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Journal Article
The Journal of cell biology, ISSN 1540-8140, 2009, Volume 184, Issue 1, pp. 83 - 99
Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with pulmonary artery endothelial cell (PAEC... 
Angiogenesis | Cell motility | Receptors | Cell growth | Small interfering RNA | Antibodies | Pseudopodia | Mice | Gene expression regulation | Endothelial cells | SIGNAL-TRANSDUCTION | II RECEPTOR | ARTERIAL-HYPERTENSION | KINASE | PLANAR CELL POLARITY | P38 MAPK | MUTATIONS | C3H10T1/2 CELLS | BMPR-II | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY | Cell Proliferation | Humans | Glycogen Synthase Kinase 3 beta | rhoA GTP-Binding Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Phosphoproteins - metabolism | Wnt Proteins - metabolism | Pulmonary Artery - metabolism | Hypertension - genetics | Dishevelled Proteins | Endothelial Cells - physiology | Bone Morphogenetic Protein Receptors, Type II - genetics | Signal Transduction | Endothelial Cells - metabolism | Glycogen Synthase Kinase 3 - metabolism | Bone Morphogenetic Protein 2 - physiology | beta Catenin - metabolism | Bone Morphogenetic Protein Receptors, Type II - metabolism | Hypertension - metabolism | Pulmonary Artery - cytology | Neovascularization, Physiologic - physiology | Pulmonary Artery - ultrastructure | Animals | Endothelial Cells - cytology | Smad1 Protein - metabolism | Wnt3 Protein | Bone Morphogenetic Protein Receptors, Type II - physiology | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | rac1 GTP-Binding Protein - metabolism | Apoptosis | Cell Movement
Journal Article
Circulation research, ISSN 0009-7330, 06/2014, Volume 115, Issue 1, pp. 176 - 188
The right ventricle (RV) is the major determinant of functional state and prognosis in pulmonary arterial hypertension. RV hypertrophy (RVH... 
Forkhead box protein O1 (FOXO1) | G protein receptor kinase 2 (GRK2) | adrenergic receptors | glycolysis | pyruvate dehydrogenase complex | fluorodeoxyglucose | glutamine | CHRONIC HEART-FAILURE | PRESSURE-OVERLOAD | CARDIAC & CARDIOVASCULAR SYSTEMS | GLUCOSE-OXIDATION | CARDIOVASCULAR MAGNETIC-RESONANCE | MITOCHONDRIAL-FUNCTION | CONTROLLED CLINICAL-TRIAL | PYRUVATE-DEHYDROGENASE | POSITRON-EMISSION-TOMOGRAPHY | FATTY-ACID OXIDATION | EJECTION FRACTION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | Humans | Heart Failure - physiopathology | Hypertension, Pulmonary - physiopathology | Familial Primary Pulmonary Hypertension | Receptors, Adrenergic, beta - physiology | Neovascularization, Pathologic - etiology | Hypertrophy, Right Ventricular - physiopathology | Animals | Cyclic Nucleotide Phosphodiesterases, Type 5 - physiology | Fibrosis | Glycolysis | Heart Ventricles - anatomy & histology | Signal Transduction - physiology | Heart Ventricles - metabolism | Hypertrophy, Right Ventricular - complications | Heart Ventricles - pathology | Ventricular Function, Right | microvascular ischemia | Congenital Heart Disease | cardiac magnetic resonance imaging (CMR) | adrenoreceptors | Right ventricular failure (RVF) | fluorodeoxyglucose positron emission tomography (FDG-PET) | aerobic glycolysis | glutaminolysis | pyruvate dehydrogenase (PDH)
Journal Article
Circulation research, ISSN 1524-4571, 2015, Volume 117, Issue 10, pp. 870 - 883
RATIONALE:The pathogenesis of pulmonary arterial hypertension (PAH) remains unclear. The 4 microRNAs representing the miR-143 and miR-145 stem loops are genomically clustered... 
microRNAs | hypertension, pulmonary | endothelium | myocytes, smooth muscle | cell movement | exosomes | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | smooth muscle | PHENOTYPE | pulmonary | CANCER | myocytes | MIR-145 | GROWTH | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | EXPRESSION | Exosomes - metabolism | Vascular Remodeling | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Hypertension, Pulmonary - physiopathology | Male | MicroRNAs - metabolism | Muscle, Smooth, Vascular - physiopathology | Case-Control Studies | Hypertension, Pulmonary - prevention & control | Pulmonary Artery - metabolism | Arterial Pressure | Transfection | Time Factors | Cattle | Female | Binding Sites | Myocytes, Smooth Muscle - metabolism | Promoter Regions, Genetic | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Cell Communication | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Mice, Knockout | Transcription Factors - metabolism | Muscle, Smooth, Vascular - pathology | Animals | MicroRNAs - genetics | Ventricular Pressure | HeLa Cells | Endothelial Cells - pathology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Function, Right | Cell Movement
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 13, pp. E1614 - E1623
Hypoxic pulmonary vasoconstriction (HPV) optimizes pulmonary ventilation-perfusion matching in regional hypoxia, but promotes pulmonary hypertension in global hypoxia... 
