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European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2014, Volume 85, pp. 418 - 437
The 2′-deoxynucleoside 5′-phosphate -hydrolase 1 (DNPH1) has been proposed as a new molecular target for cancer treatment. Here, we describe the synthesis of a... 
Inhibitor | Cross-coupling reaction | DNPH1 | Nucleoside analogues | Crystal structure | Cancer | 5'-MONOPHOSPHATE N-GLYCOSIDASE | CHEMISTRY, MEDICINAL | CYTOSTATIC 6-ARYLPURINE NUCLEOSIDES | C-MYC | HL-60 CELLS | LEAVING GROUPS | 2'-DEOXYRIBONUCLEOSIDE 5'-MONOPHOSPHATE | ANTICANCER ACTIVITY | CROSS-COUPLING REACTIONS | PROTEIN-LIGAND COMPLEXES | HYDROLASE RCL | Purine Nucleotides - pharmacology | Antineoplastic Agents - chemical synthesis | Humans | Proto-Oncogene Proteins - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Molecular Targeted Therapy | Purine Nucleotides - chemistry | N-Glycosyl Hydrolases - chemistry | Purine Nucleotides - metabolism | Antineoplastic Agents - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chemistry Techniques, Synthetic | Enzyme Inhibitors - metabolism | N-Glycosyl Hydrolases - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Rats | Nuclear Proteins - metabolism | Purine Nucleotides - chemical synthesis | Antineoplastic Agents - chemistry | Nuclear Proteins - chemistry | N-Glycosyl Hydrolases - metabolism | Animals | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Protein Conformation | Molecular Docking Simulation | Drug Screening Assays, Antitumor | Enzymes | Colon cancer | Leukemia | Crystals | Hydrolases | Nucleotides | Structure | Nuclear Proteins/chemistry | Purine Nucleotides/metabolism | Proto-Oncogene Proteins/antagonists & inhibitors | Enzyme Inhibitors/metabolism | Enzyme Inhibitors/pharmacology | Life Sciences | Antineoplastic Agents/pharmacology | N-Glycosyl Hydrolases/antagonists & inhibitors | Nuclear Proteins/antagonists & inhibitors | N-Glycosyl Hydrolases/metabolism | Nuclear Proteins/metabolism | Purine Nucleotides/chemistry | Enzyme Inhibitors/chemistry | Purine Nucleotides/chemical synthesis | Enzyme Inhibitors/chemical synthesis | Antineoplastic Agents/metabolism | N-Glycosyl Hydrolases/chemistry | Proto-Oncogene Proteins/chemistry | Biochemistry, Molecular Biology | Proto-Oncogene Proteins/metabolism | Purine Nucleotides/pharmacology | Antineoplastic Agents/chemistry | Antineoplastic Agents/chemical synthesis
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 10/2008, Volume 17, Issue 10, pp. 1533 - 1545
Journal Article
Pharmacology and Therapeutics, ISSN 0163-7258, 2009, Volume 124, Issue 1, pp. 96 - 112
Lipids serve important functions as membrane constituents and also as energy storing molecules. Besides these functions certain lipid species have now been... 
Cannabinoids | Anti-inflammatory therapy | Eicosanoids | Ceramide | Lipids | Sphingolipids | PUFAs | PPARs | EETs | Sphingosine 1-phosphate | COLLAGEN-INDUCED ARTHRITIS | CYTOSOLIC PHOSPHOLIPASE A | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ISCHEMIA-REPERFUSION INJURY | SOLUBLE EPOXIDE HYDROLASE | ACTIVATED-RECEPTOR-ALPHA | ACID AMIDE HYDROLASE | RENAL MESANGIAL CELLS | POLYUNSATURATED FATTY-ACIDS | PHARMACOLOGY & PHARMACY | NF-KAPPA-B | Fatty Acids, Unsaturated - antagonists & inhibitors | Peroxisome Proliferator-Activated Receptors - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Sphingosine - antagonists & inhibitors | Cannabinoids - antagonists & inhibitors | Humans | Leukotriene Antagonists | Lipids - physiology | Lipids - antagonists & inhibitors | Phosphorylcholine - analogs & derivatives | Receptors, Prostaglandin E, EP4 Subtype | Sphingosine - analogs & derivatives | Animals | Receptors, Prostaglandin E - antagonists & inhibitors | Lipoxins - antagonists & inhibitors | Phosphorylcholine - antagonists & inhibitors | Sphingolipids - antagonists & inhibitors | Phospholipase A2 Inhibitors | Phosphates | Anti-inflammatory drugs | Tissue plasminogen activator | Cytochrome P-450 | Transforming growth factors | Fatty acids | Platelet activating factor | Membrane proteins | Endothelium | Hydrolysis | Prostaglandins | Nitric oxide | Linolenic acids | Physiological aspects | Phospholipases | Mitogens | Protein kinases | Omega-3 fatty acids | Glutathione | Organic compounds
Journal Article
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 05/2007, Volume 14, Issue 12, pp. 1291 - 1324
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2015, Volume 58, Issue 20, pp. 8292 - 8308
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 08/2011, Volume 25, Issue 8, pp. 2711 - 2721
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions for which new therapeutic approaches are needed. Genetic and pharmacological data point... 
Fatty acid amide hydrolase | Lipopolysaccharide | Monoacylglycerol lipase | Endocannabinoid | Anandamide | monoacylglycerol lipase | endocannabinoid | CANNABINOID RECEPTOR 2 | CROHNS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ULCERATIVE-COLITIS | ENDOCANNABINOID SYSTEM | BOWEL-DISEASE | CELL BIOLOGY | fatty acid amide hydrolase | ACID AMIDE HYDROLASE | ALPHA PRODUCTION | BIOLOGY | ANTAGONIST RIMONABANT | lipopolysaccharide | anandamide | INTESTINAL PERMEABILITY | Inflammation - pathology | Endotoxemia - prevention & control | Monoacylglycerol Lipases - antagonists & inhibitors | Humans | Colitis - pathology | Male | Receptor, Cannabinoid, CB2 - antagonists & inhibitors | Arachidonic Acids - metabolism | Inflammation - metabolism | Piperidines - pharmacology | Colitis - chemically induced | Indoles - pharmacology | Endocannabinoids | Disease Models, Animal | Pyrazoles - pharmacology | Inflammatory Bowel Diseases - drug therapy | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Inflammation Mediators - blood | Glycerides - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Receptor, Cannabinoid, CB2 - metabolism | Animals | Colitis - metabolism | Inflammation - prevention & control | Mice | Trinitrobenzenesulfonic Acid - toxicity | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Colitis - prevention & control | Benzodioxoles - pharmacology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2018, Volume 61, Issue 8, pp. 3582 - 3594
The Ebola virus (EBOV) causes severe human infection that lacks effective treatment. A recent screen identified a series of compounds that block EBOV-like... 
antiviral drug screening | EBOV | QSAR | computer-aided drug design
Journal Article