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hymecromone - analogs & derivatives (787) 787
science & technology (451) 451
life sciences & biomedicine (428) 428
hymecromone - metabolism (377) 377
humans (375) 375
animals (291) 291
biological and medical sciences (280) 280
kinetics (211) 211
biochemistry & molecular biology (191) 191
fundamental and applied biological sciences. psychology (189) 189
substrate specificity (122) 122
hymecromone - pharmacology (120) 120
hydrogen-ion concentration (113) 113
male (108) 108
female (103) 103
hymecromone - chemistry (103) 103
medical sciences (97) 97
microbiology (85) 85
hydrolysis (84) 84
chemistry (79) 79
spectrometry, fluorescence (79) 79
cells, cultured (76) 76
mice (76) 76
fluorescent dyes (72) 72
physical sciences (72) 72
pharmacology & pharmacy (69) 69
rats (69) 69
enzymes (64) 64
research article (62) 62
molecular sequence data (59) 59
biochemical research methods (56) 56
fluorescence (55) 55
biotechnology & applied microbiology (53) 53
glucuronosyltransferase - metabolism (49) 49
glucosides - metabolism (47) 47
analytical, structural and metabolic biochemistry (45) 45
time factors (45) 45
umbelliferones - metabolism (45) 45
binding sites (44) 44
umbelliferones (44) 44
analysis (43) 43
cell line (43) 43
chemistry, analytical (43) 43
bacteriology (42) 42
liver - enzymology (42) 42
sensitivity and specificity (42) 42
acetylglucosamine - analogs & derivatives (41) 41
adult (41) 41
fibroblasts - enzymology (41) 41
protein binding (41) 41
culture media (40) 40
cell biology (39) 39
neuraminidase - metabolism (38) 38
4-methylumbelliferone (36) 36
glycosides - metabolism (36) 36
amino acid sequence (35) 35
enzyme inhibitors - pharmacology (35) 35
escherichia coli - isolation & purification (35) 35
glucuronosyltransferase - antagonists & inhibitors (35) 35
cattle (33) 33
recombinant proteins - metabolism (33) 33
temperature (33) 33
pharmacology. drug treatments (32) 32
pregnancy (32) 32
biophysics (30) 30
proteins (30) 30
hydrolases (29) 29
bacteriological methods and techniques used in bacteriology (28) 28
fluorescent dyes - metabolism (28) 28
in vitro techniques (28) 28
molecular weight (28) 28
research (28) 28
child (27) 27
dose-response relationship, drug (27) 27
glycosides (26) 26
metabolic diseases (26) 26
enzymes and enzyme inhibitors (25) 25
escherichia coli - enzymology (25) 25
hymecromone - chemical synthesis (25) 25
leukocytes - enzymology (25) 25
lipids (25) 25
lysosomes - enzymology (25) 25
structure-activity relationship (25) 25
water microbiology (25) 25
galactosides - metabolism (24) 24
glucuronosyltransferase - genetics (24) 24
middle aged (24) 24
catalysis (23) 23
errors of metabolism (23) 23
glucuronidase - metabolism (23) 23
hot temperature (23) 23
hyaluronic acid (23) 23
hymecromone - analysis (23) 23
indicators and reagents (23) 23
beta-galactosidase - metabolism (22) 22
carbohydrates (22) 22
galactosides (22) 22
glucuronides - metabolism (22) 22
hyaluronan (22) 22
oligosaccharides - metabolism (22) 22
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1. Full Text Evaluation of Quinazoline Analogues as Glucocerebrosidase Inhibitors with Chaperone Activity
by Marugan, Juan J and Zheng, Wei and Motabar, Omid and Southall, Noel and Goldin, Ehud and Westbroek, Wendy and Stubblefield, Barbara K and Sidransky, Ellen and Aungst, Ronald A and Lea, Wendy A and Simeonov, Anton and Leister, William and Austin, Christopher P
Journal of medicinal chemistry, ISSN 0022-2623, 02/2011, Volume 54, Issue 4, pp. 1033 - 1058
