X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (701) 701
Publication (26) 26
Book Review (9) 9
Newsletter (6) 6
Dissertation (3) 3
Paper (3) 3
Magazine Article (1) 1
Trade Publication Article (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
hydrochlorothiazide (465) 465
humans (455) 455
male (278) 278
pharmacology & pharmacy (277) 277
hypertension (251) 251
hypertension - drug therapy (222) 222
pharmacokinetics (215) 215
index medicus (212) 212
adult (194) 194
female (191) 191
hydrochlorothiazide - pharmacokinetics (180) 180
middle aged (168) 168
diuretics (160) 160
hydrochlorothiazide - administration & dosage (152) 152
drug combinations (126) 126
antihypertensive agents - therapeutic use (121) 121
blood pressure - drug effects (120) 120
hydrochlorothiazide - therapeutic use (117) 117
antihypertensive agents - pharmacokinetics (112) 112
drug therapy, combination (108) 108
animals (104) 104
aged (98) 98
antihypertensive agents - administration & dosage (97) 97
hydrochlorothiazide - pharmacology (89) 89
chemistry, analytical (86) 86
hydrochlorothiazide - blood (85) 85
blood-pressure (78) 78
antihypertensive agents - adverse effects (77) 77
drug interactions (74) 74
tablets (73) 73
valsartan (72) 72
treatment outcome (71) 71
hydrochlorothiazide - adverse effects (70) 70
drug therapy (68) 68
cross-over studies (65) 65
efficacy (65) 65
hypertension - physiopathology (65) 65
biological availability (62) 62
research (62) 62
administration, oral (61) 61
amlodipine (60) 60
double-blind method (59) 59
antihypertensive agents - pharmacology (57) 57
blood pressure (57) 57
human plasma (55) 55
adolescent (54) 54
combination (53) 53
peripheral vascular disease (53) 53
area under curve (52) 52
biochemical research methods (50) 50
kinetics (50) 50
drugs (48) 48
pharmacodynamics (48) 48
rats (48) 48
reproducibility of results (48) 48
tetrazoles - pharmacokinetics (48) 48
therapy (48) 48
urine (48) 48
double-blind (47) 47
health aspects (45) 45
analysis (44) 44
dosage and administration (44) 44
internal medicine (44) 44
losartan (44) 44
diuretics - pharmacokinetics (43) 43
antihypertensive agents - blood (40) 40
chromatography, high pressure liquid (40) 40
performance liquid-chromatography (40) 40
tetrazoles - administration & dosage (40) 40
time factors (40) 40
bioavailability (39) 39
chromatography, high pressure liquid - methods (39) 39
clinical trials as topic (39) 39
dose-response relationship, drug (39) 39
therapeutic equivalency (39) 39
bioequivalence (38) 38
medicine & public health (38) 38
tetrazoles - therapeutic use (38) 38
diuretics - administration & dosage (37) 37
diuretics - therapeutic use (37) 37
combination therapy (36) 36
mass spectrometry (36) 36
valine - analogs & derivatives (36) 36
young adult (36) 36
furosemide (35) 35
pharmacology/toxicology (35) 35
telmisartan (35) 35
validation (35) 35
hplc (34) 34
liquid chromatography (34) 34
antihypertensive drugs (33) 33
irbesartan (33) 33
pharmacotherapy (33) 33
hydrochlorothiazide - metabolism (32) 32
methods (32) 32
toxicology (32) 32
diuretics - pharmacology (31) 31
sensitivity and specificity (31) 31
sodium chloride symporter inhibitors - therapeutic use (31) 31
cardiac & cardiovascular systems (30) 30
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (680) 680
German (12) 12
Russian (7) 7
Chinese (4) 4
Croatian (2) 2
French (2) 2
Italian (2) 2
Japanese (2) 2
Polish (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Pharmaceutics, ISSN 1543-8384, 08/2012, Volume 9, Issue 8, pp. 2358 - 2363
The aims of this work were to study pharmacokinetics of randomly selected drugs in plasma and saliva samples in healthy human volunteers, and to introduce a... 
