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Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2018, Volume 20, Issue 3, pp. 620 - 628
Aim To evaluate the safety and tolerability of dapagliflozin, a highly selective sodium‐glucose co‐transporter‐2 inhibitor, in patients with type 2 diabetes... 
antidiabetic drug | type 2 diabetes | SGLT2 inhibitor | dapagliflozin | METFORMIN | METAANALYSIS | EFFICACY | SGLT2 INHIBITORS | KETOACIDOSIS | CANAGLIFLOZIN | TOLERABILITY | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | BONE | EMPAGLIFLOZIN | Sodium-Glucose Transporter 2 Inhibitors - adverse effects | Double-Blind Method | Humans | Middle Aged | Blood Volume - physiology | Male | Treatment Outcome | Clinical Trials, Phase III as Topic | Glomerular Filtration Rate - drug effects | Reproductive Tract Infections - chemically induced | Benzhydryl Compounds - adverse effects | Urinary Tract Infections - chemically induced | Fractures, Spontaneous - chemically induced | Adult | Female | Aged | Amputation - statistics & numerical data | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemia - chemically induced | Hypoglycemic Agents - adverse effects | Glucosides - adverse effects | Clinical Trials, Phase II as Topic | Diabetic Ketoacidosis - chemically induced | Type 2 diabetes | Clinical trials | Complications and side effects | Urinary tract infections | Hypoglycemic agents | Glucose transporter | Creatinine | Renal function | Diabetes mellitus | Data processing | Urinary tract | Ketonuria | Hypoglycemia | Fractures | Sodium | Ketoacidosis | Amputation | Diabetes | Acidosis | Diabetes mellitus (non-insulin dependent) | Metabolic acidosis | Original
Journal Article
The New England journal of medicine, ISSN 1533-4406, 2018, Volume 379, Issue 12, pp. 1107 - 1117
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2011, Volume 65, Issue 2, pp. 320 - 327
Journal Article
Nature Reviews Endocrinology, ISSN 1759-5029, 06/2016, Volume 12, Issue 6, pp. 337 - 346
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2016, Volume 18, Issue 8, pp. 812 - 819
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2014, Volume 124, Issue 12, pp. 5175 - 5190
.... Here, we evaluated mice lacking mitochondrial 3-hydroxymethylglutaryl CoA synthase (HMGCS2) to determine the role of ketogenesis in preventing diet-induced steatohepatitis... 
MEDICINE, RESEARCH & EXPERIMENTAL | PPAR-ALPHA | CONTROL MECHANISMS | INSULIN-RESISTANCE | MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL-COA SYNTHASE | CARDIOVASCULAR-DISEASE | KETONE-BODY METABOLISM | ACID OXIDATION | COENZYME-A METABOLISM | MASS-SPECTROMETRY | ADIPOSE-TISSUE | Mitochondrial Diseases - pathology | Non-alcoholic Fatty Liver Disease - pathology | Gluconeogenesis - drug effects | Hydroxymethylglutaryl-CoA Synthase - genetics | Mitochondrial Diseases - metabolism | Acyl Coenzyme A - genetics | Male | Hydroxymethylglutaryl-CoA Synthase - metabolism | Hypoglycemia - pathology | Hyperglycemia - genetics | Hyperglycemia - chemically induced | Non-alcoholic Fatty Liver Disease - chemically induced | Mice, Mutant Strains | Hyperglycemia - pathology | Hydroxymethylglutaryl-CoA Synthase - deficiency | Acyl Coenzyme A - metabolism | Hypoglycemia - genetics | Mitochondrial Diseases - genetics | Dietary Fats - adverse effects | Non-alcoholic Fatty Liver Disease - genetics | Citric Acid Cycle - drug effects | Metabolism, Inborn Errors - metabolism | Glucose - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Hypoglycemia - metabolism | Metabolism, Inborn Errors - genetics | Hyperglycemia - metabolism | Citric Acid Cycle - genetics | Animals | Gluconeogenesis - genetics | Glucose - metabolism | Mice | Metabolism, Inborn Errors - pathology | Enzymes | Carbohydrates | Liver diseases | Pathogenesis | Liver | Lipids | Glucose | Metabolism | Fatty acids | Studies | Nutrition research | Metabolites | Rodents | Diabetes
Journal Article