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1. Full Text Immobilization methods for the rapid total chemical synthesis of proteins on microtiter plates
by Zitterbart, Robert and Krumrey, Michael and Seitz, Oliver
Journal of Peptide Science, ISSN 1075-2617, 07/2017, Volume 23, Issue 7-8, pp. 539 - 548
The chemical synthesis of proteins typically involves the solid‐phase peptide synthesis of unprotected peptide fragments that are stitched together in solution... 
surface chemistry | hydrazone ligation | binding assay | protein synthesis | click chemistry | protein arrays | native chemical ligation | protein functional analysis | CHEMISTRY, ANALYTICAL | SOLID-PHASE SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-PURIFICATION | LIGATION | TERMINAL ALKYNES | PEPTIDE HYDRAZIDES | SH3 DOMAINS | POLYPEPTIDES | CYCLOADDITION | DESULFURIZATION | BOVINE SERUM-ALBUMIN | Chemistry Techniques, Synthetic | Peptides - chemical synthesis | Peptides - chemistry | Chromatography, Liquid | Proteins - chemistry | Proteins - chemical synthesis | Solid-Phase Synthesis Techniques - methods | Proteins | Analysis | Protein biosynthesis | Chemical synthesis | Methods | High performance liquid chromatography | Protein binding | Desulfurization | Chemical industry | Peptides | Saturation | Fragments | Immobilization | Fluorescence | Functional analysis | Liquid chromatography | High-performance liquid chromatography | Chromatography | Fragmentation | Solid phase methods | Cycloaddition | Nickel | Peptide synthesis | Laboratory apparatus | Plates | Desulfurizing | Index Medicus
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2. Full Text Thioether-Based Fluorescent Covalent Organic Framework for Selective Detection and Facile Removal of Mercury(II)
by Ding, San-Yuan and Dong, Ming and Wang, Ya-Wen and Chen, Yan-Tao and Wang, Huai-Zhen and Su, Cheng-Yong and Wang, Wei
Journal of the American Chemical Society, ISSN 0002-7863, 03/2016, Volume 138, Issue 9, pp. 3031 - 3037
Heavy metal ions are highly toxic and widely spread as environmental pollutants. New strategies are being developed to simultaneously detect and remove these... 
HG2 | CHEMOSENSOR | CHEMICAL SENSORS | OFF-ON | HEAVY-METALS | AQUEOUS-MEDIA | SINGLE-CRYSTAL STRUCTURE | METAL-IONS | CHEMISTRY, MULTIDISCIPLINARY | MERCURIC ION | WATER | Cations, Divalent - isolation & purification | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Photoelectron Spectroscopy | Mercury - analysis | Mercury - isolation & purification | Cations, Divalent - analysis | Sulfides - chemistry | Sulfides - chemical synthesis | Hydrazones - chemical synthesis | Hydrazones - chemistry | Magnetic Resonance Imaging | Macromolecular Substances - chemistry | Macromolecular Substances - chemical synthesis | Chemical properties | Chemical synthesis | Analysis | Organosulfur compounds | Mercury compounds | Index Medicus
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3. Full Text Synthesis and chemical reactivity of the novel 3-chloro-3-(4-chlorocoumarin-3-yl)prop-2-enal
by El-Kazak, Azza M and El-Gohary, Nasser M and Badran, Al-Shimaa and Ibrahim, Magdy A
Tetrahedron, ISSN 0040-4020, 07/2019, Volume 75, Issue 29, pp. 3923 - 3932
Vilsmeier-Haack formylation of 3-acetyl-4-hydroxycoumarin ( ) afforded the unexpected 3-chloro-3-(4-chlorocoumarin-3-yl)prop-2-enal ( ). Compound reacted with... 
Chromenopyrazoles | Cyclocondensation | Nucleophilic reaction | Coumarin | Pyrazolylcoumarin | Vilsmeier-Haack | ANTIMYCOBACTERIAL | DESIGN | CHEMISTRY, ORGANIC | MOLECULAR DOCKING | ANTICANCER | HYDRAZONE | BIOLOGICAL EVALUATION | COUMARIN-DITHIOCARBAMATE HYBRIDS | INHIBITORS | DERIVATIVES | FLUORESCENT-PROBE | Schiff bases
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4. Full Text Rhodium(III)‐Catalyzed CH Activation and Indole Synthesis With Hydrazone as an Auto‐Formed and Auto‐Cleavable Directing Group
by Zheng, Liyao and Hua, Ruimao
Chemistry – A European Journal, ISSN 0947-6539, 02/2014, Volume 20, Issue 8, pp. 2352 - 2356
An efficient, practical, and external‐oxidant‐free indole synthesis from readily available aryl hydrazines was developed, by using hydrazone as a directing... 
