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Arteriosclerosis, thrombosis, and vascular biology, ISSN 1079-5642, 04/2015, Volume 35, Issue 4, pp. 948 - 959
Objective-Activation of liver X receptor (LXR) inhibits atherosclerosis but induces hypertriglyceridemia. In vitro, it has been shown that mitogen-activated... 
atherosclerosis | foam cells | hypertriglyceridemia | lipogenesis | extracellular signal-regulated map kinases | liver X receptor | TRIGLYCERIDE | HOMEOSTASIS | PROTEIN-KINASE | CELL ACTIVATION | REVERSE CHOLESTEROL TRANSPORT | DISEASE | PERIPHERAL VASCULAR DISEASE | LIGAND | HEMATOLOGY | EXPRESSION | LIVER-X-RECEPTOR | Apolipoproteins E - deficiency | Fatty Liver - pathology | Atherosclerosis - genetics | Humans | Male | Fatty Liver - chemically induced | Orphan Nuclear Receptors - metabolism | Liver - drug effects | Fatty Liver - enzymology | Aortic Diseases - prevention & control | Foam Cells - pathology | Disease Models, Animal | Chemical and Drug Induced Liver Injury - prevention & control | Atherosclerosis - pathology | Butadienes - pharmacology | Liver - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Orphan Nuclear Receptors - agonists | Fatty Liver - prevention & control | Foam Cells - enzymology | Sulfonamides - pharmacology | Mice, Knockout | Aorta - pathology | Drug Synergism | Hydrocarbons, Fluorinated - toxicity | Aortic Diseases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Nitriles - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Hydrocarbons, Fluorinated - pharmacology | Hypertriglyceridemia - pathology | Foam Cells - drug effects | Atherosclerosis - enzymology | Liver X Receptors | Female | Aortic Diseases - enzymology | Chemical and Drug Induced Liver Injury - pathology | Drug Therapy, Combination | Aorta - enzymology | Chemical and Drug Induced Liver Injury - enzymology | Aortic Diseases - pathology | Aorta - drug effects | Mice, Inbred C57BL | Cholesterol - metabolism | Hep G2 Cells | Hypertriglyceridemia - enzymology | Hypertriglyceridemia - prevention & control | Hypertriglyceridemia - chemically induced | Animals | Apolipoproteins E - genetics | Sulfonamides - toxicity | Protein Kinase Inhibitors - pharmacology | Atherosclerosis - prevention & control
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 11/2013, Volume 305, Issue 9, pp. H1344 - H1353
Ca+ mishandling due to impaired activity of cardiac sarco(endo) plasmic reticulum Ca2+ ATPase (SERCA2a) has been associated with the development of left... 
Heart | Oxidative stress | Calcium | Metabolic syndrome | Sarco(endo)plasmic reticulum Ca | ATPase 2a | SUCROSE-FED RATS | CARDIAC CONTRACTILE DYSFUNCTION | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | calcium | HEART-FAILURE | HYPERTRIGLYCERIDEMIC RATS | ANTIOXIDANT ENZYMES | heart | metabolic syndrome | VENTRICULAR DIASTOLIC DYSFUNCTION | SARCOPLASMIC-RETICULUM CA2 | sarco(endo) plasmic reticulum Ca2+ ATPase 2a | INSULIN-RESISTANCE | RYANODINE RECEPTORS | PERIPHERAL VASCULAR DISEASE | TYPE-2 DIABETES-MELLITUS | oxidative stress | Phosphorylation | Reactive Oxygen Species - metabolism | Rats, Wistar | Calcium - metabolism | Male | Metabolic Syndrome - chemically induced | Myocytes, Cardiac - enzymology | Metabolic Syndrome - blood | Hyperinsulinism - enzymology | Ventricular Dysfunction, Left - enzymology | Dietary Sucrose | Hyperinsulinism - blood | Calcium Signaling | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Metabolic Syndrome - enzymology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Oxidation-Reduction | Down-Regulation | Insulin Resistance | Rats | Ventricular Dysfunction, Left - etiology | Antioxidants - pharmacology | Obesity, Abdominal - enzymology | Hypertriglyceridemia - blood | Hypertriglyceridemia - enzymology | Obesity, Abdominal - blood | Animals | Myocytes, Cardiac - drug effects | Oxidative Stress - drug effects | Heart cells | Physiological aspects | Insulin resistance | Metabolic diseases | Research | Health aspects
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e50256
We investigated the possible association between genetic variants in the Patatin like phospholipase-3 (PNPLA3) gene and nonalcoholic fatty liver disease... 
