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Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 05/2012, Volume 15, Issue 5, pp. 665 - 674
Nonalcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular and liver-related mortality. NAFLD is characterized by both triglyceride... 
RAT-LIVER | RISK-FACTORS | MACROPHAGE APOPTOSIS | PROTEIN-KINASE | ENDOCRINOLOGY & METABOLISM | HMG-COA REDUCTASE | STEATOHEPATITIS | 3-HYDROXY-3-METHYLGLUTARYL COENZYME | PREVALENCE | MICRORNA EXPRESSION | MODULATION | CELL BIOLOGY | Sirtuin 1 - metabolism | Up-Regulation | Cholesterol - blood | Humans | Middle Aged | Sterol Esterase - metabolism | Male | MicroRNAs - metabolism | Desmosterol - metabolism | Cardiovascular Diseases - genetics | Cholesterol - genetics | Sirtuin 1 - genetics | Case-Control Studies | Phosphorylation - genetics | Hydroxymethylglutaryl CoA Reductases - metabolism | Adenylate Kinase - metabolism | Non-alcoholic Fatty Liver Disease | Sterol O-Acyltransferase - metabolism | Adult | Female | Lipid Metabolism - genetics | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Liver - genetics | Receptors, LDL - genetics | Gene Expression | Fatty Liver - metabolism | Cardiovascular Diseases - metabolism | Fatty Liver - blood | Liver - metabolism | Receptors, LDL - metabolism | Cholesterol - metabolism | Cholesterol, LDL - genetics | Phenotype | Sterol Esterase - genetics | Desmosterol - blood | Cholesterol, LDL - metabolism | MicroRNAs - genetics | Sterol O-Acyltransferase - genetics | Adenylate Kinase - genetics | Hydroxymethylglutaryl CoA Reductases - genetics | Enzymes | Liver diseases | Low density lipoproteins | Genes | Esters | Triglycerides | Cholesterol | MicroRNA | Fatty liver | Blood cholesterol | Physiological aspects | Hydrolases | Blood lipids | Health aspects | Statins | Index Medicus | atherosclerosis | Nonalcoholic steatohepatitis | cholesterol | Nonalcoholic fatty liver disease | fatty liver | lipogenesis | hypercholesterolemia | HMG CoA reductase
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2010, Volume 648, Issue 1, pp. 179 - 187
Previously, we have reported that Corni Fructus possessed hypoglycemic and hypocholesterolemic effects in streptozotocin-induced type 1 diabetic rats and... 
Oxidative stress | Hyperglycemia | Advanced glycation endproducts | Loganin | db/db mice | Dyslipidemia | Db/db mice | LIPID-METABOLISM | RATS | HACHIMI-JIO-GAN | KAPPA-B | MORRONISIDE | INSULIN-RESISTANCE | DISEASE | PHARMACOLOGY & PHARMACY | TISSUES | GLYCATION END-PRODUCTS | Gene Expression Regulation, Enzymologic - drug effects | Liver - pathology | Kidney - pathology | Iridoids - isolation & purification | Body Weight - drug effects | Male | Hematologic Tests | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Inflammation - complications | Cornus - chemistry | Kidney - metabolism | Liver - drug effects | Inflammation - drug therapy | Lipid Metabolism - genetics | Lysine - metabolism | Sterol Regulatory Element Binding Protein 2 - metabolism | Fatty Acids - metabolism | Diabetes Mellitus, Type 2 - complications | Sterol Regulatory Element Binding Protein 1 - metabolism | Biomarkers - metabolism | Lysine - analogs & derivatives | Kidney - drug effects | Liver - metabolism | RNA, Messenger - genetics | Cholesterol - metabolism | Triglycerides - metabolism | Organ Size - drug effects | Animals | Transcription Factor RelA - metabolism | Iridoids - pharmacology | Glycation End Products, Advanced - metabolism | Cyclooxygenase 2 - metabolism | Lipid Metabolism - drug effects | Glucose - metabolism | Drinking - drug effects | Iridoids - therapeutic use | Mice | Diabetes Mellitus, Type 2 - pathology | Oxidative Stress - drug effects | PPAR alpha - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Nitric Oxide Synthase Type II - metabolism | Hypercholesterolemia | RNA | Type 1 diabetes | Analysis | Inflammation | Protein binding | Index Medicus
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 5, pp. 1086 - 1094
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2006, Volume 99, Issue 2, pp. 438 - 449
Hypercholesterolemia is a potential trigger of Alzheimer's disease, and is thought to increase brain levels of β‐amyloid (Aβ) and iron. However, animal models... 
