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Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
NAC (N-acetyl-L-cysteine) is commonly used to identify and test ROS (reactive oxygen species) inducers, and to inhibit ROS. In the present study, we identified... 
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | CANCER-CELLS | TARGET | APOPTOSIS | OXIDATIVE STRESS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | reactive oxygen species (ROS) | ENDOPLASMIC-RETICULUM STRESS | BORTEZOMIB | FOXM1 | INACTIVATION | proteasome inhibitor | LACTACYSTIN | catalase | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | N-acetyl-l-cysteine (NAC)
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2016, Volume 291, Issue 13, pp. 7029 - 7044
Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform... 
high throughput screening (HTS) | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NADPH oxidase inhibitors | reactive oxygen species (ROS) | CANCER | NOX INHIBITORS | reactive nitrogen species (RNS) | REACTIVE OXYGEN | EXTRACELLULAR-SUPEROXIDE | NADPH oxidase | IN-VIVO | DISEASE | BIOLOGY | superoxide ion | NITRIC-OXIDE | fluorescence probes | THERAPEUTIC TARGETS | Small Molecule Libraries - pharmacology | Tetradecanoylphorbol Acetate - pharmacology | Membrane Glycoproteins - metabolism | Phenanthridines - chemistry | Humans | NADPH Oxidases - metabolism | Coumarins - chemistry | Chromatography, High Pressure Liquid | Fluorometry | Quaternary Ammonium Compounds - chemistry | Hydrogen Peroxide - chemistry | Membrane Glycoproteins - antagonists & inhibitors | Enzyme Inhibitors - chemistry | Superoxides - metabolism | Peroxynitrous Acid - antagonists & inhibitors | Superoxides - antagonists & inhibitors | Gene Expression | Oxidation-Reduction | NADPH Oxidases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Superoxides - chemistry | NADPH Oxidase 2 | Hydrogen Peroxide - metabolism | Peroxynitrous Acid - biosynthesis | Small Molecule Libraries - chemistry | Molecular Probes - chemistry | High-Throughput Screening Assays | HL-60 Cells | Oxazines - chemistry | Peroxynitrous Acid - chemistry | Macrophage Activation - drug effects | Hydrogen Peroxide - antagonists & inhibitors | Medicinal Chemistry | Life Sciences | Biomolecules | Biochemistry, Molecular Biology | Chemical Sciences | Molecular Biophysics
Journal Article
Journal Article
Food and Chemical Toxicology, ISSN 0278-6915, 09/2013, Volume 59, pp. 145 - 152
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 11/2015, Volume 11, Issue 11, pp. 834 - 836
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2000, Volume 106, Issue 12, pp. 1521 - 1530
The endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several endothelium-derived relaxing factors, such as... 
MEDICINE, RESEARCH & EXPERIMENTAL | NITRIC-OXIDE SYNTHASE | BLOOD-VESSELS | DEPENDENT HYPERPOLARIZATION | PORCINE CORONARY-ARTERIES | ARACHIDONIC-ACID | SUPEROXIDE PRODUCTION | MESENTERIC-ARTERY | KNOCKOUT MICE | VASCULAR SMOOTH-MUSCLE | K+ CHANNELS
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2011, Volume 414, Issue 3, pp. 499 - 505
► NGF protects against H O -induced apoptosis in retina pigment epithelial (RPE) cells. ► Rapamycin sensitive mTOR signaling mediates NGF induced pro-survival... 
Retinal pigment epithelial cells | mTOR | Nerve growth factor | Hydrogen peroxide | Cell survival | Cell migration | MTOR | SYSTEM | POLY(ADP-RIBOSE) POLYMERASE | APOPTOSIS | OXIDATIVE STRESS | PROTEIN-KINASE | RPE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | MACULAR DEGENERATION | DEATH | BIOPHYSICS | (-)-EPIGALLOCATECHIN GALLATE | Cell Line | Cell Survival - drug effects | Apoptosis - drug effects | Humans | Hydrogen Peroxide - pharmacology | Nerve Growth Factor - pharmacology | Retinal Pigment Epithelium - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Sirolimus - pharmacology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Cell Movement - drug effects | Macular Degeneration - enzymology | Enzyme Activation | Oxidative Stress - drug effects | TOR Serine-Threonine Kinases - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Hydrogen Peroxide - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Cytoprotection | Retinal Pigment Epithelium - drug effects | Macular degeneration | Yuan (China) | Rapamycin | Sugars | Monosaccharides | TOR protein | Oxidative stress | Phosphorylation | Retina | visual field | Acuity | Eye | Regeneration | Pigments | Sensory neurons | retinal pigment epithelium | Age | Apoptosis
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 09/2011, Volume 12, Issue 9, pp. 5747 - 5761
Journal Article
Experimental Brain Research, ISSN 0014-4819, 1/2008, Volume 184, Issue 3, pp. 307 - 312
Z-ligustilide (Z-LIG) is the primary lipophilic compound of the Chinese medicine Danggui (Radix Angelica sinensis). Previous studies demonstrated that Z-LIG... 
Neurology | Neuroprotection | Neurosciences | Biomedicine | Cell apoptosis | Z-ligustilide | Phthalide derivatives | Oxidative injury | APOPTOSIS | OXIDATIVE STRESS | RATS | NEUROSCIENCES | ISCHEMIC DAMAGE | FREE-RADICALS | phthalide derivatives | oxidative injury | neuroprotection | DISEASE | cell apoptosis | CENTRAL-NERVOUS-SYSTEM | MICE | ANTIOXIDANT THERAPY | Neuroprotective Agents - therapeutic use | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Oxidative Stress - physiology | Cytoprotection - physiology | Cytotoxins - toxicity | Neurodegenerative Diseases - drug therapy | Apoptosis Regulatory Proteins - drug effects | PC12 Cells | Nerve Degeneration - chemically induced | Nerve Degeneration - metabolism | Dose-Response Relationship, Drug | Neuroprotective Agents - pharmacology | Up-Regulation - physiology | Cytoprotection - drug effects | Neurons - metabolism | Neurons - drug effects | Cytotoxins - antagonists & inhibitors | Hydrogen Peroxide - toxicity | Free Radical Scavengers - metabolism | 4-Butyrolactone - pharmacology | Rats | Mitochondria - metabolism | Antioxidants - pharmacology | Mitochondria - drug effects | Neurodegenerative Diseases - metabolism | Apoptosis Regulatory Proteins - metabolism | Up-Regulation - drug effects | Antioxidants - therapeutic use | Reactive Oxygen Species - antagonists & inhibitors | Animals | Neurodegenerative Diseases - physiopathology | 4-Butyrolactone - therapeutic use | 4-Butyrolactone - analogs & derivatives | Apoptosis - physiology | Oxidative Stress - drug effects | Hydrogen Peroxide - antagonists & inhibitors | Nerve Degeneration - drug therapy | Hydrogen peroxide
Journal Article