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Toxicology, ISSN 0300-483X, 2006, Volume 217, Issue 2, pp. 213 - 220
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 03/2006, Volume 26, Issue 11, pp. 2862 - 2870
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function... 
Arachidonic acid metabolites | Retina | Calcium | Glia | ATP | Blood flow | arachidonic acid metabolites | NEURONAL-ACTIVITY | 20-HETE | calcium | RAT | ASTROCYTE-MEDIATED CONTROL | CALCIUM WAVES | ARACHIDONIC-ACID | glia | NEUROSCIENCES | HEMODYNAMIC-RESPONSE | retina | NITRIC-OXIDE | blood flow | MULLER CELLS | BRAIN | Arterioles - physiology | Cytochrome P-450 Enzyme Inhibitors | Rats, Long-Evans | Arterioles - enzymology | Nitric Oxide Synthase - physiology | Male | Vasodilation - radiation effects | Retinal Vessels - enzymology | Retinal Vessels - physiology | Hydroxyeicosatetraenoic Acids - biosynthesis | Vasoconstriction - radiation effects | Photolysis | Cyclic N-Oxides - pharmacology | Inositol 1,4,5-Trisphosphate - analogs & derivatives | Eye Proteins - antagonists & inhibitors | Purinergic Antagonists | Signal Transduction - radiation effects | Cytochrome P-450 Enzyme System - physiology | Hydrazines - pharmacology | Rats | Imidazoles - pharmacology | Retinal Vessels - drug effects | Arterioles - drug effects | Vasoconstriction - drug effects | Cytochrome P-450 CYP4A - physiology | Signal Transduction - drug effects | Miconazole - pharmacology | Eye Proteins - physiology | Retinal Vessels - radiation effects | Vasodilation - drug effects | Arterioles - radiation effects | Nitric Oxide - pharmacology | Caproates - pharmacology | Vasomotor System - drug effects | Nitric Oxide Synthase - antagonists & inhibitors | Inositol 1,4,5-Trisphosphate - pharmacology | Adenosine Triphosphate - pharmacology | Vasoconstriction - physiology | 8,11,14-Eicosatrienoic Acid - analogs & derivatives | Proadifen - pharmacology | Nitric Oxide Donors - pharmacology | Vasodilation - physiology | 8,11,14-Eicosatrienoic Acid - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Calcium Signaling - radiation effects | Cytochrome P-450 CYP4A - antagonists & inhibitors | Neuroglia - physiology | Nitric Oxide - physiology | Vasomotor System - radiation effects | Animals | Vasomotor System - physiology | Amidines - pharmacology | In Vitro Techniques
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 309 - 317
Abstract In previous studies we demonstrated that targeting the nuclear exporter protein exportin-1 (CRM1/XPO1) by a selective inhibitor of nuclear export... 
Hematology, Oncology and Palliative Medicine | NHL | XPO1 | Selective inhibitors of nuclear export | SINE | CRM1 | Exportin-1 | SURVIVAL | DRUG-RESISTANCE | MODEL | CANCER | STRATEGIES | ONCOLOGY | LINE | CHOP | PROTEINS | Vincristine - pharmacology | TOR Serine-Threonine Kinases - metabolism | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Humans | Lymphoma, Non-Hodgkin - enzymology | Lymphoma, Non-Hodgkin - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dexamethasone - pharmacology | Time Factors | Oxadiazoles - pharmacology | Acrylamides - pharmacology | Lymphoma, Non-Hodgkin - drug therapy | Cell Survival - drug effects | Hydrazines - pharmacology | Everolimus - pharmacology | Mice, SCID | Mice, Inbred ICR | Drug Synergism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Tumor Burden - drug effects | Active Transport, Cell Nucleus - drug effects | Cyclophosphamide - pharmacology | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Prednisone - pharmacology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Karyopherins - antagonists & inhibitors | Doxorubicin - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | International trade | Cyclophosphamide | Care and treatment | Dexamethasone | Analysis | Lymphomas | Prednisone | Exports | Steroids | Cancer | Drugs | TOR protein | Animal models | Laboratories | Toxicity | Xenotransplantation | Clinical trials | Cytotoxicity | Kinases | Experiments | Anticancer properties | Proteins | Cell growth | Antitumor agents | Cell cycle | Xenografts | Biocompatibility | Localization | Drug dosages | NF-κB protein | Chronic lymphatic leukemia | Hematology | Pharmacology | Chemical compounds | Patients | Lymphoma | Nuclear transport | Studies | Inhibitors | Response rates | In vivo methods and tests | Apoptosis
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 05/2016, Volume 117, Issue 5, pp. 1240 - 1249
ABSTRACT We demonstrated that in human platelets the endocannabinoid 2‐arachidonoylglycerol (2‐AG) decreased dose‐ and time‐dependently cAMP intracellular... 