cholesterol | iron | gadd153 | heme‐oxygenase‐1 | endoplasmic reticulum | Iron | Endoplasmic reticulum | Cholesterol | Heme-oxygenase-1 | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | CALRETICULIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | CEREBRAL-CORTEX | FREE-RADICALS | A beta | heme-oxygenase-1 | PRECURSOR PROTEIN | FERRITIN | BRAIN | TRANSGENIC MICE | Alzheimer Disease - etiology | Iron Metabolism Disorders - etiology | Neurons - pathology | Heme Oxygenase-1 - metabolism | Molecular Chaperones - metabolism | Blood-Brain Barrier - physiopathology | Cerebral Cortex - pathology | Nerve Degeneration - physiopathology | Cerebral Cortex - metabolism | Nerve Degeneration - metabolism | Cerebral Cortex - physiopathology | Ferritins - metabolism | Up-Regulation - physiology | Neurons - metabolism | Disease Models, Animal | Rabbits | Alzheimer Disease - physiopathology | Plaque, Amyloid - pathology | Amyloid beta-Peptides - biosynthesis | Food, Formulated - adverse effects | Hippocampus - pathology | Cholesterol - metabolism | Iron - metabolism | Nerve Degeneration - pathology | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Iron Metabolism Disorders - physiopathology | Animals | Alzheimer Disease - metabolism | Iron Metabolism Disorders - metabolism | Hypercholesterolemia - complications | Plaque, Amyloid - metabolism | Hypercholesterolemia - physiopathology | Apoptosis - physiology | Transcription Factor CHOP - metabolism | Hippocampus - physiopathology | Hypercholesterolemia - metabolism | Cholesterol - adverse effects | Index Medicus
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 11, pp. 2053 - 2063
OBJECTIVE—Experimental studies suggest that maternal hypercholesterolemia may be relevant for the early onset of cardiovascular disease in offspring. We... 
Apolipoproteins E | Hypercholesterolemia | Atherosclerosis | Trimethylamine-N-oxide | Bile | atherosclerosis | ATHEROGENESIS | RISK-FACTORS | SUSCEPTIBILITY | LOW-DENSITY-LIPOPROTEIN | DEFICIENT MICE | bile | hypercholesterolemia | PREGNANCY | trimethylamine-N-oxide | MATERNAL-HYPERCHOLESTEROLEMIA | apolipoproteins E | PERIPHERAL VASCULAR DISEASE | ACCUMULATION | DYSLIPIDEMIA | HEMATOLOGY | EXPRESSION | Prenatal Exposure Delayed Effects | Age Factors | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Male | Aorta - metabolism | Aortic Diseases - metabolism | Atherosclerosis - etiology | DNA Methylation | Oxygenases - metabolism | Female | Aortic Diseases - pathology | Disease Models, Animal | Methylamines - metabolism | Animals, Newborn | Promoter Regions, Genetic | Receptors, LDL - genetics | Atherosclerosis - pathology | Genetic Predisposition to Disease | Gallbladder - metabolism | Liver - metabolism | Receptors, LDL - metabolism | Bile Acids and Salts - metabolism | Scavenger Receptors, Class B - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Cholesterol - metabolism | Plaque, Atherosclerotic | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Pregnancy | Cholesterol 7-alpha-Hydroxylase - genetics | Aortic Diseases - genetics | Phenotype | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Apolipoproteins E - genetics | Hypercholesterolemia - complications | Hypercholesterolemia - genetics | Oxygenases - genetics | Scavenger Receptors, Class B - metabolism | Hypercholesterolemia - metabolism | Aortic Diseases - etiology | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5986, pp. 1689 - 1693
Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood.... 