CH activation | indoles | NN cleavage | hydrazones | rhodium catalysis | N-N cleavage | C-H activation | CATALYZED OXIDATIVE ANNULATION | O BOND | EFFICIENT SYNTHESIS | INTERNAL ALKYNES | ISOQUINOLONE SYNTHESIS | CHEMISTRY, MULTIDISCIPLINARY | FUNCTIONALIZATION | CH activation | ANILINES | NN cleavage | OXIDANT | N BOND FORMATION | CYCLIZATION | Isoquinolines - chemistry | Heterocyclic Compounds - chemistry | Isoquinolines - chemical synthesis | Indoles - chemical synthesis | Heterocyclic Compounds - chemical synthesis | Molecular Structure | Catalysis | Indoles - chemistry | Hydrazones - chemistry | Rhodium - chemistry | Index Medicus | Hydrazines | Synthesis | Aromatic compounds | Hydrazones | Strategy | Activation | Indoles | Alkynes
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5. Full Text Catalytic 1,2-dihydronaphthalene and: E -aryl-diene synthesis via CoIII-Carbene radical and o -quinodimethane intermediates
by Te Grotenhuis, Colet and Das, Braja G and Kuijpers, Petrus F and Hageman, Wouter and Trouwborst, Mees and De Bruin, Bas
Chemical Science, ISSN 2041-6520, 2017, Volume 8, Issue 12, pp. 8221 - 8230
Catalytic synthesis of substituted 1,2-dihydronaphthalenes via metalloradical activation of o-styryl N-tosyl hydrazones ((E)-2-(prop-1-en-1-yl)benzene-N-tosyl... 
Trapping | Aromatic compounds | Benzene | Hydrazones | Catalysis | Dienes | Chemical synthesis | Cobalt | Substrates
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6. Full Text Accelerated Chemical Reactions and Organic Synthesis in Leidenfrost Droplets
by Bain, Ryan M and Pulliam, Christopher J and Thery, Fabien and Cooks, R. Graham
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2016, Volume 55, Issue 35, pp. 10478 - 10482
Leidenfrost levitated droplets can be used to accelerate chemical reactions in processes that appear similar to reaction acceleration in charged microdroplets... 
synthesis | mass spectrometry | reaction acceleration | reaction kinetics | Leidenfrost effect | STRONG ELECTRIC-FIELDS | FILM | CHEMISTRY | DYNAMICS | IONIZATION MASS-SPECTROMETRY | CHEMISTRY, MULTIDISCIPLINARY | ELECTROSPRAY-IONIZATION | Surface active agents | Chemical reaction, Rate of | Ionization | Mass spectrometry | Analysis | Chemical reactions | Multiplexing | Ketones | Vessels | Pyridinium | Condensation | Conversion | Condensates | Microreactors | Droplets | Acceleration | Chemical synthesis
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7. Full Text 1-Acylthiosemicarbazides, 1,2,4-triazole-5(4 H)-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones: Synthesis, analgesic-anti-inflammatory and antimicrobial activities
by Salgın-Gökşen, Umut and Gökhan-Kelekçi, Nesrin and Göktaş, Özgür and Köysal, Yavuz and Kılıç, Ekrem and Işık, Şamil and Aktay, Göknur and Özalp, Meral
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 17, pp. 5738 - 5751
A novel series of 1-acylthiosemicarbazides, 1,2,4-triazole-5-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones was synthesized... 
