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Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2014, Volume 58, Issue 11, pp. 6413 - 6423
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2009, Volume 29, Issue 41, pp. 12994 - 13005
In Alzheimer's disease (AD), rod-like cofilin aggregates (cofilin-actin rods) and thread-like inclusions containing phosphorylated microtubule-associated... 
F-ACTIN | OXIDATIVE STRESS | ROD FORMATION | AMYLOID-BETA | DISEASE | NEURONS | CHICK BRAIN | TAU | FILAMENT TURNOVER | NEUROSCIENCES | MITOCHONDRIAL FISSION | Phosphorylation - physiology | Neurons - pathology | RNA, Small Interfering - genetics | Oxidants - pharmacology | Actin Depolymerizing Factors - genetics | Amyloid beta-Peptides - pharmacology | Humans | Actins - metabolism | tau Proteins - metabolism | Neurons - cytology | Peptide Fragments - pharmacology | Depsipeptides - pharmacology | Green Fluorescent Proteins - genetics | Antimycin A - pharmacology | Alzheimer Disease - pathology | Actin Depolymerizing Factors - metabolism | Adenosine Triphosphate - pharmacology | Chick Embryo - cytology | Transfection - methods | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Neurons - drug effects | Thiazolidines - pharmacology | Ionophores - pharmacology | Neurites - drug effects | Organ Culture Techniques | Animals, Newborn | p21-Activated Kinases - genetics | Antimycin A - analogs & derivatives | Cells, Cultured | Enzyme Inhibitors - pharmacology | Hydrogen Peroxide - pharmacology | Rats | Neurites - metabolism | p21-Activated Kinases - metabolism | Serine - metabolism | Amino Acid Motifs - physiology | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Animals | Brain - pathology | Fluorescence Resonance Energy Transfer - methods | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Antimicrobial agents and chemotherapy, ISSN 1098-6596, 2016, Volume 60, Issue 4, pp. 2281 - 2291
Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially... 
TARGET | NATURAL-PRODUCT | THYMIDYLATE KINASE | BIOSYNTHESIS | ESCHERICHIA-COLI | ALANINE LIGASE | D-CYCLOSERINE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | MASS-SPECTROMETRY | PATHOGENS | Acyltransferases - antagonists & inhibitors | Metabolomics | Nucleoside-Phosphate Kinase - genetics | Ceftazidime - pharmacology | Escherichia coli - drug effects | Humans | Triclosan - metabolism | Triclosan - pharmacology | Acyltransferases - metabolism | Threonine - metabolism | Acyltransferases - genetics | Fosfomycin - metabolism | Pyrimidines - metabolism | DNA, Bacterial - antagonists & inhibitors | Ceftazidime - metabolism | Cell Wall - drug effects | Terpenes - antagonists & inhibitors | Terpenes - metabolism | Carbonyl Cyanide m-Chlorophenyl Hydrazone - pharmacology | Mass Spectrometry | Escherichia coli - metabolism | HEK293 Cells | Chromatography, Liquid | Hydroxamic Acids - pharmacology | Fosfomycin - analogs & derivatives | Carbonyl Cyanide m-Chlorophenyl Hydrazone - metabolism | Gene Expression | DNA, Bacterial - biosynthesis | Fosfomycin - pharmacology | Nucleoside-Phosphate Kinase - antagonists & inhibitors | Anti-Bacterial Agents - metabolism | Adenosine - pharmacology | Cell Wall - chemistry | Pyrimidines - pharmacology | Threonine - analogs & derivatives | Hydroxamic Acids - metabolism | Threonine - pharmacology | Metabolome - drug effects | Escherichia coli - genetics | Cell Wall - metabolism | Adenosine - metabolism | Anti-Bacterial Agents - pharmacology | Nucleoside-Phosphate Kinase - metabolism
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 7, p. 1521
Natural products are an important source of pesticide discovery. A series of N-amino-maleimide derivatives containing hydrazone group were designed and... 
