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Bulletin of Experimental Biology and Medicine, ISSN 0007-4888, 12/2016, Volume 162, Issue 2, pp. 228 - 230
Journal Article
Nature Medicine, ISSN 1078-8956, 2014, Volume 20, Issue 4, pp. 425 - 429
Journal Article
Blood, ISSN 0006-4971, 03/2012, Volume 119, Issue 11, pp. 2579 - 2589
Journal Article
Science, ISSN 0036-8075, 8/2009, Volume 325, Issue 5942, pp. 834 - 840
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 08/2010, Volume 132, Issue 31, pp. 10842 - 10846
Journal Article
Circulation, ISSN 0009-7322, 07/2012, Volume 126, Issue 4, pp. 455 - 467
Background-Epigenetic programming, dynamically regulated by histone acetylation, is a key mechanism regulating cell proliferation and survival. Little is known... 
genetic | epigenesis | vorinostat | histone deacetylation | pulmonary | valproic acid | hypertension | TARGET | CELLS | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | ACETYLATION | hypertension, pulmonary | epigenesis, genetic | PROLIFERATION | EMERGENCE | ARTERIAL-HYPERTENSION | PROSTATE-CANCER | IN-VIVO | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Muscle, Smooth, Vascular - metabolism | Humans | Male | Valproic Acid - pharmacology | Pulmonary Artery - metabolism | Histone Deacetylase 1 - antagonists & inhibitors | Valproic Acid - therapeutic use | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Hydroxamic Acids - pharmacology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Lung - pathology | Cells, Cultured | Rats | Histone Deacetylases - metabolism | Hypertension, Pulmonary - metabolism | Hypoxia - complications | Platelet-Derived Growth Factor - pharmacology | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | Muscle, Smooth, Vascular - pathology | Animals | Lung - drug effects | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylases - drug effects | Hydroxamic Acids - therapeutic use | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Hypertension, Pulmonary - etiology | Pulmonary Artery - pathology | Histone Deacetylase 1 - metabolism | Cell proliferation | Divalproex | Care and treatment | Usage | Enzyme inhibitors | Physiological aspects | Research | Valproic acid | Health aspects | Pulmonary hypertension | Index Medicus | Abridged Index Medicus
Journal Article
Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7327, pp. 1119 - 1123
Interaction of pathogens with cells of the immune system results in activation of inflammatory gene expression. This response, although vital for immune... 
MACHINES | BINDING MODULES | CHROMATIN | MULTIDISCIPLINARY SCIENCES | COMPLEXES | GENE-EXPRESSION | BROMODOMAIN PROTEIN BRD4 | TRANSCRIPTIONAL ELONGATION | P-TEFB | Sepsis - prevention & control | Salmonella Infections - immunology | Shock, Septic - prevention & control | Salmonella Infections - physiopathology | Salmonella typhimurium | Heterocyclic Compounds, 4 or More Rings - pharmacology | Sepsis - drug therapy | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Inflammation - drug therapy | Shock, Septic - drug therapy | Anti-Inflammatory Agents - therapeutic use | Hydroxamic Acids - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | Salmonella Infections - drug therapy | Genome-Wide Association Study | Epigenomics | Anti-Inflammatory Agents - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Heterocyclic Compounds, 4 or More Rings - chemistry | Kaplan-Meier Estimate | Models, Molecular | Salmonella Infections - prevention & control | Benzodiazepines | Gene Expression Regulation - drug effects | Acetylation - drug effects | Animals | Anti-Inflammatory Agents - chemistry | Lipopolysaccharides - pharmacology | Histone Deacetylase Inhibitors - pharmacology | Macrophages - drug effects | Inflammation - prevention & control | Mice | Proteins | Pathology | Eukaryotes | Chromatin | Immunology | Pharmacology | Gene expression | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 482 - 485
Despite antiretroviral therapy, proviral latency of human immunodeficiency virus type 1 (HIV-1) remains a principal obstacle to curing the infection(1).... 
CELLS | ACTIVATION | SUBEROYLANILIDE HYDROXAMIC ACID | MULTIDISCIPLINARY SCIENCES | IN-VIVO | VALPROIC ACID | INFECTION | HISTONE DEACETYLASE INHIBITORS | TYPE-1 | EXPRESSION | PCR | Gene Expression Regulation, Viral - drug effects | Humans | Hydroxamic Acids - adverse effects | Histone Deacetylase Inhibitors - administration & dosage | RNA, Viral - blood | Virus Latency - drug effects | Proviruses - drug effects | HIV-1 - growth & development | Proviruses - genetics | Hydroxamic Acids - administration & dosage | Anti-HIV Agents - therapeutic use | CD4-Positive T-Lymphocytes - virology | Hydroxamic Acids - pharmacology | Biomarkers - metabolism | HIV Infections - blood | Risk Assessment | HIV-1 - drug effects | CD4-Positive T-Lymphocytes - cytology | HIV Infections - virology | RNA, Viral - biosynthesis | CD4-Positive T-Lymphocytes - metabolism | Viremia - drug therapy | HIV-1 - genetics | Proviruses - growth & development | Histones - drug effects | Up-Regulation - drug effects | Acetylation - drug effects | Viremia - virology | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Histone Deacetylase Inhibitors - adverse effects | Physiological aspects | Antiviral agents | HIV patients | Health aspects | Vorinostat | Antiretroviral drugs | Plasma | Cell culture | Lymphocytes | Human immunodeficiency virus--HIV | Genomes | Drug therapy | Drug dosages | Index Medicus
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2011, Volume 17, Issue 16, pp. 5311 - 5321
Purpose: The success of bortezomib therapy for treatment of multiple myeloma (MM) led to the development of structurally and pharmacologically distinct novel... 
THERAPY | CANCER CELLS | ONCOLOGY | INDUCED APOPTOSIS | GROWTH | DRUG-RESISTANCE | BORTEZOMIB | COMBINATION | NF-KAPPA-B | GENETIC ABNORMALITIES | P53 | Glycine - analogs & derivatives | Caspase 9 - metabolism | Apoptosis - drug effects | Humans | Caspase 3 - metabolism | Caspase 8 - metabolism | Biological Availability | NF-kappa B - metabolism | Thalidomide - pharmacology | Thalidomide - analogs & derivatives | Multiple Myeloma - drug therapy | Dexamethasone - pharmacology | Antineoplastic Agents - pharmacology | Glycine - pharmacokinetics | Boron Compounds - pharmacology | Cell Survival - drug effects | Bortezomib | Administration, Oral | Boron Compounds - pharmacokinetics | Enzyme Activation - drug effects | Mice, SCID | Multiple Myeloma - metabolism | Blotting, Western | Drug Synergism | Xenograft Model Antitumor Assays | Multiple Myeloma - pathology | Animals | Glycine - pharmacology | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Proteasome Inhibitors | Pyrazines - pharmacology | Boronic Acids - pharmacology | Index Medicus | Histone deacetylase | Animal models | Dexamethasone | Multiple myeloma | proteasomes | Hydroxamic acid | proteasome inhibitors | Caspase-3 | Stress | p53 protein | Caspase-8 | Angiogenesis | E2F protein | Caspase-9 | Xenografts | Antitumor activity | Endoplasmic reticulum | Apoptosis | Cancer | Tumors | Novel therapeutics | Myeloma | Proteasome inhibitor | Proteasome
Journal Article