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1. Full Text UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?
by Troberg, Johanna and Järvinen, Erkka and Ge, Guang-Bo and Yang, Ling and Finel, Moshe
Molecular pharmaceutics, ISSN 1543-8384, 09/2017, Volume 14, Issue 9, pp. 2875 - 2883
estrone | SN-38 | bavachinin | UDP-glucuronosyltransferase | intestinal glucuronidation | AMC | recombinant UGT1A10 | estradiol | intestine microsomes | morphine | NCHN | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Coumarins - metabolism | Estradiol - metabolism | Camptothecin - metabolism | Humans | Microsomes, Liver - metabolism | Intestines - metabolism | Chromatography, High Pressure Liquid | Hymecromone - metabolism | Blotting, Western | Animals | Glucuronosyltransferase - metabolism | Estrone - metabolism | Flavonoids - metabolism | Kinetics | Camptothecin - analogs & derivatives | Diclofenac - metabolism | Index Medicus
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2. Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice
by Zamek-Gliszczynski, Maciej J and Nezasa, Ken-Ichi and Tian, Xianbin and Bridges, Arlene S and Lee, Kun and Belinsky, Martin G and Kruh, Gary D and Brouwer, Kim L. R
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1485 - 1491
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Acetaminophen - metabolism | Analgesics, Non-Narcotic - pharmacokinetics | Bile - metabolism | Hymecromone - metabolism | Hymecromone - analogs & derivatives | Glucuronides - metabolism | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Hymecromone - pharmacokinetics | Multidrug Resistance-Associated Proteins - genetics | Harmine - pharmacokinetics | Sulfates - metabolism | Harmine - analogs & derivatives | Liver - metabolism | Analgesics, Non-Narcotic - metabolism | Blotting, Western | Harmine - metabolism | Mice, Knockout | Animals | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Acetaminophen - pharmacokinetics | In Vitro Techniques | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism
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3. Full Text The "albumin effect" and drug glucuronidation: Bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities
by Rowland, Andrew and Knights, Kathleen M and Mackenzie, Peter I and Miners, John O
Drug metabolism and disposition, ISSN 0090-9556, 06/2008, Volume 36, Issue 6, pp. 1056 - 1062
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Biological and medical sciences | Pharmacology. Drug treatments | Medical sciences | Recombinant Proteins - metabolism | Cell Line | Humans | Microsomes, Liver - metabolism | Middle Aged | Male | Recombinant Proteins - genetics | Serum Albumin, Bovine - metabolism | Hymecromone - metabolism | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Animals | Glucuronides - metabolism | Glucuronosyltransferase - metabolism | Cattle | Propofol - metabolism | Adult | Female | Aged | Serum Albumin - metabolism | Index Medicus
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4. Full Text Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism
by Terabe, Kenya and Ohashi, Yoshifumi and Tsuchiya, Saho and Ishizuka, Shinya and Knudson, Cheryl B and Knudson, Warren
The Journal of biological chemistry, ISSN 0021-9258, 11/2019, Volume 294, Issue 47, pp. 17799 - 17817
chondrocyte | metabolomics | inflammation | hyaluronan | matrix metalloproteinase (MMP) | osteoarthritis | glycolysis | 4-methylumbelliferone (4MU) | pro-catabolic phenotype | extracellular matrix | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Inflammation - pathology | Interleukin-1beta - pharmacology | Hyaluronan Synthases - metabolism | Humans | Middle Aged | Male | Glycolysis - drug effects | Acetylglucosamine - metabolism | Chondrocytes - drug effects | Cartilage, Articular - metabolism | Cattle | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Adenylate Kinase - metabolism | Deoxyglucose - pharmacology | Cytoprotection - drug effects | Female | Hymecromone - pharmacology | Phosphorylation - drug effects | Chondrocytes - metabolism | Acylation | Chondrocytes - pathology | Cell Hypoxia - drug effects | Matrix Metalloproteinase 13 - metabolism | Phenotype | Animals | Signal Transduction - drug effects | Dichloroacetic Acid - pharmacology | Cartilage, Articular - drug effects | Energy Metabolism - drug effects | Index Medicus | Glycobiology and Extracellular Matrices
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5. Full Text Arginine-259 of UGT2B7 Confers UDP-Sugar Selectivity
by Nair, Pramod C and Chau, Nuy and McKinnon, Ross A and Miners, John O
Molecular pharmacology, ISSN 0026-895X, 12/2020, Volume 98, Issue 6, pp. 710 - 718
