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Cancer Research, ISSN 0008-5472, 12/2012, Volume 72, Issue 23, pp. 6142 - 6152
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR... 
SELECTIVE INHIBITOR | DIHYDROTESTOSTERONE LEVELS | ONCOLOGY | ABIRATERONE ACETATE | THERAPEUTIC IMPLICATIONS | RECEPTOR | INCREASED SURVIVAL | CYP17 INHIBITOR | CASTRATION | I CLINICAL-TRIAL | HORMONAL-THERAPY | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Immunohistochemistry | Neoplasms, Hormone-Dependent - metabolism | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Transcriptome | Androgens - biosynthesis | Data Mining | Male | Hydroxyprostaglandin Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - genetics | RNA, Messenger - biosynthesis | Neoplasm Metastasis | Prostatic Neoplasms - genetics | Cytochrome P-450 CYP3A - genetics | Receptors, Androgen - biosynthesis | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Neoplasms, Hormone-Dependent - enzymology | Cytochrome P-450 CYP3A - biosynthesis | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Receptors, Androgen - genetics | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Neoplasms, Hormone-Dependent - pathology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Cell Line, Tumor | Prostatic Neoplasms - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus | abiraterone | androgen synthesis | testosterone | dihydrotestosterone | AKR1C3 | CYP17 | MDV3100 (enzalutamide) | Prostate cancer
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2010, Volume 335, Issue 3, pp. 533 - 545
Doxorubicin (DOX) and daunorubicin (DAUN) are effective anticancer drugs; however, considerable interpatient variability exists in their pharmacokinetics. This... 
DIHYDRODIOL DEHYDROGENASE ISOFORMS | QUINONE REDUCTASE | HUMAN CARBONYL REDUCTASE | ENZYMES | ANTHRACYCLINE-INDUCED CARDIOTOXICITY | SUPERFAMILY | PHARMACOLOGY & PHARMACY | HUMAN LIVER | ALDEHYDE REDUCTASE | SINGLE NUCLEOTIDE POLYMORPHISMS | PROSTAGLANDIN-F SYNTHASE | Aldehyde Reductase - genetics | Humans | Polymorphism, Single Nucleotide - physiology | Mitochondrial Proteins - genetics | NAD(P)H Dehydrogenase (Quinone) - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Alcohol Oxidoreductases - genetics | Recombinant Proteins - isolation & purification | Mitochondrial Proteins - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Aldehyde Reductase - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Doxorubicin - metabolism | Daunorubicin - metabolism | Glyceraldehyde - metabolism | Phenanthrenes - metabolism | Recombinant Proteins - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Biocatalysis | Oxidoreductases - metabolism | Oxidoreductases - genetics | Gene Frequency | Indans - metabolism | Models, Molecular | Alcohol Oxidoreductases - metabolism | Recombinant Proteins - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductases | Vitamin K 3 - metabolism | Aldo-Keto Reductase Family 1 Member C3 | NAD(P)H Dehydrogenase (Quinone) - metabolism | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Index Medicus
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 03/2011, Volume 39, Issue 3, pp. 510 - 521
Boceprevir (SCH 503034), a protease inhibitor, is under clinical development for the treatment of human hepatitis C virus infections. In human liver... 
METABOLISM | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | NS3 PROTEASE | ALDO-KETO REDUCTASES | CARBONYL REDUCTION | NEUROSTEROIDS | SUPERFAMILY | PHARMACOLOGY & PHARMACY | AGENTS | DEHYDROGENASE | HIV-INTEGRASE INHIBITOR | Liver - enzymology | Proline - metabolism | Stereoisomerism | Humans | Drugs, Investigational - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Urea - chemistry | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Drugs, Investigational - chemistry | Serine Proteinase Inhibitors - chemistry | Cytochrome P-450 CYP3A - genetics | Urea - analogs & derivatives | 3-Hydroxysteroid Dehydrogenases - metabolism | Hydroxysteroid Dehydrogenases - metabolism | Urea - metabolism | Molecular Structure | Oligopeptides - chemistry | Recombinant Proteins - metabolism | Oxidation-Reduction | Proline - analogs & derivatives | Subcellular Fractions - drug effects | Enzyme Inhibitors - pharmacology | Serine Proteinase Inhibitors - metabolism | Hydroxysteroid Dehydrogenases - genetics | Oligopeptides - metabolism | Subcellular Fractions - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Proline - chemistry | Hepacivirus - enzymology | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Cytochrome P-450 CYP3A Inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Cytochrome P-450 CYP3A - metabolism | Biotransformation - drug effects | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Kinetics | 3-Hydroxysteroid Dehydrogenases - genetics | Viral Nonstructural Proteins - antagonists & inhibitors | Subcellular Fractions - enzymology | Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2008, Volume 93, Issue 6, pp. 2366 - 2374
Context: Experimental and clinical studies in a variety of nonprimate species demonstrate that progesterone withdrawal leads to changes in gene expression that... 
