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index medicus (473) 473
humans (374) 374
hydroxyprostaglandin dehydrogenases - genetics (364) 364
hydroxyprostaglandin dehydrogenases - metabolism (297) 297
female (235) 235
animals (212) 212
aldo-keto reductase family 1 member c3 (135) 135
male (132) 132
3-hydroxysteroid dehydrogenases - genetics (104) 104
3-hydroxysteroid dehydrogenases - metabolism (92) 92
mice (92) 92
oncology (88) 88
15-hydroxyprostaglandin dehydrogenase (84) 84
cell line, tumor (84) 84
expression (83) 83
dinoprostone - metabolism (77) 77
biochemistry & molecular biology (68) 68
pregnancy (68) 68
prostaglandins (66) 66
adult (65) 65
molecular sequence data (65) 65
enzymes (63) 63
middle aged (63) 63
endocrinology & metabolism (62) 62
gene expression (62) 62
cancer (60) 60
rna, messenger - genetics (60) 60
cyclooxygenase 2 - metabolism (58) 58
rna, messenger - metabolism (58) 58
cells, cultured (55) 55
immunohistochemistry (54) 54
article (51) 51
base sequence (51) 51
cyclooxygenase 2 - genetics (50) 50
amino acid sequence (49) 49
prostaglandin-e synthases (49) 49
abridged index medicus (48) 48
hydroxyprostaglandin dehydrogenases - biosynthesis (48) 48
cell biology (47) 47
metabolism (47) 47
hydroxyprostaglandin dehydrogenases - antagonists & inhibitors (45) 45
physiological aspects (45) 45
reverse transcriptase polymerase chain reaction (43) 43
gene expression regulation, enzymologic (41) 41
intramolecular oxidoreductases - genetics (41) 41
cyclooxygenase-2 (39) 39
blotting, western (37) 37
gene expression regulation, neoplastic (37) 37
genes (37) 37
prostaglandins - metabolism (37) 37
aged (36) 36
analysis (36) 36
pharmacology & pharmacy (36) 36
hydroxyprostaglandin dehydrogenases - chemistry (33) 33
rna, messenger - analysis (33) 33
reproductive biology (32) 32
15-pgdh (31) 31
gene-expression (31) 31
signal transduction (31) 31
akr1c3 (30) 30
prostaglandin (30) 30
3-hydroxysteroid dehydrogenases - antagonists & inhibitors (29) 29
tumor-suppressor (29) 29
aldo-keto reductases (28) 28
cattle (28) 28
cells (28) 28
kinetics (28) 28
prostaglandin e-2 (28) 28
care and treatment (27) 27
colorectal-cancer (27) 27
cox-2 (27) 27
intramolecular oxidoreductases - metabolism (27) 27
transfection (27) 27
enzyme inhibitors - pharmacology (26) 26
genetic aspects (26) 26
progesterone (26) 26
prostaglandin e2 (26) 26
research article (26) 26
substrate specificity (26) 26
cloning, molecular (25) 25
gene expression regulation, enzymologic - drug effects (25) 25
lipids (25) 25
prostaglandin-endoperoxide synthases - genetics (25) 25
proteins (25) 25
recombinant proteins - metabolism (25) 25
research (25) 25
aldo-keto reductase (24) 24
breast cancer (24) 24
gene expression regulation, neoplastic - drug effects (24) 24
prostate-cancer (24) 24
rats (24) 24
cell line (23) 23
receptor (23) 23
apoptosis (22) 22
case-control studies (22) 22
gene expression profiling (22) 22
hydroxysteroid dehydrogenases - genetics (22) 22
lung-cancer (22) 22
nonsteroidal antiinflammatory drugs (22) 22
toxicology (22) 22
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Journal Article
Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 23, pp. 6142 - 6152
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR... 
SELECTIVE INHIBITOR | DIHYDROTESTOSTERONE LEVELS | ONCOLOGY | ABIRATERONE ACETATE | THERAPEUTIC IMPLICATIONS | RECEPTOR | INCREASED SURVIVAL | CYP17 INHIBITOR | CASTRATION | I CLINICAL-TRIAL | HORMONAL-THERAPY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Immunohistochemistry | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Androgens - biosynthesis | Data Mining | Male | Hydroxyprostaglandin Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - genetics | RNA, Messenger - biosynthesis | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Cytochrome P-450 CYP3A - genetics | Receptors, Androgen - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - enzymology | Cytochrome P-450 CYP3A - biosynthesis | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Receptors, Androgen - genetics | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Neoplasms, Hormone-Dependent - pathology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Cell Line, Tumor | Prostatic Neoplasms - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus | abiraterone | androgen synthesis | testosterone | dihydrotestosterone | AKR1C3 | CYP17 | MDV3100 (enzalutamide) | Prostate cancer
Journal Article
Nature Genetics, ISSN 1061-4036, 06/2008, Volume 40, Issue 6, pp. 789 - 793
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 210 - 217
► In endometrial cancer progesterone biosynthesis genes are down-regulated. ► Expression of most progesterone metabolism genes is not altered in cancerous... 
