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1. Full Text Uric Acid Level and Elevated Blood Pressure in US Adolescents: National Health and Nutrition Examination Survey, 1999–2006
by Loeffler, Lauren F and Navas-Acien, Ana and Brady, Tammy M and Miller, Edgar R and Fadrowski, Jeffrey J
Hypertension, ISSN 0194-911X, 04/2012, Volume 59, Issue 4, pp. 811 - 817
Uric acid is associated with cardiovascular disease and cardiovascular disease risk factors in adults, including chronic kidney disease, coronary artery... 
blood pressure | adolescents | children | essential hypertension | NHANES | uric acid | cross-sectional studies | CHRONIC HEART-FAILURE | METABOLIC SYNDROME | ENDOTHELIAL FUNCTION | HYPERURICEMIA | PLASMA CREATININE | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | CHRONIC KIDNEY-DISEASE | INCIDENT HYPERTENSION | CARDIOVASCULAR RISK | United States - epidemiology | Prevalence | Cross-Sectional Studies | Nutrition Surveys | Humans | Male | Biomarkers - blood | Hypertension - physiopathology | Incidence | Hypertension - blood | Adolescent | Cardiovascular Diseases - epidemiology | Female | Blood Pressure - physiology | Retrospective Studies | Uric Acid - blood | Hypertension - epidemiology | Child | Cohort Studies | hypertension | essential
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2. Full Text Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial
by Feig, Daniel I and Soletsky, Beth and Johnson, Richard J
JAMA, ISSN 0098-7484, 08/2008, Volume 300, Issue 8, pp. 924 - 932
CONTEXT Hyperuricemia is a predictor for the development of hypertension and is commonly present in new-onset essential hypertension. Experimentally increasing... 
CHRONIC HEART-FAILURE | INDEPENDENT MECHANISM | MEDICINE, GENERAL & INTERNAL | METABOLIC SYNDROME | HEALTHY-CHILDREN | RISK-FACTORS | HYPERURICEMIA | CARDIOVASCULAR-DISEASE | ENDOTHELIAL FUNCTION | CHILDHOOD | SERUM URIC-ACID | Double-Blind Method | Humans | Enzyme Inhibitors - pharmacology | Hypertension - drug therapy | Male | Enzyme Inhibitors - therapeutic use | Hyperuricemia - drug therapy | Cross-Over Studies | Allopurinol - therapeutic use | Adolescent | Hypertension - complications | Allopurinol - pharmacology | Female | Blood Pressure - drug effects | Uric Acid - blood | Hyperuricemia - complications | Xanthine Oxidase - antagonists & inhibitors | Care and treatment | Usage | Allopurinol | Causes of | Diagnosis | Children | Health aspects | Hypotension | Hypertension | Clinical trials | Teenagers | Drug therapy | Medical diagnosis
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3. Full Text Metabolic effects of replacing sugar-sweetened beverages with artificially-sweetened beverages in overweight subjects with or without hepatic steatosis: A randomized control clinical trial
by Campos, Vanessa and Despland, Camille and Brandejsky, Vaclav and Kreis, Roland and Schneiter, Philippe and Boesch, Chris and Tappy, Luc
Nutrients, ISSN 2072-6643, 03/2017, Volume 9, Issue 3, p. 202
Objective: Addition of fructose to the diet of normal weight and overweight subjects can increase postprandial plasma triglyceride and uric acid concentration.... 
Cardiovascular risk factors | Hypertriglyceridemia | Intrahepatocellular lipid concentration | Fructose | METAANALYSIS | intrahepatocellular lipid concentration | FRUCTOSE-CONTAINING SUGARS | FATTY LIVER-DISEASE | hypertriglyceridemia | fructose | cardiovascular risk factors | EXERCISE | CHILDREN | CARDIOVASCULAR-DISEASE RISK | OBESITY | NUTRITION & DIETETICS | HYPERURICEMIA | URIC-ACID | CONSUMPTION | Body Mass Index | Fatty Liver - blood | Lactic Acid - blood | Humans | Sweetening Agents - adverse effects | Male | Treatment Outcome | Insulin - blood | Glucagon - blood | Obesity - blood | Young Adult | Nutritive Sweeteners - adverse effects | Diet | Overweight - blood | Postprandial Period | Triglycerides - blood | Nutritive Sweeteners - administration & dosage | Adult | Fatty Acids, Nonesterified - blood | Female | Uric Acid - blood | Blood Glucose - metabolism | Meals | Sweetening Agents - administration & dosage | Clinical trials | Obesity | Lipids | Uric acid | Metabolism | Beverages
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4. Full Text Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults
by De Oliveira, Erick Prado and Moreto, Fernando and Silveira, Liciana Vaz De Arruda and Burini, Roberto Carlos
Nutrition Journal, ISSN 1475-2891, 2013, Volume 12, Issue 1, pp. 11 - 11
Background: High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk... 
