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hyperuricemia (132) 132
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animals (85) 85
male (80) 80
uric acid (68) 68
gout (64) 64
hyperuricemia - enzymology (61) 61
uric acid - blood (50) 50
hyperuricemia - drug therapy (48) 48
xanthine oxidase - metabolism (47) 47
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pharmacology & pharmacy (32) 32
uric-acid (32) 32
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metabolism (20) 20
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purines (18) 18
hypoxanthine phosphoribosyltransferase - genetics (17) 17
mutation (17) 17
urate oxidase (17) 17
biotechnology & applied microbiology (16) 16
hypertension (16) 16
hyperuricemia - chemically induced (16) 16
xanthine (16) 16
expression (15) 15
hyperuricemia - genetics (15) 15
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serum uric-acid (15) 15
time factors (15) 15
urate oxidase - metabolism (15) 15
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rats, sprague-dawley (14) 14
urate oxidase - chemistry (14) 14
biomarkers - blood (13) 13
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gout - enzymology (13) 13
gout suppressants - therapeutic use (13) 13
metabolic syndrome (13) 13
proteins (13) 13
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dose-response relationship, drug (12) 12
uricase (12) 12
allopurinol - therapeutic use (11) 11
gout suppressants - pharmacology (11) 11
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urate oxidase - genetics (11) 11
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Journal Article
Kidney International, ISSN 0085-2538, 01/2018, Volume 93, Issue 1, pp. 69 - 80
Journal Article
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 07/2015, Volume 309, Issue 1, pp. G42 - G51
Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Numerous recent studies have revealed the likelihood... 
Xanthine oxidase inhibitor | Hyperuricemia | Nonalcoholic steatohepatitis | Uric acid | Febuxostat | xanthine oxidase inhibitor | METABOLIC SYNDROME | PHYSIOLOGY | OXIDOREDUCTASE | ATHEROSCLEROSIS | INJURY | SERUM URIC-ACID | nonalcoholic steatohepatitis | hyperuricemia | FRUCTOSE | DISEASE | febuxostat | HYPERTENSION | GASTROENTEROLOGY & HEPATOLOGY | uric acid | Non-alcoholic Fatty Liver Disease - pathology | Liver - pathology | Liver - enzymology | Apoptosis - drug effects | Hyperuricemia - pathology | Non-alcoholic Fatty Liver Disease - etiology | Choline Deficiency - complications | Liver Cirrhosis, Experimental - prevention & control | Non-alcoholic Fatty Liver Disease - blood | Liver Cirrhosis, Experimental - enzymology | Liver - drug effects | Diet, High-Fat | Non-alcoholic Fatty Liver Disease - enzymology | Liver Cirrhosis, Experimental - pathology | Uric Acid - blood | Xanthine Oxidase - antagonists & inhibitors | Cytoprotection | Methionine - deficiency | Xanthine Oxidase - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Hyperuricemia - etiology | Hyperuricemia - drug therapy | Hyperuricemia - blood | Animals | Non-alcoholic Fatty Liver Disease - prevention & control | Gout Suppressants - pharmacology | Thiazoles - pharmacology | Hyperuricemia - enzymology | Medicine, Experimental | Medical research | Care and treatment | Liver diseases | Research | Oxidases | Molybdenum compounds | Fatty acids | Analysis | Liver
Journal Article
Gene, ISSN 0378-1119, 11/2012, Volume 509, Issue 1, pp. 154 - 157
The manifestations of glycogen storage disease type 1a (GSD 1a) are usually so prominent in childhood that it is readily diagnosed by pediatricians. However, a... 
Hepatocellular carcinoma | Glycogen storage disease type 1a | Hyperuricemia | Hyperlipidemia | DIAGNOSIS | HEPCIDIN | IDENTIFICATION | HEPATOCELLULAR-CARCINOMA | MESSENGER-RNA | GLUCOSE-6-PHOSPHATASE GENE | GENETICS & HEREDITY | MUTATIONS | JAPANESE PATIENTS | EXPRESSION | Glucose-6-Phosphatase - genetics | Hyperlipidemias - genetics | Humans | DNA, Complementary - genetics | Child, Preschool | Male | Arthritis, Gouty - genetics | Mutation, Missense | Hyperlipidemias - enzymology | Diagnostic Errors | Base Sequence | Carcinoma, Hepatocellular - genetics | Adult | Female | Liver Neoplasms - enzymology | Glucose-6-Phosphatase - chemistry | Liver Function Tests | Recombinant Proteins - metabolism | Liver Neoplasms - genetics | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Recombinant Proteins - genetics | Carcinoma, Hepatocellular - enzymology | Arthritis, Gouty - enzymology | Glucose-6-Phosphatase - metabolism | Glycogen Storage Disease Type I - diagnosis | Glycogen Storage Disease Type I - enzymology | Homozygote | Hyperuricemia - genetics | Phenotype | Fatty Liver - diagnosis | Glycogen Storage Disease Type I - genetics | Pedigree | Mutant Proteins - chemistry | Adolescent | Heterozygote | Consanguinity | Hyperuricemia - enzymology | Liver cancer | Phosphatases | RNA | Blood sugar | Glycogen | Genes | Transplantation of organs, tissues, etc | Fluorescence | Youth | Teenagers | Glycoproteins | Adolescence | Fasting | Benign | Arthritis | Infants | Glucose | transaminase | Hypoglycemia | Blood | Metastases | Glycogenosis | Children | Mutation | Liver transplantation | Siblings | Tumors
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2010, Volume 107, Issue 38, pp. 16625 - 16630
With the notable exception of humans, uric acid is degraded to (S)-allantoin in a biochemical pathway catalyzed by urate oxidase, 5-hydroxyisourate (HIU)... 
