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International Journal of Radiation Oncology, Biology, Physics, ISSN 0360-3016, 2015, Volume 91, Issue 4, pp. 721 - 729
Purpose To evaluate candidate fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging biomarkers for head-and-neck... 
Radiology | Hematology, Oncology and Palliative Medicine | FDG-PET/CT | PREDICTS | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | HUMAN-PAPILLOMAVIRUS | RADIOTHERAPY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | ACCURACY | Fluorodeoxyglucose F18 - pharmacokinetics | Confidence Intervals | Prognosis | Follow-Up Studies | Humans | Middle Aged | Tomography, X-Ray Computed - methods | Laryngeal Neoplasms - diagnostic imaging | Male | Oropharyngeal Neoplasms - pathology | Positron-Emission Tomography - instrumentation | Head and Neck Neoplasms - metabolism | Laryngeal Neoplasms - pathology | Laryngeal Neoplasms - therapy | Adult | Female | Tomography, X-Ray Computed - instrumentation | Chemoradiotherapy - methods | Radiopharmaceuticals - pharmacokinetics | Blood Glucose - analysis | Head and Neck Neoplasms - diagnostic imaging | Laryngeal Neoplasms - metabolism | Head and Neck Neoplasms - therapy | Lymphatic Metastasis | Positron-Emission Tomography - methods | Head and Neck Neoplasms - pathology | Hypopharyngeal Neoplasms - therapy | Disease-Free Survival | Phenotype | Hypopharyngeal Neoplasms - metabolism | Hypopharyngeal Neoplasms - pathology | Aged | Neoplasm Staging | Hypopharyngeal Neoplasms - diagnostic imaging | Sects | Radiotherapy | Radiation | Cancer | HEAD | PATIENTS | NEOPLASMS | BIOMEDICAL RADIOGRAPHY | BIOLOGICAL MARKERS | POSITRON COMPUTED TOMOGRAPHY | FLUORODEOXYGLUCOSE | UPTAKE | RADIOLOGY AND NUCLEAR MEDICINE | NECK | COMBINED THERAPY
Journal Article
Journal of Laryngology and Otology, ISSN 0022-2151, 01/2017, Volume 131, Issue 1, pp. S36 - S40
Journal Article
Journal of Surgical Oncology, ISSN 0022-4790, 09/2018, Volume 118, Issue 4, pp. 644 - 650
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 2014, Volume 111, Issue 1, pp. 81 - 87
Abstract Objective To investigate the effect of radiation dose-escalation on local control in hypoxic versus non-hypoxic hypoxic tumours defined using [18... 
Hematology, Oncology and Palliative Medicine | Single dose irradiation | Squamous cell carcinoma | Dose escalation | Local control | [18F]FMISO positron emission tomography | Human tumour xenografts | Hypoxic volume | OXYGEN-TENSION | RADIATION ONCOLOGY | [F-18]FMISO positron emission tomography | ADVANCED HEAD | NECK-CANCER | TUMOR-CONTROL | POSITRON-EMISSION-TOMOGRAPHY | F-18 FLUOROMISONIDAZOLE | ONCOLOGY | SQUAMOUS-CELL CARCINOMA | F-18-FLUOROMISONIDAZOLE PET | FRACTIONATED-IRRADIATION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Neoplasm Recurrence, Local - radiotherapy | Cell Hypoxia - radiation effects | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Misonidazole - administration & dosage | Carcinoma, Squamous Cell - diagnostic imaging | Carcinoma, Squamous Cell - radiotherapy | Head and Neck Neoplasms - metabolism | Neoplasm Recurrence, Local - pathology | Squamous Cell Carcinoma of Head and Neck | Radiation-Sensitizing Agents - administration & dosage | Fluorine Radioisotopes - administration & dosage | Neoplasm Recurrence, Local - diagnostic imaging | Female | Neoplasm Recurrence, Local - metabolism | Head and Neck Neoplasms - diagnostic imaging | Misonidazole - analogs & derivatives | Random Allocation | Head and Neck Neoplasms - pathology | Radiopharmaceuticals - administration & dosage | Xenograft Model Antitumor Assays | Head and Neck Neoplasms - radiotherapy | Hypopharyngeal Neoplasms - radiotherapy | Animals | Hypopharyngeal Neoplasms - metabolism | Mice, Nude | Hypopharyngeal Neoplasms - pathology | Radionuclide Imaging | Cell Line, Tumor | Mice | Dose-Response Relationship, Radiation | Hypopharyngeal Neoplasms - diagnostic imaging | Nuclear radiation | Index Medicus
Journal Article
Applied Immunohistochemistry and Molecular Morphology, ISSN 1541-2016, 08/2018, Volume 26, Issue 7, pp. e79 - e85
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 12/2011, Volume 103, Issue 23, pp. 1778 - 1798
The microenvironment plays an important role in regulating tumor response to radiotherapy. Ionizing radiation can disrupt tumor vasculature, and Notch pathway... 
