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Journal Article
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2009, Volume 41, Issue 10, pp. 1110 - 1115
Journal Article
Clinical Chemistry, ISSN 0009-9147, 02/2008, Volume 54, Issue 2, pp. 256 - 263
BACKGROUND: Hypoglycemia in infants and children can lead to seizures, developmental delay, and permanent brain damage. Hyperinsulinism (HI) is the most common... 
GLUTAMATE-DEHYDROGENASE | NEONATAL HYPERINSULINISM | BECKWITH-WIEDEMANN-SYNDROME | FASTING HYPOGLYCEMIA | DEFICIENT GLYCOPROTEIN SYNDROME | PANCREATIC BETA-CELLS | TERM-FOLLOW-UP | ACTIVATING GLUCOKINASE MUTATION | SULFONYLUREA RECEPTOR | MEDICAL LABORATORY TECHNOLOGY | DIFFUSE CONGENITAL HYPERINSULINISM | Pancreatic Neoplasms - diagnosis | Autoantibodies - blood | Humans | Beckwith-Wiedemann Syndrome - diagnosis | Child, Preschool | Infant | Insulin - blood | Congenital Hyperinsulinism - genetics | Hypopituitarism - diagnosis | Hyperinsulinism - genetics | Insulin Antibodies - blood | Hypoglycemia - chemically induced | Receptor, Insulin - immunology | Child | Infant, Newborn | Hypoglycemia - diagnosis | Diagnosis, Differential | Congenital Hyperinsulinism - diagnosis | Hyperinsulinism - therapy | Congenital Hyperinsulinism - therapy | Insulinoma - diagnosis | Mutation | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Congenital Disorders of Glycosylation - diagnosis | Hyperinsulinism - diagnosis | Ammonia | Genetic disorders | Blood sugar | Isoenzymes | Brain damage | Amino acids | Genetic aspects | Seizures (Medicine) | Glutamate | Fatty acids | Insulin | Plasma | Disease | Medical treatment | Mental retardation | Cells | Children & youth | Babies | Surgery | Genetic testing | Metabolic disorders | Binding sites
Journal Article
Journal Article
PLoS Medicine, ISSN 1549-1277, 04/2007, Volume 4, Issue 4, pp. 760 - 769
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 06/2007, Volume 92, Issue 6, pp. 2292 - 2299
Aim/Hypothesis: Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is... 
3T3-L1 ADIPOCYTES | SUBCUTANEOUS FAT-CELLS | BETA-ADRENERGIC STIMULATION | WEIGHT-REDUCTION | TISSUE | ENDOCRINOLOGY & METABOLISM | UPPER-BODY OBESITY | PPAR-GAMMA | SKELETAL-MUSCLE METABOLISM | TNF-ALPHA | LIPOPROTEIN-LIPASE | Hyperinsulinism - metabolism | Obesity - diet therapy | Humans | Middle Aged | Sterol Esterase - metabolism | Adipose Tissue - pathology | Male | Lipase - metabolism | RNA, Messenger - metabolism | Diet, Reducing | Obesity - metabolism | Obesity - pathology | Gene Expression Regulation, Enzymologic | Hyperinsulinism - pathology | Regression Analysis | Sterol Esterase - genetics | Biopsy | Insulin Resistance - physiology | Weight Loss - physiology | Adult | Female | Adipose Tissue - enzymology | Hyperinsulinism - diet therapy | Lipase - genetics | Obesity | Sterol Esterase | Biochemistry, Molecular Biology | Insulin Resistance | Lipase | Life Sciences | Weight Loss | Adipose Tissue | RNA, Messenger | Hyperinsulinism | Obesity is associated with increased triacylglycerol (TAG) storage in adipose tissue and insulin resistance. The mobilization of stored TAG is mediated by hormone-sensitive lipase (HSL) and the recently discovered adipose triglyceride lipase (ATGL). The aim of the present study was to examine whether ATGL and HSL mRNA and protein expression are altered in insulin-resistant conditions. In addition | gender | indicating a tight coregulation and transcriptional control. CONCLUSIONS: In obese subjects | Medical and Health Sciences | Medicin och hälsovetenskap | before and just after a 10-wk hypocaloric diet. ATGL and HSL protein and mRNA expression was determined by Western blot and quantitative RT-PCR | and body composition. Both mRNA and protein levels of ATGL and HSL were reduced in insulin-resistant compared with insulin-sensitive subjects (P < 0.05). Weight reduction significantly decreased ATGL and HSL mRNA and protein expression. A positive correlation between the decrease in leptin and the decrease in ATGL protein level after weight reduction was observed. Finally | we investigated whether a possible impaired expression could be reversed by a period of weight reduction. METHODS: Adipose tissue biopsies were taken from obese subjects (n = 44) with a wide range of insulin resistance | respectively. RESULTS: Fasting insulin levels and the degree of insulin resistance (using the homeostasis model assessment index for insulin resistance) were negatively correlated with ATGL and HSL protein expression | Klinisk medicin | independent of fat mass. Data on weight reduction indicated that also other factors (e.g. leptin) relate to ATGL and HSL protein expression | Clinical Medicine | Endokrinologi och diabetes | ATGL and HSL mRNA and protein levels seem to be highly correlated | independent of age | insulin resistance and hyperinsulinemia are strongly associated with ATGL and HSL mRNA and protein expression | fat cell size | Endocrinology and Diabetes
Journal Article
The American journal of medicine, ISSN 0002-9343, 05/2019
Journal Article