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1. Full Text UGT1A10 Is a High Activity and Important Extrahepatic Enzyme: Why Has Its Role in Intestinal Glucuronidation Been Frequently Underestimated?
by Troberg, Johanna and Järvinen, Erkka and Ge, Guang-Bo and Yang, Ling and Finel, Moshe
Molecular Pharmaceutics, ISSN 1543-8384, 09/2017, Volume 14, Issue 9, pp. 2875 - 2883
The aim of this work was to highlight a considerable and broad problem in UGT1A10 activity assessment that has led to underestimation of its role in intestinal... 
estrone | SN-38 | bavachinin | UDP-glucuronosyltransferase | intestinal glucuronidation | AMC | recombinant UGT1A10 | estradiol | intestine microsomes | morphine | NCHN | MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN TISSUES | ISOFORMS | HUMAN UDP-GLUCURONOSYLTRANSFERASES | QUANTIFICATION | TANDEM MASS-SPECTROMETRY | TRANSFERASE 1A | IN-VITRO | UGT ENZYMES | PHARMACOLOGY & PHARMACY | EXPRESSION | SELECTIVITY | Coumarins - metabolism | Estradiol - metabolism | Camptothecin - metabolism | Humans | Microsomes, Liver - metabolism | Intestines - metabolism | Chromatography, High Pressure Liquid | Hymecromone - metabolism | Blotting, Western | Animals | Glucuronosyltransferase - metabolism | Estrone - metabolism | Flavonoids - metabolism | Kinetics | Camptothecin - analogs & derivatives | Diclofenac - metabolism | Index Medicus
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2. Full Text Evaluation of the role of multidrug resistance-associated protein (Mrp) 3 and Mrp4 in hepatic basolateral excretion of sulfate and glucuronide metabolites of acetaminophen, 4-methylumbelliferone, and harmol in Abcc3-/- and Abcc4-/- mice
by Zamek-Gliszczynski, Maciej J and Nezasa, Ken-Ichi and Tian, Xianbin and Bridges, Arlene S and Lee, Kun and Belinsky, Martin G and Kruh, Gary D and Brouwer, Kim L. R
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1485 - 1491
Although glucuronide and sulfate conjugates of many drugs and endogenous compounds undergo appreciable hepatic basolateral excretion into sinusoidal blood, the... 
OBSTRUCTIVE CHOLESTASIS | ORGANIC ANION TRANSPORTER | ALTERED HEPATOBILIARY DISPOSITION | LACKING | CONJUGATED HYPERBILIRUBINEMIA | RAT | BILIARY-EXCRETION | LIVER | PHARMACOLOGY & PHARMACY | KNOCKOUT MICE | KIDNEY | Acetaminophen - metabolism | Analgesics, Non-Narcotic - pharmacokinetics | Bile - metabolism | Hymecromone - metabolism | Hymecromone - analogs & derivatives | Glucuronides - metabolism | ATP-Binding Cassette Transporters - genetics | ATP-Binding Cassette Transporters - metabolism | Hymecromone - pharmacokinetics | Multidrug Resistance-Associated Proteins - genetics | Harmine - pharmacokinetics | Sulfates - metabolism | Harmine - analogs & derivatives | Liver - metabolism | Analgesics, Non-Narcotic - metabolism | Blotting, Western | Harmine - metabolism | Mice, Knockout | Animals | ATP Binding Cassette Transporter, Sub-Family B - metabolism | Mice | Acetaminophen - pharmacokinetics | In Vitro Techniques | ATP Binding Cassette Transporter, Sub-Family B - genetics | Multidrug Resistance-Associated Proteins - metabolism | Index Medicus
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3. Full Text Binding of Inhibitory Fatty Acids Is Responsible for the Enhancement of UDP-Glucuronosyltransferase 2B7 Activity by Albumin: Implications for in Vitro-in Vivo Extrapolation
by Andrew Rowland and Paraskevi Gaganis and David J. Elliot and Peter I. Mackenzie and Kathleen M. Knights and John O. Miners
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 04/2007, Volume 321, Issue 1, pp. 137 - 147
Studies were performed to elucidate the mechanism responsible for the reduction in K m values of UDP-glucuronosyltransferase 2B7 (UGT2B7) substrates observed... 
