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Current Pharmaceutical Design, ISSN 1381-6128, 2013, Volume 19, Issue 14, pp. 2574 - 2593
Journal Article
Circulation Research, ISSN 0009-7330, 06/2012, Volume 111, Issue 1, pp. 37 - 49
RATIONALE:Hyperhomocysteinemia (HHcy) accelerates atherosclerosis and increases inflammatory monocytes (MC) in peripheral tissues. However, its causative role... 
atherosclerosis | hyperhomocysteinemia | HOMOCYSTEINE | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDIAL-INFARCTION | STROKE PREVENTION | inflammatory monocyte | CYSTATHIONINE BETA-SYNTHASE | RANDOMIZED CONTROLLED-TRIAL | ACCELERATES ATHEROSCLEROSIS | FOLIC-ACID | VASCULAR-DISEASE | DENSITY-LIPOPROTEIN | PERIPHERAL VASCULAR DISEASE | CHEMOATTRACTANT PROTEIN-1 | HEMATOLOGY | Oxidative Stress | Atherosclerosis - genetics | Tumor Necrosis Factor-alpha - blood | Male | Green Fluorescent Proteins - genetics | Inflammation - blood | Bone Marrow Cells - immunology | Bone Marrow Transplantation | Cell Differentiation | Disease Models, Animal | Hyperlipidemias - immunology | Hyperhomocysteinemia - enzymology | Atherosclerosis - pathology | Aorta - immunology | Mice, Transgenic | Chemokine CCL2 - blood | Inflammation - etiology | Macrophages - enzymology | Mice, Knockout | Aorta - pathology | Atherosclerosis - blood | Green Fluorescent Proteins - biosynthesis | Mice | Hyperhomocysteinemia - complications | Inflammation - enzymology | Lyases - deficiency | Bone Marrow Cells - enzymology | Hyperlipidemias - enzymology | Atherosclerosis - etiology | Atherosclerosis - enzymology | Hyperhomocysteinemia - immunology | Interleukin-6 - blood | Lipids - blood | Receptors, LDL - deficiency | Superoxides - metabolism | Bone Marrow Cells - drug effects | Lyases - genetics | Aorta - enzymology | Hyperlipidemias - complications | Macrophages - immunology | Severity of Illness Index | Receptors, LDL - genetics | Hyperhomocysteinemia - blood | Aorta - drug effects | Mice, Inbred C57BL | Cells, Cultured | Inflammation Mediators - blood | Inflammation - immunology | Antioxidants - pharmacology | Vitamin B Complex - pharmacology | Animals | Hyperhomocysteinemia - genetics | Macrophages - drug effects
Journal Article
Kidney International, ISSN 0085-2538, 07/2006, Volume 70, Issue 1, pp. 88 - 96
Ceramide-activated NAD(P)H oxidase has been reported to participate in homocysteine (Hcys)-induced abnormal metabolism of the extracellular matrix (ECM) in rat... 
homocysteine | kidney | end-stage renal disease | sphingolipid | oxidative stress | Sphingolipid | End-stage renal disease | Oxidative stress | Homocysteine | Kidney | NADPH OXIDASE | ACTIVATION | ENDOTHELIAL DYSFUNCTION | DIFFERENTIAL REGULATION | RAC GTPASE | MESANGIAL CELLS | UROLOGY & NEPHROLOGY | EXTRACELLULAR-MATRIX | TIMP-1 EXPRESSION | STAGE RENAL-DISEASE | Enzyme Inhibitors | Fatty Acids, Monounsaturated - pharmacology | NADPH Oxidases - metabolism | RNA, Messenger - analysis | rac GTP-Binding Proteins - metabolism | Kidney Diseases - enzymology | RNA, Messenger - metabolism | rac GTP-Binding Proteins - antagonists & inhibitors | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Acetophenones - pharmacology | Matrix Metalloproteinase 1 - genetics | Hyperhomocysteinemia - enzymology | Kidney Glomerulus - enzymology | Hyperhomocysteinemia - pathology | Ceramides - metabolism | Oxidation-Reduction | Kidney Diseases - pathology | Kidney Glomerulus - drug effects | NADPH Oxidases - antagonists & inhibitors | Homocysteine - blood | Rats | Ceramides - analysis | Kidney Glomerulus - pathology | Rats, Sprague-Dawley | Extracellular Matrix - enzymology | Tissue Inhibitor of Metalloproteinase-1 - genetics | Animals | Signal Transduction - drug effects | Kidney Cortex - chemistry | Enzyme Activation | Kidney Diseases - etiology | Matrix Metalloproteinase 1 - metabolism | Hyperhomocysteinemia - complications | Kidney Cortex - enzymology
Journal Article
FASEB Journal, ISSN 0892-6638, 11/2008, Volume 22, Issue 11, pp. 3823 - 3835
Hyperhomocysteinemia (HHcy)-abnormally elevated plasma levels of homocysteine (Hcy)-has been associated with the development of neurodegenerative dementia and... 