Immunohistochemistry | Quinazolines - chemical synthesis | Glucosylceramidase - chemistry | Humans | Lysosomes - enzymology | Structure-Activity Relationship | Molecular Chaperones - chemistry | Hymecromone - analogs & derivatives | Molecular Chaperones - chemical synthesis | Lysosomes - metabolism | Spectrometry, Mass, Electrospray Ionization | Spleen - enzymology | Fibroblasts | Quinazolines - chemistry | Gaucher Disease - drug therapy | Gaucher Disease - enzymology | Molecular Chaperones - pharmacology | Lysosomes - drug effects | Cell Line | Magnetic Resonance Spectroscopy | Glucosylceramidase - metabolism | Glucosylceramidase - antagonists & inhibitors | Hymecromone - analysis | Microscopy, Confocal | Spleen - metabolism | Quinazolines - pharmacology | Index Medicus
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2. 4-Methylumbelliferones Analogues as Anticancer Agents: Synthesis and in Cell Pharmacological Studies
by Huang, Ri-Zhen and Hua, Shi-Xian and Wang, Cai-Yi and Pan, Ying-Ming and Qin, Jian-Mei and Ding, Zhan-Yu and Zhang, Ye and Wang, Heng-Shan
Anti-cancer agents in medicinal chemistry, ISSN 1871-5206, 2017, Volume 17, Issue 4, pp. 576 - 589
4-Methylumbelliferones | apoptosis | cell cycle | cytotoxicity | urea/thioureas piperazine | Pharmacology & Pharmacy | Oncology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Hymecromone - analogs & derivatives | Hymecromone - chemical synthesis | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Hymecromone - chemistry | Molecular Structure | Hymecromone - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor
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3. Full Text Glucosamine‐6‐sulfamate Analogues of Heparan Sulfate as Inhibitors of Endosulfatases
by Schelwies, Mathias and Brinson, Diana and Otsuki, Shuhei and Hong, Young‐Hoon and Lotz, Martin K and Wong, Chi‐Huey and Hanson, Sarah R
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 11/2010, Volume 11, Issue 17, pp. 2393 - 2397
hydrolases | inhibitors | sulfatases | heparan sulfate | inflammation | Heparan sulfate | Sulfatases | Hydrolases | Inflammation | Inhibitors | Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Sulfotransferases - genetics | Glucosamine - analogs & derivatives | Humans | Enzyme Inhibitors - pharmacology | Substrate Specificity | Glucosamine - chemistry | Hymecromone - metabolism | Arylsulfatases - metabolism | Dose-Response Relationship, Drug | Hymecromone - analogs & derivatives | Sulfotransferases - antagonists & inhibitors | Time Factors | Enzyme Inhibitors - chemistry | Heparitin Sulfate - analogs & derivatives | HEK293 Cells | Sulfotransferases - metabolism | Hymecromone - chemistry | Molecular Structure | Kinetics | Index Medicus
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4. Structure-inhibition relationship of podophyllotoxin (PT) analogues towards UDP-glucuronosyltransferase (UGT) isoforms
by Qi, Jia-Qi and Cao, Yun-Feng and Sun, Xiao-Yu and Hong, Mo and Fang, Zhong-Ze and Meng, Da-Li and Sun, Dong-Xue
Pharmazie, ISSN 0031-7144, 04/2015, Volume 70, Issue 4, pp. 239 - 243
Physical Sciences | Chemistry | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Chemistry, Medicinal | Chemistry, Multidisciplinary | Science & Technology | Estradiol - metabolism | Camptothecin - metabolism | Podophyllotoxin - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Trifluoperazine - metabolism | Substrate Specificity | Structure-Activity Relationship | Hymecromone - metabolism | Binding, Competitive - drug effects | Drug Interactions | Glucuronides - metabolism | Microsomes, Liver - drug effects | Enzyme Inhibitors - chemistry | Glucuronosyltransferase - antagonists & inhibitors | Microsomes, Liver - enzymology | In Vitro Techniques | Podophyllotoxin - chemistry | Isoenzymes - antagonists & inhibitors | Camptothecin - analogs & derivatives
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5. Full Text Selectivity in the Efflux of Glucuronides by Human Transporters: MRP4 Is Highly Active toward 4‑Methylumbelliferone and 1‑Naphthol Glucuronides, while MRP3 Exhibits Stereoselective Propranolol Glucuronide Transport
by Järvinen, Erkka and Troberg, Johanna and Kidron, Heidi and Finel, Moshe
