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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2006, Volume 319, Issue 3, pp. 1485 - 1491
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 7, pp. 2613 - 2623
Journal Article
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 02/2016, Volume 1861, Issue 2, pp. 78 - 90
Increased synthesis of hyaluronic acid (HA) is often associated with increased metastatic potential and invasivity of tumor cells. 4-Methylumbelliferone (MU)... 
Ceramide | 4-Methylumbelliforone | NSMase2 | Hyaluronic acid | Anticancer | CANCER-CELLS | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | SIRT1 | CELL BIOLOGY | ADHESION DYNAMICS | IN-VITRO | BIOPHYSICS | CALPAIN-MEDIATED PROTEOLYSIS | NEUTRAL SPHINGOMYELINASE 2 | PROSTATE-CANCER | MELANOMA-CELLS | EXPRESSION | Sirtuin 1 - metabolism | Sphingomyelin Phosphodiesterase - genetics | Calpain - metabolism | Apoptosis - drug effects | Neuroglia - pathology | Humans | Caspase 3 - metabolism | Gene Expression Regulation, Neoplastic | Calpain - genetics | Sirtuin 1 - genetics | Ceramides - biosynthesis | Proto-Oncogene Proteins c-akt - genetics | Tumor Suppressor Protein p53 - genetics | Neuroglia - drug effects | Glucuronosyltransferase - genetics | Sphingomyelin Phosphodiesterase - metabolism | Caspase 3 - genetics | Antineoplastic Agents - pharmacology | Hyaluronan Synthases | Hymecromone - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Signal Transduction | Protein Phosphatase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Hyaluronic Acid - antagonists & inhibitors | Cell Movement - drug effects | Animals | Glucuronosyltransferase - metabolism | Hyaluronic Acid - metabolism | Protein Phosphatase 2 - metabolism | Cell Line, Tumor | Neuroglia - metabolism | Mice | Enzyme Activation | Ceramides | Calpain | Plant lipids | Tumor proteins | Tumors | Phosphatases | Metastasis | Mass spectrometry
Journal Article
Experimental Cell Research, ISSN 0014-4827, 2009, Volume 315, Issue 11, pp. 1914 - 1923
Hyaluronan accumulation on cancer cells and their surrounding stroma predicts an unfavourable disease outcome, suggesting that hyaluronan enhances tumor growth... 
Hyaluronan synthesis | 4-Methylumbelliferone | Hyaluronan synthase | UDP-glucuronic acid | ACTIVATES HYALURONAN | MAMMALIAN-CELLS | CELL BIOLOGY | BREAST-CANCER CELLS | SUGAR NUCLEOTIDES | RETINOIC ACID | ONCOLOGY | EPIDERMAL-GROWTH-FACTOR | PROSTATE-CANCER | STROMAL HYALURONAN | DERMAL FIBROBLASTS | MELANOMA-CELLS | Neoplasms - metabolism | Uridine Diphosphate Glucuronic Acid - metabolism | Humans | Neoplasm Invasiveness - prevention & control | DNA Primers - genetics | RNA, Messenger - metabolism | RNA, Neoplasm - metabolism | Breast Neoplasms - metabolism | Glucuronosyltransferase - genetics | Hymecromone - analogs & derivatives | Neoplasms - genetics | Hyaluronic Acid - biosynthesis | Melanoma - genetics | Base Sequence | Female | Hyaluronan Synthases | Hymecromone - pharmacology | Melanoma - metabolism | RNA, Messenger - genetics | Down-Regulation - drug effects | Breast Neoplasms - drug therapy | Neoplasms - drug therapy | Cell Movement - drug effects | Breast Neoplasms - genetics | Glucuronosyltransferase - metabolism | Melanoma - drug therapy | Cell Line, Tumor | RNA, Neoplasm - genetics | Cell Proliferation - drug effects | Phosphates | Squamous cell carcinoma | Synthesis | Messenger RNA | Reverse transcriptase | Ionization | Melanoma | Lipids | Liquid chromatography | Hyaluronic acid | Mass spectrometry | Cellular biology | Protein synthesis | Cancer | Index Medicus | MAMMARY GLANDS | CATTLE | GLUCURONIC ACID | MASS SPECTROSCOPY | MELANOMAS | 60 APPLIED LIFE SCIENCES | HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | ENDOPLASMIC RETICULUM | INHIBITION | POLYMERASE CHAIN REACTION | MESSENGER-RNA | PHOSPHATES | MICROSTRUCTURE | HYALURONIDASE
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2010, Volume 285, Issue 30, pp. 23276 - 23284
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 7/2015, Volume 36, Issue 1, pp. 113 - 122
Epithelial-mesenchymal transition (EMT), a process closely related to tumor development, is regulated by a variety of signaling pathways and growth factors,... 