HEPATOCYTES | KINETIC-DATA | METABOLISM | HUMAN DRUG GLUCURONIDATION | MORPHINE | QUANTITATIVE PREDICTION | ISOFORM SELECTIVITY | PHARMACOLOGY & PHARMACY | HUMAN LIVER-MICROSOMES | LIPID-COMPOSITION | INTRINSIC CLEARANCE | Recombinant Proteins - metabolism | Microsomes - metabolism | Serum Albumin, Bovine - pharmacology | Zidovudine - metabolism | Data Interpretation, Statistical | Humans | Chromatography, High Pressure Liquid | Hymecromone - metabolism | Blotting, Western | Hymecromone - analogs & derivatives | Albumins - pharmacology | Animals | Glucuronides - metabolism | Glucuronosyltransferase - metabolism | Serum Albumin - pharmacology | Cattle | Protein Binding | Anti-HIV Agents - metabolism | Kinetics | In Vitro Techniques | Fatty Acids - metabolism | Index Medicus
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4. Full Text The "albumin effect" and drug glucuronidation: Bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities
by Rowland, Andrew and Knights, Kathleen M and Mackenzie, Peter I and Miners, John O
Drug Metabolism and Disposition, ISSN 0090-9556, 06/2008, Volume 36, Issue 6, pp. 1056 - 1062
Bovine serum albumin (BSA) and fatty acid-free human serum albumin (HSAFAF) reduce the Km values for UGT2B7 substrates by sequestering inhibitory long-chain... 
VIVO METABOLIC-CLEARANCE | EXPLANATION | IN-VITRO | 3'-AZIDO-3'-DEOXYTHYMIDINE | PHARMACOKINETICS | KINETICS | PHARMACOLOGY & PHARMACY | HUMAN LIVER-MICROSOMES | BINDING | DISPOSITION | PROPOFOL | Recombinant Proteins - metabolism | Cell Line | Humans | Microsomes, Liver - metabolism | Middle Aged | Male | Recombinant Proteins - genetics | Serum Albumin, Bovine - metabolism | Hymecromone - metabolism | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Animals | Glucuronides - metabolism | Glucuronosyltransferase - metabolism | Cattle | Propofol - metabolism | Adult | Female | Aged | Serum Albumin - metabolism | Index Medicus
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5. Full Text Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis
by Zucchi, Paola C and Zick, Michael
Molecular Biology of the Cell, ISSN 1059-1524, 12/2011, Volume 22, Issue 23, pp. 4635 - 4646
The fusion of sealed biological membranes joins their enclosed aqueous compartments while mixing their membrane bilayers. Reconstituted fusion reactions are... 
DOCKING | YEAST VACUOLES | PURIFICATION | ALPHA-SNAP | RELEASE | RECONSTITUTION | VERTEX RING DOMAIN | REGULATORY LIPIDS | PHOSPHOINOSITIDES | HOMOTYPIC VACUOLE FUSION | CELL BIOLOGY | rab GTP-Binding Proteins - metabolism | Molecular Chaperones - metabolism | Membrane Fusion | Biotin - pharmacokinetics | Vesicular Transport Proteins - metabolism | Proteolipids - metabolism | Intracellular Membranes | Adenosine Triphosphatases - metabolism | Permeability | Protein Transport | Cell Compartmentation | Hymecromone - analogs & derivatives | Lipids - chemistry | Saccharomyces cerevisiae Proteins - metabolism | Hymecromone - pharmacokinetics | Vacuoles - metabolism | Dithionite - pharmacokinetics | SNARE Proteins - metabolism | Proteolipids - chemistry | Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins - metabolism | Index Medicus
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6. Full Text Antioxidative capacity in the fat body of Bombyx mori is increased following oral administration of 4-methylumbelliferone
by Fang, Yan and Wang, Lu and Wang, Hua and Zhu, Wenjuan and Liu, Hengjiang and He, Yue and Xu, Xu and Xu, Shiqing and Yin, Weimin and Sima, Yanghu
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 01/2014, Volume 159, Issue 1, pp. 31 - 37
Plant sources of umbelliferones have tumor-inhibitory effects at the cellular level. However, their physiological functions in animals are largely unresolved.... 