Myeloid cells | Leukocytosis | Transgenic animals | HDL lipoproteins | REPORTS | Atherosclerosis | Transgenes | Macrophages | Lesions | Cholesterols | Progenitor cells | CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | MACROPHAGE ABCA1 | LIPID RAFTS | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | ACCUMULATION | ABCG1 | HIGH-DENSITY-LIPOPROTEIN | APOLIPOPROTEIN-A-I | Cell Proliferation | Lipoproteins - genetics | Lipoproteins, HDL - metabolism | Apolipoprotein A-I - genetics | Leukocytosis - metabolism | ATP-Binding Cassette Transporters - genetics | Atherosclerosis - therapy | Leukocytosis - therapy | Myeloproliferative Disorders - metabolism | Bone Marrow Transplantation | Leukocytosis - physiopathology | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Hematopoietic Stem Cells - physiology | Mice, Inbred DBA | ATP Binding Cassette Transporter 1 | Multipotent Stem Cells - physiology | ATP Binding Cassette Transporter, Subfamily G, Member 1 | Myeloproliferative Disorders - therapy | Signal Transduction | Atherosclerosis - physiopathology | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Receptors, Interleukin-3 - metabolism | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Macrophages - metabolism | Phenotype | Animals | Myeloid Progenitor Cells - physiology | Myeloproliferative Disorders - physiopathology | Mice | Hypercholesterolemia - metabolism | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Cell proliferation | High density lipoproteins | Physiological aspects | Development and progression | Research | Health aspects | Hematopoietic stem cells | Adenosine triphosphate | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2010, Volume 5, Issue 8, pp. e12386 - e12386
Journal Article
Antioxidants & Redox Signaling, ISSN 1523-0864, 05/2015, Volume 22, Issue 13, pp. 184 - 1096
Aims: This study hypothesized that activation of endothelial nucleotide oligomerization domain-like receptor protein with pyrin domain containing 3 (Nlrp3)... 
Forum Original Research Communications | INDUCED GLOMERULAR INJURY | STERILE INFLAMMATION | HIGH-FAT DIET | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | THIOREDOXIN-INTERACTING PROTEIN | SMOOTH-MUSCLE-CELLS | NLRP3 INFLAMMASOME | REDOX SIGNALING PLATFORMS | ACID SPHINGOMYELINASE | NALP3 INFLAMMASOME | Acetylcholine - adverse effects | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Pyroptosis - drug effects | NLR Family, Pyrin Domain-Containing 3 Protein | Caspase 1 - metabolism | Male | Coronary Vessels - metabolism | Inflammation - metabolism | Glycyrrhizic Acid - pharmacology | Hypercholesterolemia - pathology | HMGB1 Protein - metabolism | Superoxides - metabolism | Cytoskeletal Proteins - metabolism | Viral Proteins - pharmacology | Disease Models, Animal | Coronary Vessels - drug effects | Coronary Vessels - pathology | Endothelial Cells - metabolism | Bradykinin - adverse effects | Mice, Inbred C57BL | Receptors, Cell Surface - metabolism | Nucleotides - metabolism | Serpins - pharmacology | Pyrin | Animals | Carrier Proteins - metabolism | Poloxamer | Cholesterol - pharmacology | Hypercholesterolemia - chemically induced | Vasodilation - drug effects | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Endothelial Cells - drug effects | Complications and side effects | Blood circulation disorders | Usage | Hypercholesterolemia | Confocal microscopy | Inflammation | Research | Risk factors | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 05/2009, Volume 296, Issue 5, pp. 1281 - 1288
The nitrite anion is an endogenous product of mammalian nitric oxide (NO) metabolism, a key intermediate in the nitrogen cycle in plants, and a constituent of... 