Molecular pharmaceutics, ISSN 1543-8384, 10/2017, Volume 14, Issue 10, pp. 3299 - 3311
hydroxypyrene | 1-naphthol | ABCG2/BCRP | MRP4/ABCC4 | MRP3/ABCC3 | MRP2/ABCC2 | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Recombinant Proteins - metabolism | Estradiol - analogs & derivatives | Glucuronides - pharmacokinetics | Stereoisomerism | Humans | Pyrenes - metabolism | Glucuronates - metabolism | Neoplasm Proteins - metabolism | ATP Binding Cassette Transporter, Sub-Family G, Member 2 - metabolism | Glucuronates - pharmacokinetics | Propranolol - pharmacokinetics | Spodoptera | Estradiol - pharmacokinetics | Hymecromone - analogs & derivatives | Biological Transport, Active | Sf9 Cells | Animals | Hymecromone - pharmacokinetics | Biological Assay | Propranolol - chemical synthesis | Propranolol - analogs & derivatives | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus
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6. Full Text A comparative study of acetylcholinesterase and general-esterase activity assays using different substrates, in vitro and in vivo exposures and model organisms
by Cao, Yi and Herrero-Nogareda, Laia and Cedergreen, Nina
Ecotoxicology and environmental safety, ISSN 0147-6513, 02/2020, Volume 189, pp. 109954 - 109954
In vivo | Enzyme activity | Esterase | Chironomus riparius | In vitro | Daphnia magna | Environmental Sciences & Ecology | Toxicology | Life Sciences & Biomedicine | Science & Technology | Environmental Sciences | Acetylthiocholine - analogs & derivatives | Esterases - metabolism | Naphthols - metabolism | Enzyme Assays | Hymecromone - metabolism | Xenobiotics - pharmacology | Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide - pharmacology | Hymecromone - analogs & derivatives | Daphnia - drug effects | Animals | Cholinesterase Inhibitors - pharmacology | Acetylthiocholine - metabolism | Daphnia - enzymology | Chironomidae - drug effects | Chironomidae - enzymology | Kinetics | Acetylcholinesterase - metabolism | Index Medicus
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7. Full Text Molecular insight into substrate recognition by human cytosolic sialidase NEU2
by Mozzi, Alessandra and Mazzacuva, Pietro and Zampella, Giuseppe and Forcella, Matilde Emma and Fusi, Paola Alessandra and Monti, Eugenio
Proteins, structure, function, and bioinformatics, ISSN 0887-3585, 04/2012, Volume 80, Issue 4, pp. 1123 - 1132
molecular docking | sialic acid | site‐directed mutagenesis | glycohydrolases | ganglioside(s) | active site | oligosaccharide(s) | Oligosaccharide(s) | Ganglioside(s) | Sialic acid | Active site | Glycohydrolases | Site-directed mutagenesis | Molecular docking | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Catalytic Domain | Mutagenesis, Site-Directed | Humans | Lactose - analogs & derivatives | Models, Molecular | Neuraminidase - genetics | Substrate Specificity | Crystallography, X-Ray | Enzyme Assays | Escherichia coli - chemistry | Sialic Acids - chemistry | Cytosol - chemistry | Galactose - analogs & derivatives | Hymecromone - analogs & derivatives | Galactose - chemistry | Escherichia coli - genetics | Influenza A Virus, H1N1 Subtype - enzymology | Computer Simulation | Neuraminidase - chemistry | Protein Binding | Lactose - chemistry | Hymecromone - chemistry | Enzyme Activation | Index Medicus
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8. Full Text Near‐IR Light‐Mediated Cleavage of Antibody–Drug Conjugates Using Cyanine Photocages
by Nani, Roger R and Gorka, Alexander P and Nagaya, Tadanobu and Kobayashi, Hisataka and Schnermann, Martin J
Angewandte Chemie (International ed.), ISSN 1433-7851, 11/2015, Volume 54, Issue 46, pp. 13635 - 13638