Steroidogenic acute regulatory protein | 5α-Reductase | Pre-receptor metabolism | Side-chain cleavage enzyme | 3-Keto/20-keto-reductase | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROID 5-ALPHA-REDUCTASE | RECEPTOR-A | 5 alpha-Reductase | ER-ALPHA | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | KETO REDUCTASE SUPERFAMILY | ESTROGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | YOUNG-WOMEN | TYPE-2 | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Progesterone Reductase - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Multienzyme Complexes - metabolism | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Endometrial Neoplasms - genetics | Phosphoproteins | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Progesterone - biosynthesis | Membrane Proteins - metabolism | Steroid Isomerases - genetics | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Progesterone - metabolism | Aged | Progesterone - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Endometrial cancer | RNA | Genes | Cytochrome P-450 | Physiological aspects | Genetic aspects | Progesterone | Cancer | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2017, Volume 16, Issue 1, pp. 35 - 44
Abiraterone suppresses intracrine androgen synthesis via inhibition of CYP17A1. However, clinical evidence suggests that androgen synthesis is not fully... 
STEROIDOGENIC ENZYME AKR1C3 | CYP17A1 INHIBITION | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | INCREASED SURVIVAL | ENZALUTAMIDE RESISTANCE | ANTITUMOR-ACTIVITY | ANDROGEN RECEPTOR GENE | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Male | Androstenes - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Transcription, Genetic | Prostatic Neoplasms - drug therapy | Disease Models, Animal | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Cell Transformation, Neoplastic - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Animals | Aldo-Keto Reductase Family 1 Member C3 | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasm Staging | Medical research | Transcription | Medical services | Clinical trials | Activation | Signaling | Androgens | Synthesis | Steroidogenesis | Indomethacin | Inhibition | Prostate cancer | Prostate | Cancer | Index Medicus | AKR1C3 | prostate cancer | intracrine androgens | abiraterone | indomethacin
Journal Article
Oncology Reports, ISSN 1021-335X, 03/2017, Volume 37, Issue 4, pp. 2025 - 2032
Resistance to anticancer medications often leads to poor outcomes. The present study explored an effective approach for enhancing chemotherapy targeted against... 
aldo-keto reductase | cisplatin | mefenamic acid | 5-FU | Cisplatin, 5-FU | Mefenamic acid | Aldo-keto reductase | HUMAN OVARIAN | AKR1C3 | CISPLATIN RESISTANCE | TUMOR-CELLS | CHEMOTHERAPY | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | LUNG-CANCER | CARCINOMA CELL-LINE | ONCOLOGY | SUPERFAMILY | EXPRESSION | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 3-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Humans | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Cisplatin - administration & dosage | Neoplasms - drug therapy | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Fluorouracil - administration & dosage | 20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Mefenamic Acid - administration & dosage | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxysteroid Dehydrogenases - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Oxidoreductases | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Patient outcomes | Genetic aspects | Drug resistance | Gene expression | Health aspects | Methods | Cancer | Studies | Enzymes | Oxidative stress | Chemotherapy | Genes | Rodents | Prostate | Experiments | Cancer therapies | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 06/2015, Volume 234, pp. 309 - 319
Estrogens have important roles in the pathogenesis of endometrial cancer. They can have carcinogenic effects through stimulation of cell proliferation or... 
Aromatase pathway | Sulfatase pathway | Phase I and phase II estrogen metabolism | Aldo–keto reductase 1C3 (AKR1C3) | 17β-Hydroxysteroid dehydrogenases (17β-HSDs, HSD17B) | Catechol-O-methyl transferase (COMT) | 17b-Hydroxysteroid dehydrogenases | (17b-HSDs HSD17B)Aldoketo reductase 1C3 (AKR1C3) | 17 beta-Hydroxysteroid dehydrogenases (17 beta-HSDs, HSD17B) | DEHYDROGENASES | QUINONES | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROGESTERONE ACTION | 17-BETA-ESTRADIOL | CARCINOGENESIS | OVARIAN ENDOMETRIOSIS | Aldo-keto reductase 1C3 (AKR1C3) | ENZYMES | PHARMACOLOGY & PHARMACY | TOXICOLOGY | PHASE-I | CARCINOMA | PRE-RECEPTOR REGULATION | Sulfatases - genetics | Progesterone Reductase - metabolism | Humans | Endometrial Neoplasms - metabolism | Aromatase - metabolism | Catechol O-Methyltransferase - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Catechol O-Methyltransferase - metabolism | Aromatase - genetics | Endometrial Neoplasms - genetics | Sulfatases - metabolism | Estrogens - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Sulfotransferases - metabolism | Estrogens - metabolism | Quinones - pharmacology | Glutathione S-Transferase pi - genetics | Sulfotransferases - genetics | Estrone - genetics | Quinone Reductases - metabolism | Androstenedione - genetics | Glutathione S-Transferase pi - metabolism | Estrogens - biosynthesis | RNA, Messenger - genetics | Transcriptome - genetics | Progesterone Reductase - genetics | Arylsulfotransferase - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Estrone - analogs & derivatives | Aldo-Keto Reductase Family 1 Member C3 | Estrone - metabolism | Cell Line, Tumor | Quinone Reductases - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | Arylsulfotransferase - metabolism | Physiological aspects | Endometrial cancer | Sulfates | Genes | Estrogen | Steroids | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1256 - 1264
textabstractAndrogen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might... 