INSULIN | ADIPOSE TRIGLYCERIDE LIPASE | GREEN TEA | LIFE-STYLE | MESSENGER-RNA EXPRESSION | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY | POLYMORPHISM | GENOME-WIDE ASSOCIATION | ADIPONUTRIN | INDEXES | Haplotypes | Liver - pathology | Hypertriglyceridemia - genetics | Liver - enzymology | Humans | Middle Aged | Fatty Liver - complications | Male | Risk | Fatty Liver - ethnology | Obesity - genetics | Case-Control Studies | Fatty Liver - enzymology | Non-alcoholic Fatty Liver Disease | Adult | Female | Membrane Proteins - metabolism | Hypertension - enzymology | Hypertension - genetics | Fatty Liver - genetics | Genetic Predisposition to Disease | Membrane Proteins - genetics | Obesity - complications | Obesity - ethnology | Lipase - metabolism | Hypertriglyceridemia - enzymology | Hypertriglyceridemia - ethnology | Tea | Asian Continental Ancestry Group | Hypertriglyceridemia - complications | Hypertension - ethnology | Alleles | Hypertension - complications | Obesity - enzymology | Polymorphism, Single Nucleotide | Lipase - genetics | Hypertension | Fatty liver | Genes | Development and progression | Disease susceptibility | Genetic aspects | Single nucleotide polymorphisms | Health care | Laboratories | Liver | Association analysis | Genomes | Single-nucleotide polymorphism | Adipocytes | Epidemiology | Hepatitis | Ultrasonic imaging | Education | Rodents | Gastroenterology | Population | Genotypes | Public health | Obesity | Enzymes | Liver diseases | Statistical analysis | Drinking behavior | Health risks | Triglycerides | Regression analysis | Abdomen | Genetic variance | Phospholipase | Ethnicity | Hospitals | Hypertriglyceridemia | Tagging | Insulin resistance | Diabetes | Cancer
Journal Article
Molecular and Cellular Biochemistry, ISSN 0300-8177, 4/2012, Volume 363, Issue 1, pp. 85 - 91
Manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1), and catalase (CAT) provide the primary antioxidant defense system. Impaired... 
Life Sciences | Biochemistry, general | Type 2 diabetes | Catalase | Medical Biochemistry | Oncology | Cardiology | Diabetic cardiovascular disease | Manganese superoxide dismutase | Glutathione peroxidase-1 | OXIDATIVE STRESS | VARIANTS | MITOCHONDRIAL | MELLITUS | CELL BIOLOGY | GENE | COMPLICATIONS | DYSFUNCTION | ASSOCIATION | INDIANS | Superoxide Dismutase - genetics | Hypertriglyceridemia - genetics | Cardiovascular Diseases - ethnology | Diabetes Mellitus, Type 2 - genetics | Humans | Asian Continental Ancestry Group - genetics | Male | Cardiovascular Diseases - enzymology | Cardiovascular Diseases - genetics | Case-Control Studies | Diabetes Mellitus, Type 2 - ethnology | Polymerase Chain Reaction | Cardiovascular Diseases - blood | Female | Diabetes Complications - genetics | Genetic Predisposition to Disease | Diabetes Complications - ethnology | Risk Assessment | Catalase - genetics | Gene Frequency | Risk Factors | Diabetes Mellitus, Type 2 - enzymology | China - epidemiology | Chi-Square Distribution | Diabetes Complications - blood | Glutathione Peroxidase - genetics | Hypertriglyceridemia - blood | Polymorphism, Genetic | Hypertriglyceridemia - enzymology | Hypertriglyceridemia - ethnology | Diabetes Mellitus, Type 2 - blood | Phenotype | Triglycerides - blood | Aged | Diabetes Complications - enzymology | Manganese compounds | Plasma | Oxidation | Patients | Polymorphism
Journal Article
Journal Article
Clinica Chimica Acta, ISSN 0009-8981, 2005, Volume 357, Issue 2, pp. 93 - 112
In this paper, I review the origins of Clinical Enzymology with special emphasis on the years between 1960 and 1980 when the greatest advances in the subject... 