antibodies | drug delivery | fluorescence | conjugation | cyanines | Cell Survival - drug effects | Carbocyanines - chemistry | Humans | Antineoplastic Agents, Phytogenic - chemistry | Stilbenes - chemistry | Structure-Activity Relationship | Stilbenes - pharmacology | Receptor, Epidermal Growth Factor - chemistry | Dose-Response Relationship, Drug | Neoplasms, Experimental - pathology | Hymecromone - analogs & derivatives | Animals | MCF-7 Cells | Photolysis | Infrared Rays | Cell Line, Tumor | Hymecromone - chemistry | Mice | Hymecromone - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Neoplasms, Experimental - drug therapy | Antibodies, Monoclonal - chemistry | Drug Screening Assays, Antitumor | Drugs | Viral antibodies | Antibodies | Drug delivery systems | Biopharmaceutics | Vehicles | Index Medicus | Conjugates | Biomedical materials | Accessibility | In vivo testing | Strategy | Cleavage
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9. Full Text Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells
by Okuda, Hiroshi and Kobayashi, Aya and Xia, Bo and Watabe, Misako and Pai, Sudha K and Hirota, Shigeru and Xing, Fei and Liu, Wen and Pandey, Puspa R and Fukuda, Koji and Modur, Vishnu and Ghosh, Arnab and Wilber, Andrew and Watabe, Kounosuke
Cancer research (Chicago, Ill.), ISSN 0008-5472, 01/2012, Volume 72, Issue 2, pp. 537 - 547
Life Sciences & Biomedicine | Oncology | Science & Technology | Gynecology. Andrology. Obstetrics | Mammary gland diseases | Pharmacology. Drug treatments | Biological and medical sciences | Medical sciences | Antineoplastic agents | Tumors | Up-Regulation | Stromal Cells - pathology | Humans | Gene Expression Regulation, Neoplastic | Bone Neoplasms - secondary | Gene Expression Profiling | Bone Neoplasms - pathology | Cell Movement - physiology | Hymecromone - analogs & derivatives | Breast Neoplasms - enzymology | Stromal Cells - enzymology | Neoplastic Stem Cells - pathology | Female | Bone Neoplasms - genetics | Hyaluronan Synthases | Hymecromone - pharmacology | Bone Neoplasms - enzymology | Macrophages - pathology | Neoplasm Invasiveness | Disease Progression | Macrophages - enzymology | Animals | Breast Neoplasms - genetics | Glucuronosyltransferase - metabolism | Breast Neoplasms - pathology | Cell Adhesion - physiology | Mice, Nude | Glucuronosyltransferase - antagonists & inhibitors | Mice | Neoplastic Stem Cells - enzymology | Index Medicus | Bone cancer | microenvironment | tumor associated macrophages | HAS2
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10. Full Text NEU1 and NEU3 sialidase activity expressed in human lung microvascular endothelia: NEU1 restrains endothelial cell migration, whereas NEU3 does not
by Cross, Alan S and Hyun, Sang Won and Miranda-Ribera, Alba and Feng, Chiguang and Liu, Anguo and Nguyen, Chinh and Zhang, Lei and Luzina, Irina G and Atamas, Sergei P and Twaddell, William S and Guang, Wei and Lillehoj, Erik P and Puché, Adam C and Huang, Wei and Wang, Lai-Xi and Passaniti, Antonino and Goldblum, Simeon E
The Journal of biological chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 19, pp. 15966 - 15980
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Kidney - enzymology | Neuraminidase - genetics | Substrate Specificity | Immunoblotting | Cell Nucleus - enzymology | Lung - enzymology | Cytosol - enzymology | Hymecromone - analogs & derivatives | Flow Cytometry | RNA Interference | Carotid Arteries - enzymology | Hymecromone - pharmacology | Aorta - enzymology | Cell Line | Endothelial Cells - metabolism | Neuraminidase - metabolism | Reverse Transcriptase Polymerase Chain Reaction | N-Acetylneuraminic Acid - metabolism | Gene Expression Regulation, Enzymologic | Cell Membrane - enzymology | Microscopy, Confocal | Cerebral Arteries - enzymology | N-Acetylneuraminic Acid - analogs & derivatives | Neuraminidase - antagonists & inhibitors | Endothelial Cells - enzymology | Cell Movement | Index Medicus | Sialic Acid | Glycobiology | Signal Transduction | Endothelial Dysfunction | Lung | Vascular Biology | Migration | Neuraminidase | Glycobiology and Extracellular Matrices | Wound Healing | Sialidase