Antifungal activity | Methyllinderone | Linderone | Maleimide | LINDERA-ERYTHROCARPA | maleimide | MOIETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | linderone | methyllinderone | antifungal activity | INSECTICIDE | CHEMISTRY, MULTIDISCIPLINARY | Plant Extracts - chemistry | Nitriles - pharmacology | Lindera - chemistry | Maleimides - pharmacology | Ascomycota - drug effects | Biological Products - pharmacology | Structure-Activity Relationship | Ascomycota - growth & development | Fungicides, Industrial - pharmacology | Microbial Sensitivity Tests | Maleimides - chemical synthesis | Culex - drug effects | Drug Design | Rhizoctonia - growth & development | Flavonoids - pharmacology | Molecular Structure | Carbamates - pharmacology | Biomimetic Materials - chemical synthesis | Pesticides - chemical synthesis | Culex - physiology | Cyclopentanes - pharmacology | Drug Discovery | Biological Products - isolation & purification | Biomimetic Materials - pharmacology | Biological Products - chemistry | Animals | Rhizoctonia - drug effects | Benzimidazoles - pharmacology | Alkenes - pharmacology | Pesticides - pharmacology | Fungicides | Bioassays | Pesticides | Hydrazones | Derivatives | Aquatic insects | Biological activity | Fungi | Synthesis | Fungicidal activity | Natural products | Chlorothalonil | Carbendazim | Phytopathogenic fungi
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 02/2012, Volume 19, Issue 4, pp. 569 - 612
There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory,... 
Antimicrobial | Antimalarial | Anti-trypnosomal | Hydrazide | Antioxidant | Antiarthritis | Diuretic | Analgesic | Biological activities | Synthesis | Antiviral | Hydrazone | Anticancer | Anti-inflammatory | Antimycobacterial | ANTIOXIDANT ACTIVITY | ANTIMYCOBACTERIAL ACTIVITY | DESIGN | IN-VITRO | ANTICONVULSANT ACTIVITY | PHARMACOLOGY & PHARMACY | HYDRAZONES | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACYLHYDRAZONE DERIVATIVES | ANTIMALARIAL ACTIVITY | PHARMACOLOGICAL EVALUATION | ANTIMICROBIAL ACTIVITY | Hydrazines - pharmacology | Antioxidants - chemistry | Anticonvulsants - chemical synthesis | Anti-Infective Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Anticonvulsants - pharmacology | Anti-Infective Agents - chemical synthesis | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hydrazines - chemistry | Hydrazines - chemical synthesis | Animals | Organometallic Compounds - chemical synthesis | Anti-Infective Agents - chemistry | Anticonvulsants - chemistry | Organometallic Compounds - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Organometallic Compounds - pharmacology
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2001, Volume 276, Issue 27, pp. 25096 - 25100
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2013, Volume 89, Issue 2, p. 43
We have previously shown that fatty acid oxidation (FAO) is required for AMP-activated protein kinase (PRKA)-induced maturation in vitro. In the present study,... 
Fatty acid oxidation | AMPK | Meiotic resumption | PRKA | Oocyte maturation | BETA-OXIDATION | VITRO | ACTIVATED PROTEIN-KINASE | MURINE OOCYTES | meiotic resumption | DEVELOPMENTAL COMPETENCE | EARLY EMBRYO DEVELOPMENT | REPRODUCTIVE BIOLOGY | EPIDERMAL-GROWTH-FACTOR | fatty acid oxidation | oocyte maturation | ENERGY-METABOLISM | POTENTIAL ROLE | CARNITINE PALMITOYLTRANSFERASE-I | Meiosis - physiology | AMP-Activated Protein Kinases - metabolism | Amphiregulin | Glycoproteins - pharmacology | Aminophenols - pharmacology | Aminoimidazole Carboxamide - pharmacology | Follicle Stimulating Hormone - pharmacology | Ribonucleotides - pharmacology | Meiosis - drug effects | Ovarian Follicle - drug effects | Cumulus Cells - drug effects | Epoxy Compounds - pharmacology | EGF Family of Proteins | Cumulus Cells - metabolism | Ovarian Follicle - physiology | Oocytes - drug effects | Female | Acyl Coenzyme A - metabolism | Fatty Acids - metabolism | Ovarian Follicle - metabolism | Cumulus Cells - physiology | Oxidation-Reduction | Malonyl Coenzyme A - pharmacology | Oocytes - metabolism | Hydrazones - pharmacology | Animals | Oocytes - physiology | Aminoimidazole Carboxamide - analogs & derivatives | Thioglycolates - pharmacology | Intercellular Signaling Peptides and Proteins - pharmacology | Mice | Epidermal Growth Factor - pharmacology
Journal Article
Cell Reports, ISSN 2211-1247, 05/2017, Volume 19, Issue 8, pp. 1669 - 1684
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established... 
