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1. Full Text Drug therapy: Insulin analogues
by Hirsch, IB
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 01/2005, Volume 352, Issue 2, pp. 174 - 183
ACTION PROFILE | SUBCUTANEOUS INJECTION | MEDICINE, GENERAL & INTERNAL | TYPE-1 DIABETES-MELLITUS | GLUCOSE CONTROL | REGULAR HUMAN INSULIN | BEDTIME NPH INSULIN | BASAL INSULIN | GLARGINE HOE 901 | INDUCED HYPOGLYCEMIA | IMPROVED GLYCEMIC CONTROL
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2. Drug therapy for epilepsy
: anticonvulsant drugs: usage, metabolism and untoward reactions (prevention, detection and management) by Samuel Livingston. Assisted by Irving M. Pruce
by Livingston, Samuel, 1908
1966, 234
Anticonvulsants | Epilepsy | Hypoglycemia
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3. Full Text Effects on clinical outcomes of intensifying triple oral antidiabetic drug (OAD) therapy by initiating insulin versus enhancing OAD therapy in patients with type 2 diabetes: A nationwide population‐based, propensity‐score‐matched cohort study
by Kuo, Shihchen and Yang, Chun‐Ting and Wu, Jin‐Shang and Ou, Huang‐Tz
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 02/2019, Volume 21, Issue 2, pp. 312 - 320
Aims To compare the effects of initiating insulin as a fourth-line antidiabetic therapy with the effects of enhancing oral antidiabetic drug (OAD) therapy in... 
antidiabetic drug | cardiovascular disease | cohort study | type 2 diabetes | insulin therapy | hypoglycaemia | SEVERE HYPOGLYCEMIA | CARDIOVASCULAR EVENTS | VALIDATION | METFORMIN TREATMENT | BETA-CELL FUNCTION | ALL-CAUSE MORTALITY | INSURANCE RESEARCH DATABASE | INCREASED RISK | ENDOCRINOLOGY & METABOLISM | ACUTE MYOCARDIAL-INFARCTION | ISCHEMIC-STROKE | Heart failure | Myocardial infarction | Cerebral infarction | Stroke | Mortality | Diabetes mellitus | Cardiovascular disease | Population studies | Hypoglycemia | Insulin | Coronary artery disease | Clinical outcomes | Vascular diseases | Diabetes | Health risk assessment | Diabetes mellitus (non-insulin dependent) | Heart diseases
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4. Full Text Drug therapy - Insulin lispro
by Holleman, F and Hoekstra, JBL
NEW ENGLAND JOURNAL OF MEDICINE, ISSN 0028-4793, 07/1997, Volume 337, Issue 3, pp. 176 - 183
DEPENDENT DIABETES-MELLITUS | PRO(B29)>-HUMAN INSULIN | SUBCUTANEOUS INJECTION | MEDICINE, GENERAL & INTERNAL | ANALOG | PHARMACOKINETICS | K PY MEDICINE, GENERAL & INTERNAL | HYPOGLYCEMIA UNAWARENESS | IDDM PATIENTS | RECEPTOR-BINDING | SOLUBLE HUMAN INSULIN | GROWTH-FACTOR-I
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5. Full Text 2200-PUB: Interest among T1D and T2D Patients Taking Insulin in Adding a New Drug Therapy to Prevent Nocturnal Hypoglycemia
by LIGGINS, RICHARD and PICHE, CLAUDE and RIDDELL, MICHAEL and WOOD, RICHARD and PANG, CHRISTIANNE and LAFONTAINE, MARTIN and MIDMER, MICHAEL
Diabetes, ISSN 0012-1797, 06/2019, Volume 68, Issue Supplement 1, p. 2200
Hypoglycemia (HG) and fear of HG are well-known problems for people using insulin, impacting quality of life, glycemic control, and health care cost. We... 
Anxiety | Hypoglycemia | Patients | Insulin | Quality of life
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6. Full Text Evaluating associations between the benefits and risks of drug therapy in type 2 diabetes: A joint modeling approach
by Dennis, John M and Shields, Beverley M and Jones, Angus G and Pearson, Ewan R and Hattersley, Andrew T and Henley, William E and MASTERMIND Consortium and MASTERMIND consortium
Clinical Epidemiology, ISSN 1179-1349, 2018, Volume 10, pp. 1869 - 1877
Objective: Precision medicine drug therapy seeks to maximize efficacy and minimize harm for individual patients. This will be difficult if drug response and... 