Reactive oxygen species | Bombyx mori | Fat body | 4-Methylumbelliferone | Anti-oxidant | Oxidative stress response | ZOOLOGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | ENDOCRINOLOGY & METABOLISM | SILKWORM | TOXICOLOGY | Glutathione Peroxidase - metabolism | Reactive Oxygen Species - metabolism | Glutathione - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | Larva - metabolism | Bombyx - drug effects | Hydrogen Peroxide - metabolism | Catalase - metabolism | Bombyx - metabolism | Animals | Larva - drug effects | Fat Body - drug effects | Hymecromone - pharmacology | NADP - metabolism | Oxidative Stress - drug effects | Fat Body - metabolism | Coumarins | Analysis | Index Medicus
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7. Full Text Antitumor activity of hyaluronic acid synthesis inhibitor 4-methylumbelliferone in prostate cancer cells
by Lokeshwar, Vinata B and Lopez, Luis E and Munoz, Daniel and Chi, Andrew and Shirodkar, Samir P and Lokeshwar, Soum D and Escudero, Diogo O and Dhir, Neetika and Altman, Norman
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 7, pp. 2613 - 2623
4-Methylumbelliferone (4-MU) is a hyaluronic acid (HA) synthesis inhibitor with anticancer properties; the mechanism of its anticancer effects is unknown. We... 
CARCINOMA-CELLS | BLADDER-CANCER | ACTIVATION | ONCOLOGY | SYNTHASE SUPPRESSOR | MOLECULAR DETERMINANT | RECEPTOR | MELANOMA-CELLS | GROWTH-FACTOR | EXPRESSION | HYAL1 HYALURONIDASE | Prostatic Neoplasms - metabolism | Apoptosis - drug effects | Humans | Male | Neovascularization, Pathologic - pathology | Hymecromone - analogs & derivatives | Hymecromone - pharmacology | Interleukin-8 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - blood supply | Prostatic Neoplasms - pathology | Receptors, Interleukin-8 - metabolism | Cell Growth Processes - drug effects | Neoplasm Invasiveness | Hyaluronic Acid - antagonists & inhibitors | Chemotaxis - drug effects | Down-Regulation - drug effects | Receptors, CXCR4 - metabolism | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Neovascularization, Pathologic - drug therapy | Hyaluronic Acid - metabolism | Cell Line, Tumor | Mice | Neovascularization, Pathologic - metabolism | Index Medicus | 4-methylumbelliferone | prostate cancer | Hyaluronic acid | Hyaluronic acid receptors
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8. Full Text The hyaluronic acid inhibitor 4-methylumbelliferone is an NSMase2 activator—role of Ceramide in MU anti-tumor activity
by Qin, Jingdong and Kilkus, John and Dawson, Glyn
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 02/2016, Volume 1861, Issue 2, pp. 78 - 90
Increased synthesis of hyaluronic acid (HA) is often associated with increased metastatic potential and invasivity of tumor cells. 4-Methylumbelliferone (MU)... 