Inflammation | Uric acid | Diet | Body composition | Metabolic syndrome components | METABOLIC SYNDROME | OXIDATIVE STRESS | SKELETAL-MUSCLE MASS | DAIRY-PRODUCTS | DENSITY-LIPOPROTEIN-CHOLESTEROL | VISCERAL FAT ACCUMULATION | NUTRITION & DIETETICS | HYPERURICEMIA | PURINE-RICH FOODS | 3RD NATIONAL-HEALTH | CARDIOVASCULAR RISK-FACTORS | Blood Pressure | Body Composition | Metabolic Syndrome - etiology | Life Style | Humans | Middle Aged | Male | Urea - blood | Young Adult | Calcium - blood | Metabolic Syndrome - blood | Aged, 80 and over | Cardiovascular Diseases - blood | Adult | Cholesterol, LDL - blood | Female | Uric Acid - blood | C-Reactive Protein - analysis | Odds Ratio | Uric Acid - adverse effects | Body Mass Index | Cardiovascular Diseases - etiology | Cross-Sectional Studies | Blood Glucose | Biomarkers - blood | Electric Impedance | Energy Intake | Serum Albumin - analysis | Fatty Acids, Unsaturated - blood | Waist Circumference | Triglycerides - blood | Cholesterol, HDL - blood | Creatinine - blood | Aged | Fatty Acids, Unsaturated - administration & dosage | Body mass index | Obesity | Insulin resistance | Exercise
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5. Full Text Predicting Out-of-Office Blood Pressure in the Clinic (PROOF-BP): Derivation and Validation of a Tool to Improve the Accuracy of Blood Pressure Measurement in Clinical Practice
by Sheppard, James P and Stevens, Richard and Gill, Paramjit and Martin, Una and Godwin, Marshall and Hanley, Janet and Heneghan, Carl and Hobbs, F.D Richard and Mant, Jonathan and McKinstry, Brian and Myers, Martin and Nunan, David and Ward, Alison and Williams, Bryan and McManus, Richard J
Hypertension, ISSN 0194-911X, 05/2016, Volume 67, Issue 5, pp. 941 - 950
Patients often have lower (white coat effect) or higher (masked effect) ambulatory/home blood pressure readings compared with clinic measurements, resulting in... 
ambulatory blood pressure monitoring | masked hypertension | hypertension | white coat hypertension | INDEPENDENT MECHANISM | LIFE-STYLE INTERVENTIONS | ATHEROSCLEROSIS | CHILDHOOD | SERUM URIC-ACID | OBESITY | HYPERURICEMIA | ADOLESCENTS | DISEASE | PERIPHERAL VASCULAR DISEASE | ESSENTIAL-HYPERTENSION | Predictive Value of Tests | Office Visits | Risk Assessment | United States | Humans | Middle Aged | Linear Models | Male | United Kingdom | Circadian Rhythm | Masked Hypertension - diagnosis | Blood Pressure Determination - methods | Canada | Algorithms | Sensitivity and Specificity | Adult | Female | ROC Curve | Aged | White Coat Hypertension - diagnosis | Blood Pressure Monitoring, Ambulatory - methods | Cohort Studies | Databases, Factual | 10072 | 10121 | 10111 | 10069 | Original
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6. Full Text Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based colaus study
by Lyngdoh, Tanica and Marques-Vidal, Pedro and Paccaud, Fred and Preisig, Martin and Waeber, Gérard and Bochud, Murielle and Vollenweider, Peter
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 5, p. e19901
Background: The relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have been inconsistent. We analyzed... 
