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1. Full Text Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
by Evangelou, Evangelos and Warren, Helen R and Mosen-Ansorena, David and Mifsud, Borbala and Pazoki, Raha and Gao, He and Ntritsos, Georgios and Dimou, Niki and Cabrera, Claudia P and Karaman, Ibrahim and Ng, Fu Liang and Evangelou, Marina and Witkowska, Katarzyna and Tzanis, Evan and Hellwege, Jacklyn N and Giri, Ayush and Velez Edwards, Digna R and Sun, Yan V and Cho, Kelly and Gaziano, J Michael and Wilson, Peter W F and Tsao, Philip S and Kovesdy, Csaba P and Esko, Tonu and Mägi, Reedik and Milani, Lili and Almgren, Peter and Boutin, Thibaud and Debette, Stéphanie and Ding, Jun and Giulianini, Franco and Holliday, Elizabeth G and Jackson, Anne U and Li-Gao, Ruifang and Prins, Bram Peter and Verweij, Niek and Zhao, Jing-Hua and Borst, Martin H de and Hartman, Catharina A and Lin, Li and Nolte, Ilja M and Oldehinkel, Albertine J and Penninx, Brenda W J H and Riese, Harriëtte and Smith, Albert V and Snieder, Harold and Swertz, Morris A and Vaez, Ahmad and van der Most, Peter J and van der Harst, Pim and Million Vet Program and Million Veteran Program and the Million Veteran Program and The Million Veteran Program
Nature genetics, ISSN 1061-4036, 10/2018, Volume 50, Issue 10, pp. 1412 - +
CARDIOVASCULAR-DISEASE RISK | UK BIOBANK | METAANALYSIS | VARIANTS | RARE | HYPERALDOSTERONISM | COMMON | HEALTH | HYPERTENSION | GENOME-WIDE ASSOCIATION | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Human Umbilical Vein Endothelial Cells | Genetic Predisposition to Disease | Genome-Wide Association Study | Life Style | Blood Pressure - genetics | Humans | Middle Aged | Risk Factors | Cells, Cultured | Male | Genetic Loci | Cardiovascular Diseases - genetics | Genetic Testing - methods | Genetics, Population - methods | Aged, 80 and over | Cardiovascular Diseases - epidemiology | Adult | Female | Aged | Polymorphism, Single Nucleotide | Hypertension - genetics | Quantitative Trait Loci | Quantitative trait loci | Blood circulation disorders | Genetic susceptibility | Genetic research | Genetic aspects | Research | Identification and classification | Health aspects | Risk factors | Hypertension | Medical colleges | Analysis | Blood pressure | Health risks | Cardiovascular disease | Genomes | Risk analysis | Loci | Blood | Meta-analysis | Studies | Consortia | Genetic analysis | Gene loci | Lifestyles | Cardiovascular diseases | Health risk assessment | Index Medicus | Kardiologi | Medicinsk genetik | Basic Medicine | Medical Genetics | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper | Klinisk medicin
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2. Full Text Genetic and Molecular Aspects of Hypertension
by Padmanabhan, Sandosh and Caulfield, Mark and Dominiczak, Anna F
Circulation research, ISSN 0009-7330, 03/2015, Volume 116, Issue 6, pp. 937 - 959
blood pressure | uromodulin | exome | hypertension | natriuretic peptide, brain | genome-wide association study | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | Kidney Diseases - physiopathology | Paraganglioma - physiopathology | Oligonucleotide Array Sequence Analysis | Sodium, Dietary - adverse effects | Blood Pressure - genetics | Humans | Hypertension - drug therapy | Male | Sympathetic Nervous System - physiopathology | Hypotension - genetics | Kidney Diseases - genetics | Pheochromocytoma - physiopathology | Hypertension, Pregnancy-Induced - genetics | Bartter Syndrome - genetics | Hyperaldosteronism - physiopathology | Glucocorticoids - physiology | Female | Blood Pressure - physiology | Neoplastic Syndromes, Hereditary - genetics | Hypertension - genetics | Mineralocorticoids - physiology | Genetic Predisposition to Disease | Genome-Wide Association Study | Models, Cardiovascular | Paraganglioma - genetics | Hyperaldosteronism - genetics | Hypertension, Pregnancy-Induced - physiopathology | Renin-Angiotensin System - genetics | Renin-Angiotensin System - physiology | Hypertension - physiopathology | Pregnancy | Adrenal Gland Neoplasms - physiopathology | Sodium, Dietary - pharmacokinetics | Neoplastic Syndromes, Hereditary - physiopathology | Pheochromocytoma - genetics | Bartter Syndrome - physiopathology | Polymorphism, Single Nucleotide | Mutation | Adrenal Gland Neoplasms - genetics | Index Medicus
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3. Full Text K⁺ Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension
