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Journal Article
Journal Article
Journal Article
Nature Reviews Drug Discovery, ISSN 1474-1776, 2014, Volume 13, Issue 6, pp. 433 - 444
The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These transcription factors control the expression of a battery of genes... 
BINDING CASSETTE TRANSPORTER | BILIARY STEROL SECRETION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REVERSE CHOLESTEROL TRANSPORT | ALZHEIMERS-DISEASE | LOW-DENSITY-LIPOPROTEIN | PROLIFERATOR-ACTIVATED RECEPTOR | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | EXPRESSION IN-VITRO | ATHEROSCLEROSIS SUSCEPTIBILITY | LXR-ALPHA | Intestines - drug effects | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - therapeutic use | Intestines - metabolism | Orphan Nuclear Receptors - metabolism | Brain - metabolism | Drugs, Investigational - chemistry | Protein Isoforms - metabolism | Liver - drug effects | Alzheimer Disease - prevention & control | Liver X Receptors | Drug Design | Neurons - metabolism | Hypolipidemic Agents - chemistry | Drug Evaluation, Preclinical | Neurons - drug effects | Hypolipidemic Agents - adverse effects | Nerve Tissue Proteins - antagonists & inhibitors | Molecular Targeted Therapy - adverse effects | Atherosclerosis - drug therapy | Liver - metabolism | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Clinical Trials as Topic | Hypolipidemic Agents - pharmacology | Nootropic Agents - adverse effects | Nootropic Agents - chemistry | Drug Discovery | Atherosclerosis - metabolism | Brain - drug effects | Nerve Tissue Proteins - metabolism | Orphan Nuclear Receptors - antagonists & inhibitors | Animals | Signal Transduction - drug effects | Alzheimer Disease - metabolism | Lipid Metabolism - drug effects | Hypolipidemic Agents - therapeutic use | Atherosclerosis - prevention & control | Nootropic Agents - pharmacology | Protein Isoforms - antagonists & inhibitors | Care and treatment | Research | Drug discovery | Patient outcomes | Risk factors | Atherosclerosis
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 04/2015, Volume 164, pp. 229 - 238
(Gaertn.) DC. (RG) has been widely used as traditional Chinese herbal medicine for treatment of diabetes and its complications. The polysaccharide fraction of... 
Oxidative stress | Rehmannia glutinosa | Inflammation | Diabetes | Polysaccharide | Insulin | Oxidativestress | CHEMISTRY, MEDICINAL | NITRIC-OXIDE SYNTHASE | INSULIN-SECRETION | FACTOR-ALPHA | PLANT SCIENCES | TUMOR-NECROSIS-FACTOR | PANCREATIC-ISLETS | INTEGRATIVE & COMPLEMENTARY MEDICINE | CULTURED U937 MONOCYTES | MEMBRANE LIPID-PEROXIDATION | PHARMACOLOGY & PHARMACY | CORONARY-HEART-DISEASE | MOLECULAR-MECHANISMS | Diabetes Mellitus, Experimental - drug therapy | Antioxidants - chemistry | Streptozocin | Cholesterol - blood | Diabetes Mellitus, Type 1 - metabolism | Superoxide Dismutase - blood | Male | Diabetes Mellitus, Experimental - blood | Glycogen - metabolism | Liver - drug effects | Anti-Inflammatory Agents - therapeutic use | Polysaccharides - chemistry | Molecular Structure | Hypolipidemic Agents - chemistry | Diabetes Mellitus, Experimental - metabolism | Cytokines - blood | Hypoglycemic Agents - therapeutic use | Polysaccharides - therapeutic use | Anti-Inflammatory Agents - pharmacology | Glutathione Peroxidase - blood | Liver - metabolism | Pancreas - drug effects | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Pancreas - metabolism | Hypolipidemic Agents - pharmacology | Polysaccharides - pharmacology | Diabetes Mellitus, Type 1 - drug therapy | Hypoglycemic Agents - pharmacology | Antioxidants - therapeutic use | Insulin - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Rehmannia | Diabetes Mellitus, Type 1 - blood | Triglycerides - blood | Hypolipidemic Agents - therapeutic use | Mice | Polysaccharides | Hyperglycemia
Journal Article
Food and Function, ISSN 2042-6496, 12/2014, Volume 6, Issue 1, pp. 296 - 33
Beneficial effects of green tea ( Camellia sinensis , Theaceae) extracts against obesity have been reported; however, the anti-obesity ability of the major... 
