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Cellular and Molecular Life Sciences, ISSN 1420-682X, 01/2009, Volume 66, Issue 1, pp. 27 - 42
The glucokinase (GCK) gene was one of the first candidate genes to be identified as a human “diabetes gene". Subsequently, important advances were made in... 
Biochemistry, general | hepatocyte | insulin | Biomedicine general | Cell Biology | Life Sciences | islet of Langerhans | MODY | Life Sciences, general | Glucokinase | diabetes | glucose metabolism | hexokinase | Glucose metabolism | Hepatocyte | Islet of Langerhans | Diabetes | Insulin | Hexokinase | INSULIN-DEPENDENT INDUCTION | HEPATIC GLYCOGEN-SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ELEMENT-BINDING PROTEIN-1C | YOUNG TYPE-2 MODY-2 | BETA-CELL GLUCOKINASE | CELL BIOLOGY | PERSISTENT HYPERINSULINEMIC HYPOGLYCEMIA | GENE-EXPRESSION | REGULATORY PROTEIN | LIVER-X-RECEPTOR | GROWTH-FACTOR-I | Hexokinase - physiology | Liver - enzymology | Insulin - physiology | Islets of Langerhans - enzymology | Diabetes Mellitus, Type 2 - genetics | Humans | Diabetes Mellitus, Type 2 - enzymology | Gene Expression Regulation | Brain - enzymology | Congenital Hyperinsulinism - enzymology | Congenital Hyperinsulinism - genetics | Homeostasis - physiology | Glucose - metabolism | Mitochondrial Membranes - enzymology | Adaptor Proteins, Signal Transducing - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Hexokinase - genetics | Hexokinase - chemistry | Homeostasis - genetics | Anopheles | Isoenzymes | Analysis | Physiological aspects | Glucose | Gene expression | Dextrose | Proteins | Enzymes | Biochemistry | Molecular biology | Review
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2008, Volume 105, Issue 24, pp. 8452 - 8457
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce β-cell function and survival. An unbiased proteomic screen was used to... 
Obesity | Gels | Nonesterified fatty acids | Palmitates | Type 2 diabetes mellitus | Diabetes | Islets of Langerhans | Insulin | Fatty acids | Apoptosis | Type 2 diabetes | 2D difference gel electrophoresis proteomics | Hyperproinsulinemia | Mechanisms of β-cell lipotoxicity | Free fatty acids | LEVELS PREDICT | HUMAN PANCREATIC-ISLETS | ENZYME-ACTIVITY | MULTIDISCIPLINARY SCIENCES | mechanisms of beta-cell lipotoxicity | INSULIN-SECRETION | free fatty acids | ENDOPLASMIC-RETICULUM STRESS | type 2 diabetes | PYRUVATE-DEHYDROGENASE ACTIVITY | PROHORMONE CONVERTASES | FREE FATTY-ACIDS | LINE INS-1 | TRIGLYCERIDE ACCUMULATION | hyperproinsulinemia | Endoplasmic Reticulum - enzymology | Golgi Apparatus - enzymology | Cell Survival | Diabetes Mellitus, Type 2 - genetics | Humans | Cells, Cultured | Diabetes Mellitus, Type 2 - enzymology | Apoptosis - genetics | Proteome | Hyperglycemia - genetics | Insulin-Secreting Cells - ultrastructure | Animals | Insulin-Secreting Cells - drug effects | Mice, Mutant Strains | Palmitates - pharmacology | Carboxypeptidase H - metabolism | Hyperglycemia - enzymology | Hyperinsulinism - enzymology | Hyperinsulinism - genetics | Mice | Palmitates - metabolism | Carboxypeptidase H - genetics | Insulin-Secreting Cells - enzymology | Biological Sciences | mechanisms of β-cell lipotoxicity
Journal Article
Gut, ISSN 0017-5749, 10/2011, Volume 60, Issue 10, pp. 1394 - 1402
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 11/2013, Volume 305, Issue 9, pp. H1344 - H1353
Ca+ mishandling due to impaired activity of cardiac sarco(endo) plasmic reticulum Ca2+ ATPase (SERCA2a) has been associated with the development of left... 