Thiosemicarbazide | Triazol | Hydrazone | Analgesic-anti-inflammatory and antimicrobial activities | Thiadiazole | 2-Benzoxazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | hydrazone | 2-benzoxazolinone | CYCLOOXYGENASE | analgesic-anti-inflammatory and antimicrobial | ACYLARYLHYDRAZONES | triazol | ACID-DERIVATIVES | IN-VITRO | thiosemicarbazide | ANTITUBERCULOSIS ACTIVITY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | activities | thiadiazole | NITRIC-OXIDE | 2-BENZOXAZOLINONE DERIVATIVES | AGENTS | ANTIFUNGAL | Analgesics - pharmacology | Triazoles - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Anti-Bacterial Agents - chemistry | Hydrazones - therapeutic use | Semicarbazides - pharmacology | Semicarbazides - chemistry | Anti-Inflammatory Agents - therapeutic use | Triazoles - chemical synthesis | Molecular Structure | Thiadiazoles - pharmacology | Triazoles - therapeutic use | Microbial Viability - drug effects | Anti-Inflammatory Agents - pharmacology | Models, Molecular | Edema - drug therapy | Hydrazones - chemical synthesis | Semicarbazides - therapeutic use | Hydrazones - chemistry | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Semicarbazides - chemical synthesis | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzoxazoles - chemistry | Thiadiazoles - chemical synthesis | Analgesics - chemistry | Hindlimb - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Mice | Methylation | Edema - pathology | Index Medicus
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8. Full Text Frontispiece: Catalytic Dibenzocyclooctene Synthesis via Cobalt(III)–Carbene Radical and ortho‐Quinodimethane Intermediates
by te Grotenhuis, Colet and van den Heuvel, Naudin and van der Vlugt, Jarl Ivar and de Bruin, Bas
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2018, Volume 57, Issue 1, p. n/a
Medium‐Ring Compounds In their Communication on page 140 ff., B. de Bruin et al. show that a cobalt(II) catalyst enables the synthesis of a series of unique... 
dibenzocyclooctenes | metalloradicals | quinodimethanes | ortho | cobalt | carbene radicals | Cobalt | Hydrazones | Catalysis | Cobalt compounds | Chemical synthesis | Cyclic compounds | Intermediates
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9. Full Text Facile synthesis of 1,2,4-triazoles via a copper-catalyzed tandem addition-oxidative cyclization
by Ueda, Satoshi and Nagasawa, Hideko
Journal of the American Chemical Society, ISSN 0002-7863, 10/2009, Volume 131, Issue 42, pp. 15080 - 15081
A simple one-step synthesis of 1,2,4-triazole derivatives is provided by a copper-catalyzed oxidative coupling reaction under an atmosphere of air. The process... 
HYDRAZONES | ONE-STEP SYNTHESIS | AMIDINES | NITRILES | AMINES | N BOND FORMATION | EFFICIENT | CHEMISTRY, MULTIDISCIPLINARY | Triazoles - chemical synthesis | Molecular Structure | Copper - chemistry | Catalysis | Cyclization | Oxidation-Reduction | Oxidation-reduction reaction | Chemical properties | Copper | Triazoles | Analysis | Index Medicus
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10. Full Text Synthesis of isoquinolines via Rh(III)-catalyzed C-H activation using hydrazone as a new oxidizing directing group
by Chuang, Sheng-Chieh and Gandeepan, Parthasarathy and Cheng, Chien-Hong
Organic Letters, ISSN 1523-7060, 11/2013, Volume 15, Issue 22, pp. 5750 - 5753
An efficient and mechanistically interesting method for the synthesis of highly substituted isoquinolines by a Rh(III)-catalyzed hydrazone directed ortho C H... 
ASYMMETRIC CATALYSIS | ELECTROCHEMICAL PROPERTIES | IRIDIUM COMPLEXES | RHODIUM(III)-CATALYZED SYNTHESIS | BETA-PHENYLETHYLAMINES | CHEMISTRY, ORGANIC | N BOND FORMATION | ARYL KETONES | INTERNAL ALKYNES | SALTS | ALKALOIDS | Isoquinolines - chemistry | Hydrogen Bonding | Isoquinolines - chemical synthesis | Molecular Structure | Catalysis | Hydrazones - chemistry | Rhodium - chemistry | Index Medicus
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11. Full Text Enantioselective α‐Alkylation of Aldehydes by Photoredox Organocatalysis: Rapid Access to Pharmacophore Fragments from β‐Cyanoaldehydes
by Welin, Eric R and Warkentin, Alexander A and Conrad, Jay C and MacMillan, David W. C
Angewandte Chemie International Edition, ISSN 1433-7851, 08/2015, Volume 54, Issue 33, pp. 9668 - 9672
The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α‐cyanoalkylation of aldehydes. This... 