by Murim Choi and Ute I. Scholl and Peng Yue and Peyman Björklund and Bixiao Zhao and Carol Nelson-Williams and Weizhen Ji and Yoonsang Cho and Aniruddh Patel and Clara J. Men and Elias Lolis and Max V. Wisgerhof and David S. Geller and Shrikant Mane and Per Hellman and Gunnar Westin and Göran Åkerström and Wenhui Wang and Tobias Carling and Richard P. Lifton
Science (American Association for the Advancement of Science), ISSN 0036-8075, 2/2011, Volume 331, Issue 6018, pp. 768 - 772
Depolarization | Hypertension | Somatic mutation | Cell growth | Hyperaldosteronism | REPORTS | Loss of heterozygosity | Adenoma | Genetic mutation | Sequencing | Tumors | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Classical genetics, quantitative genetics, hybrids | Human | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | Adrenal Glands - pathology | Potassium - metabolism | Cell Proliferation | Humans | Hyperaldosteronism - pathology | Hyperplasia | Protein Multimerization | Zona Glomerulosa - pathology | Male | Hyperaldosteronism - metabolism | Sodium - metabolism | Aldosterone - metabolism | Adrenocortical Adenoma - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Hypertension - genetics | Adrenal Cortex Neoplasms - metabolism | Cell Line | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Hyperaldosteronism - genetics | Mutant Proteins - genetics | Mutant Proteins - metabolism | Zona Glomerulosa - metabolism | Adrenal Cortex Neoplasms - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - pathology | Adrenocortical Adenoma - metabolism | Hypertension - metabolism | Adrenal Cortex Neoplasms - genetics | Mutant Proteins - chemistry | Mutation | Index Medicus
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4. Full Text Case Report: Nodule Development From Subcapsular Aldosterone-Producing Cell Clusters Causes Hyperaldosteronism
by Nishimoto, Koshiro and Seki, Tsugio and Kurihara, Isao and Yokota, Kenichi and Omura, Masao and Nishikawa, Tetsuo and Shibata, Hirotaka and Kosaka, Takeo and Oya, Mototsugu and Suematsu, Makoto and Mukai, Kuniaki
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 01/2016, Volume 101, Issue 1, pp. 6 - 9
Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Thyroid Nodule - genetics | Sodium-Potassium-Exchanging ATPase - genetics | Aldosterone - biosynthesis | Humans | Hyperaldosteronism - genetics | Steroid 11-beta-Hydroxylase - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Mutation - genetics | Adrenal Cortex Neoplasms - genetics | DNA - genetics | Hyperaldosteronism - etiology | Thyroid Nodule - pathology | Adrenocortical Adenoma - genetics | Adult | Female | Thyroid Nodule - complications | Cytochrome P-450 CYP11B2 - genetics | Index Medicus | Abridged Index Medicus
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5. Full Text Genetics of primary hyperaldosteronism
by Dutta, Ravi Kumar and Söderkvist, Peter and Gimm, Oliver
Endocrine-related cancer, ISSN 1351-0088, 10/2016, Volume 23, Issue 10, pp. R437 - R454
Review | Genetics | Primary aldosteronism | Sporadic | Calcium channel | Familial | Oncology | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Adrenal Cortex Neoplasms - genetics | Adrenal Glands - pathology | Aldosterone - genetics | Genetic Predisposition to Disease | Adrenal Cortex Neoplasms - secretion | Animals | Hyperplasia - genetics | Humans | Hyperaldosteronism - genetics | Adrenocortical Adenoma - genetics | Aldosterone - secretion | Adrenocortical Adenoma - secretion | Index Medicus
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6. Full Text Genetic Spectrum and Clinical Correlates of Somatic Mutations in Aldosterone-Producing Adenoma
by Fernandes-Rosa, Fabio Luiz and Williams, Tracy Ann and Riester, Anna and Steichen, Olivier and Beuschlein, Felix and Boulkroun, Sheerazed and Strom, Tim M and Monticone, Silvia and Amar, Laurence and Meatchi, Tchao and Mantero, Franco and Cicala, Maria-Verena and Quinkler, Marcus and Fallo, Francesco and Allolio, Bruno and Bernini, Giampaolo and Maccario, Mauro and Giacchetti, Gilberta and Jeunemaitre, Xavier and Mulatero, Paolo and Reincke, Martin and Zennaro, Maria-Christina
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 08/2014, Volume 64, Issue 2, pp. 354 - 361
