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Cell Reports, ISSN 2211-1247, 05/2017, Volume 19, Issue 8, pp. 1669 - 1684
Although non-small cell lung cancer (NSCLC) patients benefit from standard taxane-platin chemotherapy, many relapse, developing drug resistance. We established... 
lung cancer | histone methylation | taxane-platin chemotherapy | JIB-04 | GSK-J4 | KDM | histone demethylases | demethylase inhibitors | Jumonji demethylases | drug resistance | CELLS | MELANOMA | THERAPY | CHEMOTHERAPY REGIMENS | MECHANISM | GENE-EXPRESSION | LEUKEMIA | MULTIDRUG-RESISTANCE | CELL BIOLOGY | Lung Neoplasms - drug therapy | Transcription, Genetic - drug effects | Taxoids - pharmacology | Benzazepines - adverse effects | Humans | Aminopyridines - adverse effects | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Gene Expression Profiling | Taxoids - therapeutic use | Hydrazones - adverse effects | Aminopyridines - therapeutic use | Carboplatin - therapeutic use | Hydrazones - therapeutic use | Jumonji Domain-Containing Histone Demethylases - antagonists & inhibitors | Bridged-Ring Compounds - pharmacology | Neoadjuvant Therapy | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Bridged-Ring Compounds - therapeutic use | Carcinoma, Non-Small-Cell Lung - genetics | Enzyme Inhibitors - pharmacology | Benzazepines - pharmacology | Pyrimidines - pharmacology | Enzyme Inhibitors - therapeutic use | Hydrazones - pharmacology | Disease-Free Survival | Drug Resistance, Neoplasm - genetics | Animals | Benzazepines - therapeutic use | Pyrimidines - therapeutic use | Aminopyridines - pharmacology | Pyrimidines - adverse effects | Cell Line, Tumor | Mice | Carcinoma, Non-Small-Cell Lung - drug therapy | Histones - metabolism | Carboplatin - pharmacology | Methylation | Jumonji Domain-Containing Histone Demethylases - metabolism | Drug Resistance, Neoplasm - drug effects | Index Medicus
Journal Article
Nature communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 2035 - 2035
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2017, Volume 376, Issue 21, pp. 2021 - 2031
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 03/2016, Volume 225, pp. 240 - 251
Targeting breast cancer and more specifically cancer stem cell (CSC) subpopulation, responsible for tumor growth, resistance and self-renewal, using... 
Salinomycin | Single walled carbon nanotubes | Breast cancer stem cells | Drug delivery system | Noninvasive imaging | Paclitaxel | DELIVERY-SYSTEMS | RESISTANCE | PHARMACOLOGY & PHARMACY | CHEMISTRY, MULTIDISCIPLINARY | CARBON NANOTUBES | CHALLENGES | Antigens, Tumor-Associated, Carbohydrate - blood | Drug Carriers - therapeutic use | Neoplastic Stem Cells - drug effects | Antibodies - chemistry | Humans | Drug Carriers - administration & dosage | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Drug Carriers - chemistry | Paclitaxel - chemistry | Pyrans - chemistry | Hydrazones - therapeutic use | Female | Paclitaxel - administration & dosage | Pyrans - therapeutic use | Antibodies - therapeutic use | Cell Survival - drug effects | Hydrazones - administration & dosage | Antineoplastic Agents - chemistry | Breast Neoplasms - drug therapy | Paclitaxel - therapeutic use | Hydrazones - chemistry | Antibodies - administration & dosage | Animals | Tumor Burden - drug effects | Breast Neoplasms - pathology | Mice, Nude | Nanotubes, Carbon - chemistry | Mucin-1 - blood | Breast Neoplasms - blood | Cell Line, Tumor | Hyaluronan Receptors - immunology | Mice, Inbred BALB C | Pyrans - administration & dosage | Drugs | Breast cancer | Transplantation | Health aspects | Stem cells | Index Medicus
Journal Article
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2017, Volume 376, Issue 21, pp. 2032 - 2042
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2007, Volume 15, Issue 17, pp. 5738 - 5751
A novel series of 1-acylthiosemicarbazides, 1,2,4-triazole-5-thiones, 1,3,4-thiadiazoles and hydrazones containing 5-methyl-2-benzoxazolinones was synthesized... 
Thiosemicarbazide | Triazol | Hydrazone | Analgesic-anti-inflammatory and antimicrobial activities | Thiadiazole | 2-Benzoxazolinone | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | hydrazone | 2-benzoxazolinone | CYCLOOXYGENASE | analgesic-anti-inflammatory and antimicrobial | ACYLARYLHYDRAZONES | triazol | ACID-DERIVATIVES | IN-VITRO | thiosemicarbazide | ANTITUBERCULOSIS ACTIVITY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | activities | thiadiazole | NITRIC-OXIDE | 2-BENZOXAZOLINONE DERIVATIVES | AGENTS | ANTIFUNGAL | Analgesics - pharmacology | Triazoles - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Thiadiazoles - therapeutic use | Anti-Bacterial Agents - chemistry | Hydrazones - therapeutic use | Semicarbazides - pharmacology | Semicarbazides - chemistry | Anti-Inflammatory Agents - therapeutic use | Triazoles - chemical synthesis | Molecular Structure | Thiadiazoles - pharmacology | Triazoles - therapeutic use | Microbial Viability - drug effects | Anti-Inflammatory Agents - pharmacology | Models, Molecular | Edema - drug therapy | Hydrazones - chemical synthesis | Semicarbazides - therapeutic use | Hydrazones - chemistry | Hydrazones - pharmacology | Anti-Bacterial Agents - chemical synthesis | Semicarbazides - chemical synthesis | Triazoles - pharmacology | Animals | Anti-Inflammatory Agents - chemistry | Benzoxazoles - chemistry | Thiadiazoles - chemical synthesis | Analgesics - chemistry | Hindlimb - drug effects | Anti-Bacterial Agents - pharmacology | Anti-Inflammatory Agents - chemical synthesis | Mice | Methylation | Edema - pathology | Index Medicus
Journal Article