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science & technology (171) 171
life sciences & biomedicine (170) 170
hyporesponsiveness (130) 130
humans (113) 113
male (95) 95
female (86) 86
animals (80) 80
biological and medical sciences (67) 67
immunology (60) 60
medical sciences (57) 57
adult (43) 43
middle aged (39) 39
rats (31) 31
mice (30) 30
aged (27) 27
urology & nephrology (24) 24
medicine, research & experimental (23) 23
research & experimental medicine (23) 23
pharmacology & pharmacy (22) 22
fundamental and applied biological sciences. psychology (21) 21
anemia (20) 20
anemia - drug therapy (20) 20
erythropoietin (20) 20
dose-response relationship, drug (19) 19
hemodialysis (19) 19
adolescent (18) 18
vaccination (18) 18
health aspects (17) 17
t-lymphocytes - immunology (17) 17
transplantation (17) 17
vascular hyporesponsiveness (17) 17
allergy and immunology (16) 16
antibodies, bacterial - blood (16) 16
analysis (15) 15
cell biology (15) 15
erythropoietin - therapeutic use (15) 15
infectious diseases (15) 15
lipopolysaccharides - pharmacology (15) 15
mice, inbred balb c (15) 15
nitric oxide (15) 15
rats, wistar (15) 15
surgery (15) 15
child (14) 14
child, preschool (14) 14
inflammation (14) 14
mice, inbred c57bl (14) 14
vaccines (14) 14
anesthesia. intensive care medicine. transfusions. cell therapy and gene therapy (13) 13
cells, cultured (13) 13
general & internal medicine (13) 13
infant (13) 13
lipopolysaccharide (13) 13
microbiology (13) 13
risk factors (13) 13
t cells (13) 13
tolerance (13) 13
abridged index medicus (12) 12
anemia - etiology (12) 12
cytokines (12) 12
intensive care medicine (12) 12
kidney failure, chronic - therapy (12) 12
renal dialysis - adverse effects (12) 12
research (12) 12
treatment outcome (12) 12
erythropoietin hyporesponsiveness (11) 11
hematology (11) 11
immune tolerance (11) 11
immunoglobulin g - blood (11) 11
physiological aspects (11) 11
pneumococcal vaccines - immunology (11) 11
polysaccharides (11) 11
recombinant proteins (11) 11
sepsis (11) 11
chronic kidney disease (10) 10
dendritic cells (10) 10
donor-specific hyporesponsiveness (10) 10
drug resistance (10) 10
follow-up studies (10) 10
hematinics - therapeutic use (10) 10
hemoglobin (10) 10
immunotherapy (10) 10
kidney failure, chronic - complications (10) 10
rats, sprague-dawley (10) 10
signal transduction (10) 10
age (9) 9
anaemia (9) 9
antigens (9) 9
dendritic cells - immunology (9) 9
disease models, animal (9) 9
donor‐specific hyporesponsiveness (9) 9
enzyme-linked immunosorbent assay (9) 9
esa hyporesponsiveness (9) 9
in vitro techniques (9) 9
kidney failure, chronic - blood (9) 9
pharmacology. drug treatments (9) 9
pneumococcal vaccines - administration & dosage (9) 9
retrospective studies (9) 9
transplantation, homologous (9) 9
young adult (9) 9
anemia - blood (8) 8
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1. Full Text Acetate Promotes T Cell Effector Function during Glucose Restriction
by Qiu, Jing and Villa, Matteo and Sanin, David E and Buck, Michael D and O’Sullivan, David and Ching, Reagan and Matsushita, Mai and Grzes, Katarzyna M and Winkler, Frances and Chang, Chih-Hao and Curtis, Jonathan D and Kyle, Ryan L and Van Teijlingen Bakker, Nikki and Corrado, Mauro and Haessler, Fabian and Alfei, Francesca and Edwards-Hicks, Joy and Maggi, Leonard B and Zehn, Dietmar and Egawa, Takeshi and Bengsch, Bertram and Klein Geltink, Ramon I and Jenuwein, Thomas and Pearce, Edward J and Pearce, Erika L
Cell reports (Cambridge), ISSN 2211-1247, 05/2019, Volume 27, Issue 7, pp. 2063 - 2074.e5