Heart | Oxidative stress | Calcium | Metabolic syndrome | Sarco(endo)plasmic reticulum Ca | ATPase 2a | SUCROSE-FED RATS | CARDIAC CONTRACTILE DYSFUNCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | calcium | HEART-FAILURE | HYPERTRIGLYCERIDEMIC RATS | ANTIOXIDANT ENZYMES | heart | metabolic syndrome | VENTRICULAR DIASTOLIC DYSFUNCTION | SARCOPLASMIC-RETICULUM CA2 | sarco(endo) plasmic reticulum Ca2+ ATPase 2a | INSULIN-RESISTANCE | RYANODINE RECEPTORS | PERIPHERAL VASCULAR DISEASE | TYPE-2 DIABETES-MELLITUS | oxidative stress | Phosphorylation | Reactive Oxygen Species - metabolism | Rats, Wistar | Calcium - metabolism | Male | Metabolic Syndrome - chemically induced | Myocytes, Cardiac - enzymology | Metabolic Syndrome - blood | Hyperinsulinism - enzymology | Ventricular Dysfunction, Left - enzymology | Dietary Sucrose | Hyperinsulinism - blood | Calcium Signaling | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Metabolic Syndrome - enzymology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Oxidation-Reduction | Down-Regulation | Insulin Resistance | Rats | Ventricular Dysfunction, Left - etiology | Antioxidants - pharmacology | Obesity, Abdominal - enzymology | Hypertriglyceridemia - blood | Hypertriglyceridemia - enzymology | Obesity, Abdominal - blood | Animals | Myocytes, Cardiac - drug effects | Oxidative Stress - drug effects | Heart cells | Physiological aspects | Insulin resistance | Metabolic diseases | Research | Health aspects
Journal Article
Oncology Reports, ISSN 1021-335X, 4/2015, Volume 33, Issue 4, pp. 1657 - 1666
The molecular mechanisms underlying the progression of nonalcoholic steatohepatitis (NASH) have not been fully elucidated. The aim of this study was to... 
nonalcoholic steatohepatitis | Mmp13 | Grip1 | insulin secretion | Sptlc3 | Cxcl14 | Nonalcoholic steatohepatitis | Insulin secretion | NOVO CERAMIDE SYNTHESIS | FIBROSIS | FATTY LIVER-DISEASE | MmpI3 | CANCER | INDUCED INSULIN-RESISTANCE | INHIBITION | DIET | ONCOLOGY | INFLAMMATION | GROWTH | ALPHA-FETOPROTEIN | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Liver - enzymology | Diabetes Mellitus, Experimental - enzymology | Streptozocin | Diabetes Mellitus, Experimental - genetics | Diet, High-Fat - adverse effects | Hyperglycemia - complications | Choline Deficiency - complications | Male | Alanine Transaminase - blood | Gene Expression Profiling | Serine C-Palmitoyltransferase - genetics | Liver Cirrhosis - enzymology | alpha-Fetoproteins - analysis | Non-alcoholic Fatty Liver Disease - complications | RNA, Messenger - biosynthesis | Non-alcoholic Fatty Liver Disease - enzymology | Hyperinsulinism - enzymology | Diabetes Mellitus, Experimental - complications | Serine C-Palmitoyltransferase - biosynthesis | Precancerous Conditions - complications | Liver Cirrhosis - etiology | Precancerous Conditions - enzymology | Hyperinsulinism - complications | Mice, Inbred C57BL | RNA, Messenger - genetics | Disease Progression | Liver Neoplasms, Experimental - etiology | Cocarcinogenesis | Receptors, Leptin - deficiency | Animals | Aspartate Aminotransferases - blood | Hyperglycemia - enzymology | Liver Cirrhosis - pathology | Liver Neoplasms, Experimental - enzymology | Mice | Development and progression | Coenzymes | Models | Fatty liver | Hepatoma | Health aspects | Obesity | Liver diseases | Pathogenesis | Genes | Metabolic syndrome | Studies | Pathology | Liver cancer | Hyperglycemia | Diet | Rodents | Insulin resistance | Blood pressure | Diabetes
Journal Article
Nature, ISSN 0028-0836, 11/2002, Volume 420, Issue 6913, pp. 333 - 336
Journal Article
Diabetes, ISSN 0012-1797, 10/2010, Volume 59, Issue 10, pp. 2444 - 2452
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2010, Volume 285, Issue 41, pp. 31806 - 31818
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2009, Volume 106, Issue 29, pp. 12121 - 12126
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2014, Volume 19, Issue 1, pp. 109 - 121
Journal Article