aldosteronism | mutation | adrenal cortex | mineralocorticoids | aldosterone | potassium channels | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Adrenals. Adrenal axis. Renin-angiotensin system (diseases) | Arterial hypertension. Arterial hypotension | Non tumoral diseases. Target tissue resistance. Benign neoplasms | Biological and medical sciences | Endocrinopathies | Medical sciences | Blood and lymphatic vessels | Adrenal Cortex Neoplasms - complications | Genetic Predisposition to Disease | Sodium-Potassium-Exchanging ATPase - genetics | Age Factors | Genetic Association Studies | Plasma Membrane Calcium-Transporting ATPases - genetics | Humans | Middle Aged | Hyperaldosteronism - genetics | Male | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Adrenocortical Adenoma - metabolism | Adrenal Cortex Neoplasms - genetics | Aldosterone - metabolism | Calcium Channels, L-Type - genetics | Hyperaldosteronism - etiology | Sex Factors | Adrenocortical Adenoma - genetics | Adult | Female | Potassium - blood | Mutation | Adrenocortical Adenoma - complications | Adrenal Cortex Neoplasms - metabolism | Index Medicus
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7. Full Text Somatic ATP1A1, ATP2B3, and KCNJ5 Mutations in Aldosterone-Producing Adenomas
by Williams, Tracy Ann and Monticone, Silvia and Schack, Vivien R and Stindl, Julia and Burrello, Jacopo and Buffolo, Fabrizio and Annaratone, Laura and Castellano, Isabella and Beuschlein, Felix and Reincke, Martin and Lucatello, Barbara and Ronconi, Vanessa and Fallo, Francesco and Bernini, Giampaolo and Maccario, Mauro and Giacchetti, Gilberta and Veglio, Franco and Warth, Richard and Vilsen, Bente and Mulatero, Paolo
Hypertension (Dallas, Tex. 1979), ISSN 0194-911X, 01/2014, Volume 63, Issue 1, pp. 188 - 195
Hypertension | Potassium channels | Sodium-potassium-exchanging ATPase | Adrenal glands | Conn adenoma | Aldosterone | Peripheral Vascular Disease | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Arterial hypertension. Arterial hypotension | Medical sciences | Blood and lymphatic vessels | Adrenal Cortex Neoplasms - complications | Gene Expression | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Aldosterone - biosynthesis | Humans | Middle Aged | Hyperaldosteronism - genetics | Male | Hyperaldosteronism - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Hypertension - etiology | Hypertension - metabolism | Adrenal Cortex Neoplasms - genetics | Aldosterone - genetics | Hyperaldosteronism - etiology | Adrenocortical Adenoma - genetics | Adult | Female | Hypertension - genetics | Mutation | Adrenocortical Adenoma - complications | Cytochrome P-450 CYP11B2 - genetics | Index Medicus
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8. Full Text Genetics of adrenocortical tumours
by Åkerström, T and Carling, T and Beuschlein, F and Hellman, P
Journal of internal medicine, ISSN 0954-6820, 12/2016, Volume 280, Issue 6, pp. 540 - 550
Adrenal tumours | genetics | Adrenal Cortex Neoplasms - genetics | Adenoma - genetics | DNA Mutational Analysis | Adenoma - secretion | Genomics | Humans | Hyperaldosteronism - genetics | Carcinoma - genetics | Glucocorticoids - secretion | Genetic aspects | Corticosteroids | Methylation | Analysis | Tumors | Protein binding | Index Medicus
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9. Full Text Somatic and inherited mutations in primary aldosteronism
by Fernandes-Rosa, Fabio Luiz and Boulkroun, Sheerazed and Zennaro, Maria-Christina
Journal of molecular endocrinology, ISSN 0952-5041, 07/2017, Volume 59, Issue 1, pp. R47 - R63
Review | Calcium channels | Familial hyperaldosteronism | Primary aldosteronism | Somatic mutations | Aldosterone-producing adenoma | ATPase | Germline mutations | Potassium channels | Wnt/β-catenin pathway | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Adrenal Glands - pathology | Sodium-Potassium-Exchanging ATPase - genetics | Plasma Membrane Calcium-Transporting ATPases - genetics | Adenoma - genetics | Humans | Hyperaldosteronism - pathology | Hyperaldosteronism - metabolism | Adrenal Hyperplasia, Congenital - genetics | Adenoma - metabolism | Plasma Membrane Calcium-Transporting ATPases - metabolism | Hyperaldosteronism - diagnosis | Adrenal Hyperplasia, Congenital - diagnosis | Hypokalemia - metabolism | Adrenal Hyperplasia, Congenital - pathology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Hypertension - genetics | Hypertension - diagnosis | Hypokalemia - pathology | Adenoma - diagnosis | Gene Expression | Genetic Predisposition to Disease | Adrenal Hyperplasia, Congenital - metabolism | Hyperaldosteronism - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | beta Catenin - metabolism | Hypertension - pathology | beta Catenin - genetics | Hypertension - metabolism | Hypokalemia - diagnosis | Sodium-Potassium-Exchanging ATPase - metabolism | Calcium Channels, L-Type - genetics | Adrenal Glands - metabolism | Adenoma - pathology | Calcium Channels, L-Type - metabolism | Mutation | Hypokalemia - genetics | Cell proliferation | Hyperplasia | Adenoma | Membrane potential | Aldosterone | Age | Index Medicus
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