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Circulation (New York, N.Y.), ISSN 1524-4539, 2018, Volume 137, Issue 17, pp. 1796 - 1810
BACKGROUND:We hypothesized that pulmonary venous hypertension in heart failure (HF) leads to predominate remodeling of pulmonary veins and that the severity of venous remodeling is associated with the severity of pulmonary hypertension... 
heart failure | CARDIAC & CARDIOVASCULAR SYSTEMS | SILDENAFIL | MITRAL-STENOSIS | VENOOCCLUSIVE DISEASE | pulmonary hypertension | pulmonary function | EXERCISE CAPACITY | PATHOLOGY | CLINICAL STATUS | HEMODYNAMICS | diffusing capacity of the lungs for carbon monoxide | heart failure with preserved ejection fraction | right ventricle | COMMUNITY | ARTERIAL-HYPERTENSION | PERIPHERAL VASCULAR DISEASE | PHOSPHODIESTERASE-5 INHIBITION | Pulmonary Veins - pathology | Vascular Remodeling | Humans | Middle Aged | Heart Failure - physiopathology | Hypertension, Pulmonary - diagnostic imaging | Hypertension, Pulmonary - physiopathology | Male | Pulmonary Artery - diagnostic imaging | Case-Control Studies | Arterial Pressure | Autopsy | Aged, 80 and over | Female | Registries | Ventricular Dysfunction, Right - physiopathology | Heart Failure - diagnostic imaging | Severity of Illness Index | Pulmonary Veins - physiopathology | Lung - physiopathology | Pulmonary Artery - physiopathology | Pulmonary Veins - diagnostic imaging | Heart Failure - pathology | Stroke Volume | Pulmonary Diffusing Capacity | Venous Pressure | Aged | Lung - blood supply | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Dysfunction, Right - pathology | Ventricular Function, Right | Ventricular Dysfunction, Right - diagnostic imaging | Heart failure | Pulmonary veins | Cardiac output | Research | Pulmonary hypertension | Risk factors
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2009, Volume 54, Issue 1, pp. S3 - S9
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 2015, Volume 65, Issue 18, pp. 1976 - 1997
Abstract Pulmonary hypertension (PH) is common and may result from a number of disorders, including left heart disease, lung disease, and chronic thromboembolic disease... 
Cardiovascular | Internal Medicine | endothelin receptor antagonists | pulmonary arterial hypertension | phosphodiesterase type 5 inhibitors | hemodynamics | echocardiography | prostacyclins | 5 INHIBITOR THERAPY | CARDIAC & CARDIOVASCULAR SYSTEMS | LONG-TERM SURVIVAL | PRESERVED EJECTION FRACTION | RANDOMIZED CONTROLLED-TRIAL | CONTINUOUS INTRAVENOUS EPOPROSTENOL | SOLUBLE GUANYLATE-CYCLASE | CALCIUM-CHANNEL BLOCKERS | ENDOTHELIN RECEPTOR ANTAGONIST | CONTROLLED CLINICAL-TRIAL | DOUBLE-BLIND | Medical History Taking | Tunica Media - pathology | Hypertension, Pulmonary - diagnosis | Vascular Remodeling | Echocardiography | Hypertension, Pulmonary - classification | Atrial Septum - surgery | Humans | Calcium Channel Blockers - therapeutic use | Antihypertensive Agents - therapeutic use | Hypertension, Pulmonary - therapy | Cardiac Catheterization | Exercise Test | Lung Transplantation | Extracorporeal Membrane Oxygenation | Tunica Intima - pathology | Physical Examination | Registries | Phosphodiesterase 5 Inhibitors - therapeutic use | Endothelin Receptor Antagonists - therapeutic use | Hypertension, Pulmonary - etiology | Heart Ventricles - pathology | Pulmonary Artery - pathology | Medical colleges | Respiratory tract diseases | Thromboembolism | Heart diseases | Pulmonary hypertension | Heart | Lupus | Pulmonary arteries | Mortality | Cardiovascular disease | Family medical history | Tropical diseases | Signs | Human immunodeficiency virus--HIV | Medical prognosis | Classification | Mutation | Drug therapy | Cardiology | Veins & arteries
Journal Article
Circulation research, ISSN 1524-4571, 2009, Volume 104, Issue 2, pp. 236 - 244
Inflammatory cytokine interleukin (IL)-6 is elevated in the serum and lungs of patients with pulmonary artery hypertension (PAH... 