lung cancer | histone methylation | taxane-platin chemotherapy | JIB-04 | GSK-J4 | KDM | histone demethylases | demethylase inhibitors | Jumonji demethylases | drug resistance | CELLS | MELANOMA | THERAPY | CHEMOTHERAPY REGIMENS | MECHANISM | GENE-EXPRESSION | LEUKEMIA | MULTIDRUG-RESISTANCE | CELL BIOLOGY | Lung Neoplasms - drug therapy | Transcription, Genetic - drug effects | Taxoids - pharmacology | Benzazepines - adverse effects | Humans | Aminopyridines - adverse effects | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Taxoids - therapeutic use | Hydrazones - adverse effects | Aminopyridines - therapeutic use | Carboplatin - therapeutic use | Hydrazones - therapeutic use | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Bridged-Ring Compounds - pharmacology | Neoadjuvant Therapy | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Bridged-Ring Compounds - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Enzyme Inhibitors - pharmacology | Benzazepines - pharmacology | Pyrimidines - pharmacology | Enzyme Inhibitors - therapeutic use | Hydrazones - pharmacology | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Benzazepines - therapeutic use | Pyrimidines - therapeutic use | Aminopyridines - pharmacology | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Histones - metabolism | Carboplatin - pharmacology | Methylation | Jumonji Domain-Containing Histone Demethylases - metabolism | Drug Resistance, Neoplasm - drug effects
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 09/2014, Volume 64, Issue 3, pp. 256 - 265
Levosimendan is a calcium-sensitizing agent shown to prevent myocardical contractile depression in various heart diseases. In this study, we investigated the... 
Mitochondrial ATP-sensitive potassium channel | Hypothermic preservation | Levosimendan | Inducible nitric oxide synthase | CARDIAC & CARDIOVASCULAR SYSTEMS | HEART-FAILURE | levosimendan | INJURY | inducible nitric oxide synthase | BALANCE | mitochondrial ATP-sensitive potassium channel | hypothermic preservation | CARDIOMYOCYTE APOPTOSIS | K-ATP CHANNEL | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | DYSFUNCTION | Histidine - administration & dosage | Histidine - pharmacology | Hydroxy Acids - pharmacology | Simendan | Apoptosis - drug effects | Electrolytes - administration & dosage | Male | Pyridazines - pharmacology | Mannitol - pharmacology | Disaccharides - pharmacology | Glutathione - pharmacology | Myocardium - metabolism | Disaccharides - administration & dosage | Pyridazines - administration & dosage | Benzamides - pharmacology | Decanoic Acids - pharmacology | Ventricular Function, Left - drug effects | Hydrazones - administration & dosage | Rats | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Hydrazones - pharmacology | Animals | Cardiotonic Agents - administration & dosage | Glutathione - administration & dosage | Myocytes, Cardiac - drug effects | Mannitol - administration & dosage | Glutamates - pharmacology | Glutamates - administration & dosage | Myocytes, Cardiac - metabolism | Electrolytes - pharmacology | Nitric Oxide Synthase Type II - metabolism
Journal Article