organocatalysis | alkylation | aldehydes | photoredox catalysis | total synthesis | METALATED CHIRAL HYDRAZONES | CATALYSIS | BENZYLATION | POTENTIALS | CHEMISTRY, MULTIDISCIPLINARY | HALOACETONITRILES | ENANTIOMERICALLY PURE | ELECTRON-TRANSFER | NITRILES | ASYMMETRIC ALKYLATION | CARBOXYLIC-ACID DERIVATIVES | Biological Products - chemical synthesis | Lactones - chemical synthesis | Oxidation-Reduction | Aldehydes - chemical synthesis | Stereoisomerism | Models, Molecular | Lignans - chemical synthesis | Catalysis | Alkylation | Aldehydes - chemistry | Photochemical Processes | Index Medicus | Synthesis | Natural products | Lignans | Joining | Derivatives | Aldehydes | Arrays
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12. Full Text Total Synthesis of (−)‐Lundurine A and Determination of its Absolute Configuration
by Jin, Shuaijiang and Gong, Jing and Qin, Yong
Angewandte Chemie International Edition, ISSN 1433-7851, 02/2015, Volume 54, Issue 7, pp. 2228 - 2231
A 15‐step total synthesis of (−)‐lundurine A ( 1 ) from easily accessible ( S )‐pyrrolidinone 18 is reported. A Simmons‐Smith reaction allows the efficient,... 
cyclopropyl ring | Simmons–Smith reaction | total synthesis | lundurine | absolute configuration | Simmons-Smith reaction | Cyclopropyl ring | Lundurine | Total synthesis | Absolute configuration | HYDRAZONES | OXIDATION | LAPIDILECTA ALKALOID (+/-)-LAPIDILECTINE-B | (+/-)-KOPSIDASINE-N-OXIDE | (+/-)-LUNDURINE | CHEMISTRY, MULTIDISCIPLINARY | SULFURANES | CYCLOPROPYL MOIETY | A-C | INDOLE ALKALOIDS | KOPSIA-LAPIDILECTA | Biological Products - chemical synthesis | Polycyclic Compounds - chemistry | Pyrrolidinones - chemical synthesis | Biological Products - chemistry | Apocynaceae - chemistry | Polycyclic Compounds - chemical synthesis | Stereoisomerism | Molecular Conformation | Alkaloids - chemical synthesis | Pyrrolidinones - chemistry | Alkaloids - chemistry | Index Medicus
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13. Full Text Catalytic Dibenzocyclooctene Synthesis via Cobalt(III)–Carbene Radical and ortho‐Quinodimethane Intermediates
by te Grotenhuis, Colet and van den Heuvel, Naudin and van der Vlugt, Jarl Ivar and de Bruin, Bas
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2018, Volume 57, Issue 1, pp. 140 - 145
The metalloradical activation of ortho ‐benzallylaryl N ‐tosyl hydrazones with [Co(TPP)] (TPP=tetraphenylporphyrin) as the catalyst enabled the controlled... 
dibenzocyclooctenes | metalloradicals | quinodimethanes | ortho | cobalt | carbene radicals | ortho-quinodimethanes | REAGENTS | 8-MEMBERED RINGS | CYCLOPROPANATION | CHEMISTRY, MULTIDISCIPLINARY | N-TOSYLHYDRAZONES | VERSATILE | CONSTRUCTION | CYCLIZATION | Hydrogen | Cobalt | Catalysis | Hydrazones | Reaction mechanisms | Base metal | Chemical synthesis | Intermediates | Exploitation | Communications | Communication
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14. Full Text Dynamic kinetic cross-coupling strategy for the asymmetric synthesis of axially chiral heterobiaryls
by Ros, Abel and Estepa, Beatriz and Ramírez-López, Pedro and Álvarez, Eleuterio and Fernández, Rosario and Lassaletta, José M
Journal of the American Chemical Society, ISSN 0002-7863, 2013, Volume 135, Issue 42, pp. 15730 - 15733
A dynamic kinetic asymmetric transformation (DYKAT) technique has been designed for the synthesis of 2'-substituted 2-aryl pyridines/isoquinolines and related... 