Salivary Excretion Classification System | effective permeability | pharmacokinetics | protein binding | bioequivalence | SimCYP | MEDICINE, RESEARCH & EXPERIMENTAL | RELATIVE BIOAVAILABILITY | PERMEABILITY | CLINICAL PHARMACOKINETICS | BIOLOGICAL FLUID | DRUGS | PHARMACOLOGY & PHARMACY | Quinolines - blood | Acetates - blood | Fluorobenzenes - pharmacokinetics | Hydrochlorothiazide - pharmacokinetics | Triazoles - blood | Piroxicam - blood | Azithromycin - blood | Humans | Losartan - blood | Saliva - secretion | Male | Naphthalenes - blood | Benzhydryl Compounds - blood | Fluorobenzenes - pharmacology | Quinolines - pharmacokinetics | Sulfonamides - blood | Azithromycin - pharmacokinetics | Tolterodine Tartrate | Female | Triazoles - pharmacokinetics | Naphthalenes - pharmacokinetics | Piroxicam - analogs & derivatives | Sitagliptin Phosphate | Hydrochlorothiazide - blood | Losartan - pharmacokinetics | Benzhydryl Compounds - pharmacokinetics | Metformin - blood | Cresols - blood | Phenylpropanolamine - blood | Metformin - pharmacokinetics | Rosuvastatin Calcium | Cloxacillin - pharmacokinetics | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Cinacalcet Hydrochloride | Cloxacillin - blood | Saliva - metabolism | Pyrazines - pharmacokinetics | Piroxicam - pharmacokinetics | Pyrimidines - pharmacokinetics | Cresols - pharmacokinetics | Anthraquinones - blood | Anthraquinones - pharmacokinetics | Phenylpropanolamine - pharmacokinetics | Pyrazines - blood | Acetates - pharmacokinetics
Journal Article
Clinical Pharmacology in Drug Development, ISSN 2160-763X, 11/2015, Volume 4, Issue 6, pp. 407 - 417
LCZ696 is a first-in-class angiotensin receptor neprilysin inhibitor in development for treatments of hypertension and heart failure indications. In 3 separate... 
LCZ696 | pharmacokinetic drug–drug interaction | amlodipine | hydrochlorothiazide | carvedilol | Pharmacokinetic drug-drug interaction | Amlodipine | Hydrochlorothiazide | Carvedilol | STEADY-STATE PHARMACOKINETICS | ANTAGONIST | NATRIURETIC PEPTIDES | pharmacokinetic drug-drug interaction | HEART-FAILURE | EXCRETION | PHARMACOLOGY & PHARMACY | DYSFUNCTION | VALSARTAN | Hydrochlorothiazide - pharmacokinetics | Diuretics - pharmacokinetics | Humans | Middle Aged | Male | Metabolic Clearance Rate | Tetrazoles - blood | Adrenergic beta-Antagonists - pharmacokinetics | Drug Interactions | Tetrazoles - administration & dosage | Adrenergic beta-Antagonists - adverse effects | Amlodipine - administration & dosage | Arizona | Diuretics - blood | Hydrochlorothiazide - adverse effects | Diuretics - administration & dosage | Administration, Oral | Amlodipine - adverse effects | Propanolamines - adverse effects | Antihypertensive Agents - adverse effects | Antihypertensive Agents - blood | Cross-Over Studies | Models, Biological | Calcium Channel Blockers - administration & dosage | Protease Inhibitors - blood | Calcium Channel Blockers - blood | Propanolamines - administration & dosage | Diuretics - adverse effects | Tetrazoles - pharmacokinetics | Angiotensin Receptor Antagonists - adverse effects | Angiotensin Receptor Antagonists - pharmacokinetics | Calcium Channel Blockers - adverse effects | Area Under Curve | Protease Inhibitors - pharmacokinetics | Carbazoles - administration & dosage | Aminobutyrates - adverse effects | Antihypertensive Agents - administration & dosage | Healthy Volunteers | Propanolamines - pharmacokinetics | Amlodipine - pharmacokinetics | Aminobutyrates - pharmacokinetics | Protease Inhibitors - administration & dosage | Protease Inhibitors - adverse effects | Adult | Female | Carbazoles - blood | Aminobutyrates - administration & dosage | Drug Therapy, Combination | Propanolamines - blood | Hydrochlorothiazide - blood | Adrenergic beta-Antagonists - administration & dosage | Adrenergic beta-Antagonists - blood | Carbazoles - adverse effects | Amlodipine - blood | Drug Administration Schedule | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Neprilysin - metabolism | Aminobutyrates - blood | Angiotensin Receptor Antagonists - blood | Carbazoles - pharmacokinetics | Neprilysin - antagonists & inhibitors | Tetrazoles - adverse effects | Calcium Channel Blockers - pharmacokinetics | Angiotensin Receptor Antagonists - administration & dosage | Index Medicus
Journal Article
American Journal of Cardiovascular Drugs, ISSN 1175-3277, 04/2010, Volume 10, Issue 2, pp. 95 - 103
Background The Polycap™ (polypill; aspirin [acetylsalicylic acid], ramipril, simvastatin, atenolol, and hydrochlorothiazide) was found to be safe and effective... 
