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Cell Metabolism, ISSN 1550-4131, 12/2013, Volume 18, Issue 6, pp. 920 - 933
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2014, Volume 124, Issue 12, pp. 5175 - 5190
Nonalcoholic fatty liver disease (NAFLD) spectrum disorders affect approximately 1 billion individuals worldwide. However, the drivers of progressive... 
MEDICINE, RESEARCH & EXPERIMENTAL | PPAR-ALPHA | CONTROL MECHANISMS | INSULIN-RESISTANCE | MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE | CARDIOVASCULAR-DISEASE | KETONE-BODY METABOLISM | ACID OXIDATION | COENZYME-A METABOLISM | MASS-SPECTROMETRY | ADIPOSE-TISSUE | Mitochondrial Diseases - pathology | Non-alcoholic Fatty Liver Disease - pathology | Gluconeogenesis - drug effects | Hydroxymethylglutaryl-CoA Synthase - genetics | Mitochondrial Diseases - metabolism | Acyl Coenzyme A - genetics | Male | Hydroxymethylglutaryl-CoA Synthase - metabolism | Hypoglycemia - pathology | Hyperglycemia - genetics | Hyperglycemia - chemically induced | Non-alcoholic Fatty Liver Disease - chemically induced | Mice, Mutant Strains | Hyperglycemia - pathology | Hydroxymethylglutaryl-CoA Synthase - deficiency | Acyl Coenzyme A - metabolism | Hypoglycemia - genetics | Mitochondrial Diseases - genetics | Dietary Fats - adverse effects | Non-alcoholic Fatty Liver Disease - genetics | Citric Acid Cycle - drug effects | Metabolism, Inborn Errors - metabolism | Glucose - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Hypoglycemia - metabolism | Metabolism, Inborn Errors - genetics | Hyperglycemia - metabolism | Citric Acid Cycle - genetics | Animals | Gluconeogenesis - genetics | Glucose - metabolism | Mice | Metabolism, Inborn Errors - pathology | Enzymes | Carbohydrates | Liver diseases | Pathogenesis | Liver | Lipids | Glucose | Metabolism | Fatty acids | Studies | Nutrition research | Metabolites | Rodents | Diabetes
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 09/2005, Volume 24, Issue 43, pp. 6465 - 6481
Protein kinase B (PKB/Akt) has been shown to play a role in protection from apoptosis, cell proliferation and cell growth. It is also involved in mediating the... 
SREBP | PKB/Akt | Transcription | Microarray | Cholesterol and fatty acid biosynthesis | PROTEIN-KINASE-B | transcription | cholesterol and fatty acid biosynthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-PROTEIN | DIFFERENTIAL REGULATION | CELL BIOLOGY | SYNTHASE PROMOTER | TARGET PROMOTERS | microarray | ONCOLOGY | PROSTATE-CANCER | GENETICS & HEREDITY | GENE-EXPRESSION | STEROL-REGULATORY-ELEMENT | NF-KAPPA-B | LIVER-X-RECEPTOR | Pigment Epithelium of Eye - drug effects | Fatty Acid Synthases - metabolism | Humans | Hydroxymethylglutaryl-CoA Synthase - genetics | Gene Expression Profiling | Hydroxymethylglutaryl-CoA Synthase - metabolism | Hydroxymethylglutaryl-CoA Synthase - drug effects | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | Hydroxymethylglutaryl CoA Reductases - metabolism | Enzymes - genetics | Transcription, Genetic | Cell Membrane - metabolism | Fatty Acid Synthases - genetics | Enzymes - metabolism | Protein-Serine-Threonine Kinases - metabolism | CCAAT-Enhancer-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Insulin - pharmacology | Proto-Oncogene Proteins - drug effects | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Epidermal Growth Factor - metabolism | Proto-Oncogene Proteins - genetics | Pigment Epithelium of Eye - metabolism | Proto-Oncogene Proteins c-akt | Transcription Factors - metabolism | Insulin - metabolism | Protein-Serine-Threonine Kinases - drug effects | Tamoxifen - pharmacology | Tamoxifen - analogs & derivatives | Epidermal Growth Factor - pharmacology | Pigment Epithelium of Eye - cytology | Cholesterol - biosynthesis | Sterol Regulatory Element Binding Protein 1 | Hydroxymethylglutaryl CoA Reductases - genetics | Sterol Regulatory Element Binding Protein 2 | Fatty Acids - biosynthesis
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 04/2018, Volume 233, Issue 4, pp. 3306 - 3314
Mitochondrial 3‐hydroxy‐3‐methylglutaryl‐CoA (HMG‐CoA) synthase (HMGCS2) catalyses the first step of ketogenesis and is critical in various metabolic... 