Pulmonary artery hypertension | Proliferation | Interleukin-6 | CARDIAC & CARDIOVASCULAR SYSTEMS | pulmonary artery hypertension | proliferation | UP-REGULATES EXPRESSION | interleukin-6 | VASCULAR STRUCTURE | ARTERIAL-HYPERTENSION | PLEXIFORM LESIONS | ENDOTHELIAL-CELLS | GENE-EXPRESSION | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | INFLAMMATORY CYTOKINES | HEMATOLOGY | NEOINTIMAL FORMATION | TRANSGENIC MICE | Blood Pressure | Up-Regulation | Cell Proliferation | Microtubule-Associated Proteins - metabolism | Arterioles - immunology | Hyperplasia | Repressor Proteins | Hypertension, Pulmonary - physiopathology | Muscle, Smooth, Vascular - immunology | Vascular Endothelial Growth Factor A - metabolism | Muscle, Smooth, Vascular - physiopathology | Hypertrophy, Right Ventricular - physiopathology | Time Factors | Hypertrophy, Right Ventricular - pathology | Interleukin-6 - metabolism | Proto-Oncogene Proteins - metabolism | Vascular Resistance | Inhibitor of Apoptosis Proteins | Interleukin-6 - genetics | Mice, Inbred C57BL | Hypertension, Pulmonary - immunology | Mice, Transgenic | Hypoxia - complications | Pulmonary Artery - physiopathology | Proto-Oncogene Proteins c-myc - metabolism | Endothelial Cells - immunology | Arterioles - pathology | Muscle, Smooth, Vascular - pathology | Animals | Hypertrophy, Right Ventricular - immunology | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Ventricular Pressure | Proto-Oncogene Proteins c-bcl-2 | Endothelial Cells - pathology | Chronic Disease | Hypertension, Pulmonary - pathology | Transforming Growth Factor beta - metabolism | Pulmonary Artery - pathology | Ventricular Function, Right | Apoptosis | Mitogen-Activated Protein Kinases - metabolism | Pulmonary Artery - immunology
Journal Article
The European respiratory journal, ISSN 0903-1936, 01/2019, Volume 53, Issue 1
.... Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post- capillary involvement of pulmonary vessels... 
ADVENTITIAL FIBROBLASTS | MICROVASCULAR DISEASE | TO-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | RESPIRATORY SYSTEM | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | VASCULAR-LESIONS | MITOCHONDRIAL-FUNCTION | SMOOTH-MUSCLE-CELLS | PROTEIN-RECEPTOR 2
Journal Article
Circulation research, ISSN 1524-4571, 2015, Volume 117, Issue 10, pp. 870 - 883
RATIONALE:The pathogenesis of pulmonary arterial hypertension (PAH) remains unclear. The 4 microRNAs representing the miR-143 and miR-145 stem loops are genomically clustered... 
microRNAs | hypertension, pulmonary | endothelium | myocytes, smooth muscle | cell movement | exosomes | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISM | smooth muscle | PHENOTYPE | pulmonary | CANCER | myocytes | MIR-145 | GROWTH | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | hypertension | EXPRESSION | Exosomes - metabolism | Vascular Remodeling | Muscle, Smooth, Vascular - metabolism | Humans | Myocytes, Smooth Muscle - pathology | Hypertension, Pulmonary - physiopathology | Male | MicroRNAs - metabolism | Muscle, Smooth, Vascular - physiopathology | Case-Control Studies | Hypertension, Pulmonary - prevention & control | Pulmonary Artery - metabolism | Arterial Pressure | Transfection | Time Factors | Cattle | Female | Binding Sites | Myocytes, Smooth Muscle - metabolism | Promoter Regions, Genetic | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Cell Communication | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Mice, Knockout | Transcription Factors - metabolism | Muscle, Smooth, Vascular - pathology | Animals | MicroRNAs - genetics | Ventricular Pressure | HeLa Cells | Endothelial Cells - pathology | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Ventricular Function, Right | Cell Movement
Journal Article
Journal Article