acetate | T cell hyporesponsiveness | effector functions | chromatin remodeling | T cell exhaustion | tumor-infiltrating lymphocytes | tumor immunity | acetyl-CoA synthetase | T cells | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus
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2. Full Text Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
by Presotto, Danilo and Erdes, Efe and Duong, Minh Ngoc and Allard, Mathilde and Regamey, Pierre-Olivier and Quadroni, Manfredo and Doucey, Marie-Agnès and Rufer, Nathalie and Hebeisen, Michael
Frontiers in immunology, ISSN 1664-3224, 2017, Volume 8, p. 1564
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3. Full Text Ventral–striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: A meta-analytic review of the fMRI literature
by Plichta, M.M and Scheres, A.P.J
Neuroscience and biobehavioral reviews, ISSN 0149-7634, 2014, Volume 38, pp. 125 - 134
ADHD | Hyporesponsiveness | Impulsivity | Ventral striatum | Reward | Ventral-striatal hypoactivation | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Behavioral Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Behavioral psychophysiology | Psychology. Psychoanalysis. Psychiatry | Attention deficit disorders. Hyperactivity | Psychology. Psychophysiology | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Child clinical studies | Attention Deficit Disorder with Hyperactivity - physiopathology | Basal Ganglia - physiopathology | Humans | Anticipation, Psychological - physiology | Male | Impulsive Behavior - physiopathology | Young Adult | Magnetic Resonance Imaging | Adolescent | Adult | Female | Models, Neurological | Psychotherapy | Magnetic resonance imaging | Analysis | Attention-deficit hyperactivity disorder | Index Medicus | Ventral–striatal hypoactivation
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4. Full Text TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion
by Seo, Hyungseok and Chen, Joyce and González-Avalos, Edahí and Samaniego-Castruita, Daniela and Das, Arundhoti and Wang, Yueqiang H and López-Moyado, Isaac F and Georges, Romain O and Zhang, Wade and Onodera, Atsushi and Wu, Cheng-Jang and Lu, Li-Fan and Hogan, Patrick G and Bhandoola, Avinash and Rao, Anjana
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 06/2019, Volume 116, Issue 25, pp. 12410 - 12415
T cell hyporesponsiveness | TOX2 | TOX | NR4A | CD8 | NFAT | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Tumor Microenvironment | Lymphocyte Depletion | Transcription Factors - genetics | Transcription Factors - metabolism | Neoplasms - therapy | Animals | Neoplasms - immunology | Immunotherapy | Protein Binding | Mice | CD8-Positive T-Lymphocytes - immunology | Lymphocytes, Tumor-Infiltrating - immunology | Antigens | Transcription factors | Calcium | Cytokines | Tumor-infiltrating lymphocytes | CD8 antigen | Calcineurin | Leukemia | Activator protein 1 | Lymphocytes T | Leucine | NF-AT protein | Nuclear receptors | Leucine zipper proteins | Chimeric antigen receptors | Receptors | Lymphocytes | Exhaustion | Disruption | Solid tumors | Tumors | Index Medicus | Biological Sciences | CD8+ T cell hyporesponsiveness
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5. Full Text Using dynamic treatment regimes to understand erythropoietin-stimulating agent hyporesponsiveness
by Pollack, Ari H and Oron, Assaf P and Flynn, Joseph T and Munshi, Raj
Pediatric nephrology (Berlin, West), ISSN 0931-041X, 8/2018, Volume 33, Issue 8, pp. 1411 - 1417
