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Journal Article
Oncology Reports, ISSN 1021-335X, 03/2017, Volume 37, Issue 4, pp. 2025 - 2032
Resistance to anticancer medications often leads to poor outcomes. The present study explored an effective approach for enhancing chemotherapy targeted against... 
aldo-keto reductase | cisplatin | mefenamic acid | 5-FU | Cisplatin, 5-FU | Mefenamic acid | Aldo-keto reductase | HUMAN OVARIAN | AKR1C3 | CISPLATIN RESISTANCE | TUMOR-CELLS | CHEMOTHERAPY | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | LUNG-CANCER | CARCINOMA CELL-LINE | ONCOLOGY | SUPERFAMILY | EXPRESSION | 20-Hydroxysteroid Dehydrogenases - biosynthesis | 3-Hydroxysteroid Dehydrogenases - biosynthesis | 20-Hydroxysteroid Dehydrogenases - genetics | Humans | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Cisplatin - administration & dosage | Neoplasms - drug therapy | 3-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxyprostaglandin Dehydrogenases - antagonists & inhibitors | Fluorouracil - administration & dosage | 20-Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Neoplasms - genetics | Aldo-Keto Reductase Family 1 Member C3 | Mefenamic Acid - administration & dosage | Hydroxysteroid Dehydrogenases - antagonists & inhibitors | Hydroxysteroid Dehydrogenases - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | HeLa Cells | Oxidoreductases | 3-Hydroxysteroid Dehydrogenases - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Care and treatment | Patient outcomes | Genetic aspects | Drug resistance | Gene expression | Health aspects | Methods | Cancer | Studies | Enzymes | Oxidative stress | Chemotherapy | Genes | Rodents | Prostate | Experiments | Cancer therapies | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
FASEB Journal, ISSN 0892-6638, 09/2015, Volume 29, Issue 9, pp. 3806 - 3816
Hydroxysteroid (17 beta)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to... 
Ovary | HSD17B enzymes | Fertility | Estrogen | estrogen | SEX REVERSAL | GRANULOSA-CELLS | CHORIONIC-GONADOTROPIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | fertility | ER-ALPHA | CELL BIOLOGY | BREAST-CANCER | ovary | MESSENGER-RNA | IN-VIVO | BIOLOGY | ESTROGEN-RECEPTORS ALPHA | FOLLICLE-STIMULATING-HORMONE | RAT 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1 | Cholesterol Side-Chain Cleavage Enzyme - biosynthesis | Male | Infertility, Female - genetics | Cholesterol Side-Chain Cleavage Enzyme - genetics | Female | Progesterone - biosynthesis | Infertility, Female - enzymology | Estrous Cycle | Ovary - metabolism | Ovary - pathology | Phosphoproteins - biosynthesis | Sexual Maturation - genetics | Luteinization | Phosphoproteins - genetics | Mice, Knockout | Pregnancy | 17-Hydroxysteroid Dehydrogenases - biosynthesis | Animals | 17-Hydroxysteroid Dehydrogenases - deficiency | 17-Hydroxysteroid Dehydrogenases - genetics | Steroid 17-alpha-Hydroxylase - genetics | Mice | Progesterone - genetics | 17-Hydroxysteroid Dehydrogenases - metabolism | Steroid 17-alpha-Hydroxylase - biosynthesis | Index Medicus | UTANEN M | P2639 | P386 | Biology | Biochemistry & Molecular Biology | LEAN MP | Endokrinologi och diabetes | V65 | 1993 | 1992 | Physiology | V133 | ENDOCRINOLOGY | Endocrinology and Diabetes | INTERNATIONAL JOURNAL OF CANCER | Fysiologi | 1990 | P757 | P1796 | Cell Biology | URNETDULGUEROV N | V50 | 1987 | V126 | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2015, Volume 10, Issue 11, pp. e0139311 - e0139311
Background Etomidate is a rapid hypnotic intravenous anesthetic agent. The major side effect of etomidate is the reduced plasma concentration of... 