17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | UTERINE CERVIX | ENDOCRINOLOGY & METABOLISM | PRETERM BIRTH | 5-ALPHA-REDUCTASE TYPE-1 | DEHYDROGENASE-ACTIVITY | HUMAN-ENDOMETRIUM | GUINEA-PIG | RECEPTOR-A | EXPRESSION | INTERLEUKIN-8 PRODUCTION | Cervical Ripening - metabolism | Cervix Uteri - metabolism | Humans | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Myometrium - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - metabolism | Estrogens - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Oxidoreductases - metabolism | Oxidoreductases - genetics | Cervix Uteri - enzymology | Parturition - genetics | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Gestational Age | Hydroxyprostaglandin Dehydrogenases - genetics | Gene Expression Regulation, Enzymologic | Pregnancy | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cervix Uteri - physiology | Progesterone - metabolism | Mice | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Parturition - metabolism | Index Medicus | Abridged Index Medicus | Original
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 02/2009, Volume 296, Issue 2, pp. 244 - 255
The objective was to examine pathways of androgen metabolism in abdominal adipose tissue in women. Abdominal subcutaneous (SC) and omental (OM) adipose tissue... 
Omental visceral fat | Adipocyte differentiation | Short-chain dehydrogenases | Aldo-keto reductases | Estrogen | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | AROMATASE-ACTIVITY | estrogen | PHYSIOLOGY | short-chain dehydrogenases | adipocyte differentiation | omental visceral fat | HUMAN PREADIPOCYTES | 20-ALPHA-HYDROXYSTEROID DEHYDROGENASE | ESTROGEN-RECEPTOR-BETA | OBESITY | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | aldo-keto reductases | DIFFERENTIATION | STROMAL CELLS | Adipose Tissue - physiology | Humans | Middle Aged | Gene Expression Regulation, Enzymologic - physiology | Hydroxyprostaglandin Dehydrogenases - metabolism | Adipogenesis - physiology | Adipose Tissue - metabolism | Subcutaneous Fat - metabolism | Omentum - enzymology | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Hydroxysteroid Dehydrogenases - metabolism | Metabolic Networks and Pathways - physiology | Body Fat Distribution | Adipogenesis - genetics | Cells, Cultured | Hydroxysteroid Dehydrogenases - genetics | Omentum - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Abdominal Fat - metabolism | Metabolic Networks and Pathways - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | Models, Biological | 17-Hydroxysteroid Dehydrogenases - genetics | Abdominal Fat - enzymology | Adipose Tissue - enzymology | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | 17-Hydroxysteroid Dehydrogenases - metabolism | Subcutaneous Fat - enzymology | Women | Tissue | Enzymes | Androgens | Body fat | Metabolism | Ribonucleic acid--RNA | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 210 - 217
► In endometrial cancer progesterone biosynthesis genes are down-regulated. ► Expression of most progesterone metabolism genes is not altered in cancerous... 
Steroidogenic acute regulatory protein | 5α-Reductase | Pre-receptor metabolism | Side-chain cleavage enzyme | 3-Keto/20-keto-reductase | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASES | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | STEROID 5-ALPHA-REDUCTASE | RECEPTOR-A | 5 alpha-Reductase | ER-ALPHA | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | KETO REDUCTASE SUPERFAMILY | ESTROGEN | PHARMACOLOGY & PHARMACY | TOXICOLOGY | YOUNG-WOMEN | TYPE-2 | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Progesterone Reductase - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Multienzyme Complexes - metabolism | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | Cholesterol Side-Chain Cleavage Enzyme - genetics | Endometrial Neoplasms - genetics | Phosphoproteins | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Adult | Female | Progesterone - biosynthesis | Membrane Proteins - metabolism | Steroid Isomerases - genetics | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | Steroid Isomerases - metabolism | RNA, Messenger - genetics | Multienzyme Complexes - genetics | Progesterone Reductase - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Estradiol Dehydrogenases - metabolism | Progesterone - metabolism | Aged | Progesterone - genetics | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Endometrial cancer | RNA | Genes | Cytochrome P-450 | Physiological aspects | Genetic aspects | Progesterone | Cancer | Index Medicus
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2006, Volume 248, Issue 1, pp. 126 - 135
Endometrial cancer is the most common malignancy of the female genital tract. Its incidence correlates with prolonged estrogen stimulation unopposed by... 