C-REACTIVE PROTEIN | METABOLIC SYNDROME | OBESITY | HYPERURICEMIA | HEART-FAILURE | BIOLOGY | RENAL-DISEASE | HYPERTENSION | INTERLEUKIN-6 | BLOOD-PRESSURE | CARDIOVASCULAR RISK-FACTORS | Cross-Sectional Studies | Humans | Middle Aged | Tumor Necrosis Factor-alpha - blood | Male | Inflammation - epidemiology | Inflammation - blood | Interleukin-1beta - blood | C-Reactive Protein - metabolism | Flow Cytometry | Interleukin-6 - blood | Switzerland - epidemiology | Adult | Female | Aged | Uric Acid - blood | Cytokines - blood | Inflammation | C-reactive protein | Uric acid | Interleukins | Tumor necrosis factor | Analysis | Multiplexing | Flow cytometry | Laboratories | Urate oxidase | Interleukin | Smooth muscle | Cardiovascular disease | Alcohol | Population studies | Metabolic syndrome | Interleukin 6 | Body mass index | Population | Tumor necrosis factor-TNF | Hypertension | Obesity | Cytokines | Nutrition | Internal medicine | Neutrophils | Preventive medicine | Tumor necrosis factor-α | Disease prevention | Studies | Acids | Body mass | Body size | Biomarkers | Insulin resistance | Diabetes | Cancer | Apoptosis
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7. Full Text Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders
by Lu, Jie and Hou, Xu and Yuan, Xuan and Cui, Lingling and Liu, Zhen and Li, Xinde and Li, Changgui and Ma, Lidan and Cheng, Xiaoyu and Xin, Ying and Wang, Can and Wang, Xuefeng and Zhang, Keke and Ren, Wei and Sun, Ruixia and Jia, Zhaotong and Tian, Zibin and Mi, Qing-Sheng
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 69 - 80
The urate oxidase ( ) gene encodes uricase that in the rodent liver degrades uric acid into allantoin, forming an obstacle for establishing stable mouse models... 
apoptosis | inflammation | diabetes | renal pathology | GOUT | MENDELIAN RANDOMIZATION | SERUM URIC-ACID | DISEASE | CAUSAL | UROLOGY & NEPHROLOGY | MICE | SECRETION | HYPERTENSION | Blood Pressure | Dyslipidemias - genetics | Liver - enzymology | Kidney - pathology | Diabetes Mellitus, Experimental - enzymology | Blood Urea Nitrogen | Diabetes Mellitus, Experimental - genetics | Male | Insulin - blood | Dyslipidemias - enzymology | Diabetes Mellitus, Experimental - blood | Dyslipidemias - blood | Kidney - metabolism | Urate Oxidase - genetics | Time Factors | Lipids - blood | Female | Uric Acid - blood | Hypertension - enzymology | Hypertension - genetics | Kidney - physiopathology | Disease Models, Animal | Genetic Predisposition to Disease | Mice, Inbred C57BL | Biomarkers - blood | Disease Progression | Hypertension - physiopathology | Hyperuricemia - drug therapy | Mice, Knockout | Hyperuricemia - genetics | Hyperuricemia - blood | Phenotype | Animals | Creatinine - blood | Gout Suppressants - pharmacology | Urate Oxidase - deficiency | Blood Glucose - metabolism | Hyperuricemia - enzymology
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8. Full Text Association between elevated serum alanine aminotransferase and cardiometabolic risk factors in rural Chinese population: A cross-sectional study
by Chen, Shuang and Guo, Xiaofan and Zhang, Xingang and Yu, Shasha and Yang, Hongmei and Jiang, Mohan and Sun, Guozhe and Sun, Yingxian
BMC Cardiovascular Disorders, ISSN 1471-2261, 07/2015, Volume 15, Issue 1, p. 65
Background: Elevated alanine aminotransferase (ALT) levels may be associated with metabolic syndrome and cardiovascular diseases. This study aimed to... 