COLON-CANCER | INITIATING CELLS | STEM-LIKE CELLS | INHIBITION | ANGIOGENESIS | ONCOLOGY | ENDOTHELIAL-CELLS | IN-VIVO | NOTCH | HUMAN BREAST-CANCER | IONIZING-RADIATION | Immunohistochemistry | Neoplasms - metabolism | Carcinoma, Squamous Cell - metabolism | Humans | Colorectal Neoplasms - radiotherapy | Immunoblotting | Transplantation, Heterologous | Luminescent Measurements | Carcinoma, Squamous Cell - radiotherapy | Necrosis | Dibenzazepines - pharmacology | Receptors, Notch - antagonists & inhibitors | Adenocarcinoma - metabolism | Neoplasms - radiotherapy | Neovascularization, Pathologic - prevention & control | Antineoplastic Agents - pharmacology | Neovascularization, Pathologic - radiotherapy | Colorectal Neoplasms - metabolism | Adenocarcinoma - radiotherapy | Radiation, Ionizing | Signal Transduction | Ultrasonography, Doppler | Antibodies, Monoclonal - pharmacology | Neoplasms - blood supply | Combined Modality Therapy | Adenocarcinoma - blood supply | Hypopharyngeal Neoplasms - radiotherapy | Animals | Hypopharyngeal Neoplasms - metabolism | Mice, Nude | Blood Flow Velocity | Cell Line, Tumor | Carcinoma, Squamous Cell - blood supply | Mice | Neovascularization, Pathologic - metabolism | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - immunology | Animal experimentation | Doppler ultrasonography | Control | Usage | Xenotransplantation | Patient outcomes | Drug therapy | Radiotherapy | Health aspects | Tumors
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62002
Cancer stem cells contribute to the malignant phenotypes of a variety of cancers, but markers to identify human hypopharyngeal cancer (HPC) stem cells remain... 
INITIATING CELLS | RECEPTOR P75(NTR) | MULTIDISCIPLINARY SCIENCES | ORAL-CANCER | RESISTANCE | SELF-RENEWAL | NANOG | IDENTIFICATION | CARCINOMA | EXPRESSION | NECK-CANCER | Neoplasm Transplantation | Hypopharyngeal Neoplasms - genetics | Matrix Metalloproteinases - genetics | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Homeodomain Proteins - metabolism | Humans | Gene Expression Regulation, Neoplastic | Hypopharynx - metabolism | Transplantation, Heterologous | Receptors, Nerve Growth Factor - metabolism | Hypopharyngeal Neoplasms - mortality | Carcinoma, Squamous Cell - mortality | Neoplastic Stem Cells - metabolism | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Nanog Homeobox Protein | Hypopharynx - pathology | Cisplatin - pharmacology | Mice, SCID | Nerve Tissue Proteins - genetics | Homeodomain Proteins - genetics | Receptors, Nerve Growth Factor - genetics | Nerve Tissue Proteins - metabolism | Animals | Hypopharyngeal Neoplasms - metabolism | Hypopharyngeal Neoplasms - pathology | Survival Analysis | Mice, Inbred NOD | Biomarkers, Tumor - genetics | Mice | Matrix Metalloproteinases - metabolism | Neoplasm Staging | Throat cancer | Analysis | Stem cells | CD34 antigen | Prognosis | Matrix metalloproteinases | Oral cancer | Invasiveness | Immunodeficiency | Stem cell transplantation | Biology | Metastasis | Radiation therapy | Esophagus | Medicine | Studies | Pathology | Chemotherapy | Allografts | Medical prognosis | Surgery | Laboratory animals | Growth factors | Tumors | Cancer | University graduates
Journal Article
Modern Pathology, ISSN 0893-3952, 08/2012, Volume 25, Issue 8, pp. 1069 - 1078
Evidence indicates that human ether a-go-go-related gene 1 (HERG1) voltage-gated potassium channels could represent new valuable membrane therapeutic targets... 