2‐ARACHIDONOYLGLYCEROL | HUMAN PLATELETS | PHOSPHODIESTERASE 3A | cAMP | 2-ARACHIDONOYLGLYCEROL | CELLS | ACTIVATION | PHOSPHORYLATION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCANNABINOID SYSTEM | ARACHIDONIC-ACID | CELL BIOLOGY | BLOOD-PLATELETS | CYCLIC-AMP | CB1 | CANNABINOID RECEPTOR-LIGAND | Endocannabinoids - pharmacology | Phosphodiesterase 3 Inhibitors - pharmacology | Humans | Maleimides - pharmacology | Type C Phospholipases - metabolism | Immunoblotting | Phosphatidylinositol 3-Kinases - metabolism | Cannabinoid Receptor Agonists - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Blood Platelets - cytology | Protein Kinase C - metabolism | Estrenes - pharmacology | Pyrrolidinones - pharmacology | Receptors, Thromboxane - antagonists & inhibitors | Indoles - pharmacology | Platelet Aggregation - drug effects | Blood Platelets - drug effects | Chromones - pharmacology | Cyclic AMP - metabolism | Milrinone - pharmacology | Hydrazines - pharmacology | Adenine - analogs & derivatives | Intracellular Space - drug effects | Adenylyl Cyclase Inhibitors - pharmacology | Cells, Cultured | Morpholines - pharmacology | Adenine - pharmacology | Protein Kinase C - antagonists & inhibitors | Adenylyl Cyclases - metabolism | Arachidonic Acids - pharmacology | Glycerides - pharmacology | Blood Platelets - metabolism | Intracellular Space - metabolism | Receptors, Thromboxane - metabolism
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2006, Volume 108, Issue 2, pp. 188 - 192
The methanol extract from Wall (Dipsacaceae) was found to show antioxidant activity against free radical and Cu -mediated LDL oxidation. In further study, to... 
Dicaffeoyl quinic acid | Low-density lipoprotein | Free radicals | Dipsacus asper Wall | Antioxidant | Dipsacaceae | antioxidant | free radicals | CHEMISTRY, MEDICINAL | LOW-DENSITY-LIPOPROTEIN | COPPER | dicaffeoyl quinic acid | IDENTIFICATION | low-density lipoprotein | PLANT SCIENCES | IN-VITRO | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | LDL OXIDATION | Free Radical Scavengers - pharmacology | Plant Extracts - chemistry | Gallic Acid - pharmacology | Antioxidants - chemistry | Chlorogenic Acid - pharmacology | Free Radical Scavengers - chemistry | Plant Extracts - pharmacology | Humans | Quinic Acid - isolation & purification | Caffeic Acids - pharmacology | Biphenyl Compounds - metabolism | Dose-Response Relationship, Drug | Chlorogenic Acid - analogs & derivatives | Copper - chemistry | Chlorogenic Acid - isolation & purification | Lipid Peroxidation - drug effects | Picrates | Lipoproteins, LDL - metabolism | Molecular Structure | Quinic Acid - pharmacology | Gallic Acid - analogs & derivatives | alpha-Tocopherol - pharmacology | Gallic Acid - chemistry | Methanol | Gallic Acid - isolation & purification | Malondialdehyde - metabolism | Quinic Acid - analogs & derivatives | Plants, Medicinal - chemistry | Dipsacaceae - chemistry | Copper - pharmacology | Quinic Acid - chemistry | Plant Extracts - isolation & purification | Thiobarbituric Acid Reactive Substances - metabolism | Antioxidants - pharmacology | Free Radical Scavengers - isolation & purification | Hydrazines - metabolism | Antioxidants - isolation & purification | Plant Roots - chemistry | Butylated Hydroxytoluene - pharmacology | Monosaccharides - pharmacology | Chlorogenic Acid - chemistry | Monosaccharides - chemistry | Monosaccharides - isolation & purification | Hydroxides | Derivatives (Financial instruments) | Free radicals (Chemistry) | Toluene | Low density lipoproteins | Pharmacy
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 2010, Volume 55, Issue 5, pp. 928 - 940
Diabetic nephropathy is the leading cause of end-stage renal disease, and both the incidence and prevalence of diabetic nephropathy continue to increase.... 
