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Science (American Association for the Advancement of Science), ISSN 1095-9203, 2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol
Journal Article
Journal Article
Journal of hepatology, ISSN 0168-8278, 2011, Volume 55, Issue 5, pp. 1086 - 1094
... liver diseases [3,4] . These cytokines are produced in the liver by Kupffer cells and hepatocytes, playing roles in lipid metabolism and hepatic inflammation [5–7... 
Gastroenterology and Hepatology | Fatty liver | Cytokines | IL-1 | Steatohepatitis | Inflammation | Mouse model | Lipid metabolism | OXIDATIVE STRESS | PRECURSOR | IL-1-ALPHA | IL-1 RECEPTOR ANTAGONIST | TNF-ALPHA | GASTROENTEROLOGY & HEPATOLOGY | HEPATIC STEATOSIS | EXPRESSION | PROGRESSION | Tumor Necrosis Factor-alpha - metabolism | Interleukin-1 - genetics | Fatty Liver - pathology | P-Selectin - metabolism | Tumor Necrosis Factor-alpha - genetics | Interleukin-1alpha - metabolism | Male | Chemokine CXCL1 - genetics | Interleukin-1beta - genetics | RNA, Messenger - metabolism | Interleukin-1beta - deficiency | Matrix Metalloproteinase 9 - metabolism | Interleukin-1beta - metabolism | Matrix Metalloproteinase 9 - genetics | Hepatitis - metabolism | Liver Cirrhosis - metabolism | Collagen - genetics | Interleukin-1alpha - genetics | Chemokine CXCL1 - metabolism | Interleukin-1 - metabolism | Gene Expression | Fatty Liver - metabolism | Serum Amyloid A Protein - metabolism | Mice, Inbred C57BL | Hepatitis - pathology | P-Selectin - genetics | Disease Progression | Mice, Knockout | Collagen - metabolism | Diet, Atherogenic | Animals | Transforming Growth Factor beta - genetics | Analysis of Variance | Interleukin-1alpha - deficiency | Liver Cirrhosis - pathology | Hypercholesterolemia - complications | Mice | Transforming Growth Factor beta - metabolism
Journal Article
Scientific reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 10654 - 15
Journal Article
Journal of neurochemistry, ISSN 0022-3042, 10/2006, Volume 99, Issue 2, pp. 438 - 449
Hypercholesterolemia is a potential trigger of Alzheimer's disease, and is thought to increase brain levels of β‐amyloid (Aβ) and iron. However, animal models... 
cholesterol | iron | gadd153 | heme‐oxygenase‐1 | endoplasmic reticulum | Iron | Endoplasmic reticulum | Cholesterol | Heme-oxygenase-1 | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | CALRETICULIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | CEREBRAL-CORTEX | A beta | heme-oxygenase-1 | TRANSFERRIN | A-BETA | PRECURSOR PROTEIN | ACCUMULATION | FERRITIN | Alzheimer Disease - etiology | Iron Metabolism Disorders - etiology | Neurons - pathology | Heme Oxygenase-1 - metabolism | Molecular Chaperones - metabolism | Blood-Brain Barrier - physiopathology | Cerebral Cortex - pathology | Nerve Degeneration - physiopathology | Cerebral Cortex - metabolism | Nerve Degeneration - metabolism | Cerebral Cortex - physiopathology | Ferritins - metabolism | Up-Regulation - physiology | Neurons - metabolism | Disease Models, Animal | Rabbits | Alzheimer Disease - physiopathology | Plaque, Amyloid - pathology | Amyloid beta-Peptides - biosynthesis | Food, Formulated - adverse effects | Hippocampus - pathology | Cholesterol - metabolism | Iron - metabolism | Nerve Degeneration - pathology | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Iron Metabolism Disorders - physiopathology | Animals | Alzheimer Disease - metabolism | Iron Metabolism Disorders - metabolism | Hypercholesterolemia - complications | Plaque, Amyloid - metabolism | Hypercholesterolemia - physiopathology | Apoptosis - physiology | Transcription Factor CHOP - metabolism | Hippocampus - physiopathology | Hypercholesterolemia - metabolism | Cholesterol - adverse effects
Journal Article
Clinical and experimental pharmacology & physiology, ISSN 1440-1681, 02/2008, Volume 35, Issue 2, pp. 192 - 200
SUMMARY • The present study evaluated the effect of diabetes, hypercholesterolaemia and their combination on the contribution of nitric oxide (NO) and... 
