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Food and Chemical Toxicology, ISSN 0278-6915, 09/2015, Volume 83, pp. 111 - 124
The concept of using phytochemicals has ushered in a new revolution in pharmaceuticals. Naturally occurring polyphenols (like curcumin, morin, resveratrol,... 
Neurodegenerative disease | Curcumin | Inflammation | Diabetes | Antioxidant | Cancer | OXIDATIVE STRESS | WINGLESS SIGNALING PATHWAY | FOOD SCIENCE & TECHNOLOGY | DOWN-REGULATION | CELL-CYCLE ARREST | ENDOPLASMIC-RETICULUM STRESS | FORKHEAD TRANSCRIPTION FACTORS | ARJUNOLIC ACID | IN-VITRO | RETRACTED ARTICLE. SEE | TOXICOLOGY | NF-KAPPA-B | Neoplasms - metabolism | Neuroprotective Agents - therapeutic use | Arthritis - metabolism | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Cardiovascular Diseases - prevention & control | Humans | Neurodegenerative Diseases - prevention & control | Neoplasms - prevention & control | Curcumin - metabolism | Neuroprotective Agents - metabolism | Antineoplastic Agents, Phytogenic - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Dietary Supplements - adverse effects | Neuroprotective Agents - adverse effects | Antineoplastic Agents, Phytogenic - therapeutic use | Arthritis - prevention & control | Antineoplastic Agents, Phytogenic - adverse effects | Diabetes Complications - prevention & control | Hypoglycemic Agents - therapeutic use | Cardiovascular Diseases - metabolism | Curcumin - therapeutic use | Diabetes Complications - metabolism | Curcumin - adverse effects | Neurodegenerative Diseases - metabolism | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Antioxidants - adverse effects | Hypoglycemic Agents - adverse effects | Antioxidants | Polyphenols | Nervous system diseases | Arthritis | Resveratrol | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2355 - 2369
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-CHAIN | SKELETAL-MUSCLE | PHOSPHOENOLPYRUVATE CARBOXYKINASE | ACTIVATED PROTEIN-KINASE | GLUCOKINASE TRANSLOCATION | GLUCOSE-METABOLISM | COACTIVATOR TORC2 | AICA RIBOSIDE | UPSTREAM KINASE | ISOLATED RAT HEPATOCYTES | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Metformin - metabolism | AMP-Activated Protein Kinases | Hyperglycemia - genetics | Liver - drug effects | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Glucose - genetics | Glucose - pharmacology | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Hyperglycemia - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Up-Regulation - drug effects | Animals | Gluconeogenesis - genetics | Glucose-6-Phosphatase - biosynthesis | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Protein-Serine-Threonine Kinases - pharmacology | Type 2 diabetes | Control | Usage | Genetic aspects | Research | Metformin | Gene expression | Drug therapy | Health aspects | Gluconeogenesis | Up-Regulation | Glucose-6-Phosphatase | gluconeogenesis, animal models | Liver | Protein-Serine-Threonine Kinases | Glucose | LKB1 | Life Sciences | Hypoglycemic Agents | Phosphoenolpyruvate Carboxykinase (ATP) | Human health and pathology | Hyperglycemia | Hepatocytes | AMPK | Endocrinology and metabolism | Diabetes Mellitus, Type 2
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 03/2016, Volume 23, Issue 8, pp. 774 - 791
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of... 
Natural drug | Polyphenol | Morin | Anti-oxidant | Anti-diabetic | Anti-inflammatory | Flavonoid | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | anti-oxidant | polyphenol | PSIDIUM-GUAJAVA | ANTIOXIDANT ACTIVITY RELATIONSHIPS | P-GLYCOPROTEIN | IN-VITRO | INDUCED DIABETIC-RATS | anti-inflammatory | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | flavonoid | anti-diabetic | NATURALLY-OCCURRING FLAVONOIDS | HUMAN MAST-CELLS | natural drug | QUANTITATIVE STRUCTURE | Antihypertensive Agents - pharmacology | Antioxidants - chemistry | Hypoglycemic Agents - metabolism | Antioxidants - metabolism | Humans | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Biological Products - pharmacology | Antihypertensive Agents - metabolism | Neuroprotective Agents - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Antineoplastic Agents - metabolism | Neuroprotective Agents - pharmacology | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Flavonoids - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Neuroprotective Agents - chemistry | Anti-Bacterial Agents - metabolism | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Antihypertensive Agents - chemistry | Biological Products - chemistry | Animals | Flavonoids - metabolism | Biological Products - metabolism | Anti-Bacterial Agents - pharmacology | Flavonoids - chemistry
Journal Article
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 08/2007, Volume 35, Issue 8, pp. 1308 - 1314
Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic... 