Nephrology | advanced glycation | Diabetic nephropathy | therapy | CONTROLLED-TRIAL | DB/DB MICE | PKC-BETA INHIBITOR | KINASE-C-ALPHA | CONVERTING ENZYME-INHIBITORS | TISSUE GROWTH-FACTOR | EARLY RENAL-DISEASE | UROLOGY & NEPHROLOGY | CROSS-LINK BREAKER | GLYCATION END-PRODUCTS | NADPH OXIDASE INHIBITOR | Receptors, Immunologic - physiology | Humans | Diabetic Nephropathies - drug therapy | Nitric Oxide Synthase - antagonists & inhibitors | Guanidines - pharmacology | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Diabetic Nephropathies - physiopathology | Transforming Growth Factor beta - antagonists & inhibitors | Pyridoxamine - pharmacology | Pentoxifylline - pharmacology | Diabetic Nephropathies - prevention & control | Receptor for Advanced Glycation End Products | Endothelin Receptor Antagonists | Glycosaminoglycans - pharmacology | Amides - pharmacology | Hydrazines - pharmacology | Kidney - drug effects | Connective Tissue Growth Factor - antagonists & inhibitors | Diabetic Nephropathies - metabolism | NADPH Oxidases - antagonists & inhibitors | Phosphodiesterase Inhibitors - pharmacology | Clinical Trials as Topic | Pyrimidines - pharmacology | Vitamin B Complex - pharmacology | Disease Progression | Animals | Glycation End Products, Advanced - pharmacology | Glycation End Products, Advanced - blood | Pyridines - pharmacology
Journal Article
Thorax, ISSN 0040-6376, 12/2011, Volume 66, Issue 12, pp. 1029 - 1035
Journal Article
Cardiovascular Research, ISSN 0008-6363, 4/2008, Volume 78, Issue 1, pp. 130 - 138
Aims The present study examined the hypothesis that prostaglandin E2 (PGE2) through activation of prostaglandin E (EP) receptor contributes to... 
Endothelium-derived contracting factor | Endothelial function | Endothelial factors | Vasoconstriction/dilation | Immunohistochemistry | Propionates - pharmacology | Rats, Inbred WKY | Endothelium, Vascular - drug effects | Xanthones - pharmacology | Vasodilation | Dose-Response Relationship, Drug | Phenylephrine - pharmacology | Potassium Chloride - pharmacology | Receptors, Thromboxane - antagonists & inhibitors | Prostaglandin Antagonists - pharmacology | Aorta, Thoracic - drug effects | Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide - pharmacology | Disease Models, Animal | Rats, Inbred SHR | Vasoconstrictor Agents - pharmacology | Dinoprostone - pharmacology | Hydrazines - pharmacology | Endothelium, Vascular - physiopathology | Aorta, Thoracic - metabolism | Rats | Aorta, Thoracic - physiopathology | Sulfonamides - pharmacology | Vasoconstriction - drug effects | Blotting, Western | Hypertension - physiopathology | Hypertension - metabolism | Naphthalenes - pharmacology | Dinoprostone - metabolism | Animals | Endothelium, Vascular - metabolism | Receptors, Prostaglandin E - antagonists & inhibitors | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Dinoprostone - analogs & derivatives | Receptors, Thromboxane - metabolism | Receptors, Prostaglandin E, EP1 Subtype | Carbazoles - pharmacology | Receptors, Prostaglandin E - metabolism
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 02/2012, Volume 19, Issue 4, pp. 569 - 612
There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory,... 
Antimicrobial | Antimalarial | Anti-trypnosomal | Hydrazide | Antioxidant | Antiarthritis | Diuretic | Analgesic | Biological activities | Synthesis | Antiviral | Hydrazone | Anticancer | Anti-inflammatory | Antimycobacterial | ANTIOXIDANT ACTIVITY | ANTIMYCOBACTERIAL ACTIVITY | DESIGN | IN-VITRO | ANTICONVULSANT ACTIVITY | PHARMACOLOGY & PHARMACY | HYDRAZONES | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACYLHYDRAZONE DERIVATIVES | ANTIMALARIAL ACTIVITY | PHARMACOLOGICAL EVALUATION | ANTIMICROBIAL ACTIVITY | Hydrazines - pharmacology | Antioxidants - chemistry | Anticonvulsants - chemical synthesis | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Anticonvulsants - pharmacology | Anti-Infective Agents - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hydrazines - chemistry | Hydrazines - chemical synthesis | Animals | Organometallic Compounds - chemical synthesis | Anti-Infective Agents - chemistry | Anticonvulsants - chemistry | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Organometallic Compounds - pharmacology
Journal Article