Ceramide | 4-Methylumbelliforone | NSMase2 | Hyaluronic acid | Anticancer | CANCER-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIRT1 | CELL BIOLOGY | ADHESION DYNAMICS | IN-VITRO | BIOPHYSICS | CALPAIN-MEDIATED PROTEOLYSIS | NEUTRAL SPHINGOMYELINASE 2 | PROSTATE-CANCER | MELANOMA-CELLS | EXPRESSION | Sirtuin 1 - metabolism | Sphingomyelin Phosphodiesterase - genetics | Calpain - metabolism | Apoptosis - drug effects | Neuroglia - pathology | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Calpain - genetics | Sirtuin 1 - genetics | Ceramides - biosynthesis | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Neuroglia - drug effects | Glucuronosyltransferase - genetics | Sphingomyelin Phosphodiesterase - metabolism | Caspase 3 - genetics | Antineoplastic Agents - pharmacology | Hyaluronan Synthases | Hymecromone - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Protein Phosphatase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Hyaluronic Acid - antagonists & inhibitors | Cell Movement - drug effects | Animals | Glucuronosyltransferase - metabolism | Hyaluronic Acid - metabolism | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Neuroglia - metabolism | Mice | Enzyme Activation | Ceramides | Calpain | Plant lipids | Tumor proteins | Tumors | Phosphatases | Metastasis | Mass spectrometry
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9. Full Text Silkworm as a model animal to evaluate drug candidate toxicity and metabolism
by Hamamoto, Hiroshi and Tonoike, Akiko and Narushima, Kazuya and Horie, Ryo and Sekimizu, Kazuhisa
Comparative Biochemistry and Physiology, Part C, ISSN 1532-0456, 2009, Volume 149, Issue 3, pp. 334 - 339
To evaluate the feasibility of using the silkworm as a model animal for screening drug candidates, we examined whether the lethal dose of cytotoxic chemicals... 
Animal model | Pharmacodynamics | Metabolism | Toxicity | Insect | Silkworm | RAT-LIVER | EMBRYONIC-DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | INFECTION MODEL | DROSOPHILA | PATHOGENESIS | BOMBYX-MORI | ZOOLOGY | CLONING | BIOSYNTHESIS | LARVAE | ENDOCRINOLOGY & METABOLISM | TOXICOLOGY | Drug Evaluation, Preclinical - methods | Larva - metabolism | Coumarins - pharmacokinetics | Cytochrome P-450 Enzyme System - metabolism | Hemolymph - metabolism | Glucuronates - metabolism | Bombyx - drug effects | Lethal Dose 50 | Umbelliferones - pharmacokinetics | Feasibility Studies | Hymecromone - analogs & derivatives | Bombyx - metabolism | Animals | Feces - chemistry | Larva - drug effects | Biotransformation | Bombyx - enzymology | Hymecromone - pharmacokinetics | Models, Animal | Toxicity Tests - methods | Insect Proteins - metabolism | Drugs | Analysis | Physiological aspects | Coumarins | Models | Glucose | Sulfates | Dextrose | Index Medicus
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10. Full Text 4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3
by Kultti, Anne and Pasonen-Seppänen, Sanna and Jauhiainen, Marjo and Rilla, Kirsi J and Kärnä, Riikka and Pyöriä, Emma and Tammi, Markku I and Tammi, Raija H
Experimental Cell Research, ISSN 0014-4827, 2009, Volume 315, Issue 11, pp. 1914 - 1923
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth... 