RAT | SEVERE RHABDOMYOLYSIS | COMBINATION THERAPY | LIVER | PHARMACOLOGY & PHARMACY | CERIVASTATIN | HEPATIC-UPTAKE | TRANSPLANT RECIPIENTS | ROSUVASTATIN | POLYPEPTIDE | FAMILY | Organic Anion Transporters, Sodium-Independent - genetics | Fatty Acids, Monounsaturated - pharmacology | Cricetulus | Hypolipidemic Agents - metabolism | Hypoglycemic Agents - metabolism | Taurocholic Acid - metabolism | Humans | Hepatocytes - metabolism | Simvastatin - pharmacology | Organic Anion Transporters - metabolism | Chromans - metabolism | Hepatocytes - cytology | Indoles - metabolism | Organic Anion Transporters - genetics | Drug Interactions | Anticholesteremic Agents - metabolism | Chromans - pharmacology | Fatty Acids, Monounsaturated - metabolism | Organic Anion Transporters, Sodium-Independent - metabolism | Indoles - pharmacology | Biological Transport - drug effects | Thiazolidinediones - pharmacology | Hepatocytes - drug effects | Solute Carrier Organic Anion Transporter Family Member 1B3 | CHO Cells | Pravastatin - pharmacology | Recombinant Proteins - metabolism | Taurocholic Acid - pharmacology | Cell Line | Cricetinae | Pravastatin - metabolism | Simvastatin - metabolism | Gemfibrozil - pharmacokinetics | Gemfibrozil - pharmacology | Hypolipidemic Agents - pharmacology | Thiazolidinediones - metabolism | Hypoglycemic Agents - pharmacology | Animals | Estrone - analogs & derivatives | Estrone - metabolism | Protein Binding | Fatty Acids, Monounsaturated - pharmacokinetics | Indoles - pharmacokinetics | Kinetics | Solute Carrier Organic Anion Transporter Family Member 1b1 | Anticholesteremic Agents - pharmacology | Gemfibrozil - metabolism
Journal Article
Drug Metabolism and Disposition, ISSN 0090-9556, 09/2012, Volume 40, Issue 9, pp. 1744 - 1756
Interindividual variability in activity of uptake transporters is evident in vivo, yet limited data exist in vitro, confounding in vitro-in vivo extrapolation.... 
DRUG TRANSPORTERS | IN-VITRO CLEARANCE | CRYOPRESERVED HUMAN HEPATOCYTES | HMG-COA REDUCTASE | PHARMACOLOGY & PHARMACY | ANION TRANSPORTING POLYPEPTIDES | HEPATIC-UPTAKE | HEALTHY-VOLUNTEERS | METABOLIC ENZYMES | RECEPTOR ANTAGONIST | PREDICTION | Antihypertensive Agents - pharmacology | Tetrazoles - pharmacology | Species Specificity | Valsartan | Hypoglycemic Agents - metabolism | Benzoates - metabolism | Humans | Antihypertensive Agents - metabolism | Hepatocytes - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Angiotensin II Type 1 Receptor Blockers - metabolism | Organic Anion Transporters - metabolism | Pyrimidines - metabolism | Quinolines - pharmacology | Tetrazoles - metabolism | Carbamates - metabolism | Dose-Response Relationship, Drug | Fluorobenzenes - pharmacology | Drug Interactions | Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism | Biological Transport | Piperidines - pharmacology | Hepatocytes - drug effects | Carbamates - pharmacology | Pravastatin - pharmacology | Fluorobenzenes - metabolism | Piperidines - metabolism | Pravastatin - metabolism | Valine - analogs & derivatives | Rats | Rosuvastatin Calcium | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Hypoglycemic Agents - pharmacology | Quinolines - metabolism | Animals | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Valine - metabolism | Models, Biological | Benzimidazoles - metabolism | Sulfonamides - metabolism | Benzoates - pharmacology | Benzimidazoles - pharmacology | Kinetics | Valine - pharmacology | Organic Anion Transporters - drug effects
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 06/2009, Volume 23, Issue 6, pp. 1946 - 1957
Omega-3-polyunsaturated fatty acids (omega 3-PUFAs) have well-documented protective effects that are attributed not only to eicosanoid inhibition but also to... 
adiponectin | BIOCHEMISTRY & MOLECULAR BIOLOGY | adipose tissue | MICE LACKING ADIPONECTIN | TANDEM MASS-SPECTROMETRY | LIVER-DISEASE | fatty liver disease | CELL BIOLOGY | lipid mediators | GAMMA AGONISTS | DOCOSAHEXAENOIC ACID | BIOLOGY | POLYUNSATURATED FATTY-ACIDS | PPAR-GAMMA | TNF-ALPHA | ADIPOSE-TISSUE | Dietary Fats - metabolism | AMP-Activated Protein Kinases - metabolism | Resistin - genetics | Glucose Transporter Type 4 - metabolism | Fatty Liver - pathology | Hypoglycemic Agents - metabolism | Eicosapentaenoic Acid - analogs & derivatives | Fatty Acids, Omega-3 - chemistry | Adipose Tissue - cytology | Male | Muscle, Skeletal - metabolism | Insulin Receptor Substrate Proteins - metabolism | PPAR gamma - metabolism | Adipose Tissue - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Chemokine CCL2 - metabolism | Insulin Receptor Substrate Proteins - genetics | PPAR gamma - genetics | Fatty Liver - diet therapy | Resistin - metabolism | Fatty Acids, Omega-3 - metabolism | Fatty Liver - metabolism | Glucose Transporter Type 4 - genetics | Eicosapentaenoic Acid - metabolism | Insulin Resistance | Chemokine CCL2 - genetics | Thiazolidinediones - metabolism | Obesity - metabolism | Obesity - pathology | Animals | Diet | Fatty Acids, Omega-3 - therapeutic use | Mice, Obese | Mice | Docosahexaenoic Acids - metabolism
Journal Article
Journal Article
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 10/2009, Volume 187, Issue 1, pp. 61 - 70
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-lβ (IL-1β) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential... 
