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European Heart Journal, ISSN 0195-668X, 06/2014, Volume 35, Issue 23, pp. 1515 - 1525
Vascular calcifications (VCs) are actively regulated biological processes associated with crystallization of hydroxyapatite in the extracellular matrix and in... 
Vascular molecular biology and genetics | CALCIUM-PHOSPHATE DEPOSITION | ATHEROSCLEROTIC LESIONS | FETUIN-A LEVELS | NONINVASIVE EVALUATION | CARDIAC & CARDIOVASCULAR SYSTEMS | PSEUDOXANTHOMA ELASTICUM | EXTRACELLULAR CALCIUM | MONCKEBERGS SCLEROSIS | Vascular function | ARTERY CALCIFICATION | SMOOTH-MUSCLE-CELLS | CHRONIC KIDNEY-DISEASE | Vascular calcifications | Monckeberg's media sclerosis | Tunica Media - pathology | Prognosis | Monckeberg Medial Calcific Sclerosis - physiopathology | Humans | Tunica Intima - physiopathology | Male | Monckeberg Medial Calcific Sclerosis - therapy | Diabetic Angiopathies - physiopathology | Monckeberg Medial Calcific Sclerosis - pathology | Diabetic Angiopathies - pathology | Vascular Calcification - physiopathology | Adult | Female | Biomarkers - metabolism | Arteriosclerosis - physiopathology | Terminology as Topic | Vascular Calcification - pathology | Phosphates - physiology | Renal Insufficiency, Chronic - physiopathology | Diabetes Mellitus, Type 2 - physiopathology | Tunica Intima - pathology | Calcium-Binding Proteins - physiology | Diabetes Mellitus, Type 2 - pathology | Vascular Calcification - therapy | Hyperphosphatemia - physiopathology | Tunica Media - physiopathology | Arteriosclerosis - pathology | Index Medicus | Life Sciences | Human health and pathology | Cardiology and cardiovascular system | Mönckeberg's media sclerosis | Reviews
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2012, Volume 27, Issue 2, pp. 474 - 485
Vascular calcification is closely related to cardiovascular morbidity and mortality. Accumulating data indicate that oxidative stress is associated with... 
ARTERIAL MEDIAL CALCIFICATION | OXIDATIVE STRESS | CHRONIC KIDNEY DISEASE | TEMPOL | ANTIOXIDANT | VITAMIN-D | BONE DISORDER | AORTIC-VALVE | ALL-CAUSE | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR MORTALITY | HEMODIALYSIS-PATIENTS | ANIMAL-MODELS | CARDIAC-VALVE CALCIFICATION | SMOOTH-MUSCLE-CELLS | STAGE RENAL-DISEASE | Tunica Media - pathology | Kidney - pathology | Tunica Media - drug effects | Myocytes, Smooth Muscle - pathology | NADPH Oxidases - metabolism | Male | Spin Labels | Aorta, Abdominal - drug effects | Hyperphosphatemia - pathology | Hyperphosphatemia - blood | Kidney - metabolism | Calcinosis - etiology | Uremia - pathology | Cyclic N-Oxides - pharmacology | Kidney Failure, Chronic - pathology | Cell Transdifferentiation - drug effects | Aorta, Abdominal - pathology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Biomarkers - metabolism | Hyperphosphatemia - complications | Kidney - drug effects | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Arteries - drug effects | Antioxidants - pharmacology | Arteries - pathology | Calcinosis - blood | Uremia - complications | Aorta, Abdominal - enzymology | Rats, Sprague-Dawley | Osteoblasts - pathology | Phenotype | Animals | Kidney Failure, Chronic - blood | Uremia - blood | Kidney Failure, Chronic - complications | Calcinosis - prevention & control | Oxidative Stress - drug effects | Calcinosis - pathology | Osteoblasts - metabolism
Journal Article
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 07/2011, Volume 26, Issue 7, pp. 1543 - 1553
Vascular calcifications can occur in the elderly and in patients suffering from various diseases. Interestingly, depending on the pathology, different regions... 