dysplasia | metastasis | cancer risk | HERG1 | potassium channel | immunohistochemistry | head and neck squamous cell carcinoma | CANCER-CELLS | PROTEIN | CARDIAC-ARRHYTHMIA | PROLIFERATION | EAG | PATHOLOGY | FAMILY | THERAPEUTIC TARGETS | ION CHANNELS | K+ CHANNEL | EXPRESSION | Hypopharyngeal Neoplasms - genetics | Larynx - metabolism | Prognosis | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Ether-A-Go-Go Potassium Channels - metabolism | Male | Precancerous Conditions - metabolism | Hypopharyngeal Neoplasms - mortality | Carcinoma, Squamous Cell - diagnosis | Carcinoma, Squamous Cell - mortality | Precancerous Conditions - diagnosis | Hypopharyngeal Neoplasms - diagnosis | Precancerous Conditions - mortality | Cell Transformation, Neoplastic - genetics | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Laryngeal Neoplasms - genetics | Gene Expression | Laryngeal Neoplasms - metabolism | Kaplan-Meier Estimate | Survival Rate | Ether-A-Go-Go Potassium Channels - genetics | Cell Transformation, Neoplastic - metabolism | Precancerous Conditions - genetics | Disease Progression | Larynx - pathology | Laryngeal Neoplasms - mortality | Hypopharyngeal Neoplasms - metabolism | Spain - epidemiology | Cell Line, Tumor | Cell Transformation, Neoplastic - pathology | Neoplasm Staging | Laryngeal Neoplasms - diagnosis
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2012, Volume 227, Issue 9, pp. 3344 - 3353
Journal Article
Anticancer Research, ISSN 0250-7005, 04/2013, Volume 33, Issue 4, pp. 1555 - 1562
Journal Article
Oral Oncology, ISSN 1368-8375, 2013, Volume 50, Issue 2, pp. 128 - 134
Summary Objectives Head and neck squamous cell carcinomas (HNSCCs) are characterized by marked heterogeneity in their biological behavior and response to... 
Otolaryngology | Hematology, Oncology and Palliative Medicine | Immunohistochemistry | Squamous cell carcinoma | 5-Fluorouracil | Outcome | Chemotherapy response | Biomarkers | Head and neck cancer | Cisplatin | INDUCTION CHEMOTHERAPY | INDUCED APOPTOSIS | CYCLIN D1 | TUMOR RESPONSE | CANCER | ONCOLOGY | DENTISTRY, ORAL SURGERY & MEDICINE | PROTEIN EXPRESSION | FACTOR RECEPTOR EXPRESSION | P53 GENE STATUS | INHIBITOR | Cyclin D1 - metabolism | Prognosis | Carcinoma, Squamous Cell - metabolism | Humans | Middle Aged | Caspase 3 - metabolism | Male | Antineoplastic Agents - therapeutic use | Neoplasm Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p16 | Fluorouracil - therapeutic use | Proto-Oncogene Proteins c-bcl-2 - metabolism | Receptor, Epidermal Growth Factor - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Biomarkers, Tumor - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Laryngeal Neoplasms - drug therapy | Adult | Female | Proto-Oncogene Proteins c-akt - metabolism | Laryngeal Neoplasms - metabolism | Tumor Suppressor Protein p53 - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Carcinoma, Squamous Cell - drug therapy | Cisplatin - therapeutic use | Hypopharyngeal Neoplasms - metabolism | Aged | Hypopharyngeal Neoplasms - drug therapy | Proliferating Cell Nuclear Antigen - metabolism | Chemotherapy | Cancer
Journal Article