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Medicago truncatula | Uridine Diphosphate Glucuronic Acid - metabolism | Zidovudine - metabolism | Mutagenesis, Site-Directed | Humans | Morphine - metabolism | Crystallography, X-Ray | Binding Sites - genetics | Substrate Specificity - genetics | Hymecromone - metabolism | Molecular Dynamics Simulation | Sequence Homology, Amino Acid | Coenzymes - metabolism | Glucuronosyltransferase - genetics | Plant Proteins - genetics | Glucuronides - metabolism | Glucuronosyltransferase - metabolism | Glycosides - metabolism | Arginine - genetics | HEK293 Cells | Mutation | Plant Proteins - ultrastructure | Glucosyltransferases - genetics | Glucosyltransferases - ultrastructure | Index Medicus
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6. Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: Implications for in vitro-in vivo extrapolation
by Rowland, Andrew and Gaganis, Paraskevi and Elliot, David J and Mackenzie, Peter I and Knights, Kathleen M and Miners, John O
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 04/2007, Volume 321, Issue 1, pp. 137 - 147
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Recombinant Proteins - metabolism | Microsomes - metabolism | Serum Albumin, Bovine - pharmacology | Zidovudine - metabolism | Data Interpretation, Statistical | Humans | Chromatography, High Pressure Liquid | Hymecromone - metabolism | Blotting, Western | Hymecromone - analogs & derivatives | Albumins - pharmacology | Animals | Glucuronides - metabolism | Glucuronosyltransferase - metabolism | Serum Albumin - pharmacology | Cattle | Protein Binding | Anti-HIV Agents - metabolism | Kinetics | In Vitro Techniques | Fatty Acids - metabolism
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7. Full Text 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
by Kultti, Anne and Pasonen-Seppänen, Sanna and Jauhiainen, Marjo and Rilla, Kirsi J and Kärnä, Riikka and Pyöriä, Emma and Tammi, Raija H and Tammi, Markku I
Experimental cell research, ISSN 0014-4827, 2009, Volume 315, Issue 11, pp. 1914 - 1923
Hyaluronan synthesis | 4-Methylumbelliferone | Hyaluronan synthase | UDP-glucuronic acid | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplasms - metabolism | Uridine Diphosphate Glucuronic Acid - metabolism | Humans | Neoplasm Invasiveness - prevention & control | DNA Primers - genetics | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Breast Neoplasms - metabolism | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Neoplasms - genetics | Hyaluronic Acid - biosynthesis | Melanoma - genetics | Base Sequence | Female | Hyaluronan Synthases | Hymecromone - pharmacology | Melanoma - metabolism | RNA, Messenger - genetics | Down-Regulation - drug effects | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Cell Movement - drug effects | Breast Neoplasms - genetics | Glucuronosyltransferase - metabolism | Melanoma - drug therapy | Cell Line, Tumor | RNA, Neoplasm - genetics | Cell Proliferation - drug effects | Phosphates | Squamous cell carcinoma | Synthesis | Messenger RNA | Reverse transcriptase | Ionization | Melanoma | Lipids | Liquid chromatography | Hyaluronic acid | Mass spectrometry | Cellular biology | Protein synthesis | Cancer | Index Medicus | MAMMARY GLANDS | CATTLE | GLUCURONIC ACID | MASS SPECTROSCOPY | MELANOMAS | 60 APPLIED LIFE SCIENCES | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | ENDOPLASMIC RETICULUM | INHIBITION | POLYMERASE CHAIN REACTION | MESSENGER-RNA | PHOSPHATES | MICROSTRUCTURE | HYALURONIDASE
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8. Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells
by Li, Lingmei and Qi, Lisha and Liang, Zhijie and Song, Wangzhao and Liu, Yanxue and Wang, Yalei and Sun, Baocun and Zhang, Bin and Cao, Wenfeng
International journal of molecular medicine, ISSN 1107-3756, 07/2015, Volume 36, Issue 1, pp. 113 - 122
Epithelial-mesenchymal transition | Hyaluronan | Epidermal growth factor | Transforming growth factor-β1 | CD44 | Epithelial-Mesenchymal Transition - physiology | Humans | Transforming Growth Factor beta1 - metabolism | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Receptor, Epidermal Growth Factor - metabolism | MCF-7 Cells | RNA Interference | Hyaluronan Receptors - metabolism | Female | Hyaluronan Synthases | Hymecromone - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Transforming Growth Factor beta1 - pharmacology | Receptor, Epidermal Growth Factor - biosynthesis | Epidermal Growth Factor - metabolism | Signal Transduction - genetics | Hyaluronan Receptors - biosynthesis | Enzyme Activation - drug effects | Hyaluronan Receptors - genetics | Glucuronosyltransferase - metabolism | Breast Neoplasms - pathology | Hyaluronic Acid - metabolism | Cell Line, Tumor | Glucuronosyltransferase - antagonists & inhibitors | RNA, Small Interfering | Neoplasm Invasiveness - genetics
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9. Full Text Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells
by Twarock, Sören and Tammi, Markku I and Savani, Rashmin C and Fischer, Jens W