Rural Chinese population | Sex-related differences | Alanine aminotransferase | Cardiometabolic risk factors | Rural Chinese Population | METABOLIC SYNDROME | CARDIAC & CARDIOVASCULAR SYSTEMS | FATTY LIVER-DISEASE | WAIST | DISORDERS | AUTOIMMUNE ACTIVATION | LIPOPROTEIN(A) | WOMEN | COMMUNITY | HEALTH | Blood Pressure | Diabetes Mellitus - blood | Age Factors | Humans | Middle Aged | Male | Alanine Transaminase - blood | Obesity - blood | Hypertension - blood | Metabolic Syndrome - blood | Dyslipidemias - blood | Obesity, Abdominal - epidemiology | Cardiovascular Diseases - blood | Cardiovascular Diseases - epidemiology | Adult | Cholesterol, LDL - blood | Female | Uric Acid - blood | Hypertension - epidemiology | Metabolic Syndrome - epidemiology | Hypercholesterolemia - epidemiology | Body Mass Index | Hypercholesterolemia - blood | Rural Population - statistics & numerical data | Cross-Sectional Studies | Risk Factors | China - epidemiology | Hypertriglyceridemia - blood | Obesity, Abdominal - blood | Hypertriglyceridemia - epidemiology | Hyperuricemia - blood | Waist Circumference | Dyslipidemias - epidemiology | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Obesity - epidemiology | Sex Factors | Triglycerides - blood | Cholesterol, HDL - blood | Aged | Hyperuricemia - epidemiology | Hypertension | Amino acids | Exercise | Low density lipoproteins | Risk factors
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9. Full Text Childhood Uric Acid Predicts Adult Blood Pressure: The Bogalusa Heart Study
by Alper, Arnold B and Chen, Wei and Yau, Lillian and Srinivasan, Sathanur R and Berenson, Gerald S and Hamm, L Lee
Hypertension, ISSN 0194-911X, 01/2005, Volume 45, Issue 1, pp. 34 - 38
Uric acid has been proposed as an important risk factor in the development of primary hypertension in humans. However, limited information is available linking... 
Blood pressure | Children | Uric acid | UNITED-STATES | blood pressure | INDEPENDENT MECHANISM | SODIUM | RISK-FACTORS | NATIONAL-HEALTH | HYPERURICEMIA | children | SALT-SENSITIVE HYPERTENSION | DISEASE | PERIPHERAL VASCULAR DISEASE | POTASSIUM | uric acid | Prognosis | Age Factors | Diastole | Follow-Up Studies | Humans | African Americans | Child, Preschool | Systole | Incidence | Hypertension - blood | Adult | Uric Acid - blood | Hypertension - epidemiology | Child | Kidney - physiopathology | Louisiana - epidemiology | Cross-Sectional Studies | Risk Factors | European Continental Ancestry Group | Hyperuricemia - physiopathology | Disease Progression | Hypertension - physiopathology | Hypertension - ethnology | Adolescent | Hyperuricemia - epidemiology | Hyperuricemia - ethnology
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10. Full Text Comparison of Febuxostat and Allopurinol for Hyperuricemia in Cardiac Surgery Patients (NU-FLASH Trial)
by Sezai, Akira and Soma, Masayoshi and Nakata, Kin-ichi and Hata, Mitsumasa and Yoshitake, Isamu and Wakui, Shinji and Hata, Hiroaki and Shiono, Motomi
Circulation Journal, ISSN 1346-9843, 2013, Volume 77, Issue 8, pp. 2043 - 2049
Background: Febuxostat has been reported to have a stronger effect on hyperuricemia than allopurinol. Methods and Results: Cardiac surgery patients with... 
Febuxostat | Hyperuricemia | Allopurinol | CARDIAC & CARDIOVASCULAR SYSTEMS | RENAL-DISEASE | CHRONIC KIDNEY-DISEASE | INHIBITOR | ASSOCIATION | FAILURE | BLOOD-PRESSURE | PROGRESSION | SERUM URIC-ACID | Pulse Wave Analysis | Cystatin C - blood | Albuminuria - blood | Cholesterol - blood | Humans | Middle Aged | Arachidonic Acid - blood | Male | Thiazoles - administration & dosage | Albuminuria - physiopathology | Cardiac Surgical Procedures | C-Reactive Protein - metabolism | Female | Blood Pressure - drug effects | Uric Acid - blood | Hyperuricemia - therapy | Albuminuria - therapy | Stroke Volume - drug effects | Hyperuricemia - physiopathology | Gout Suppressants - administration & dosage | Hyperuricemia - blood | Allopurinol - administration & dosage | Creatinine - blood | Aged | Lipoproteins, LDL - blood
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11. Full Text Association of plasma free amino acids with hyperuricemia in relation to diabetes mellitus, dyslipidemia, hypertension and metabolic syndrome
by Mahbub, Mh and Yamaguchi, Natsu and Takahashi, Hidekazu and Hase, Ryosuke and Ishimaru, Yasutaka and Sunagawa, Hiroshi and Amano, Hiroki and Kobayashi-Miura, Mikiko and Kanda, Hideyuki and Fujita, Yasuyuki and Yamamoto, Hiroshi and Yamamoto, Mai and Kikuchi, Shinya and Ikeda, Atsuko and Kageyama, Naoko and Nakamura, Mina and Tanabe, Tsuyoshi
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 17616 - 12
Previous studies demonstrated independent contributions of plasma free amino acids (PFAAs) and high uric acid (UA) concentrations to increased risks of... 