Hyaluronan synthesis | 4-Methylumbelliferone | Hyaluronan synthase | UDP-glucuronic acid | ACTIVATES HYALURONAN | MAMMALIAN-CELLS | CELL BIOLOGY | BREAST-CANCER CELLS | SUGAR NUCLEOTIDES | RETINOIC ACID | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | PROSTATE-CANCER | STROMAL HYALURONAN | DERMAL FIBROBLASTS | MELANOMA-CELLS | Neoplasms - metabolism | Uridine Diphosphate Glucuronic Acid - metabolism | Humans | Neoplasm Invasiveness - prevention & control | DNA Primers - genetics | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Breast Neoplasms - metabolism | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Neoplasms - genetics | Hyaluronic Acid - biosynthesis | Melanoma - genetics | Base Sequence | Female | Hyaluronan Synthases | Hymecromone - pharmacology | Melanoma - metabolism | RNA, Messenger - genetics | Down-Regulation - drug effects | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Cell Movement - drug effects | Breast Neoplasms - genetics | Glucuronosyltransferase - metabolism | Melanoma - drug therapy | Cell Line, Tumor | RNA, Neoplasm - genetics | Cell Proliferation - drug effects | Phosphates | Squamous cell carcinoma | Synthesis | Messenger RNA | Reverse transcriptase | Ionization | Melanoma | Lipids | Liquid chromatography | Hyaluronic acid | Mass spectrometry | Cellular biology | Protein synthesis | Cancer | Index Medicus | MAMMARY GLANDS | CATTLE | GLUCURONIC ACID | MASS SPECTROSCOPY | MELANOMAS | 60 APPLIED LIFE SCIENCES | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | ENDOPLASMIC RETICULUM | INHIBITION | POLYMERASE CHAIN REACTION | MESSENGER-RNA | PHOSPHATES | MICROSTRUCTURE | HYALURONIDASE
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11. Full Text Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells
by Twarock, Sören and Tammi, Markku I and Savani, Rashmin C and Fischer, Jens W
Journal of Biological Chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 30, pp. 23276 - 23284
Hyaluronan (HA) is a polysaccharide component in the parenchyma and stroma of human esophageal squamous cell carcinoma (ESCC). Clinically, esophageal cancer... 
CANCER-CELLS | COLON-CANCER | TRANSFORMATION | OVEREXPRESSION | ACTIVATED PROTEIN-KINASE | METASTASIS | RECEPTOR RHAMM | BIOCHEMISTRY & MOLECULAR BIOLOGY | CULTURED-CELLS | HUMAN TUMORS | CD44 | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Molecular Sequence Data | Esophageal Neoplasms - pathology | Gene Knockdown Techniques | Pseudopodia - drug effects | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Hyaluronic Acid - biosynthesis | Base Sequence | Esophageal Neoplasms - metabolism | Hyaluronan Receptors - metabolism | Hyaluronan Synthases | Hymecromone - pharmacology | Extracellular Matrix Proteins - metabolism | Amino Acid Sequence | Glucuronosyltransferase - deficiency | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Cell Movement - drug effects | Focal Adhesions - drug effects | Phenotype | Animals | Pseudopodia - metabolism | Focal Adhesions - metabolism | Hyaluronic Acid - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Index Medicus | Cancer Therapy | Cell Surface | Extracellular Matrix | Hyaluronan Synthase | Cytoskeleton | Esophageal Cancer | Glycobiology and Extracellular Matrices | Hyaluronate | Cell Adhesion
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12. Full Text Transforming growth factor-β1 induces EMT by the transactivation of epidermal growth factor signaling through HA/CD44 in lung and breast cancer cells
by LI, LINGMEI and QI, LISHA and LIANG, ZHIJIE and SONG, WANGZHAO and LIU, YANXUE and WANG, YALEI and SUN, BAOCUN and ZHANG, BIN and CAO, WENFENG
International Journal of Molecular Medicine, ISSN 1107-3756, 7/2015, Volume 36, Issue 1, pp. 113 - 122
Epithelial-mesenchymal transition (EMT), a process closely related to tumor development, is regulated by a variety of signaling pathways and growth factors,... 