Drug-interactions | Ramipril, pharmacokinetics | Aspirin, pharmacokinetics | Hydrochlorothiazide, pharmacokinetics | Hydrochlorothiazide/atenolol/ramipril/simvastatin/aspirin, pharmacokinetics | Salicylic-acid, pharmacokinetics | Atenolol, pharmacokinetics | Risk-factors | Hydrochlorothiazide/atenolol/ramipril/simvastatin/aspirin, drug interactions | Simvastatin, pharmacokinetics | Cardiovascular-disorders, treatment | Pharmacotherapy | Medicine & Public Health | Cardiology | Pharmacology/Toxicology | CYTOCHROME-P450 | CARDIAC & CARDIOVASCULAR SYSTEMS | LOW-DOSE ASPIRIN | PHARMACOKINETICS | METABOLISM | FORMULATIONS | SIMVASTATIN ACID | CARDIOVASCULAR-DISEASE | PHARMACOLOGY & PHARMACY | BIOEQUIVALENCE | Hydrochlorothiazide - pharmacokinetics | Simvastatin - adverse effects | Area Under Curve | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Aspirin - pharmacokinetics | Biological Availability | Male | Aspirin - administration & dosage | Ramipril - administration & dosage | Young Adult | Capsules | Drug Interactions | Aspirin - adverse effects | Atenolol - pharmacokinetics | Platelet Aggregation Inhibitors - administration & dosage | Adult | Platelet Aggregation Inhibitors - pharmacokinetics | Atenolol - administration & dosage | Ramipril - adverse effects | Tandem Mass Spectrometry - methods | Platelet Aggregation Inhibitors - adverse effects | Hydrochlorothiazide - adverse effects | Cardiovascular Diseases - etiology | Hypolipidemic Agents - adverse effects | Administration, Oral | Simvastatin - administration & dosage | Risk Factors | Ramipril - pharmacokinetics | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Simvastatin - pharmacokinetics | Antihypertensive Agents - adverse effects | Cross-Over Studies | Adolescent | Hypolipidemic Agents - administration & dosage | Atenolol - adverse effects | Chromatography, Liquid - methods | Hypolipidemic Agents - pharmacokinetics | Drug Combinations | Prevention | Complications and side effects | Drug interactions | Dosage and administration | Research | Cardiovascular diseases | Risk factors | Cardiovascular agents
Journal Article
Journal Article
Journal of Clinical Pharmacology, ISSN 0091-2700, 04/2011, Volume 51, Issue 4, pp. 575 - 585
Drug interactions are a significant clinical concern, particularly in patients with conditions such as heart disease and hypertension, in whom coadministration... 