HYDRAZONES | ENANTIOSELECTIVE SYNTHESIS | ACIDS | BIARYL COMPOUNDS | COMPLEXES | EFFICIENT SYNTHESIS | MONOPHOSPHINE LIGANDS | SUZUKI-MIYAURA REACTION | 2+2+2 CYCLOADDITION | CHEMISTRY, MULTIDISCIPLINARY | Research | Chemical properties | Chemical synthesis | Heterocyclic compounds | Chirality
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15. Full Text Synthesis of a novel hydrazone derivative and biophysical studies of its interactions with bovine serum albumin by spectroscopic, electrochemical, and molecular docking methods
by Tian, Fang-Fang and Jiang, Feng-Lei and Han, Xiao-Le and Xiang, Chen and Ge, Yu-Shu and Li, Jia-Han and Zhang, Yue and Li, Ran and Ding, Xin-Liang and Liu, Yi
Journal of Physical Chemistry B, ISSN 1520-6106, 11/2010, Volume 114, Issue 46, pp. 14842 - 14853
Hydrazone derivatives possess potential antitumor activities based on modulation of the iron metabolism in cancer cell. A novel hydrazone,... 
RIBONUCLEOTIDE REDUCTASE | CELLS | ANTIPROLIFERATIVE ACTIVITY | CHELATORS | THIOSEMICARBAZONES | BIOLOGICAL-ACTIVITY | CHEMISTRY, PHYSICAL | DISORDERS | IRON OVERLOAD DISEASE | CANCER | Protein Structure, Secondary | Antineoplastic Agents - chemical synthesis | Models, Molecular | Hydrazones - chemical synthesis | Antineoplastic Agents - chemistry | Hydrazones - chemistry | Thermodynamics | Animals | Cattle | Spectrum Analysis - methods | Protein Binding | Electrochemical Techniques - methods | Protein Conformation | Serum Albumin, Bovine - chemistry | Molecular Structure | Circular Dichroism | Fluorescence | Chemical properties | Chemical synthesis | Hydrazine | Analysis | Index Medicus
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16. Full Text Pd-Catalyzed Highly Regio- and Stereoselective Formation of C-C Double Bonds: An Efficient Method for the Synthesis of Benzofuran-, Dihydrobenzofuran-, and Indoline-Containing Alkenes
by Gao, Yang and Xiong, Wenfang and Chen, Huoji and Wu, Wanqing and Peng, Jianwen and Gao, Yinglan and Jiang, Huanfeng
Journal of Organic Chemistry, ISSN 0022-3263, 08/2015, Volume 80, Issue 15, pp. 7456 - 7467
A highly regio- and stereoselective C-C double bond formation reaction via Pd-catalyzed Heck-type cascade process with N-tosylhydrazones has been developed.... 
CROSS-COUPLING REACTIONS | CASCADE REACTIONS | OLEFIN SYNTHESIS | MIGRATORY INSERTION | METAL CARBENE | 3-COMPONENT REACTION | CHEMISTRY, ORGANIC | N-TOSYL HYDRAZONES | DIAZO-COMPOUNDS | SELECTIVE SYNTHESIS | OXIDATIVE ADDITION | Palladium catalysts | Chemical bonds | Research | Chemical properties | Chemical synthesis | Olefins
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17. Full Text One-step synthesis of sulfonamides from N-tosylhydrazones
by Tsai, Andy S and Curto, John M and Rocke, Benjamin N and Dechert-Schmitt, Anne-Marie R and Ingle, Gajendrasingh K and Mascitti, Vincent
Organic Letters, ISSN 1523-7060, 02/2016, Volume 18, Issue 3, pp. 508 - 511
The first described reaction between N-tosylhydrazone and SO2 is reported to provide alkyl sulfonamides in the presence of various amines. In this procedurally... 
ORGANIC-SYNTHESIS | ONE-POT SYNTHESIS | AMINES | CONTINUOUS-FLOW GENERATION | SULFUR-DIOXIDE | ENE REACTION | CHEMISTRY, ORGANIC | PALLADIUM-CATALYZED AMINOSULFONYLATION | 3-COMPONENT | CARBON-DIOXIDE | ARYLBORONIC ACIDS | Amines - chemistry | Sulfonamides - chemical synthesis | Sulfur Dioxide - chemistry | Sulfonamides - chemistry | Ketones - chemistry | Molecular Structure | Catalysis | Hydrazones - chemistry | Aldehydes - chemistry | Index Medicus
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