transforming growth factor-β1 | epithelial-mesenchymal transition | epidermal growth factor | CD44 | hyaluronan | Epithelial-mesenchymal transition | Hyaluronan | Epidermal growth factor | Transforming growth factor-β1 | Epithelial-Mesenchymal Transition - physiology | Humans | Transforming Growth Factor beta1 - metabolism | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Receptor, Epidermal Growth Factor - metabolism | MCF-7 Cells | RNA Interference | Hyaluronan Receptors - metabolism | Female | Hyaluronan Synthases | Hymecromone - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Transforming Growth Factor beta1 - pharmacology | Receptor, Epidermal Growth Factor - biosynthesis | Epidermal Growth Factor - metabolism | Signal Transduction - genetics | Hyaluronan Receptors - biosynthesis | Enzyme Activation - drug effects | Hyaluronan Receptors - genetics | Glucuronosyltransferase - metabolism | Breast Neoplasms - pathology | Hyaluronic Acid - metabolism | Cell Line, Tumor | Glucuronosyltransferase - antagonists & inhibitors | RNA, Small Interfering | Neoplasm Invasiveness - genetics | Studies | Rodents | Extracellular matrix | Physiology | Breast cancer | Metastasis | Localization | Kinases | Cell adhesion & migration
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13. Full Text Pediatric Development of Glucuronidation: The Ontogeny of Hepatic UGT1A4
by Shogo J. Miyagi and Abby C. Collier
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2007, Volume 35, Issue 9, pp. 1587 - 1592
This article reports on the development of UDP-glucuronosyltransferase (UGT) enzyme activity in pediatric livers. The substrates 4-methylumbelliferone (4MU)... 
GLUCURONYLTRANSFERASE ACTIVITY | BILIRUBIN | TRIFLUOPERAZINE | HUMAN PLACENTA | HUMAN UDP-GLUCURONOSYLTRANSFERASES | KINETICS | PHARMACOLOGY & PHARMACY | POSTNATAL-DEVELOPMENT | COS-1 CELLS | HUMAN-LIVER-MICROSOMES | EXPRESSION | Humans | Microsomes, Liver - metabolism | Middle Aged | Glucuronidase - metabolism | Child, Preschool | Infant | Male | Hymecromone - metabolism | Liver - growth & development | Hymecromone - analogs & derivatives | Ethnic Groups | Glucuronides - metabolism | Adult | Female | Child | Enterohepatic Circulation - physiology | Infant, Newborn | Liver Circulation - physiology | Liver - metabolism | Trifluoperazine - metabolism | Sex Characteristics | Hydrolysis | Glucuronosyltransferase - metabolism | Adolescent | Antipsychotic Agents - metabolism | Aged | Aging - metabolism | Index Medicus
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14. Full Text Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9
by Manevski, Nenad and Moreolo, Paolo Svaluto and Yli-Kauhaluoma, Jari and Finel, Moshe
Drug metabolism and disposition: the biological fate of chemicals, ISSN 0090-9556, 11/2011, Volume 39, Issue 11, pp. 2117 - 2129
The human UDP-glucuronosyltransferase (UGT) enzymes UGT1A9 and UGT2B7 play important roles in the hepatic glucuronidation of many drugs. The presence of bovine... 
Recombinant Proteins - metabolism | Nitriles - metabolism | Serum Albumin, Bovine - pharmacology | Uridine Diphosphate Glucuronic Acid - metabolism | Zidovudine - metabolism | Glucuronides - pharmacokinetics | Humans | Microsomes, Liver - metabolism | Catechols - pharmacokinetics | Zidovudine - pharmacokinetics | Serum Albumin, Bovine - metabolism | Hymecromone - metabolism | Nitriles - pharmacokinetics | Hymecromone - analogs & derivatives | Animals | Drug Interactions | Glucuronides - metabolism | Glucuronosyltransferase - metabolism | Cattle | Cell Membrane - metabolism | Microsomes, Liver - enzymology | Kinetics | Catechols - metabolism | Index Medicus
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15. Full Text Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-Glucuronosyltransferases
by Yong Liu and Jacqueline Ramírez and Larry House and Mark J. Ratain
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 32 - 39
We aimed to investigate and compare the effects of erlotinib and gefitinib on UDP-glucuronosyltransferase (UGT) activities and to quantitatively evaluate their... 