Edema | ADOPT | Precision medicine | Diabetes mellitus | Type 2 | Drug-related side effects | Joint model | Metformin | Hypoglycemia | HbA1c | Sulfonylurea compounds | Thiazolidinediones | SURVIVAL | thiazolidinediones | type 2 | edema | metformin | diabetes mellitus | joint model | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | sulfonylurea compounds | drug-related side effects | hypoglycemia | precision medicine | EXPOSURE | TO-EVENT DATA | Drugs | Type 2 diabetes | Complications and side effects | Glycosylated hemoglobin | Models | Drug therapy | Diabetes therapy | Consortia | Medicine | Fractures | Diabetes | Patients | Drug-Related Side Effects and Adverse Reactions | Glycated Hemoglobin A | Precision Medicine
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7. Full Text Efficacy and Safety of Canagliflozin, an Inhibitor of Sodium-Glucose Cotransporter 2, When Used in Conjunction With Insulin Therapy in Patients With Type 2 Diabetes
by Neal, Bruce and Perkovic, Vlado and de Zeeuw, Dick and Mahaffey, Kenneth W and Fulcher, Greg and Ways, Kirk and Desai, Mehul and Shaw, Wayne and Capuano, George and Alba, Maria and Jiang, Joel and Vercruysse, Frank and Meininger, Gary and Matthews, David and CANVAS Trial Collaborative Grp and CANVAS Trial Collaborative Group
Diabetes Care, ISSN 0149-5992, 03/2015, Volume 38, Issue 3, pp. 403 - 411
OBJECTIVE There are limited data about the effects of sodium-glucose cotransporter 2 inhibitors when used with insulin. We report the efficacy and safety of... 
METFORMIN | GLYCEMIC CONTROL | PLACEBO | MONOTHERAPY | SULFONYLUREA | SITAGLIPTIN | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | RANDOMIZED-TRIAL | POOLED ANALYSIS | MELLITUS | Glycosuria - chemically induced | Hypovolemia - chemically induced | Thiophenes - adverse effects | Humans | Middle Aged | Glycated Hemoglobin A - drug effects | Male | Thiophenes - administration & dosage | Weight Loss - drug effects | Dose-Response Relationship, Drug | Glomerular Filtration Rate - drug effects | Hypoglycemic Agents - administration & dosage | Urinary Tract Infections - chemically induced | Female | Blood Pressure - drug effects | Drug Therapy, Combination | Glucosides - adverse effects | Double-Blind Method | Insulin - administration & dosage | Treatment Outcome | Hypoglycemia - drug therapy | Sodium-Glucose Transporter 2 - antagonists & inhibitors | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - blood | Diabetes Mellitus, Type 2 - physiopathology | Canagliflozin | Glucosides - administration & dosage | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Mycoses - chemically induced | Clinical trials | Prescription drugs | Diabetes | Safety | Drug therapy | Index Medicus
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8. Full Text Effect of Sensor-Augmented Insulin Pump Therapy and Automated Insulin Suspension vs Standard Insulin Pump Therapy on Hypoglycemia in Patients With Type 1 Diabetes: A Randomized Clinical Trial
by Ly, Trang T and Nicholas, Jennifer A and Retterath, Adam and Lim, Ee Mun and Davis, Elizabeth A and Jones, Timothy W
JAMA, ISSN 0098-7484, 09/2013, Volume 310, Issue 12, pp. 1240 - 1247
IMPORTANCE Hypoglycemia is a critical obstacle to the care of patients with type 1 diabetes. Sensor-augmented insulin pump with automated low-glucose insulin... 
