tumours | extracellular matrix | oxidative stress
Journal Article
Journal Article
Biomacromolecules, ISSN 1525-7797, 10/2013, Volume 14, Issue 10, pp. 3581 - 3588
Injectable hydrogels are useful in biomedical applications. We have synthesized hyaluronic acids chemically modified with azide groups (HA–A) and cyclooctyne... 
Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Chemistry, Organic | Life Sciences & Biomedicine | Polymer Science | Science & Technology | Biocompatible Materials - metabolism | NIH 3T3 Cells | Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry | Hyaluronoglucosaminidase - metabolism | Biocompatible Materials - chemistry | Cross-Linking Reagents - pharmacology | Hyaluronic Acid - pharmacology | Male | Structure-Activity Relationship | Azides - chemistry | Cross-Linking Reagents - chemical synthesis | Dose-Response Relationship, Drug | Injections, Subcutaneous | Alkynes - metabolism | Alkynes - pharmacology | Cyclooctanes - pharmacology | Hydrogel, Polyethylene Glycol Dimethacrylate - pharmacology | Molecular Structure | Azides - pharmacology | Azides - metabolism | Copper | Fibroblasts - metabolism | Hydrogel, Polyethylene Glycol Dimethacrylate - metabolism | Cell Survival - drug effects | Click Chemistry | Hyaluronic Acid - chemistry | Injections, Intraperitoneal | Cyclooctanes - metabolism | Alkynes - chemistry | Biocompatible Materials - pharmacology | Hyaluronoglucosaminidase - chemistry | Mice, Inbred ICR | Cross-Linking Reagents - metabolism | Animals | Cyclization | Fibroblasts - drug effects | Hyaluronic Acid - metabolism | Cyclooctanes - chemistry | Hydrogel, Polyethylene Glycol Dimethacrylate - chemical synthesis | Mice | Index Medicus
Journal Article
Cancer cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 418 - 429
Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates... 
Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Adenocarcinoma - pathology | Cell Adhesion Molecules - administration & dosage | Stromal Cells - pathology | Pancreatic Neoplasms - blood supply | Deoxycytidine - pharmacology | Hyaluronic Acid - physiology | Polyethylene Glycols - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Stromal Cells - drug effects | Hyaluronoglucosaminidase - administration & dosage | Drug Evaluation, Preclinical | Hyaluronoglucosaminidase - therapeutic use | Tumor Microenvironment - drug effects | Animals, Genetically Modified | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Microvessels - drug effects | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Extracellular Fluid - drug effects | Polyethylene Glycols - administration & dosage | Adenocarcinoma - blood supply | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hyaluronic Acid - metabolism | Mice | Carcinoma, Pancreatic Ductal - blood supply | Cell Adhesion Molecules - therapeutic use | Deoxycytidine - analogs & derivatives | Enzymes | Medical colleges | Care and treatment | Glycosaminoglycans | Oncology, Experimental | Research | Chemotherapy | Universities and colleges | Drug therapy | Hyaluronic acid | Public health | Tumors | Cancer | Index Medicus
Journal Article
Current topics in medicinal chemistry, ISSN 1568-0266, 09/2016, Volume 16, Issue 23, pp. 2525 - 2531
Journal Article