Short-chain dehydrogenase reductase | 17β-Hydroxysteroid dehydrogenase | 20α-Hydroxysteroid dehydrogenase | Aldo-keto reductase | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | HYDROXYSTEROID DEHYDROGENASES | ER-BETA | short-chain dehydrogenase reductase | RECEPTOR-B | CELL BIOLOGY | INACTIVATION | CARCINOGENESIS | KETO REDUCTASE SUPERFAMILY | ENDOCRINOLOGY & METABOLISM | 20 alpha-hydroxysteroid dehydrogenase | aldo-keto reductase | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | CARCINOMA | HORMONES | Humans | Endometrial Neoplasms - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Estrogens - analysis | Endometrial Neoplasms - genetics | Isoenzymes - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Progesterone - biosynthesis | Tumor Cells, Cultured | Estradiol - biosynthesis | Endometrium - metabolism | Progesterone - analysis | 20-Hydroxysteroid Dehydrogenases - genetics | Estrogens - biosynthesis | Endometrial Neoplasms - chemistry | Oxidoreductases - metabolism | Isoenzymes - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Endometrium - chemistry | Animals | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases | 3-Hydroxysteroid Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Enzymes | Care and treatment | Endometrial cancer | Phenols | Hormones | Progesterone | Estradiol | Cancer | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 02/2010, Volume 70, Issue 3, pp. 1256 - 1264
textabstractAndrogen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (CRPC). Intratumoral androgen production might... 
XENOGRAFT MODELS | INCREASED EXPRESSION | ONCOLOGY | PATHWAY | IN-VIVO | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | AGGRESSIVENESS | RECEPTOR GENE | PROGRESSION | DIHYDROTESTOSTERONE | ANDROGEN DEPRIVATION THERAPY | Progesterone Reductase - metabolism | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Neoplasms, Experimental - enzymology | Male | Transplantation, Heterologous | RNA, Messenger - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Androstenedione - metabolism | Pregnenolone - metabolism | Neoplasms, Experimental - pathology | Testosterone - metabolism | Prostatic Neoplasms - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | Neoplasms, Experimental - genetics | Aged, 80 and over | 3-Hydroxysteroid Dehydrogenases - metabolism | Dihydrotestosterone - metabolism | Prostatic Neoplasms - pathology | RNA, Messenger - genetics | Progesterone Reductase - genetics | Reverse Transcriptase Polymerase Chain Reaction | Hydroxyprostaglandin Dehydrogenases - genetics | Orchiectomy | Gene Expression Regulation, Enzymologic | Animals | Aldo-Keto Reductase Family 1 Member C3 | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Steroid 17-alpha-Hydroxylase - genetics | Aged | Mice | Steroid 17-alpha-Hydroxylase - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Androgens - metabolism | Index Medicus
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 5, pp. 2311 - 2323
Aldo-keto reductase 1C3 (AKR1C3; type 5 17 beta-hydroxysteroid dehydrogenase) is overexpressed in castration resistant prostate cancer (CRPC) and is implicated... 
TARGET | CHEMISTRY, MEDICINAL | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PURIFICATION | BIOLOGICAL EVALUATION | AKR1C3 | ABIRATERONE ACETATE | 17-BETA-HSD1 | RESISTANT PROSTATE-CANCER | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Antineoplastic Agents - chemical synthesis | Humans | Male | Structure-Activity Relationship | Hydroxyprostaglandin Dehydrogenases - metabolism | Fenamates - pharmacology | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | 20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | 3-Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents - pharmacology | Prostatic Neoplasms - drug therapy | Fenamates - chemistry | Testosterone - biosynthesis | Cyclooxygenase Inhibitors - chemistry | Antineoplastic Agents - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Cyclooxygenase Inhibitors - pharmacology | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Aldo-Keto Reductase Family 1 Member C3 | Testosterone - antagonists & inhibitors | Cyclooxygenase 2 - metabolism | Cyclooxygenase Inhibitors - chemical synthesis | Cell Line, Tumor | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Fenamates - chemical synthesis | Cyclooxygenase 1 - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Isoenzymes - antagonists & inhibitors | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2011, Volume 437, Issue 1, pp. 53 - 61
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2017, Volume 16, Issue 1, pp. 35 - 44
Abiraterone suppresses intracrine androgen synthesis via inhibition of CYP17A1. However, clinical evidence suggests that androgen synthesis is not fully... 