POPULATION | INSULIN-RESISTANT STATE | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | BRANCHED-CHAIN | LEVEL | VISCERAL FAT ACCUMULATION | SCREENED COHORT | BLOOD-PRESSURE | SERUM URIC-ACID | Blood Pressure | Diabetes Mellitus - blood | Amino Acids - blood | Blood Glucose - analysis | Cholesterol - blood | Humans | Japan | Middle Aged | Risk Factors | Male | Hypertension - blood | Metabolic Syndrome - blood | Dyslipidemias - blood | Hyperuricemia - blood | Triglycerides - blood | Adult | Female | Aged | Uric Acid - blood | Tyrosine | Hypertension | Alanine | Threonine | Diabetes mellitus | Dyslipidemia | Proline | Amino acids | Uric acid | Metabolic syndrome | Hyperuricemia | Histidine | Arginine | Lysine | Asparagine | Diabetes | Ornithine | Metabolic disorders
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12. Full Text Molecular identification of a renal urate-anion exchanger that regulates blood urate levels
by Kanai, Yoshikatsu and Hosoya, Tatsuo and Enomoto, Atsushi and Sekine, Takashi and Shigeta, Yasuhiro and Ho Cha, Seok and Niwa, Toshimitsu and Hosoyamada, Makoto and Kikuchi, Yuichi and Kimura, Hiroaki and Jutabha, Promsuk and Matsuo, Hirotaka and Shimokata, Kaoru and Ichida, Kimiyoshi and Takeda, Michio and Endou, Hitoshi and Chairoungdua, Arthit and Igarashi, Takashi and Oda, Takashi
Nature, ISSN 0028-0836, 05/2002, Volume 417, Issue 6887, pp. 447 - 452
Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants implicated in numerous disease processes, as demonstrated by... 
HYPERURICEMIA | PEROXYNITRITE | VESICLES | MULTIDISCIPLINARY SCIENCES | P-AMINOHIPPURATE TRANSPORT | DYSFUNCTION | BRUSH-BORDER MEMBRANE | KIDNEY | EXCRETION | URIC-ACID | EXERCISE | Immunohistochemistry | Xenopus | Humans | Kidney Tubules, Proximal - chemistry | Molecular Sequence Data | Substrate Specificity | RNA, Messenger - metabolism | Kidney - metabolism | Biological Transport | Cloning, Molecular | Carrier Proteins - chemistry | Uric Acid - blood | Anions - blood | Amino Acid Sequence | Uric Acid - metabolism | Oocytes - metabolism | RNA, Messenger - genetics | Organic Cation Transport Proteins | Anions - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Organic Anion Transporters | Kidney Tubules, Proximal - metabolism | Kidney - chemistry | Mutation | Kidneys | Acids | Molecular biology | Blood
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13. Full Text Serum uric acid and its association with metabolic syndrome and carotid atherosclerosis in obese children
by Pacifico, Lucia and Cantisani, Vito and Anania, Caterina and Bonaiuto, Elisabetta and Martino, Francesco and Pascone, Roberto and Chiesa, Claudio
European Journal of Endocrinology, ISSN 0804-4643, 2009, Volume 160, Issue 1, pp. 45 - 52
Objective: The association between hyperuricemia, metabolic syndrome (MS), and atherosclerotic vascular disease has been reported in adults, but very little is... 
MORTALITY | DEFINITION | HYPERURICEMIA | INSULIN-RESISTANCE | OVERWEIGHT | ENDOCRINOLOGY & METABOLISM | PREVALENCE | HYPERTENSION | CHILDHOOD | THICKNESS | CARDIOVASCULAR RISK-FACTORS | Metabolic Syndrome - diagnostic imaging | gamma-Glutamyltransferase - blood | Cholesterol - blood | Humans | Carotid Artery Diseases - complications | Male | Alanine Transaminase - blood | Insulin - blood | Obesity - blood | Metabolic Syndrome - blood | Carotid Artery Diseases - diagnostic imaging | Ultrasonography | Female | Tunica Intima - diagnostic imaging | Blood Pressure - physiology | Uric Acid - blood | Child | Obesity - diagnostic imaging | Obesity - complications | Linear Models | Metabolic Syndrome - complications | Tunica Intima - pathology | Carotid Artery Diseases - blood | Triglycerides - blood | Creatinine - blood | Blood Glucose - metabolism | Cohort Studies
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