Oxidases | Hepatocytes | Liver | Humans | Thrombocytosis | Mice | Uric acid | Platelets | Genetic mutation | Tumors | 5-hydroxyisourate hydrolase | Hepatocellular carcinoma | N-ethyl-N-nitrosourea mutagenesis | Thrombopoietin | thrombopoietin | URATE OXIDASE | PEGLOTICASE | MULTIDISCIPLINARY SCIENCES | TREATMENT-FAILURE GOUT | SERUM URIC-ACID | ALLOPURINOL | HYPERURICEMIA | TRANSTHYRETIN-RELATED PROTEIN | RASBURICASE | THROMBOCYTOSIS | uric acid | EXPRESSION | hepatocellular carcinoma | Thrombopoietin - biosynthesis | Hepatomegaly - enzymology | Molecular Sequence Data | Male | RNA, Messenger - metabolism | Urate Oxidase - metabolism | Thrombocytosis - enzymology | Mice, Mutant Strains | Female | Amidohydrolases - deficiency | Liver Neoplasms, Experimental - genetics | Genes, Tumor Suppressor | Amidohydrolases - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Uric Acid - metabolism | Uric Acid - toxicity | Amidohydrolases - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Mutant Proteins - genetics | Models, Molecular | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | Recombinant Proteins - genetics | Hepatomegaly - genetics | Amidohydrolases - chemistry | Liver Neoplasms, Experimental - etiology | Sequence Homology, Amino Acid | Point Mutation | Phenotype | Animals | Mutagenesis | Mutant Proteins - chemistry | Liver Neoplasms, Experimental - enzymology | Mice, Inbred BALB C | Hepatocytes - enzymology | Hepatomegaly - etiology | Thrombocytosis - genetics | Enzymes | Hepatomegaly | Causes of | Hydrolases | Hepatoma | Health aspects | Index Medicus | Biological Sciences
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 2014, Volume 85, Issue 2, pp. 344 - 351
Increased serum urate predicts chronic kidney disease independent of other risk factors. The use of xanthine oxidase inhibitors coincides with improved renal... 
renal | uric acid transporter | creatinine | urate | Mendelian randomization | renal function decline | METABOLIC SYNDROME | OXIDATIVE STRESS | CONTROL SAMPLE SETS | NEW-ZEALAND MAORI | ENDOTHELIAL FUNCTION | BLOOD-PRESSURE | PACIFIC ISLAND | HYPERURICEMIA | UROLOGY & NEPHROLOGY | CHRONIC KIDNEY-DISEASE | CARDIOVASCULAR RISK | United States - epidemiology | Up-Regulation | Humans | Kidney - enzymology | Male | Organic Anion Transporters - metabolism | Recovery of Function | Renal Insufficiency, Chronic - drug therapy | Organic Anion Transporters - genetics | Mendelian Randomization Analysis | Renal Insufficiency, Chronic - genetics | Female | Uric Acid - blood | Principal Component Analysis | Kidney - physiopathology | Xanthine Oxidase - antagonists & inhibitors | Xanthine Oxidase - metabolism | European Continental Ancestry Group - genetics | Genetic Predisposition to Disease | Glomerular Filtration Rate | Kidney - drug effects | Risk Factors | Linear Models | Treatment Outcome | Biomarkers - blood | Models, Statistical | Renal Insufficiency, Chronic - enzymology | Enzyme Inhibitors - therapeutic use | Renal Insufficiency, Chronic - physiopathology | Renal Insufficiency, Chronic - blood | Phenotype | Confounding Factors (Epidemiology) | Renal Insufficiency, Chronic - ethnology | Creatinine - blood | Least-Squares Analysis | Models, Genetic | Polymorphism, Single Nucleotide
Journal Article
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 1931-857X, 08/2010, Volume 299, Issue 2, pp. 336 - 346
Journal Article