Dentate gyrus | Hyperhomocysteinemia | Neurogenesis | Subventricular zone | Dementia | hyperhomocysteinemia | subventricular zone | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MILD COGNITIVE IMPAIRMENT | HIPPOCAMPAL-NEURONS | CELL BIOLOGY | NEURAL STEM-CELLS | dentate gyrus | MAMMALIAN BRAIN | OLFACTORY-BULB | BIOLOGY | neurogenesis | NITRIC-OXIDE | dementia | LONG-TERM POTENTIATION | Humans | Dentate Gyrus - enzymology | Fibroblast Growth Factor 2 - pharmacology | Homocysteine - metabolism | Dementia - enzymology | Trigeminal Caudal Nucleus - pathology | Homocysteine - pharmacology | Aged, 80 and over | Fibroblast Growth Factor 2 - metabolism | Adult Stem Cells - pathology | Disease Models, Animal | Cognition Disorders - enzymology | Hyperhomocysteinemia - enzymology | Hyperhomocysteinemia - pathology | Dementia - pathology | Neurodegenerative Diseases - pathology | Trigeminal Caudal Nucleus - enzymology | Cells, Cultured | Cognition Disorders - pathology | Gene Expression Regulation - drug effects | Adult Stem Cells - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Neurons - enzymology | Cyclin E - biosynthesis | Folic Acid - metabolism | Aged | Cell Proliferation - drug effects | Mice | Dentate Gyrus - pathology | Mitogen-Activated Protein Kinase 1 - metabolism | Neurodegenerative Diseases - enzymology
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 09/2017, Volume 37, Issue 9, pp. 1698 - 1709
OBJECTIVE—Transdifferentiation of adventitial fibroblasts (AFs) into myofibroblasts plays a critical role during the vascular remodeling that occurs during... 
aneurysm | adventitia | NADPH oxidase | deubiquitinating enzymes | MYOFIBROBLAST | NEOINTIMAL HYPERPLASIA | INDUCED NOX4 EXPRESSION | KAPPA-B | MICROTUBULE DYNAMICS | TUMOR-SUPPRESSOR CYLD | IN-VITRO | ABDOMINAL AORTIC-ANEURYSM | INFLAMMATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | PULMONARY-FIBROSIS | Aortic Aneurysm, Abdominal - chemically induced | Reactive Oxygen Species - metabolism | Humans | NADPH Oxidases - metabolism | Extracellular Matrix - metabolism | Half-Life | Male | Ubiquitination | RNA Interference | Time Factors | Proteolysis | Homocysteine - pharmacology | Adventitia - enzymology | NADPH Oxidases - genetics | Vascular Remodeling - drug effects | Interleukin-6 - metabolism | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Hyperhomocysteinemia - enzymology | Signal Transduction | Enzyme Stability | Genotype | Adventitia - drug effects | Myofibroblasts - drug effects | Ubiquitin Thiolesterase - genetics | Rats, Sprague-Dawley | Mice, Knockout | Phenotype | Aortic Aneurysm, Abdominal - enzymology | Cysteine Endopeptidases - genetics | Adventitia - pathology | COS Cells | Hyperhomocysteinemia - complications | Cell Movement | Cercopithecus aethiops | Myofibroblasts - enzymology | Dose-Response Relationship, Drug | Calcium Phosphates | Cysteine Endopeptidases - metabolism | Transfection | Cell Transdifferentiation - drug effects | HEK293 Cells | Ubiquitin Thiolesterase - metabolism | Cysteine Endopeptidases - deficiency | Chemokine CCL2 - metabolism | Aortic Aneurysm, Abdominal - pathology | Myofibroblasts - pathology | Mice, Inbred C57BL | Aortic Aneurysm, Abdominal - genetics | NADPH Oxidase 4 | Animals | Hyperhomocysteinemia - genetics
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association, ISSN 1079-5642, 12/2002, Volume 22, Issue 12, pp. 1996 - 2002
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2015, Volume 309, Issue 2, pp. H325 - H334
Chronic failure in maintenance and regeneration of skeletal muscles leads to lower muscle mass (sarcopenia), muscle weakness, and poor response to injury.... 
Reactive oxygen species | P16 | CBS | P38 MAPK | Hyperhomocysteinemia | P21 | Skeletal muscle | hyperhomocysteinemia | OXIDATIVE STRESS | ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | PHOSPHORYLATION | SELF-RENEWAL | MECHANISMS | MYOPATHY | p38 MAPK | p21 | SKELETAL-MUSCLE | p16 | reactive oxygen species | DEFICIENT | PERIPHERAL VASCULAR DISEASE | SWITCH | DYSFUNCTION | skeletal muscle | Phosphorylation | Cell Proliferation | Reactive Oxygen Species - metabolism | Oxidative Stress | Satellite Cells, Skeletal Muscle - pathology | Cystathionine beta-Synthase - deficiency | Hyperhomocysteinemia - physiopathology | Muscle, Skeletal - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Cystathionine beta-Synthase - genetics | Disease Models, Animal | Hyperhomocysteinemia - enzymology | Cell Line | Hyperhomocysteinemia - pathology | Muscle, Skeletal - enzymology | Mice, Inbred C57BL | Mice, Knockout | Regeneration | Satellite Cells, Skeletal Muscle - drug effects | Satellite Cells, Skeletal Muscle - enzymology | Satellite Cells, Skeletal Muscle - transplantation | Sarcopenia - enzymology | Sarcopenia - physiopathology | Animals | MAP Kinase Signaling System - drug effects | Muscle, Skeletal - physiopathology | Sarcopenia - pathology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Hyperhomocysteinemia - genetics | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Muscle, Skeletal - pathology | p38 mitogen-activated protein kinases | Physiological aspects | Regeneration (Biology) | Health aspects | Muscles | Analysis | Signaling and Stress Response
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2015, Volume 589, Issue 24, pp. 3998 - 4009
Homocysteine (Hcy) is an independent risk factor for atherosclerosis, but the underlying molecular mechanisms are not known. We investigated the effects of Hcy... 