XENOGRAFT MODELS | INCREASED EXPRESSION | ONCOLOGY | PATHWAY | IN-VIVO | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | AGGRESSIVENESS | RECEPTOR GENE | PROGRESSION | DIHYDROTESTOSTERONE | ANDROGEN DEPRIVATION THERAPY | Progesterone Reductase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neoplasms, Experimental - enzymology | Male | Transplantation, Heterologous | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Pregnenolone - metabolism | Neoplasms, Experimental - pathology | Testosterone - metabolism | Prostatic Neoplasms - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Neoplasms, Experimental - genetics | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Dihydrotestosterone - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Progesterone Reductase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Animals | Aldo-Keto Reductase Family 1 Member C3 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Steroid 17-alpha-Hydroxylase - genetics | Aged | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2013, Volume 19, Issue 20, pp. 5613 - 5625
Journal Article
Clinical Endocrinology, ISSN 0300-0664, 03/2007, Volume 66, Issue 3, pp. 440 - 446
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 02/2009, Volume 296, Issue 2, pp. 244 - 255
The objective was to examine pathways of androgen metabolism in abdominal adipose tissue in women. Abdominal subcutaneous (SC) and omental (OM) adipose tissue... 
Omental visceral fat | Adipocyte differentiation | Short-chain dehydrogenases | Aldo-keto reductases | Estrogen | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | AROMATASE-ACTIVITY | estrogen | PHYSIOLOGY | short-chain dehydrogenases | adipocyte differentiation | omental visceral fat | HUMAN PREADIPOCYTES | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | ESTROGEN-RECEPTOR-BETA | OBESITY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | aldo-keto reductases | DIFFERENTIATION | STROMAL CELLS | Adipose Tissue - physiology | Humans | Middle Aged | Gene Expression Regulation, Enzymologic - physiology | Hydroxyprostaglandin Dehydrogenases - metabolism | Adipogenesis - physiology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Omentum - enzymology | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Hydroxysteroid Dehydrogenases - metabolism | Metabolic Networks and Pathways - physiology | Body Fat Distribution | Adipogenesis - genetics | Cells, Cultured | Hydroxysteroid Dehydrogenases - genetics | Omentum - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Abdominal Fat - metabolism | Metabolic Networks and Pathways - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 17-Hydroxysteroid Dehydrogenases - genetics | Abdominal Fat - enzymology | Adipose Tissue - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Subcutaneous Fat - enzymology | Women | Tissue | Enzymes | Androgens | Body fat | Metabolism | Ribonucleic acid--RNA | Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This... 
DIHYDRODIOL DEHYDROGENASE ISOFORMS | QUINONE REDUCTASE | HUMAN CARBONYL REDUCTASE | ENZYMES | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ALDEHYDE REDUCTASE | SINGLE NUCLEOTIDE POLYMORPHISMS | PROSTAGLANDIN-F SYNTHASE | Aldehyde Reductase - genetics | Humans | Polymorphism, Single Nucleotide - physiology | Mitochondrial Proteins - genetics | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Recombinant Proteins - isolation & purification | Mitochondrial Proteins - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Glyceraldehyde - metabolism | Phenanthrenes - metabolism | Recombinant Proteins - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Biocatalysis | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Frequency | Indans - metabolism | Models, Molecular | Alcohol Oxidoreductases - metabolism | Recombinant Proteins - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductases | Vitamin K 3 - metabolism | Aldo-Keto Reductase Family 1 Member C3 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2011, Volume 39, Issue 3, pp. 510 - 521
Boceprevir (SCH 503034), a protease inhibitor, is under clinical development for the treatment of human hepatitis C virus infections. In human liver... 
METABOLISM | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NS3 PROTEASE | ALDO-KETO REDUCTASES |