CELL LUNG-CANCER | 1A1 | RECEPTOR-TYROSINE KINASE | SOLID TUMORS | CYTOCHROME-P450 ENZYMES | KINETICS | IN-VITRO DATA | GLUCURONIDATION | PHARMACOLOGY & PHARMACY | HUMAN LIVER-MICROSOMES | PHASE-I | Erlotinib Hydrochloride | Bilirubin - metabolism | Area Under Curve | Humans | Middle Aged | Glucuronic Acid - metabolism | Indinavir - pharmacology | Quinazolines - pharmacokinetics | Male | Hymecromone - metabolism | Young Adult | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Biocatalysis - drug effects | Isoenzymes - metabolism | Microsomes, Liver - drug effects | Adult | Female | Microsomes, Liver - enzymology | Child | Protein Kinase Inhibitors - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Recombinant Proteins - antagonists & inhibitors | Binding, Competitive - physiology | Isoenzymes - genetics | Recombinant Proteins - genetics | Glucuronosyltransferase - metabolism | Imipramine - metabolism | Models, Biological | Adolescent | Drug Interactions - physiology | Glucuronosyltransferase - antagonists & inhibitors | Aged | Protein Kinase Inhibitors - pharmacology | Kinetics | Quinazolines - pharmacology | Isoenzymes - antagonists & inhibitors | Protein Kinase Inhibitors - metabolism | Index Medicus
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16. Full Text Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis
by Nagy, Nadine and Kaber, Gernot and Johnson, Pamela Y and Gebe, John A and Preisinger, Anton and Falk, Ben A and Sunkari, Vivekananda G and Gooden, Michel D and Vernon, Robert B and Bogdani, Marika and Kuipers, Hedwich F and Day, Anthony J and Campbell, Daniel J and Wight, Thomas N and Bollyky, Paul L
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3928 - 3940
We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients... 
MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC-ISLETS | NOD MICE | TGF-BETA | BINDING PROTEINS | IN-VIVO | REGULATORY T-CELLS | EXTRACELLULAR-MATRIX | HEPARAN-SULFATE | ACID SYNTHESIS | TYPE-1 | Prediabetic State - metabolism | Diabetes Mellitus, Experimental - drug therapy | Prediabetic State - genetics | Diabetes Mellitus, Type 1 - prevention & control | Humans | Diabetes Mellitus, Type 1 - metabolism | Extracellular Matrix - metabolism | Hyaluronic Acid - pharmacology | Prediabetic State - drug therapy | Insulin - biosynthesis | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Insulin-Secreting Cells - metabolism | Hyaluronic Acid - analysis | Hyperglycemia - pathology | Prediabetic State - pathology | Diabetes Mellitus, Type 1 - immunology | Hymecromone - pharmacology | Diabetes Mellitus, Experimental - metabolism | Disease Models, Animal | Immune Tolerance - drug effects | Forkhead Transcription Factors - biosynthesis | Cells, Cultured | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Hyaluronic Acid - antagonists & inhibitors | Mice, Transgenic | Forkhead Transcription Factors - genetics | Hyaluronan Receptors - genetics | Disease Progression | Hyperglycemia - metabolism | Receptors, Leptin - deficiency | Animals | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Hyaluronic Acid - metabolism | Diabetes Mellitus, Experimental - pathology | Hymecromone - therapeutic use | Mice, Inbred NOD | Hyaluronan Receptors - immunology | Mice | Mice, Inbred BALB C | Insulin-Secreting Cells - pathology | Extracellular Matrix - pathology | Chemical inhibitors | Patient outcomes | Dosage and administration | Autoimmune diseases | Drug therapy | Hyaluronic acid | Health aspects | Hyperglycemia | Diabetes | Rodents | Age | Index Medicus | Abridged Index Medicus
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