ANESTHETIC ETOMIDATE | BETA-HYDROXYSTEROID DEHYDROGENASE | ADRENODOXIN | INHIBITORS | RECEPTORS | MULTIDISCIPLINARY SCIENCES | Cholesterol Side-Chain Cleavage Enzyme - biosynthesis | Androgens - biosynthesis | Male | Leydig Cells - drug effects | Leydig Cells - ultrastructure | Cholesterol Side-Chain Cleavage Enzyme - genetics | Anesthetics, Intravenous - pharmacology | Etomidate - toxicity | Leydig Cells - metabolism | Etomidate - pharmacology | Mitochondria - chemistry | Testis - cytology | Membrane Proteins - genetics | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | Cells, Cultured | Gonadal Steroid Hormones - pharmacology | Rats | Anesthetics, Intravenous - toxicity | Testis - growth & development | Rats, Sprague-Dawley | Cytosol - chemistry | Gene Expression Regulation - drug effects | Microsomes - chemistry | Membrane Proteins - biosynthesis | 17-Hydroxysteroid Dehydrogenases - biosynthesis | Animals | Estradiol Dehydrogenases - genetics | 17-Hydroxysteroid Dehydrogenases - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Culture Media - pharmacology | Estradiol Dehydrogenases - biosynthesis | Drug metabolism | Physiological aspects | Growth | Patient outcomes | Etomidate | Leydig cells | Cytochrome | Corticoids | Intravenous administration | Dehydrogenases | Biosynthesis | Hormones | Hydrocortisone | Kinases | Pregnenolone | Mitochondria | Dihydrotestosterone | Radioimmunoassay | Anesthesia | Inhibition | Enzymes | Corticosteroids | Metabolism | Gene expression | Cholesterol | Microsomes | Children & youth | Testosterone | Androgens | Steroidogenesis | Progesterone | Testes | Androstenedione | Endocrinology | Index Medicus
Journal Article
Biology of Reproduction, ISSN 0006-3363, 01/2009, Volume 80, Issue 1, pp. 105 - 114
Identification of mechanisms underlying endometriosis pathogenesis will facilitate understanding and treatment of infertility and pain associated with this... 
Eutopic endometrium | Endometrial fibroblasts | Endometriosis | Steroidogenesis | 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-2 | endometrial fibroblasts | eutopic endometrium | endometriosis | steroidogenesis | FACTOR-I | DEHYDROGENASE | REPRODUCTIVE BIOLOGY | MESSENGER-RIBONUCLEIC-ACID | GENE-EXPRESSION | ESTROGEN | FACTOR-BINDING PROTEIN-1 | PROGESTERONE RESISTANCE | AROMATASE EXPRESSION | Immunohistochemistry | Endometrium - enzymology | Stromal Cells - pathology | Humans | Middle Aged | Endometrium - drug effects | Aromatase - metabolism | Prolactin - metabolism | Young Adult | RNA, Messenger - biosynthesis | Aromatase - genetics | Stromal Cells - enzymology | Decidua - enzymology | Endometriosis - enzymology | Stromal Cells - drug effects | Adult | Female | Progesterone - biosynthesis | Endometrium - cytology | Progesterone - pharmacology | Estradiol - biosynthesis | Endometrium - metabolism | Enzyme-Linked Immunosorbent Assay | 8-Bromo Cyclic Adenosine Monophosphate - pharmacology | RNA, Messenger - genetics | Stromal Cells - metabolism | Aromatase - biosynthesis | Endometriosis - pathology | Reverse Transcriptase Polymerase Chain Reaction | Decidua - metabolism | Insulin-Like Growth Factor Binding Protein 1 - metabolism | Estradiol Dehydrogenases - genetics | Endometriosis - metabolism | Estradiol Dehydrogenases - metabolism | Estradiol Dehydrogenases - biosynthesis | Index Medicus
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 02/2013, Volume 202, Issue 1-3, pp. 218 - 225
► Genes encoding P4 metabolizing enzymes are expressed in Z-12 endometriotic cells. ► Treatments with progesterone and dydrogesterone decrease expression. ►... 
Dydrogesterone | Peritoneal endometriosis | Medroxyprogesterone acetate | Pre-receptor metabolism | Progesterone resistance | Dienogest | 3-Hydroxysteroid Dehydrogenases - biosynthesis | Epithelial Cells - metabolism | Endometriosis - genetics | Epithelial Cells - drug effects | Humans | Endometrium - drug effects | Medroxyprogesterone Acetate - pharmacology | Receptors, Progesterone - genetics | Hydroxyprostaglandin Dehydrogenases - metabolism | Receptors, Progesterone - metabolism | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Female | Hydroxysteroid Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - metabolism | Membrane Proteins - metabolism | Progesterone - pharmacology | Endometrium - metabolism | 20-Hydroxysteroid Dehydrogenases - genetics | Membrane Proteins - genetics | RNA, Messenger - genetics | Cells, Cultured | Nandrolone - analogs & derivatives | Progestins - pharmacology | Hydroxyprostaglandin Dehydrogenases - biosynthesis | Hydroxysteroid Dehydrogenases - genetics | 20-Hydroxysteroid Dehydrogenases - metabolism | Down-Regulation - drug effects | Down-Regulation - genetics | Hydroxyprostaglandin Dehydrogenases - genetics | Membrane Proteins - biosynthesis | Aldo-Keto Reductase Family 1 Member C3 | Estradiol Dehydrogenases - genetics | Nandrolone - pharmacology | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics | 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - biosynthesis | Dydrogesterone - pharmacology | Endometriosis - metabolism | Estradiol Dehydrogenases - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Receptors, Progesterone - biosynthesis | Medroxyprogesterone | Physiological aspects | Progesterone | RNA | Index Medicus
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 07/2017, Volume 326, pp. 7 - 14
Journal Article