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11. Full Text The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice
by Maciej J. Zamek-Gliszczynski and Ken-ichi Nezasa and Xianbin Tian and J. Cory Kalvass and Nita J. Patel and Thomas J. Raub and Kim L. R. Brouwer
Molecular pharmacology, ISSN 0026-895X, 12/2006, Volume 70, Issue 6, pp. 2127 - 2133
ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Sulfates - metabolism | Harmine - analogs & derivatives | Mice, Inbred C57BL | Male | ATP-Binding Cassette Transporters - physiology | Mice, Knockout | Hymecromone - analogs & derivatives | Animals | Glucuronides - metabolism | Hymecromone - pharmacokinetics | Mice | Acetaminophen - pharmacokinetics | Bile - secretion | Harmine - pharmacokinetics | Index Medicus
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12. Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice
by Zamek-Gliszczynski, Maciej J and Nezasa, Ken-Ichi and Tian, Xianbin and Bridges, Arlene S and Lee, Kun and Belinsky, Martin G and Kruh, Gary D and Brouwer, Kim L. R
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1485 - 1491
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Acetaminophen - metabolism | Analgesics, Non-Narcotic - pharmacokinetics | Bile - metabolism | Hymecromone - metabolism | Hymecromone - analogs & derivatives | Glucuronides - metabolism | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Hymecromone - pharmacokinetics | Multidrug Resistance-Associated Proteins - genetics | Harmine - pharmacokinetics | Sulfates - metabolism | Harmine - analogs & derivatives | Liver - metabolism | Analgesics, Non-Narcotic - metabolism | Blotting, Western | Harmine - metabolism | Mice, Knockout | Animals | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Acetaminophen - pharmacokinetics | In Vitro Techniques | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism
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13. Full Text Thermodynamic Analysis Reveals Structural Rearrangement during the Acylation Step in Human Trypsin 4 on 4-Methylumbelliferyl 4-Guanidinobenzoate Substrate Analogue
by Júlia Tóth and Linda Gombos and Zoltán Simon and Péter Medveczky and László Szilágyi and László Gráf and András Málnási-Csizmadia
The Journal of biological chemistry, ISSN 0021-9258, 05/2006, Volume 281, Issue 18, pp. 12596 - 12602
Humans | Molecular Conformation | Entropy | Hot Temperature | Brain - metabolism | Hydrolysis | Hymecromone - analogs & derivatives | Thermodynamics | Glycine - chemistry | Time Factors | Hymecromone - chemistry | Kinetics | Mutation | Trypsin - chemistry | Acylation | Index Medicus
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14. Full Text An improved helferich method for the α/β-stereoselective synthesis of 4-methylumbelliferyl glycosides for the detection of microorganisms
by Wei, Xianhu and Ma, Yanxia and Wu, Qingping and Zhang, Jumei and Cai, Zhihe and Lu, Mianfei and Ferro, Vito
Molecules (Basel, Switzerland), ISSN 1420-3049, 12/2015, Volume 20, Issue 12, pp. 21681 - 21699
Fluorogenic substrates | Glycosyl acetates | 4-methylumbelliferyl glycosides | Stereoselective glycosylation | Peracetyl sugars | Biochemistry & Molecular Biology | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | 4-Aminopyridine - chemistry | Hymecromone - analogs & derivatives | Pyridines - chemistry | Stereoisomerism | Glycosides - chemical synthesis | Boranes - chemistry | 4-Aminopyridine - analogs & derivatives | Hymecromone - chemical synthesis | Glycosylation | Catalysis | Ethylamines - chemistry | Stereoselectivity | Pyridines | Boron | Microorganisms | Triethylamine | Glycosides | Umbelliferone | Acetic acid | Acetates | Substrates | Index Medicus | stereoselective glycosylation | fluorogenic substrates | peracetyl sugars | glycosyl acetates
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