SUPPLEMENTATION | OXIDATION | BODY-FAT | OBESITY | LIPID-METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | THEANINE | EPIGALLOCATECHIN GALLATE | CATECHINS | ANTIOXIDANT PROPERTIES | EXTRACT | Camellia sinensis - chemistry | Liver - pathology | Adipose Tissue, White - immunology | Obesity - immunology | Male | Obesity - blood | Anti-Obesity Agents - therapeutic use | Dietary Supplements - analysis | Liver - immunology | Polysaccharides - administration & dosage | Hypolipidemic Agents - chemistry | Polysaccharides - therapeutic use | Hypolipidemic Agents - analysis | Anti-Obesity Agents - administration & dosage | Specific Pathogen-Free Organisms | Anti-Inflammatory Agents, Non-Steroidal - analysis | Plant Extracts - isolation & purification | Random Allocation | Hyperlipidemias - prevention & control | Rats, Sprague-Dawley | Obesity - pathology | Anti-Obesity Agents - chemistry | Obesity - prevention & control | Polyphenols - analysis | Hypolipidemic Agents - therapeutic use | Polyphenols - therapeutic use | Plant Extracts - therapeutic use | Leptin - antagonists & inhibitors | Plant Extracts - chemistry | Caffeine - analysis | Caffeine - administration & dosage | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Anti-Obesity Agents - analysis | Plant Extracts - administration & dosage | Leptin - blood | Caffeine - therapeutic use | Polysaccharides - isolation & purification | Food Handling | Cytokines - blood | Plant Leaves - chemistry | Adipose Tissue, White - pathology | Polyphenols - isolation & purification | Polysaccharides - analysis | Caffeine - isolation & purification | Animals | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Hyperlipidemias - etiology | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Hypolipidemic Agents - administration & dosage | Cytokines - antagonists & inhibitors | Polyphenols - administration & dosage
Journal Article
Food and Function, ISSN 2042-6496, 3/2015, Volume 6, Issue 3, pp. 834 - 841
The present study investigated the anti-obesity and anti-diabetic effects of kaempferol glycoside (KG) fractions which were composed of four kaempferol... 
ENERGY-BALANCE | QUERCETIN | CELLS | OBESITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | GLUCOSIDES | KINASE | ALPHA | ABSORPTION | Glycated Hemoglobin A - analysis | Humans | Male | Anti-Obesity Agents - therapeutic use | Dietary Supplements - analysis | Soybeans - growth & development | Glycosides - isolation & purification | Kaempferols - isolation & purification | Diabetes Mellitus, Type 2 - etiology | Obesity - etiology | Hypolipidemic Agents - chemistry | Kaempferols - analysis | Glycosides - chemistry | Hypoglycemic Agents - therapeutic use | Hypolipidemic Agents - analysis | Kaempferols - chemistry | Obesity - complications | Diabetes Mellitus, Type 2 - prevention & control | Hypolipidemic Agents - isolation & purification | Lipid Metabolism | Plant Extracts - isolation & purification | Random Allocation | Hypoglycemic Agents - isolation & purification | Soybeans - chemistry | Anti-Obesity Agents - chemistry | Plant Leaves - growth & development | Obesity - prevention & control | Hypolipidemic Agents - therapeutic use | Plant Extracts - therapeutic use | Plant Extracts - chemistry | Hypoglycemic Agents - analysis | Diet, High-Fat - adverse effects | Anti-Obesity Agents - analysis | Kaempferols - therapeutic use | Diabetes Mellitus, Type 2 - metabolism | Adiposity | Diabetes Mellitus, Type 2 - complications | Plant Leaves - chemistry | Glycosides - analysis | Mice, Inbred C57BL | Insulin Resistance | Hypertriglyceridemia - metabolism | Hypoglycemic Agents - chemistry | Anti-Obesity Agents - isolation & purification | Obesity - metabolism | Hypertriglyceridemia - prevention & control | Animals | Hypertriglyceridemia - complications | Hypertriglyceridemia - etiology | Glycosides - therapeutic use
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2012, Volume 55, Issue 6, pp. 2769 - 2779
Journal Article