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Rheumatology (Oxford, England), ISSN 1462-0324, 12/2014, Volume 53, Issue 12, pp. 2167 - 2174
Journal Article
Nature Nanotechnology, ISSN 1748-3387, 10/2016, Volume 11, Issue 10, pp. 890 - 899
Journal Article
Drug Metabolism and Pharmacokinetics, ISSN 1347-4367, 01/2017, Volume 32, Issue 1, pp. S95 - S95
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Journal Article
PLoS ONE, ISSN 1932-6203, 06/2017, Volume 12, Issue 6, p. e0178593
The PI3K/Akt/mTOR signaling pathway is aberrantly activated in various pediatric tumors. We conducted a phase I study of the Akt inhibitor perifosine in... 
SURVIVAL | ACTIVATION | AKT INHIBITOR MK-2206 | CLINICAL-TRIAL | MULTIDISCIPLINARY SCIENCES | NEUROBLASTOMA | BLOOD-BRAIN-BARRIER | PI3K/AKT/MTOR PATHWAY | CELL GROWTH | CANCER | CHILDRENS ONCOLOGY GROUP | Humans | Sarcoma, Ewing - pathology | Wilms Tumor - drug therapy | Child, Preschool | Neoplasm Recurrence, Local - drug therapy | Male | Phosphorylcholine - analogs & derivatives | Ependymoma - drug therapy | Neutropenia - diagnosis | Phosphorylcholine - pharmacokinetics | Antineoplastic Agents - adverse effects | Glioma - pathology | Medulloblastoma - pathology | Ependymoma - pathology | Female | Antineoplastic Agents - pharmacokinetics | Neutropenia - chemically induced | Child | Neuroblastoma - pathology | Drug Administration Schedule | Hyperuricemia - diagnosis | Treatment Outcome | Sarcoma, Ewing - drug therapy | Wilms Tumor - pathology | Central Nervous System Neoplasms - pathology | Neuroblastoma - drug therapy | Adolescent | Phosphorylcholine - adverse effects | Medulloblastoma - drug therapy | Central Nervous System Neoplasms - drug therapy | Glioma - drug therapy | Hyperuricemia - chemically induced | Rapamycin | Dosage and administration | Research | Medulloblastoma | Central nervous system | TOR protein | Pediatrics | Phosphorylation | Toxicity | Variability | Brain tumors | Brain cancer | AKT protein | Cytotoxicity | Infections | Neuroblastoma | Kinases | Autophagy | Cancer therapies | Stomach cancer | Ewing's sarcoma | Proteins | Signal transduction | Hyperglycemia | Hyperuricemia | Cell growth | Blood-brain barrier | Age | Neutropenia | Departments | Sarcoma | Medical instruments | Fatigue | Pharmacology | Patients | Fever | 1-Phosphatidylinositol 3-kinase | Inhibitors | Glioma | Feasibility | Solid tumors | Mutation | Aberration | Pharmacokinetics | Tumors | Apoptosis
Journal Article
by Kimura, Kenjiro and Hosoya, Tatsuo and Uchida, Haruhito and Uchida, Shunya and Inaba, Masaaki and Inaba, Masahiko and Makino, Hirofumi and Maruyama, Shoichi and Maruyama, Syoichi and Ito, Takafumi and Ito, Sadayoshi and Yamamoto, Tetsuya and Tomino, Yasuhiko and Ohno, Iwao and Shibagaki, Yugo and Iimuro, Satoshi and Imai, Naohiko and Kuwabara, Masanari and Hayakawa, Hiroshi and Ohtsu, Hiroshi and Ohashi, Yasuo and Matsuo, Seiichi and Yamanaka, Hisashi and Akizawa, Tadao and Teramoto, Tamio and Kasanuki, Hiroshi and Yoshimura, Kenichi and Sato, Hiroshi and Horikoshi, Satoshi and Moriwaki, Yuji and Kaneshiro, Nagayuki and Moriya, Hidekazu and Komatsu, Yasuhiro and Kaname, Shinya and Hanaoka, Kazunari and Ogura, Makoto and Ikeda, Masato and Kasai, Kenji and Sugiura, Akira and Takahashi, Kazushi and Kojima, Kenichiro and Nitta, Kosaku and Tamai, Hirofumi and Nagaya, Hiroshi and Okuno, Senji and Kakiya, Ryusuke and Takeoka, Hiroya and Hirata, Kyouji and Asano, Kenichiro and Fukaya, Yasuo and Iwaida, Yasushi and Tsuneda, Yasuo and Nishimura, Shigeaki and Hiramatsu, Takeyuki and Isaka, Yoshitaka and Yuzawa, Yukio and Yamagata, Kunihiro and Sofue, Tadashi and Jinguji, Yoshimi and Hirano, Keita and Matsuyama, Kazuhiro and Mizumoto, Teruhiko and Shibuya, Yuko and Sugawara, Masahiro and Kadomura, Moritoshi and Teshima, Yasuaki and Ohtani, Hiroshi and Kamata, Hiroki and Okawara, Susumu and Fukushima, Masaki and Takemura, Katsumi and Kinugasa, Eriko and Kogure, Masami and Ehara, Yoichi and FEATHER Study Investigators
American Journal of Kidney Diseases, ISSN 0272-6386, 12/2018, Volume 72, Issue 6, pp. 798 - 810
Journal Article