Ceramide | Transient receptor potential canonical 6 | Pulmonary hypertension | Neutral sphingomyelinase | AIRWAY EPITHELIAL-CELLS | pulmonary hypertension | MULTIDISCIPLINARY SCIENCES | EPOXIDE HYDROLASE | transient receptor potential canonical 6 | SPHINGOSINE 1-PHOSPHATE | TRANSMEMBRANE CONDUCTANCE REGULATOR | neutral sphingomyelinase | ceramide | SMOOTH-MUSCLE | ARTERIAL-HYPERTENSION | LUNG-DISEASE | CYSTIC-FIBROSIS | GAS-EXCHANGE | Calcium - metabolism | Humans | Type C Phospholipases - metabolism | Oxygen - metabolism | Coronary Vessels - metabolism | Pulmonary Artery - metabolism | rho-Associated Kinases - metabolism | Sphingomyelin Phosphodiesterase - metabolism | Lung - metabolism | Receptors, Lysosphingolipid - metabolism | Myocytes, Smooth Muscle - metabolism | Calcium Signaling | Mice, Inbred CFTR | Lung - pathology | TRPC6 Cation Channel | Signal Transduction | Mice, Inbred C57BL | Vasoconstriction | Ceramides - chemistry | Cystic Fibrosis Transmembrane Conductance Regulator - metabolism | Hypertension, Pulmonary - metabolism | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Animals | Hypoxia - pathology | TRPC Cation Channels - metabolism | Mice | Heart failure | Care and treatment | Physiological aspects | Muscle cells | Development and progression | Sphingolipids | Research | Biological Sciences | PNAS Plus
Journal Article
Circulation research, ISSN 1524-4571, 2009, Volume 104, Issue 2, pp. 236 - 244
Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with pulmonary artery hypertension (PAH... 
Pulmonary artery hypertension | Proliferation | Interleukin-6 | CARDIAC & CARDIOVASCULAR SYSTEMS | pulmonary artery hypertension | proliferation | UP-REGULATES EXPRESSION | interleukin-6 | VASCULAR STRUCTURE | ARTERIAL-HYPERTENSION | PLEXIFORM LESIONS | ENDOTHELIAL-CELLS | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | INFLAMMATORY CYTOKINES | HEMATOLOGY | NEOINTIMAL FORMATION | TRANSGENIC MICE | Blood Pressure | Up-Regulation | Cell Proliferation | Microtubule-Associated Proteins - metabolism | Arterioles - immunology | Hyperplasia | Repressor Proteins | Hypertension, Pulmonary - physiopathology | Muscle, Smooth, Vascular - immunology | Vascular Endothelial Growth Factor A - metabolism | Muscle, Smooth, Vascular - physiopathology | Hypertrophy, Right Ventricular - physiopathology | Time Factors | Hypertrophy, Right Ventricular - pathology | Interleukin-6 - metabolism | Proto-Oncogene Proteins - metabolism | Vascular Resistance | Inhibitor of Apoptosis Proteins | Interleukin-6 - genetics | Mice, Inbred C57BL | Hypertension, Pulmonary - immunology | Mice, Transgenic | Hypoxia - complications | Pulmonary Artery - physiopathology | Proto-Oncogene Proteins c-myc - metabolism | Endothelial Cells - immunology | Arterioles - pathology | Muscle, Smooth, Vascular - pathology | Animals | Hypertrophy, Right Ventricular - immunology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Ventricular Pressure | Proto-Oncogene Proteins c-bcl-2 | Endothelial Cells - pathology | Chronic Disease | Hypertension, Pulmonary - pathology | Transforming Growth Factor beta - metabolism | Pulmonary Artery - pathology | Ventricular Function, Right | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Pulmonary Artery - immunology
Journal Article
The Journal of clinical investigation, ISSN 1558-8238, 2016, Volume 126, Issue 9, pp. 3313 - 3335
Journal Article
Journal of Thoracic and Cardiovascular Surgery, The, ISSN 0022-5223, 2014, Volume 148, Issue 1, pp. 245 - 253
Journal Article