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Biological Psychiatry, ISSN 0006-3223, 2015, Volume 78, Issue 12, pp. 860 - 870
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2014, Volume 289, Issue 32, pp. 22205 - 22220
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels control neuronal and cardiac electrical rhythmicity. There are four homologous isoforms... 
PROTEIN-KINASE-A | CONFORMATIONAL-CHANGES | STRUCTURAL BASIS | NMR CHEMICAL-SHIFTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING DOMAIN | TERMINAL REGION | CS-ROSETTA | DYNAMICS | DEPENDENT ALLOSTERY | STRUCTURE REVEALS | Humans | Protein Multimerization | Molecular Sequence Data | Potassium Channels - metabolism | Muscle Proteins - metabolism | Protein Structure, Quaternary | Nuclear Magnetic Resonance, Biomolecular | Binding Sites | Cyclic AMP - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Amino Acid Sequence | Electron Spin Resonance Spectroscopy | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Potassium Channels - genetics | Muscle Proteins - genetics | Sequence Homology, Amino Acid | Membrane Potentials | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - chemistry | Cyclic CMP - metabolism | Potassium Channels - chemistry | Muscle Proteins - chemistry | Ion Channel Gating | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics | Index Medicus | cAMP-binding Domain (CBD) | Signaling | HCN | Signal Transduction | Allosteric Regulation | Protein Conformation | Intrinsically Disordered Proteins (IDPs) | Allostery | cCMP | Cyclic AMP (cAMP) | Nuclear Magnetic Resonance (NMR)
Journal Article
Science Translational Medicine, ISSN 1946-6234, 09/2017, Volume 9, Issue 409, pp. eaam6072 - eaam6072
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 2016, Volume 311, Issue 4, pp. H892 - H903
Diaphragmatic lymphatic function is mainly sustained by pressure changes in the tissue and serosal cavities during cardiorespiratory cycles. The most... 
Lymphatic contractility | Lymphatic muscle cells | Lymphatic contraction frequency | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | FUNNY CURRENT | GUINEA-PIG MESENTERY | lymphatic muscle cells | THORACIC-DUCT | RECTIFYING CURRENT | INWARD CURRENT | lymphatic contractility | lymphatic contraction frequency | PERIPHERAL VASCULAR DISEASE | CALF PURKINJE-FIBERS | SMOOTH-MUSCLE-CELLS | ANESTHETIZED SHEEP | PACE-MAKER CURRENT | CATION CURRENTS | Immunohistochemistry | Muscle, Smooth, Vascular - metabolism | Rats, Wistar | Male | Lymphatic Vessels - drug effects | Potassium Channels - metabolism | Lymphatic Vessels - metabolism | Female | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - metabolism | Real-Time Polymerase Chain Reaction | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Lymphatic Vessels - physiology | Chlorides - pharmacology | Myocytes, Smooth Muscle - physiology | Vasoconstriction | Rats | Benzazepines - pharmacology | Pyrimidines - pharmacology | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - antagonists & inhibitors | Cardiovascular Agents - pharmacology | Potassium Channels - genetics | Cesium - pharmacology | Animals | Diaphragm | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics | Health aspects | Ion channels | Lymphatic system | Blood pressure | Muscular system | Rodents | Cells | Index Medicus
Journal Article
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 8/2016, Volume 233, Issue 15, pp. 3017 - 3029
Journal Article
Cold Spring Harbor Protocols, ISSN 1940-3402, 07/2016, Volume 2016, Issue 7, pp. 612 - 614
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are voltage-gated ion channels that activate at potentials more negative than -50 mV and are... 
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Membrane Potentials | Patch-Clamp Techniques - methods | Neurons - physiology
Journal Article
eLife, ISSN 2050-084X, 06/2018, Volume 7
Binding of TRIP8b to the cyclic nucleotide binding domain (CNBD) of mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels prevents their... 
MOLECULAR-MECHANISM | TERMINAL DOMAIN | SPECIFICITY | STRUCTURAL BASIS | BIOLOGY | TRAFFICKING | CELL-PENETRATING PEPTIDES | ION CHANNELS | SUBUNIT TRIP8B | BINDING | MODULATION | tat Gene Products, Human Immunodeficiency Virus | Humans | Sinoatrial Node - drug effects | Potassium Channels - metabolism | Peroxins - chemistry | Cyclic AMP - chemistry | Peptides - chemical synthesis | HEK293 Cells | Membrane Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Cyclic AMP - metabolism | Calcium Channels, L-Type - chemistry | Cell-Penetrating Peptides - chemistry | Cell-Penetrating Peptides - genetics | Protein Conformation, alpha-Helical | Rabbits | Gene Expression | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism | Myocytes, Cardiac - cytology | Membrane Proteins - genetics | Mice, Inbred C57BL | Sinoatrial Node - cytology | Peptides - pharmacology | Potassium Channels - genetics | Patch-Clamp Techniques | Animals | Calcium Channels, L-Type - genetics | Myocytes, Cardiac - drug effects | Membrane Proteins - chemistry | Protein Conformation, beta-Strand | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - chemistry | Peroxins - genetics | Myocytes, Cardiac - metabolism | Protein Binding | Sinoatrial Node - metabolism | Potassium Channels - chemistry | Mice | Molecular Docking Simulation | Calcium Channels, L-Type - metabolism | Peroxins - metabolism | Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics | Cell-Penetrating Peptides - metabolism | Physiological aspects | Cyclic adenylic acid | Ion channels | Observations | Protein-protein interactions | Nuclear magnetic resonance--NMR | Calcium | Peptides | Channel gating | Central nervous system | Cyclic AMP | Cardiomyocytes | Experiments | Isoforms | Calcium channels (L-type) | Laboratory animals | Gating | Hyperpolarization | Ion channels (cyclic nucleotide-gated) | Index Medicus
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