Hyperphosphatemia | Alkaline phosphatase | Smooth muscle cells | Matrix Gla protein | Vascular calcifications | Neural crest | EXPERIMENTAL CANINE ATHEROSCLEROSIS | SMOOTH MUSCLE CELLS | MATRIX GLA PROTEIN | VASCULAR CALCIFICATIONS | PATTERNS | ALKALINE PHOSPHATASE | FATE | CORONARY-ARTERIES | CARTILAGE | HYPERPHOSPHATEMIA | AORTIC HOMOGRAFTS | DISEASE | MINERALIZATION | ENDOCRINOLOGY & METABOLISM | MICE | NEURAL CREST | Extracellular Matrix Proteins - deficiency | Neural Crest - pathology | Aging - drug effects | Alkaline Phosphatase - metabolism | Mesoderm - drug effects | Myocytes, Smooth Muscle - pathology | Aorta, Abdominal - drug effects | Muscle, Smooth, Vascular - embryology | Aorta, Abdominal - pathology | Aorta, Thoracic - drug effects | Calcinosis - metabolism | Myocytes, Smooth Muscle - drug effects | Aorta, Abdominal - metabolism | Myocytes, Smooth Muscle - metabolism | Phosphates - pharmacology | Aorta, Thoracic - pathology | Extracellular Matrix Proteins - metabolism | Calcium-Binding Proteins - metabolism | Alkaline Phosphatase - genetics | Mesoderm - embryology | Cells, Cultured | Aorta, Thoracic - metabolism | Calcium-Binding Proteins - deficiency | Aging - pathology | Neural Crest - drug effects | Muscle, Smooth, Vascular - pathology | Animals | Neural Crest - embryology | Calcinosis - embryology | Mice | Kinetics | Calcinosis - pathology | Mesoderm - pathology | Life Sciences | Morphogenesis | Human health and pathology | Biochemistry, Molecular Biology | Development Biology | Molecular biology | Cellular Biology | Embryology and Organogenesis | Cardiology and cardiovascular system | Cell Behavior
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 6/2019, Volume 76, Issue 11, pp. 2077 - 2091
Medial vascular calcification has emerged as a putative key factor contributing to the excessive cardiovascular mortality of patients with chronic kidney... 
Life Sciences | Biomedicine, general | Biochemistry, general | Life Sciences, general | Phosphate | Vascular calcification | CKD | Osteogenic signaling | Vascular smooth muscle cells | Cell Biology | OXIDATIVE-STRESS | BONE MORPHOGENETIC PROTEIN-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHATE-INDUCED CALCIFICATION | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | ARTERIAL MEDIAL CALCIFICATION | IN-VITRO | CALCIUM-SENSING RECEPTOR | WNT/BETA-CATENIN | GROWTH-FACTOR 23 | CHRONIC KIDNEY-DISEASE | RANK Ligand - metabolism | Muscle, Smooth, Vascular - metabolism | Humans | Vascular Calcification - genetics | Myocytes, Smooth Muscle - pathology | Hyperphosphatemia - metabolism | NF-kappa B - metabolism | Renal Insufficiency, Chronic - complications | Hyperphosphatemia - pathology | Renal Insufficiency, Chronic - metabolism | Vascular Calcification - metabolism | Renal Insufficiency, Chronic - genetics | Vascular Calcification - complications | Cell Transdifferentiation | Receptor Activator of Nuclear Factor-kappa B - metabolism | Myocytes, Smooth Muscle - metabolism | Chondrocytes - metabolism | Hyperphosphatemia - complications | Chondrocytes - pathology | Signal Transduction | Gene Expression Regulation | Calcium Phosphates - chemistry | Vascular Calcification - pathology | Renal Insufficiency, Chronic - pathology | RANK Ligand - genetics | Osteoblasts - pathology | Muscle, Smooth, Vascular - pathology | Animals | NF-kappa B - genetics | Receptor Activator of Nuclear Factor-kappa B - genetics | Hyperphosphatemia - genetics | Osteoblasts - metabolism | Calcium Phosphates - metabolism | Chronic kidney failure | Mortality | Cardiac patients | Physiological aspects | Calcification | Calcium phosphate | Smooth muscle | Phosphorus imbalance | Precipitation (Meteorology) | Cardiology | Calcification (ectopic) | Phenotypes | Calcium | Chondroblasts | Crystals | Muscles | Intracellular signalling | Arteries | Calcium phosphates | Signal transduction | Biomedical materials | Pathways | Hyperphosphatemia | Biocompatibility | Kidney diseases | Intracellular | Cardiovascular diseases | Calcium (extracellular) | Review
Journal Article
Cardiovascular Research, ISSN 0008-6363, 06/2016, Volume 110, Issue 3, pp. 408 - 418
Reduced homoarginine plasma levels are associated with unfavourable cardiovascular outcome in chronic kidney disease (CKD). Cardiovascular events in CKD are... 