glucose | insulin | PUFA | transcription factors | fructose | HMGCS2 | gene expression | PHYSIOLOGY | LIPID-METABOLISM | RAT | PEROXISOME PROLIFERATOR | DOWN-REGULATION | PROLIFERATOR-ACTIVATED RECEPTOR | ALPHA | CELL BIOLOGY | LIVER | POLYUNSATURATED FATTY-ACIDS | KETONE-BODY METABOLISM | Forkhead Box Protein O1 - metabolism | Gene Expression Regulation, Enzymologic - drug effects | Insulin - pharmacology | Mitochondria - enzymology | Humans | Hydroxymethylglutaryl-CoA Synthase - genetics | RNA, Messenger - genetics | Fatty Acids, Unsaturated - pharmacology | Glucose - pharmacology | Hydroxymethylglutaryl-CoA Synthase - metabolism | Liver X Receptors - metabolism | Quinolones - pharmacology | Mitochondria - drug effects | Pyrimidines - pharmacology | Down-Regulation - drug effects | RNA, Messenger - metabolism | Hep G2 Cells | Up-Regulation - drug effects | Fructose - pharmacology | Liver X Receptors - agonists | Nutrients | PPAR alpha - agonists | Forkhead Box Protein O1 - antagonists & inhibitors | Unsaturated fatty acids | Gene expression | Genes | Omega-3 fatty acids | Transcription factors | Ketogenesis | Polyunsaturated fatty acids | Liver | Hepatoma | Arachidonic acid | Docosahexaenoic acid | Monosaccharides | Receptors | Mitochondria | FOXO1 protein | liver X receptors | Forkhead protein | Nutritional status | Nutrition | Health risks | Metabolism | Nuclear receptors | Insulin | Fatty acids | Fructose | Hepatocytes | Peroxisome proliferator-activated receptors | Eicosapentaenoic acid
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2015, Volume 96, Issue 3, pp. 267 - 277
Journal Article
ChemBioChem, ISSN 1439-4227, 08/2006, Volume 7, Issue 8, pp. 1206 - 1220
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2004, Volume 110, Issue 14, pp. 1933 - 1939
Background - Endothelial nitric oxide (eNO) bioavailability is severely reduced after myocardial infarction (MI) and in heart failure. Statins enhance eNO... 
Heart failure | Myocardial infarction | Nitric oxide synthase | Statins | Endothelium | CARDIAC-FUNCTION | endothelium | heart failure | CHRONIC HEART-FAILURE | CARDIAC & CARDIOVASCULAR SYSTEMS | COA REDUCTASE INHIBITORS | ANGIOGENESIS | myocardial infarction | DILATED CARDIOMYOPATHY | MICE LACKING | CORONARY-CIRCULATION | HYPERTROPHY | THERAPY | statins | PERIPHERAL VASCULAR DISEASE | nitric oxide synthase | HEMATOLOGY | EXPRESSION | Capillaries - pathology | Heart Failure - enzymology | Heptanoic Acids - therapeutic use | Heart Failure - physiopathology | Nitric Oxide Synthase - physiology | Biological Availability | Male | Myocardial Infarction - diagnostic imaging | Nitric Oxide Synthase - genetics | Nitric Oxide Synthase Type II | Mesenchymal Stromal Cells - cytology | Myocardial Infarction - pathology | Ultrasonography | Myocardial Infarction - physiopathology | Vasodilation - physiology | Pyrroles - therapeutic use | Heart Failure - etiology | Heptanoic Acids - pharmacology | Myocardial Infarction - enzymology | Collateral Circulation - drug effects | Mesenchymal Stromal Cells - drug effects | Nitric Oxide - biosynthesis | Cells, Cultured - drug effects | Mice, Inbred C57BL | Ventricular Function, Left - drug effects | Nitric Oxide Synthase Type III | Myocardium - pathology | Nitric Oxide - physiology | Random Allocation | Mice, Knockout | Atorvastatin Calcium | Drug Resistance - genetics | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Nitric Oxide Synthase - deficiency | Endothelial Cells - cytology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Fibrosis | Mice | Vasodilation - drug effects | Ventricular Remodeling - drug effects | Endothelial Cells - drug effects
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/1998, Volume 273, Issue 37, pp. 24266 - 24271
The mechanism by which 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors increase endothelial nitric oxide synthase (eNOS) expression is unknown. To... 
CORONARY-ARTERY DISEASE | INHIBITION | MESSENGER-RNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | ATHEROSCLEROSIS | REDUCTASE | DYSFUNCTION | PROTEINS | EXPRESSION | HYPERCHOLESTEROLEMIC HUMANS | Gene Expression Regulation, Enzymologic - drug effects | Lovastatin - pharmacology | Humans | Lipoproteins, LDL - physiology | ras Proteins - metabolism | Guanosine Triphosphate - metabolism | Lovastatin - analogs & derivatives | Endothelium, Vascular - enzymology | Nitric Oxide Synthase - genetics | RNA, Messenger - metabolism | GTP-Binding Proteins - genetics | rhoB GTP-Binding Protein | Botulinum Toxins | Cytotoxins - pharmacology | Sesquiterpenes | Membrane Proteins - metabolism | ADP Ribose Transferases - metabolism | Mevalonic Acid - pharmacology | Membrane Proteins - genetics | RNA Processing, Post-Transcriptional - drug effects | RNA, Messenger - genetics | Cells, Cultured | Nitric Oxide Synthase Type III | Lipoproteins, LDL - pharmacology | rhoA GTP-Binding Protein | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Escherichia coli Proteins | GTP Phosphohydrolases - metabolism | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Bacterial Toxins - pharmacology | GTP Phosphohydrolases - genetics | ADP Ribose Transferases - pharmacology | Cytosol - metabolism | Polyisoprenyl Phosphates - pharmacology | Kinetics | GTP-Binding Proteins - metabolism
Journal Article