Nitrosothiols | Leukocyte adhesion | C-reactive protein | Tetrahydrobiopterin | tetrahydrobiopterin | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | LOW-DENSITY-LIPOPROTEIN | NO HOMEOSTASIS | DEFICIENT MICE | leukocyte adhesion | BLOOD-PRESSURE | nitrosothiols | S-NITROSYLATION | OXIDE SYNTHASE | IN-VIVO | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | ISCHEMIA-REPERFUSION | Leukocyte Rolling - drug effects | Sodium Nitrite - administration & dosage | Microvessels - metabolism | Endothelium, Vascular - drug effects | Male | Anti-Inflammatory Agents - metabolism | Biopterin - analogs & derivatives | Hypercholesterolemia - drug therapy | Biopterin - metabolism | Inflammation - metabolism | C-Reactive Protein - metabolism | Liver - drug effects | Myocardium - metabolism | Vasodilator Agents - metabolism | Anti-Inflammatory Agents - administration & dosage | Blood Pressure - drug effects | Disease Models, Animal | Liver - metabolism | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Microvessels - drug effects | Inflammation - etiology | Cholesterol, Dietary - blood | Animals | Diet | Endothelium, Vascular - metabolism | Sodium Nitrite - metabolism | Triglycerides - blood | Hypercholesterolemia - complications | Hypercholesterolemia - physiopathology | Inflammation - prevention & control | Mice | Vasodilation - drug effects | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Vasodilator Agents - administration & dosage | Inflammation - physiopathology | Genotype & phenotype | Leucocytes | Nitric oxide | Genetics | Nitrogen | Metabolism | Cell adhesion & migration | Index Medicus
Journal Article
Circulation Research, ISSN 0009-7330, 05/2016, Volume 118, Issue 10, pp. 1540 - 1552
RATIONALE:CD4 T cells are involved in the pathogenesis of atherosclerosis, but atherosclerosis-specific CD4 T cells have not been described. Moreover, the... 
atherosclerosis | inflammation | Ccl5 protein, mouse | vascular diseases | Treg cells | chemokines | CCR5 protein, mouse | DIET-INDUCED ATHEROSCLEROSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | MACROPHAGES | HYPERCHOLESTEROLEMIA | FOXP3 | INTERFERON-GAMMA | PERIPHERAL VASCULAR DISEASE | MICE | CCR5 | HEMATOLOGY | LYMPHOCYTES-T | PROGRESSION | Cell Proliferation | Receptors, CCR5 - genetics | Aorta - metabolism | Interferon-gamma - metabolism | L-Selectin - genetics | Apolipoproteins E - metabolism | CD4-Positive T-Lymphocytes - physiology | Interleukins - metabolism | L-Selectin - metabolism | Receptors, CCR5 - metabolism | Interleukin-2 Receptor alpha Subunit - genetics | Forkhead Transcription Factors - metabolism | Hyaluronan Receptors - metabolism | Interferon-gamma - genetics | Atherosclerosis - pathology | Endothelial Cells - metabolism | CD4-Positive T-Lymphocytes - metabolism | Cells, Cultured | Forkhead Transcription Factors - genetics | Hyaluronan Receptors - genetics | T-Box Domain Proteins - genetics | Atherosclerosis - metabolism | T-Box Domain Proteins - metabolism | Aorta - pathology | Animals | Interleukin-2 Receptor alpha Subunit - metabolism | Apolipoproteins E - genetics | Mice | Index Medicus | chemokine | Foxp3+IFN-γ | CCR5Teff | vascular disease | T cell | CCL5 | Atherosclerosis | Treg | chemokine receptor
Journal Article
Nature Neuroscience, ISSN 1097-6256, 04/2005, Volume 8, Issue 4, pp. 468 - 475
Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases, raising the question of its normal function. In the mature brain,... 
PROTEOLIPID PROTEIN | NERVOUS-SYSTEM | SONIC HEDGEHOG | SQUALENE SYNTHASE | EMBRYONIC LETHALITY | CELL-SURFACE | SPINAL-CORD | MICE |