DNA methylation | Foam cell | Homocysteine | Atherosclerosis | Fatty acid-binding protein 4 | atherosclerosis | homocysteine | free Cholesterol | DNMT1 | S-adenosylhomocysteine | AZC | azacytidine | S-adenosylmethionine | | FABP4 | fatty acid-binding protein 4 | DNA methyltransferases 1 | HHcy | Hyperhomocysteinemia | ApoE | SAH | total Cholesterol | apolipoprotein E knockout | Cholesteryl Ester | SAM | Hcy | HYPERHOMOCYSTEINEMIA | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING PROTEIN 4 | ADIPOGENESIS | CELL BIOLOGY | BIOPHYSICS | DISEASE | PPAR-GAMMA | DIFFERENTIATION | EXPRESSION | Diet - adverse effects | Cholesterol - blood | Humans | Hyperhomocysteinemia - metabolism | Male | Monocytes - metabolism | Aorta - metabolism | Fatty Acid-Binding Proteins - metabolism | Apolipoproteins E - metabolism | Atherosclerosis - etiology | DNA Methylation | Hyperhomocysteinemia - physiopathology | Monocytes - pathology | Foam Cells - pathology | Aorta - enzymology | Foam Cells - metabolism | Genes, Reporter | Repressor Proteins - metabolism | Methionine - poisoning | Promoter Regions, Genetic | Hyperhomocysteinemia - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Repressor Proteins - genetics | Foam Cells - enzymology | Cholesterol - metabolism | Hyperhomocysteinemia - etiology | Fatty Acid-Binding Proteins - genetics | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Monocytes - enzymology | Animals | Apolipoproteins E - genetics | Cell Line, Tumor
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 5/2013, Volume 33, Issue 5, pp. 708 - 715
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 08/2008, Volume 295, Issue 2, pp. 890 - 897
Cardiomyocyte N-methyl-d-aspartate receptor-1 (NMDA-R1) activation induces mitochondrial dysfunction. Matrix metalloproteinase protease (MMP) induction is a... 
N-methyl-D-aspartate receptor-1 | Arrhythmogenesis | Calcium | Mitochondrial permeability | Myocyte | CHRONIC HEART-FAILURE | APOPTOSIS | mitochondrial permeability | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | calcium | RECEPTOR ANTAGONISTS | arrhythmogenesis | SUDDEN-DEATH | myocyte | MYOCARDIAL-ISCHEMIA | RATS | ATRIAL-FIBRILLATION | NMDA | PERIPHERAL VASCULAR DISEASE | DYSFUNCTION | PLASMA HOMOCYSTEINE | Mitochondria, Heart - ultrastructure | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Mitochondrial Membrane Transport Proteins - antagonists & inhibitors | Cyclosporine - pharmacology | Receptors, N-Methyl-D-Aspartate - metabolism | Myocardial Contraction - drug effects | Mitochondria, Heart - drug effects | Myocytes, Cardiac - enzymology | Protease Inhibitors - pharmacology | Hyperhomocysteinemia - physiopathology | Matrix Metalloproteinase 9 - metabolism | Time Factors | Mitochondrial Membranes - enzymology | Calcium Signaling | Disease Models, Animal | Hyperhomocysteinemia - enzymology | Hyperhomocysteinemia - pathology | Mitochondrial Membrane Transport Proteins - metabolism | Dipeptides - pharmacology | Mice, Inbred C57BL | Mitochondria, Heart - enzymology | Cell Size | Excitatory Amino Acid Antagonists - pharmacology | Permeability | Blotting, Western | Microscopy, Confocal | Animals | Myocytes, Cardiac - drug effects | Matrix Metalloproteinase Inhibitors | Mice | Enzyme Activation | Dizocilpine Maleate - pharmacology | Myocytes, Cardiac - ultrastructure | N-methyl-d-aspartate receptor-1
Journal Article
Mechanisms of Ageing and Development, ISSN 0047-6374, 10/2018, Volume 175, pp. 1 - 6
Journal Article
Liver International, ISSN 1478-3223, 02/2005, Volume 25, Issue 1, pp. 49 - 56
Journal Article