RESPONSES | MEDICINE, GENERAL & INTERNAL | REDUCTION | ADOLESCENTS | IDDM | ADULTS | RISK | AWARENESS | DURATION | CHILDREN | Humans | Middle Aged | Child, Preschool | Insulin - administration & dosage | Male | Treatment Outcome | Diabetes Mellitus, Type 1 - drug therapy | Blood Glucose - drug effects | Young Adult | Hypoglycemic Agents - administration & dosage | Adolescent | Adult | Female | Insulin Infusion Systems | Hypoglycemia - chemically induced | Child | Hypoglycemic Agents - adverse effects | Insulin - adverse effects | Diabetic Ketoacidosis - chemically induced | Therapy | Pumps | Clinical trials | Diabetes | Hypoglycemia | Insulin | Patients | Index Medicus | Abridged Index Medicus
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9. Full Text Type 2 Diabetes Diabetes in Older Adults: Example for Patient-Centered Drug Therapy
by Müller-Wieland, Dirk
Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 02/2018, Volume 143, Issue 4, pp. 253 - 261
type 2 diabetes | hypoglycemia | patient relevance | dementia | age
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10. Full Text Severe Hypoglycemia from Helicobacter Pylori triple-drug therapy and insulin detemir drug interaction
by Otsuka, Shelley H
Pharmacotherapy, ISSN 0277-0008, 04/2013, Volume 33, Issue 4, pp. e45 - e49
Two drugs commonly used in triple-drug therapy for treatment of a Helicobacter pylori infection, clarithromycin and omeprazole, have rarely been associated... 
Triple-drug therapy | Drug interaction | H. pylori | Insulin detemir | Hypoglycemia | CLARITHROMYCIN | triple-drug therapy | insulin detemir | drug interaction | hypoglycemia | OMEPRAZOLE | pylori | PHARMACOLOGY & PHARMACY | TREAT | Clarithromycin - adverse effects | Humans | Omeprazole - administration & dosage | Anti-Ulcer Agents - adverse effects | Male | Omeprazole - adverse effects | Insulin Detemir | Anti-Ulcer Agents - administration & dosage | Insulin, Long-Acting - adverse effects | Drug Therapy, Combination - adverse effects | Drug Interactions | Insulin, Long-Acting - administration & dosage | Helicobacter Infections - drug therapy | Aged, 80 and over | Clarithromycin - administration & dosage | Amoxicillin - adverse effects | Amoxicillin - administration & dosage | Anti-Bacterial Agents - adverse effects | Hypoglycemia - chemically induced | Anti-Bacterial Agents - administration & dosage | Hypoglycemic Agents - adverse effects | Omeprazole | Complications and side effects | Helicobacter pylori | Blood sugar | Drug interactions | Amoxicillin | Helicobacter infections | Diabetes | Drug therapy | Insulin | Diabetes therapy | Index Medicus
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11. Full Text Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add‐on therapy in subjects with new‐onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes (EDICT): a randomized trial
by Abdul‐Ghani, M. A and Puckett, C and Triplitt, C and Maggs, D and Adams, J and Cersosimo, E and DeFronzo, R. A
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2015, Volume 17, Issue 3, pp. 268 - 275
Aim: To test our hypothesis that initiating therapy with a combination of agents known to improve insulin secretion and insulin sensitivity in subjects with... 
combination therapy | glycaemic control | conventional therapy | durability | Durability | Combination therapy | Conventional therapy | Glycaemic control | GLYCEMIC CONTROL | PREVENTION | OPEN-LABEL | TREATED PATIENTS | MELLITUS | FAILURE | BETA-CELL FUNCTION | GLUCOSE | ENDOCRINOLOGY & METABOLISM | GLIMEPIRIDE | INSULIN GLARGINE | Hypoglycemic Agents - therapeutic use | Metformin - therapeutic use | Humans | Middle Aged | Glycated Hemoglobin A - drug effects | Insulin Resistance | Male | Weight Loss - drug effects | Drug Therapy, Combination - methods | Thiazolidinediones - therapeutic use | Hypoglycemia - etiology | Venoms - therapeutic use | Female | Weight Gain - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemia - chemically induced | Diabetes Mellitus, Type 2 - complications | Peptides - therapeutic use | Glucose metabolism | Care and treatment | Blood sugar | Analysis | Clinical trials | Hemoglobin | Diabetes | Index Medicus
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12. Full Text A critical analysis of the clinical use of incretin-based therapies are the GLP-1 therapies safe?
by Butler, Peter C and Elashoff, Michael and Elashoff, Robert and Gale, Edwin A.M
Diabetes Care, ISSN 0149-5992, 2013, Volume 36, Issue 7, pp. 2118 - 2125
There is no question that incretin-based glucose-lowering medications have proven to be effective glucose-lowering agents. Glucagon-like peptide 1 (GLP-1)... 