STEROIDOGENIC ENZYME AKR1C3 | CYP17A1 INHIBITION | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE AKR1C3 | INCREASED SURVIVAL | ENZALUTAMIDE RESISTANCE | ANTITUMOR-ACTIVITY | ANDROGEN RECEPTOR GENE | EXPRESSION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Prostatic Neoplasms - metabolism | Humans | Receptors, Androgen - metabolism | Gene Expression Regulation, Neoplastic | Male | Androstenes - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Prostatic Neoplasms - genetics | Cell Transformation, Neoplastic - genetics | 3-Hydroxysteroid Dehydrogenases - metabolism | Transcription, Genetic | Prostatic Neoplasms - drug therapy | Disease Models, Animal | Prostatic Neoplasms - pathology | Gene Expression | Antineoplastic Agents, Hormonal - pharmacology | Cell Transformation, Neoplastic - metabolism | Hydroxyprostaglandin Dehydrogenases - genetics | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Animals | Aldo-Keto Reductase Family 1 Member C3 | Cell Line, Tumor | Mice | Cell Transformation, Neoplastic - drug effects | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasm Staging | Medical research | Transcription | Medical services | Clinical trials | Activation | Signaling | Androgens | Synthesis | Steroidogenesis | Indomethacin | Inhibition | Prostate cancer | Prostate | Cancer | Index Medicus | AKR1C3 | prostate cancer | intracrine androgens | abiraterone | indomethacin
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2013, Volume 19, Issue 20, pp. 5613 - 5625
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2016, Volume 116, pp. 176 - 187
The clinical stage anti-cancer agent PR-104 has potential utility as a cytotoxic prodrug for exogenous bacterial nitroreductases expressed from replicating... 
Hypoxia | Aldo-keto reductase 1C3 | Prodrug | Oxidoreductase | Alkylation | CB1954 | ANTITUMOR-ACTIVITY | BYSTANDER | ESCHERICHIA-COLI NITROREDUCTASE | PHASE-I TRIAL | KETO REDUCTASE 1C3 | PHARMACOLOGY & PHARMACY | GENE-THERAPY | PRE-PRODRUG | LINKING AGENT PR-104 | Humans | Benzamides - metabolism | Mesylates - metabolism | Prodrugs - chemistry | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Colorectal Neoplasms - drug therapy | 3-Hydroxysteroid Dehydrogenases - metabolism | Antineoplastic Agents, Alkylating - chemistry | Hydroxyprostaglandin Dehydrogenases - chemistry | Carcinoma - drug therapy | Specific Pathogen-Free Organisms | Organophosphonates - therapeutic use | HCT116 Cells | Enzyme Inhibitors - pharmacology | Mesylates - therapeutic use | Models, Molecular | Recombinant Proteins - chemistry | Random Allocation | Antineoplastic Agents, Alkylating - therapeutic use | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Nitroreductases - metabolism | Aldo-Keto Reductase Family 1 Member C3 | Mice, Nude | Survival Analysis | 3-Hydroxysteroid Dehydrogenases - chemistry | Molecular Docking Simulation | 3-Hydroxysteroid Dehydrogenases - genetics | Nitroreductases - genetics | Organophosphonates - metabolism | Substrate Specificity | Antineoplastic Agents, Alkylating - pharmacology | Hydroxyprostaglandin Dehydrogenases - metabolism | Prodrugs - metabolism | Benzamides - therapeutic use | Drug Design | Activation, Metabolic - drug effects | Benzamides - pharmacology | Carcinoma - pathology | Colorectal Neoplasms - metabolism | Benzamides - chemistry | Recombinant Proteins - metabolism | Escherichia coli Proteins - metabolism | Mesylates - chemistry | Hydroxyprostaglandin Dehydrogenases - genetics | Xenograft Model Antitumor Assays | Organophosphonates - pharmacology | Animals | Tumor Burden - drug effects | Mesylates - pharmacology | Organophosphonates - chemistry | Escherichia coli Proteins - genetics | Cell Proliferation - drug effects | Prodrugs - therapeutic use | Carcinoma - metabolism | Colorectal Neoplasms - pathology | Prodrugs - pharmacology | Antineoplastic Agents, Alkylating - metabolism | Drug Resistance, Neoplasm - drug effects | Enzymes | Biopharmaceutics | Index Medicus
Journal Article
Journal Article