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Brain research, ISSN 0006-8993, 02/2019
Cocaine abuse remains a pervasive public health problem, and treatments thus far have proven ineffective for long-term abstinence maintenance. Intensive... 
Journal Article
Neurology, ISSN 0028-3878, 03/2018, Volume 90, Issue 17, pp. E1478 - E1487
OBJECTIVETo analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the... 
ATTENTION | DAYTIME SLEEPINESS | ABNORMALITY | DEPRIVATION | HYPOCRETIN/OREXIN DEFICIENCY | CATAPLEXY | DISORDERS | COGNITION | BRAIN | CLINICAL NEUROLOGY | WORKING-MEMORY
Journal Article
JOURNAL OF CLINICAL SLEEP MEDICINE, ISSN 1550-9389, 2019, Volume 15, Issue 5, pp. 803 - 805
Journal Article
Neuropharmacology, ISSN 0028-3908, 09/2019, Volume 156, pp. 107527 - 107527
Orexins, alternatively called hypocretins, are neuropeptides with crucial role in maintaining wakefulness. The orexin system is thought to mediate a... 
Genotype | Orexins | Antisocial behaviour | HCRTR1 | Aggressiveness | PERSONALITY | 5-HTTLPR | OREXIN | IMPULSIVITY | MOTIVATION | NEUROSCIENCES | PLATELET MONOAMINE-OXIDASE | ALCOHOL-USE | HYPOCRETIN/OREXIN | PEPTIDES | PHARMACOLOGY & PHARMACY | HYPOTHALAMUS | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 05/2019, Volume 149, pp. 97 - 112
Orexin has multiple physiological functions including wakefulness, appetite, nicotine intake, and nociception. The cerebral cortex receives abundant... 
Pain | Neocortex | IP3 | Insular cortex | Hypocretin | Inhibitory synaptic transmission | ACTIVATION | PERIAQUEDUCTAL GRAY | PROTEIN-KINASE | SYNAPTIC-TRANSMISSION | CORTICAL RESPONSES | NEUROSCIENCES | HYPOCRETIN OREXIN | NEURONS | PHARMACOLOGY & PHARMACY | CELL | MODULATION
Journal Article
Behavioural Brain Research, ISSN 0166-4328, 04/2019, Volume 361, pp. 26 - 31
Orexins (OXs) system has been suggested to play a key role in regulate processes related to arousal, including anxious behaviors. However, until now, the... 
Dopamine-D2-receptor | Orexins system | Anxiety | Electroencephalographic-activity | receptor | Dopamine-D | ACTIVATION | AROUSAL | INVOLVEMENT | RECEPTOR | NEUROSCIENCES | PREFRONTAL CORTEX | HYPOCRETIN OREXIN | MESSENGER-RNA | NEURONS | BEHAVIORAL SCIENCES | EXPRESSION
Journal Article
Journal of Sleep Research, ISSN 0962-1105, 06/2019, Volume 28, Issue 3, pp. e12715 - n/a
Narcolepsy is a rare sleep disorder classified in types 1 and 2. The co‐morbidities of narcolepsy type 1, with hypocretin‐1 deficiency, are established.... 
sleep | hypersomnolence | body mass index | McGill Pain Questionnaire | OBESITY | COMORBIDITIES | FREQUENCY | CATAPLEXY | NEUROSCIENCES | CLINICAL NEUROLOGY | HYPOCRETIN OREXIN | Care and treatment | Narcolepsy | Pain | Chronic pain
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 06/2018, Volume 114, pp. 45 - 52
Adenosine participates in maintaining the excitatory/inhibitory balance in neuronal circuits. Studies indicate that adenosine levels in the cortex and... 
Lateral hypothalamus | Mitochondria | Cerebral cortex | Hippocampus | Kv1.1 knockout | COMPLEX I | KCNA1-NULL MICE | RECEPTOR | OREXIN NEURONS | NEUROSCIENCES | SEIZURES | ADENINE-NUCLEOTIDES | DEPRIVATION | HYPOCRETIN/OREXIN NEURONS | BRAIN | Index Medicus
Journal Article
Current Biology, ISSN 0960-9822, 02/2019, Volume 29, Issue 3, pp. 392 - 401.e4
Rocking has long been known to promote sleep in infants and, more recently, also in adults, increasing NREM sleep stage N2 and enhancing EEG slow waves and... 
sleep | rocking mouse model | linear acceleration | otolithic organs | Otop1 | mechanosensory rhythmic stimulation | vestibular system | HIPPOCAMPAL THETA | SLOW-WAVE ACTIVITY | NUCLEUS | ORIENTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURONS | PRETERM INFANTS | AUTONOMIC FUNCTIONS | OTOCONIAL AGENESIS | WATER BEDS | HYPOCRETIN OREXIN | CELL BIOLOGY
Journal Article
Cell Metabolism, ISSN 1550-4131, 07/2018, Volume 28, Issue 1, pp. 118 - 129.e5
We investigated relationships among immune, metabolic, and sleep abnormalities in mice with non-metastatic mammary cancer. Tumor-bearing mice displayed... 
sleep | ghrelin | glucose | breast cancer | hypocretin/orexin | leptin | IL-6 | SYSTEM | INFLAMMATION | GHRELIN | ENDOCRINOLOGY & METABOLISM | COMMON | OREXIN NEURONS | CELL BIOLOGY | Neurosciences | Sleep | Interleukins | Neurons | Leptin | Monoclonal antibodies | Breast cancer | Metastasis | Glucose | Dextrose | hypocretin | orexin
Journal Article
SLEEP MEDICINE, ISSN 1389-9457, 03/2019, Volume 55, pp. 115 - 123
Objective: The purpose of this study was to enhance our understanding of clinical trends in sleep and rapid eye movement (REM) propensity on the multiple sleep... 
DIAGNOSIS | POPULATION | Hypersomnia | SLEEP LATENCY TEST | MSLT | Gender | PARAMETERS | MULTIPLE SLEEP | CLINICAL NEUROLOGY | ONSET REM PERIODS | PREDICTORS | Narcolepsy | ASSOCIATION | Age | HYPOCRETIN OREXIN DEFICIENCY | Sleep
Journal Article
Journal of Clinical Sleep Medicine, ISSN 1550-9389, 03/2018, Volume 14, Issue 3, pp. 479 - 481
Although there are reports of narcolepsy type 1 caused by lesions of the central nervous system, there are far fewer reports of narcolepsy type 2 (NT2) caused... 
Inflammatory | Narcolepsy | Immune-Mediated | Postural Tachycardia Syndrome | Autonomic | STROKE | autonomic | postural tachycardia syndrome | HYPOCRETIN/OREXIN | SLEEP | immune-mediated | narcolepsy | inflammatory | CATAPLEXY | HYPERSOMNIA | CLINICAL NEUROLOGY | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2019, Volume 154, pp. 50 - 60
Sleep/wake states are controlled by sleep- and wake-promoting systems, and transitions between states are thought to be regulated by their reciprocal... 
Neuroplasticity | Patch clamp recording | Sleep homeostasis | Orexin | Sleep deprivation | CA2+-ACTIVATED K+ CHANNELS | STATE | OREXIN/HYPOCRETIN NEURONS | NEUROSCIENCES | DISCHARGE | LOCUS-COERULEUS | PHARMACOLOGY & PHARMACY | PREOPTIC NUCLEUS | HYPOCRETIN/OREXIN NEURONS | Neurons | Neurosciences
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2007, Volume 13, Issue 2, pp. 150 - 155
Journal Article