Myocardial infarction | Creatine kinase | Exocrine pancreatic insufficiency | Lactate dehydrogenase | Ribonuclease | Vaginal fluid | Ornithine carbamoyltransferase | Chymotrypsin | 6-Phosphogluconate dehydrogenase | Viral hepatitis | Aminotransferases | Hypertriglyceridemia | Microsomal enzyme induction | Drug metabolism | Gammaglutamyl transferase | beta-Glucuronidase | Isocitrate dehydrogenase | Cervical cancer | Duodenal intubation tests | d-Glucaric acid | Beta-Glucuronidase | D-Glucaric acid | gammaglutamyl transferase | INFECTIOUS HEPATITIS | isocitrate dehydrogenase | LACTIC DEHYDROGENASE ACTIVITY | myocardial infarction | LIVER DISEASE | SERUM ENZYME CHANGES | D-glucaric acid | vaginal fluid | exocrine pancreatic insufficiency | OXALACETIC TRANSAMINASE ACTIVITY | drug metabolism | creatine kinase | chymotrypsin | aminotransferases | ribonuclease | PANCREATIC DISEASE | ornithine carbamoyltransferase | viral hepatitis | MYOCARDIAL-INFARCTION | duodenal intubation tests | hypertriglyceridemia | lactate dehydrogenase | PANCREOZYMIN-SECRETIN TEST | cervical cancer | microsomal enzyme induction | beta-glucuronidase | MEDICAL LABORATORY TECHNOLOGY | 6-phosphogluconate dehydrogenase | Liver - pathology | Enzymes - history | History, 20th Century | Humans | Liver - metabolism | Enzyme Induction | Pancreas - pathology | Microsomes - enzymology | Myocardium - pathology | United Kingdom | Pancreas - metabolism | Myocardium - enzymology | Female | Enzymes - metabolism | Pancreas - enzymology | Virus diseases | Physiological aspects | Creatine
Journal Article
Journal Article
Hepatology, ISSN 0270-9139, 12/2012, Volume 56, Issue 6, pp. 2188 - 2198
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2011, Volume 251, Issue 1, pp. 32 - 40
Consumption of beverages that contain fructose favors the increasing prevalence of metabolic syndrome alterations in humans, including non-alcoholic fatty... 
Fatty acid oxidation | NAFLD | ChREBP | NFκB | NFΚB | PPAR-ALPHA | KAPPA-B ACTIVATION | LIPID-METABOLISM | ELEMENT-BINDING PROTEIN | HYPERTRIGLYCERIDEMIA | DISEASE | FATTY LIVER | PHARMACOLOGY & PHARMACY | TOXICOLOGY | TRANSCRIPTION FACTOR | UP-REGULATION | NF kappa B | CARDIOVASCULAR RISK | Hypertriglyceridemia - drug therapy | Metallothionein - metabolism | Liver - pathology | Phosphorylation | Hepatitis - enzymology | Liver - enzymology | Fatty Liver - pathology | Male | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Dietary Carbohydrates - metabolism | Fructose - metabolism | Necrosis | Hepatitis - prevention & control | Liver - drug effects | Hepatitis - genetics | Fatty Liver - enzymology | Inflammation Mediators - metabolism | Non-alcoholic Fatty Liver Disease | Lipid Metabolism - genetics | Fatty Acids - metabolism | Heptanoic Acids - pharmacology | Disease Models, Animal | Cyclic AMP-Dependent Protein Kinases - metabolism | Fatty Liver - genetics | Hepatitis - etiology | Oxidation-Reduction | Down-Regulation | Fatty Liver - prevention & control | Rats | Rats, Sprague-Dawley | Fructokinases - metabolism | Triglycerides - metabolism | Gene Expression Regulation - drug effects | Atorvastatin Calcium | Hypertriglyceridemia - enzymology | Pyrroles - pharmacology | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hypertriglyceridemia - etiology | Lipid Metabolism - drug effects | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Fatty Liver - etiology | Liver diseases | Synthesis | Liver | Physiological aspects | Triglycerides | Beverages | Fatty acids | Fructose | Metallothionein | Antilipemic agents | Protein binding | Index Medicus | Enzymes | Transcription factors | Inflammation | Regulatory sequences | Metabolism | Dietary restrictions | reductase | Fatty liver | Molecular modelling | Hypertriglyceridemia | Atorvastatin | Fructokinase | Supplementation | steatosis | Metabolic disorders | PATIENTS | METALLOTHIONEIN | DIGESTIVE SYSTEM | RATS | TRIGLYCERIDES | HISTOLOGY | 60 APPLIED LIFE SCIENCES | FRUCTOSE | GLANDS | METABOLISM | ENZYMES | GENES | ESTERS | CHEMICAL REACTIONS | VERTEBRATES | LIPIDS | MAMMALS | HUMAN POPULATIONS | OXIDATION | TRANSCRIPTION FACTORS | ANIMALS | SACCHARIDES | CATABOLISM | RODENTS | ORGANIC COMPOUNDS | METALLOPROTEINS | INTAKE | ORGANIC ACIDS | POPULATIONS | SYMPTOMS | HEXOSES | KETONES | ORGANS | MONOSACCHARIDES | DISEASES | INGESTION | INFLAMMATION | LIVER | SYNTHESIS | CARBOXYLIC ACIDS | BEVERAGES | PROTEINS | BODY | PATHOLOGICAL CHANGES | CARBOHYDRATES | CONTROL | FOOD
Journal Article