Nebivolol | β-blockers | Drug-drug interactions | Vasodilating | Pharmacokinetics | CYP2D6 | MANAGEMENT | beta-blockers | PREVALENCE | DISPOSITION | drug-drug interactions | PROFILE | METABOLISM | pharmacokinetics | PHARMACOLOGY & PHARMACY | HYPERTENSION | vasodilating | Furosemide - administration & dosage | Hydrochlorothiazide - pharmacokinetics | Fluoxetine - pharmacokinetics | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Ethanolamines - administration & dosage | Warfarin - administration & dosage | Ramipril - administration & dosage | Young Adult | Ethanolamines - pharmacokinetics | Drug Interactions | Adult | Female | Losartan - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Furosemide - pharmacokinetics | Genotype | Ramipril - pharmacokinetics | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Digoxin - pharmacokinetics | Warfarin - pharmacokinetics | Benzopyrans - administration & dosage | Digoxin - administration & dosage | Benzopyrans - pharmacokinetics | Fluoxetine - administration & dosage | Cytochrome P-450 CYP2D6 - metabolism | Losartan - administration & dosage | Dosage and administration | Research | Drug interactions | Hypertension | Prescription drugs | Genetics | Index Medicus | Cytochrome | Drugs | Warfarin | Fluoxetine | Cytochrome P450 | Hydrochlorothiazide | digoxin | furosemide | Drug interaction | Heart diseases | CYP2D6 protein | Genotypes
Journal Article
Chromatographia, ISSN 0009-5893, 11/2018, Volume 81, Issue 11, pp. 1551 - 1557
Journal Article
Current Medical Research and Opinion, ISSN 0300-7995, 03/2008, Volume 24, Issue 3, pp. 717 - 726
Journal Article
Journal of Pharmaceutical Analysis, ISSN 2095-1779, 12/2014, Volume 4, Issue 6, pp. 399 - 406
Polypill is a fixed-dose combination that contains three or more active ingredients used as a single daily pill to achieve a large effect in preventing... 
Amlodipine | Hydrochlorothiazide | Valsartan | Exforge HCT | Polypill | Original
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 08/2016, Volume 56, Issue 8, pp. 988 - 998
Journal Article
Journal Article
International Journal of Clinical Pharmacology and Therapeutics, ISSN 0946-1965, 07/2015, Volume 53, Issue 7, pp. 573 - 581
Objectives: The aim of the present study was to compare the pharmacokinetic profiles between a new generic and a branded reference formulation of... 
Hydrochlorothiazide | Bioequivalence | Irbesartan | MS/MS | Pharmacokinetics | irbesartan | hydrochlorothiazide | LC | pharmacokinetics | PHARMACOLOGY & PHARMACY | HYPERTENSION | bioequivalence | BLOOD-PRESSURE | Hydrochlorothiazide - pharmacokinetics | Angiotensin II Type 1 Receptor Blockers - adverse effects | Diuretics - pharmacokinetics | Tablets | Area Under Curve | Humans | Antihypertensive Agents - administration & dosage | Biphenyl Compounds - adverse effects | Male | Metabolic Clearance Rate | Chromatography, High Pressure Liquid | Healthy Volunteers | Angiotensin II Type 1 Receptor Blockers - pharmacokinetics | Tetrazoles - blood | Young Adult | Tandem Mass Spectrometry | Drugs, Generic - pharmacokinetics | Tetrazoles - administration & dosage | China | Adult | Biphenyl Compounds - blood | Hydrochlorothiazide - blood | Diuretics - blood | Angiotensin II Type 1 Receptor Blockers - administration & dosage | Hydrochlorothiazide - adverse effects | Biphenyl Compounds - pharmacokinetics | Diuretics - administration & dosage | Administration, Oral | Drugs, Generic - administration & dosage | Hydrochlorothiazide - administration & dosage | Antihypertensive Agents - pharmacokinetics | Antihypertensive Agents - adverse effects | Antihypertensive Agents - blood | Cross-Over Studies | Drugs, Generic - adverse effects | Asian Continental Ancestry Group | Biphenyl Compounds - administration & dosage | Angiotensin II Type 1 Receptor Blockers - blood | Tetrazoles - adverse effects | Diuretics - adverse effects | Drug Combinations | Tetrazoles - pharmacokinetics | Therapeutic Equivalency
Journal Article
Journal Article