transforming growth factor-β1 | epithelial-mesenchymal transition | epidermal growth factor | CD44 | hyaluronan | Epithelial-mesenchymal transition | Hyaluronan | Epidermal growth factor | Transforming growth factor-β1 | Epithelial-Mesenchymal Transition - physiology | Humans | Transforming Growth Factor beta1 - metabolism | Lung Neoplasms - pathology | Extracellular Signal-Regulated MAP Kinases - metabolism | Epithelial-Mesenchymal Transition - genetics | Cell Movement - genetics | Receptor, Epidermal Growth Factor - metabolism | MCF-7 Cells | RNA Interference | Hyaluronan Receptors - metabolism | Female | Hyaluronan Synthases | Hymecromone - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Transforming Growth Factor beta1 - pharmacology | Receptor, Epidermal Growth Factor - biosynthesis | Epidermal Growth Factor - metabolism | Signal Transduction - genetics | Hyaluronan Receptors - biosynthesis | Enzyme Activation - drug effects | Hyaluronan Receptors - genetics | Glucuronosyltransferase - metabolism | Breast Neoplasms - pathology | Hyaluronic Acid - metabolism | Cell Line, Tumor | Glucuronosyltransferase - antagonists & inhibitors | RNA, Small Interfering | Neoplasm Invasiveness - genetics | Studies | Rodents | Extracellular matrix | Physiology | Breast cancer | Metastasis | Localization | Kinases | Cell adhesion & migration
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 01/2010, Volume 38, Issue 1, pp. 32 - 39
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2015, Volume 125, Issue 10, pp. 3928 - 3940
We recently reported that abundant deposits of the extracellular matrix polysaccharide hyaluronan (HA) are characteristic of autoimmune insulitis in patients... 
MEDICINE, RESEARCH & EXPERIMENTAL | PANCREATIC-ISLETS | NOD MICE | TGF-BETA | BINDING PROTEINS | IN-VIVO | REGULATORY T-CELLS | EXTRACELLULAR-MATRIX | HEPARAN-SULFATE | ACID SYNTHESIS | TYPE-1 | Prediabetic State - metabolism | Diabetes Mellitus, Experimental - drug therapy | Prediabetic State - genetics | Diabetes Mellitus, Type 1 - prevention & control | Humans | Diabetes Mellitus, Type 1 - metabolism | Extracellular Matrix - metabolism | Hyaluronic Acid - pharmacology | Prediabetic State - drug therapy | Insulin - biosynthesis | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Regulatory - immunology | Insulin-Secreting Cells - metabolism | Hyaluronic Acid - analysis | Hyperglycemia - pathology | Prediabetic State - pathology | Diabetes Mellitus, Type 1 - immunology | Hymecromone - pharmacology | Diabetes Mellitus, Experimental - metabolism | Disease Models, Animal | Immune Tolerance - drug effects | Forkhead Transcription Factors - biosynthesis | Cells, Cultured | Diabetes Mellitus, Type 1 - pathology | Diabetes Mellitus, Type 1 - genetics | Hyaluronic Acid - antagonists & inhibitors | Mice, Transgenic | Forkhead Transcription Factors - genetics | Hyaluronan Receptors - genetics | Disease Progression | Hyperglycemia - metabolism | Receptors, Leptin - deficiency | Animals | MAP Kinase Signaling System - drug effects | Cell Differentiation - drug effects | Hyaluronic Acid - metabolism | Diabetes Mellitus, Experimental - pathology | Hymecromone - therapeutic use | Mice, Inbred NOD | Hyaluronan Receptors - immunology | Mice | Mice, Inbred BALB C | Insulin-Secreting Cells - pathology | Extracellular Matrix - pathology | Chemical inhibitors | Patient outcomes | Dosage and administration | Autoimmune diseases | Drug therapy | Hyaluronic acid | Health aspects | Hyperglycemia | Diabetes | Rodents | Age | Index Medicus | Abridged Index Medicus
Journal Article