Vascular calcification | Osteo-/chondrogenic signalling | Homoarginine | Nitric oxide | Vascular smooth muscle cells | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | NITRIC-OXIDE SYNTHASE | ALKALINE-PHOSPHATASE | BLOOD-PRESSURE | chondrogenic signalling | IN-VITRO | Osteo | L-ARGININE | DEFICIENT | CALCIFICATION | MICE | CARDIOVASCULAR RISK | Chondrogenesis - drug effects | Muscle, Smooth, Vascular - metabolism | Calcium - metabolism | Humans | Vascular Calcification - genetics | Glucuronidase - metabolism | Myocytes, Smooth Muscle - pathology | Homoarginine - toxicity | Hyperphosphatemia - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Hyperphosphatemia - pathology | Dose-Response Relationship, Drug | Nephrectomy | Time Factors | Cell Transdifferentiation - drug effects | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Renal Insufficiency - genetics | Genetic Predisposition to Disease | Cholecalciferol | Osteogenesis - drug effects | Vascular Calcification - blood | Cells, Cultured | Homoarginine - blood | Renal Insufficiency - metabolism | Biomarkers - blood | Vascular Calcification - pathology | Mice, Knockout | Gene Expression Regulation - drug effects | Muscle, Smooth, Vascular - pathology | Phenotype | Animals | Glucuronidase - genetics | Renal Insufficiency - pathology | Vascular Calcification - chemically induced | Hyperphosphatemia - genetics | Nitric Oxide Synthase - metabolism | Nitric Oxide - metabolism | Index Medicus
Journal Article
Kidney International, ISSN 0085-2538, 12/2013, Volume 84, Issue 6, pp. 1145 - 1153
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2015, Volume 309, Issue 11, pp. F967 - F979
Vascular calcification (VC) is a critical complication in patients with chronic kidney disease (CKD). The effects of spironolactone (SPL), a mineralocorticoid... 
Hyperphosphatemia | Vascular calcification | Chronic kidney disease | Spironolactone | Mineralocorticoid receptor | chronic kidney disease | OXIDATIVE STRESS | PHYSIOLOGY | vascular calcification | HEART-FAILURE | CELL-PROLIFERATION | SERUM | mineralocorticoid receptor | spironolactone | PHOSPHATE | hyperphosphatemia | INFLAMMATION | REGULATED KINASE 1 | ALDOSTERONE BLOCKADE | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | CHRONIC-RENAL-FAILURE | Kidney - pathology | Apoptosis - drug effects | Humans | Uremia - physiopathology | Uremia - drug therapy | Male | Aorta, Abdominal - drug effects | Hyperphosphatemia - blood | Kidney - metabolism | Time Factors | Tunica Media - metabolism | Mineralocorticoid Receptor Antagonists - pharmacology | Aortic Diseases - prevention & control | Disease Models, Animal | Kidney - drug effects | Biomarkers - blood | Vascular Calcification - pathology | Rats, Sprague-Dawley | Renal Insufficiency, Chronic - physiopathology | Disease Progression | Signal Transduction - drug effects | Hyperphosphatemia - drug therapy | Renal Insufficiency, Chronic - chemically induced | Tunica Media - pathology | Tunica Media - drug effects | Receptors, Mineralocorticoid - metabolism | Aortic Diseases - blood | Aortic Diseases - chemically induced | Renal Insufficiency, Chronic - drug therapy | Dose-Response Relationship, Drug | Receptors, Mineralocorticoid - drug effects | Uremia - chemically induced | Spironolactone - pharmacology | Uremia - pathology | Vascular Calcification - physiopathology | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Kidney - physiopathology | Aortic Diseases - pathology | Osteogenesis - drug effects | Vascular Calcification - blood | Adenine | Vascular Calcification - prevention & control | Renal Insufficiency, Chronic - pathology | Renal Insufficiency, Chronic - blood | Aortic Diseases - physiopathology | Animals | Uremia - blood | Vascular Calcification - chemically induced | Renin-Angiotensin System - drug effects | Antiandrogens | Calcification | Corticosteroids | Chronic kidney failure | Steroids | Cellular signal transduction | Observations | Health aspects
Journal Article