Hypoglycemic Agents - therapeutic use | Receptors, Glucagon - agonists | Animals | Glucagon-Like Peptide-1 Receptor | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Diabetes Mellitus - drug therapy | Incretins - therapeutic use | Weight reducing preparations | Prevention | Complications and side effects | Obesity | Dosage and administration | Research | Hypoglycemia | Drug therapy | Risk factors | Thyroid cancer | Glucose | Pancreas | Rodents | Pancreatic cancer | Tumors | Index Medicus | Point-Counterpoint
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13. Full Text Effect of Noninsulin Antidiabetic Drugs Added to Metformin Therapy on Glycemic Control, Weight Gain, and Hypoglycemia in Type 2 Diabetes
by Phung, Olivia J and Scholle, Jennifer M and Talwar, Mehak and Coleman, Craig I
JAMA, ISSN 0098-7484, 04/2010, Volume 303, Issue 14, pp. 1410 - 1418
CONTEXT Metformin is the recommended initial drug therapy for patients with type 2 diabetes mellitus (DM). However, the optimal second-line drug when metformin... 
MEDICINE, GENERAL & INTERNAL | DIPEPTIDYL PEPTIDASE-4 INHIBITOR | EFFICACY | SAFETY | COMBINATION THERAPY | PLUS METFORMIN | VILDAGLIPTIN | CLINICAL-TRIALS | DOUBLE-BLIND | TREATED PATIENTS | MELLITUS | Hypoglycemic Agents - therapeutic use | Metformin - therapeutic use | Humans | Glycated Hemoglobin A - drug effects | Diabetes Mellitus, Type 2 - drug therapy | Drug Therapy, Combination | Hypoglycemia - drug therapy | Weight Gain | Randomized Controlled Trials as Topic | Drugs | Diabetes | Patients | Medical treatment | Index Medicus | Abridged Index Medicus
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14. Full Text Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
by Davies, Melanie J and D’Alessio, David A and Fradkin, Judith and Kernan, Walter N and Mathieu, Chantal and Mingrone, Geltrude and Rossing, Peter and Tsapas, Apostolos and Wexler, Deborah J and Buse, John B
Diabetologia, ISSN 0012-186X, 12/2018, Volume 61, Issue 12, pp. 2461 - 2498
The American Diabetes Association and the European Association for the Study of Diabetes convened a panel to update the prior position statements, published in... 
Heart failure | Costs | Weight management | Human Physiology | Patient-centred care | Glucose-lowering therapy | Hypoglycaemia | Metabolic Diseases | Internal Medicine | Cardiovascular disease | Chronic kidney disease | Type 2 diabetes mellitus | Guidelines | Medicine & Public Health | MULTIPLE DAILY INJECTIONS | FIXED-RATIO COMBINATION | COTRANSPORTER 2 INHIBITORS | GLARGINE PLUS LIXISENATIDE | RANDOMIZED CONTROLLED-TRIAL | PEPTIDE-1 RECEPTOR AGONISTS | CLINICAL-PRACTICE GUIDELINES | DIPEPTIDYL PEPTIDASE-4 INHIBITORS | ENDOCRINOLOGY & METABOLISM | INTENSIVE MEDICAL THERAPY | CARDIOVASCULAR RISK-FACTORS | Hypoglycemic Agents - therapeutic use | Sodium-Glucose Transporter 2 Inhibitors - therapeutic use | United States | Cardiovascular Diseases - drug therapy | Europe | Humans | Hyperglycemia - drug therapy | Consensus | Heart Failure - drug therapy | Renal Insufficiency, Chronic - drug therapy | Liraglutide - therapeutic use | Diabetes Mellitus, Type 2 - drug therapy | Glucagon-Like Peptide-1 Receptor - agonists | Insulin - therapeutic use | Type 2 diabetes | Hyperglycemia | Chronic kidney failure | Cardiac patients | Self-care, Health | Glucose | Business education | Dextrose | Diabetes therapy | Glucagon | Diabetes mellitus | Body weight loss | Management | Coronary artery disease | Sodium | Arteriosclerosis | Diabetes | Cardiovascular diseases | Diabetes mellitus (non-insulin dependent) | Heart diseases | Glucagon-like peptide 1 | Index Medicus
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15. Full Text Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin
by DeFronzo, Ralph A and DeFronzo, Ralph A and Lewin, Andrew and Lewin, Andrew and Patel, Sanjay and Patel, Sanjay and Liu, Dacheng and Liu, Dacheng and Kaste, Renee and Kaste, Renee and Woerle, Hans J and Woerle, Hans J and Broedl, Uli C and Broedl, Uli C
Diabetes care, ISSN 0149-5992, 03/2015, Volume 38, Issue 3, pp. 384 - 393
OBJECTIVE To evaluate the efficacy and safety of combinations of empagliflozin/linagliptin as second-line therapy in subjects with type 2 diabetes inadequately... 