endothelium-derived hyperpolarising factor | diabetes | endothelium-dependent relaxation | hypercholesterolaemia | superoxide anion | endothelium‐derived hyperpolarising factor | endothelium‐dependent relaxation | Superoxide anion | Diabetes | Hypercholesterolaemia | Endothelium-dependent relaxation | Endothelium-derived hyperpolarising factor | PHYSIOLOGY | NITRO-L-ARGININE | ACETYLCHOLINE | MELLITUS | NAD(P)H OXIDASE | ARTERIES | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | CHANNELS | DYSFUNCTION | EDHF | Body Weight | Oxidative Stress | Cholesterol - blood | Diabetes Mellitus, Type 1 - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | Guanylate Cyclase - antagonists & inhibitors | Nitroprusside - pharmacology | Apamin - pharmacology | Dose-Response Relationship, Drug | Quinoxalines - pharmacology | Charybdotoxin - pharmacology | Oxadiazoles - pharmacology | Potassium Channels, Calcium-Activated - metabolism | Superoxides - metabolism | Aorta, Thoracic - drug effects | Biological Factors - metabolism | Diabetes Mellitus, Experimental - metabolism | Potassium Channel Blockers - pharmacology | Diabetes Mellitus, Experimental - physiopathology | Disease Models, Animal | Vasodilator Agents - pharmacology | Acetylcholine - pharmacology | Diabetes Mellitus, Type 1 - physiopathology | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Aorta, Thoracic - physiopathology | Rats, Sprague-Dawley | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Nitroarginine - pharmacology | Aorta, Thoracic - enzymology | Animals | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Hypercholesterolemia - physiopathology | Nitric Oxide Synthase - metabolism | Potassium Channels, Calcium-Activated - antagonists & inhibitors | Vasodilation - drug effects | Blood Glucose - metabolism | Nitric Oxide - metabolism | Hypercholesterolemia - metabolism | Receptors, Cytoplasmic and Nuclear - metabolism | Charybdotoxin, pharmacology | Diabetes Mellitus, Type 1, physiopathology | Nitric Oxide Synthase, antagonists and inhibitors | Aorta, Thoracic, physiopathology | Potassium Channels, Calcium-Activated, antagonists and inhibitors | Hypercholesterolemia, metabolism | Quinoxalines, pharmacology | Enzyme Inhibitors, pharmacology | Aorta, Thoracic, drug effects | Aorta, Thoracic, metabolism | Receptors, Cytoplasmic and Nuclear, antagonists and inhibitors | Vasodilator Agents, pharmacology | Vasodilation | Nitric Oxide Synthase, metabolism | Cyclooxygenase Inhibitors, pharmacology | Apamin, pharmacology | Nitroarginine, pharmacology | Potassium Channel Blockers, pharmacology | Vasodilation, drug effects | Cholesterol, blood | Receptors, Cytoplasmic and Nuclear, metabolism | Biological Factors, metabolism | Diabetes Mellitus, Experimental, physiopathology | Nitric Oxide, metabolism | Acetylcholine, pharmacology | Diabetes Mellitus, Experimental, metabolism | Nitroprusside, pharmacology | Oxadiazoles, pharmacology | Blood Glucose, metabolism | Potassium Channels, Calcium-Activated, metabolism | Aorta, Thoracic, enzymology | Hypercholesterolemia, physiopathology | Diabetes Mellitus, Type 1, metabolism | Guanylate Cyclase, antagonists and inhibitors | Guanylate Cyclase, metabolism | Superoxides, metabolism | Indomethacin, pharmacology | Superoxide | Hypercholesterolemia | Endothelium-derived relaxing factors | Type 1 diabetes | Endothelium
Journal Article
Journal Article
Nature neuroscience, ISSN 1546-1726, 2005, Volume 8, Issue 4, pp. 468 - 475
Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases, raising the question of its normal function. In the mature brain,... 
PROTEOLIPID PROTEIN | NERVOUS-SYSTEM | SONIC HEDGEHOG | SQUALENE SYNTHASE | EMBRYONIC LETHALITY | CELL-SURFACE | SPINAL-CORD | MICE | BASIC-PROTEIN | EXPRESSION | NEUROSCIENCES | Silver Staining - methods | Blotting, Southern - methods | Microsomes - metabolism | Oligodendroglia - metabolism | Central Nervous System - metabolism | Spinal Cord - metabolism | Age Factors | Microscopy, Electron, Transmission - methods | Cholesterol - physiology | Mice, Mutant Strains - physiology | Apolipoproteins E - metabolism | Psychomotor Performance - physiology | Spinal Cord - ultrastructure | Oligodendroglia - ultrastructure | Myelin Sheath - metabolism | Behavior, Animal | Cloning, Molecular | Creatine - metabolism | Myelin Proteolipid Protein - metabolism | Cell Membrane - metabolism | In Situ Hybridization - methods | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | Blotting, Western - methods | RNA - analysis | Cholesterol - deficiency | Farnesyl-Diphosphate Farnesyltransferase - genetics | Chromatography, Thin Layer - methods | Mice, Inbred C57BL | Receptors, LDL - metabolism | Lipid Metabolism | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Phenotype | Animals | Farnesyl-Diphosphate Farnesyltransferase - deficiency | Blotting, Northern - methods | Mice | Myelin Sheath - ultrastructure | Mass Spectrometry - methods | Physiological aspects | Hypercholesterolemia | Research | Myelin sheath
Journal Article