The Journal of biological chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 30, pp. 23276 - 23284
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Molecular Sequence Data | Esophageal Neoplasms - pathology | Gene Knockdown Techniques | Pseudopodia - drug effects | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Hyaluronic Acid - biosynthesis | Base Sequence | Esophageal Neoplasms - metabolism | Hyaluronan Receptors - metabolism | Hyaluronan Synthases | Hymecromone - pharmacology | Extracellular Matrix Proteins - metabolism | Amino Acid Sequence | Glucuronosyltransferase - deficiency | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Cell Movement - drug effects | Focal Adhesions - drug effects | Phenotype | Animals | Pseudopodia - metabolism | Focal Adhesions - metabolism | Hyaluronic Acid - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Index Medicus | Cancer Therapy | Cell Surface | Extracellular Matrix | Hyaluronan Synthase | Cytoskeleton | Esophageal Cancer | Glycobiology and Extracellular Matrices | Hyaluronate | Cell Adhesion
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10. Full Text Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells
by Lokeshwar, Vinata B and Lopez, Luis E and Munoz, Daniel and Chi, Andrew and Shirodkar, Samir P and Lokeshwar, Soum D and Escudero, Diogo O and Dhir, Neetika and Altman, Norman
Cancer research (Chicago, Ill.), ISSN 0008-5472, 04/2010, Volume 70, Issue 7, pp. 2613 - 2623
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the urinary system | Urinary tract. Prostate gland | Gynecology. Andrology. Obstetrics | Pharmacology. Drug treatments | Nephrology. Urinary tract diseases | Biological and medical sciences | Medical sciences | Antineoplastic agents | Male genital diseases | Tumors | Prostatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Male | Neovascularization, Pathologic - pathology | Hymecromone - analogs & derivatives | Hymecromone - pharmacology | Interleukin-8 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Receptors, Interleukin-8 - metabolism | Cell Growth Processes - drug effects | Neoplasm Invasiveness | Hyaluronic Acid - antagonists & inhibitors | Chemotaxis - drug effects | Down-Regulation - drug effects | Receptors, CXCR4 - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Hyaluronic Acid - metabolism | Cell Line, Tumor | Mice | Neovascularization, Pathologic - metabolism | Index Medicus | 4-methylumbelliferone | prostate cancer | Hyaluronic acid | Hyaluronic acid receptors
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11. Full Text Antioxidative capacity in the fat body of Bombyx mori is increased following oral administration of 4-methylumbelliferone
by Fang, Yan and Wang, Hua and Zhu, Wenjuan and Wang, Lu and Liu, Hengjiang and He, Yue and Xu, Xu and Yin, Weimin and Sima, Yanghu and Xu, Shiqing
Comparative biochemistry and physiology. Toxicology & pharmacology, ISSN 1532-0456, 01/2014, Volume 159, Issue 1, pp. 31 - 37
Reactive oxygen species | Bombyx mori | Fat body | 4-Methylumbelliferone | Anti-oxidant | Oxidative stress response | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Toxicology | Life Sciences & Biomedicine | Zoology | Science & Technology | Glutathione Peroxidase - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | Larva - metabolism | Bombyx - drug effects | Hydrogen Peroxide - metabolism | Catalase - metabolism | Bombyx - metabolism | Animals | Larva - drug effects | Fat Body - drug effects | Hymecromone - pharmacology | NADP - metabolism | Oxidative Stress - drug effects | Fat Body - metabolism | Coumarins | Analysis | Index Medicus
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12. Full Text Silkworm as a model animal to evaluate drug candidate toxicity and metabolism
by Hamamoto, Hiroshi and Tonoike, Akiko and Narushima, Kazuya and Horie, Ryo and Sekimizu, Kazuhisa
Comparative biochemistry and physiology. Toxicology & pharmacology, ISSN 1532-0456, 2009, Volume 149, Issue 3, pp. 334 - 339
Animal model | Pharmacodynamics | Metabolism | Toxicity | Insect | Silkworm | Biochemistry & Molecular Biology | Endocrinology & Metabolism | Toxicology | Life Sciences & Biomedicine | Zoology | Science & Technology | Drug Evaluation, Preclinical - methods | Larva - metabolism | Coumarins - pharmacokinetics | Cytochrome P-450 Enzyme System - metabolism | Hemolymph - metabolism | Glucuronates - metabolism | Bombyx - drug effects | Lethal Dose 50 | Umbelliferones - pharmacokinetics | Feasibility Studies | Hymecromone - analogs & derivatives | Bombyx - metabolism | Animals | Feces - chemistry | Larva - drug effects | Biotransformation | Bombyx - enzymology | Hymecromone - pharmacokinetics | Models, Animal | Toxicity Tests - methods | Insect Proteins - metabolism | Drugs | Analysis | Physiological aspects | Coumarins | Models | Glucose | Sulfates | Dextrose | Index Medicus
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