ADD-ON THERAPY | DIPEPTIDYL PEPTIDASE-4 INHIBITORS | GLYCEMIC CONTROL | METAANALYSIS | COTRANSPORTER 2 INHIBITORS | SAFETY | ENDOCRINOLOGY & METABOLISM | DOUBLE-BLIND | POOLED ANALYSIS | PLACEBO-CONTROLLED TRIAL | MELLITUS | Metformin - therapeutic use | Benzhydryl Compounds - administration & dosage | Dipeptidyl-Peptidase IV Inhibitors - adverse effects | Humans | Middle Aged | Glycated Hemoglobin A - drug effects | Male | Purines - administration & dosage | Weight Loss - drug effects | Dose-Response Relationship, Drug | Benzhydryl Compounds - adverse effects | Hypoglycemic Agents - administration & dosage | Female | Quinazolines - administration & dosage | Linagliptin | Purines - adverse effects | Drug Therapy, Combination | Hypoglycemia - chemically induced | Glucosides - adverse effects | Double-Blind Method | Treatment Outcome | Dipeptidyl-Peptidase IV Inhibitors - administration & dosage | Blood Glucose - drug effects | Diabetes Mellitus, Type 2 - blood | Glucosides - administration & dosage | Quinazolines - adverse effects | Diabetes Mellitus, Type 2 - drug therapy | Hypoglycemic Agents - adverse effects | Type 2 diabetes | Clinical trials | Care and treatment | Usage | Dosage and administration | Metformin | Diabetes | Safety | Drug therapy | Index Medicus
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16. Full Text A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in Insulin-Naïve People With Type 2 Diabetes
by Kjeld Hermansen and Melanie Davies and Taudeusz Derezinski and Gabrielle Martinez Ravn and Per Clauson and Philip Home and Levemir Treat-To-Target Study Grp and on behalf of the Levemir Treat-to-Target Study Group
Diabetes Care, ISSN 0149-5992, 06/2006, Volume 29, Issue 6, pp. 1269 - 1274
A 26-Week, Randomized, Parallel, Treat-to-Target Trial Comparing Insulin Detemir With NPH Insulin as Add-On Therapy to Oral Glucose-Lowering Drugs in... 
BASAL-BOLUS REGIMEN | NOCTURNAL HYPOGLYCEMIA | GLARGINE | ASPART | WITHIN-SUBJECT VARIABILITY | ENDOCRINOLOGY & METABOLISM | WEIGHT-GAIN | IMPROVED GLYCEMIC CONTROL | MICROVASCULAR COMPLICATIONS | MELLITUS | BLOOD-PRESSURE | Body Mass Index | Glycated Hemoglobin A - analysis | Hypoglycemic Agents - therapeutic use | Body Weight | Insulin, Long-Acting | Administration, Oral | Humans | Insulin Detemir | Diabetes Mellitus, Type 2 - blood | Insulin, Isophane - therapeutic use | Hypoglycemic Agents - administration & dosage | Adult | Insulin - analogs & derivatives | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Drug Therapy, Combination | Weight Gain | Insulin - therapeutic use | Type 2 diabetes | Hypoglycemic agents | Diagnosis | Drug therapy | Health aspects | Physical examinations | Psychology | Analog | Diabetes | Participants | Hypoglycemia | Insulin | Index Medicus
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