ATP binding cassette transporters | Receptors | Monocytes | Cytokines | Secretion | Adenosine triphosphatases | Antibodies | Reports | Macrophages | Cell extracts | Vehicles | BINDING CASSETTE TRANSPORTER | CASPASE-1 | P2X RECEPTOR | INSULIN-SECRETION | MOUSE | ATP BINDING | INTERLEUKIN-1-BETA RELEASE | COLD AUTOINFLAMMATORY SYNDROME | SULFONYLUREA RECEPTOR | NALP3 INFLAMMASOME | CELL BIOLOGY | Hypoglycemic Agents - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Lipopolysaccharides - metabolism | Caspase 1 - metabolism | Male | Monocytes - metabolism | Caspase 1 - immunology | Monocytes - immunology | Adenosine Triphosphatases - immunology | Lipopolysaccharides - immunology | Adenosine Triphosphate - pharmacology | Inflammation - metabolism | Glyburide - pharmacology | Salmonella typhimurium - classification | Macrophages - immunology | Interleukin-1beta - secretion | Salmonella typhimurium - physiology | Salmonella typhimurium - genetics | Salmonella typhimurium - immunology | Mice, Inbred C57BL | Carrier Proteins - antagonists & inhibitors | Cells, Cultured | Adenosine Triphosphatases - metabolism | Glyburide - chemistry | Hypoglycemic Agents - chemistry | Inflammation - immunology | Glyburide - metabolism | Random Allocation | Enzyme Activation - drug effects | Hypoglycemic Agents - pharmacology | Mice, Knockout | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Glyburide - immunology | Lipopolysaccharides - pharmacology | Interleukin-18 - secretion | Mice | Mice, Inbred BALB C | Mutation | Inflammation - enzymology | Hypoglycemic Agents - immunology | Physiological aspects | Cellular proteins | Interleukin-1 | Research | Glibenclamide | Health aspects
Journal Article
Acta Physiologica, ISSN 1748-1708, 05/2009, Volume 196, Issue 1, pp. 81 - 98
As the liver is central in the maintenance of glucose homeostasis and energy storage, knowledge of the physiology as well as physiopathology of hepatic energy... 
hepatic glucose production | fatty liver | type 2 diabetes | AMP-activated protein kinase | liver | energy metabolism | Type 2 diabetes | Energy metabolism | Fatty liver | Hepatic glucose production | Liver | PHYSIOLOGY | LIPID-METABOLISM | CREB COACTIVATOR TORC2 | ACETYL-COA CARBOXYLASE | MICE LACKING ADIPONECTIN | LIVER-DISEASE | ISOLATED RAT HEPATOCYTES | SKELETAL-MUSCLE | FATTY-ACID OXIDATION | INSULIN-RESISTANCE | ADIPOSE-TISSUE | AMP-Activated Protein Kinases - metabolism | Liver - enzymology | Hypoglycemic Agents - metabolism | Humans | Homeostasis | Protein Subunits - metabolism | Liver Cirrhosis - metabolism | Aminoimidazole Carboxamide - metabolism | Energy Metabolism - physiology | Protein Subunits - genetics | Liver Cirrhosis - drug therapy | Dyslipidemias - drug therapy | Ribonucleotides - metabolism | Fatty Liver - metabolism | Fatty Liver - physiopathology | Lipid Metabolism | Mitochondria - metabolism | AMP-Activated Protein Kinases - chemistry | Fatty Liver - drug therapy | Gluconeogenesis - physiology | Animals | Aminoimidazole Carboxamide - analogs & derivatives | Dyslipidemias - metabolism | Glucose - metabolism | Protein Conformation | Liver - cytology | Protein Subunits - chemistry | Liver Cirrhosis - physiopathology | AMP-Activated Protein Kinases - genetics | Dyslipidemias - physiopathology | Glucose metabolism | Enzymes | Liver diseases | Physiological aspects | Protein biosynthesis | Insulin resistance | Glucose | Protein kinases | Health aspects | Fatty acids | Dextrose | cytology | Protein Subunits | Dyslipidemias | AMP-Activated Protein Kinases | therapeutic | Hypoglycemic Agents | Aminoimidazole Carboxamide | Mitochondria | genetics | Gluconeogenesis | chemistry | drug therapy | physiology | Liver Cirrhosis | enzymology | Fatty Liver | physiopathology | Ribonucleotides | Energy Metabolism | analogs & derivatives | MP-activated protein kinase | metabolism
Journal Article