Pediatrics | Nephrology | End-stage renal disease (ESRD) | Erythropoietin-stimulating agent hyporesponsiveness (ESAH) | Medicine & Public Health | Anemia | Dynamic treatment regime | Hemodialysis | Hemoglobin | Urology | Life Sciences & Biomedicine | Urology & Nephrology | Science & Technology | End-stage renal disease | Erythropoietin | Kidney diseases | Cardiovascular diseases | Patients | Kidney transplantation | Index Medicus | Erythropoietin stimulating agent hyporesponsiveness (ESAH) | End stage Renal Disease (ESRD) | Dynamic Treatment Regime
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6. Full Text Pneumococcal conjugate vaccine induced IgG and nasopharyngeal carriage of pneumococci: Hyporesponsiveness and immune correlates of protection for carriage
by Ojal, John and Hammitt, Laura L and Gaitho, John and Scott, J. Anthony G and Goldblatt, David
Vaccine, ISSN 0264-410X, 08/2017, Volume 35, Issue 35, pp. 4652 - 4657
Pneumococcal conjugate vaccine | Hyporesponsiveness | Nasopharyngeal carriage | Correlates of protection | Kenya | Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Heptavalent Pneumococcal Conjugate Vaccine - immunology | Carrier State - epidemiology | Immunoglobulin G - blood | Kenya - epidemiology | Humans | Vaccines, Conjugate - adverse effects | Carrier State - microbiology | Infant | Male | Pneumococcal Vaccines - administration & dosage | Vaccination - adverse effects | Streptococcus pneumoniae - immunology | Vaccines, Conjugate - immunology | Pneumococcal Infections - immunology | Female | Pneumococcal Vaccines - adverse effects | Nasopharynx - microbiology | Antibodies, Bacterial - blood | Infant, Newborn | Serotyping | Heptavalent Pneumococcal Conjugate Vaccine - administration & dosage | Carrier State - immunology | Serogroup | Vaccines, Conjugate - administration & dosage | Pneumococcal Infections - epidemiology | Heptavalent Pneumococcal Conjugate Vaccine - adverse effects | Pneumococcal Infections - prevention & control | Pneumococcal Vaccines - immunology | Infants | Vaccines | Immunoglobulin G | Vaccination | Medical research | Analysis | Medicine, Experimental | Police | Neonates | Immune response | Thresholds | Clinical trials | Data processing | Homology | Disease control | Clear cutting | Streptococcus infections | Carriers | Immunogenicity | Newborn babies | Serotypes | Population control | Immune system | Index Medicus
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7. Full Text Pilot Study Evaluating Regulatory T Cell–Promoting Immunosuppression and Nonimmunogenic Donor Antigen Delivery in a Nonhuman Primate Islet Allotransplantation Model
by Lei, J and Kim, J. I and Shi, S and Zhang, X and Machaidze, Z and Lee, S and Schuetz, C and Martins, P. N and Oura, T and Farkash, E. A and Rosales, I. A and Smith, R. N and Stott, R and Lee, K. M and Soohoo, J and Boskovic, S and Cappetta, K and Nadazdin, O. M and Yamada, Y and Yeh, H and Kawai, T and Sachs, D. H and Benichou, G and Markmann, J. F
American journal of transplantation, ISSN 1600-6135, 10/2015, Volume 15, Issue 10, pp. 2739 - 2749
graft survival | Donor‐specific hyporesponsiveness | donor‐specific transfusion/antigen delivery | tolerance | tolerance: depletion | donor-specific transfusion/antigen delivery | Donor-specific hyporesponsiveness | Transplantation | Life Sciences & Biomedicine | Surgery | Science & Technology | Islets of Langerhans Transplantation - immunology | Graft Survival - immunology | Pilot Projects | Animals | Graft Rejection - prevention & control | Immunosuppressive Agents - therapeutic use | Isoantigens - immunology | Primates | Lymphocyte Transfusion - methods | Graft Rejection - immunology | Drug Therapy, Combination | T-Lymphocytes, Regulatory - immunology | Antigens | Analysis | Immunotherapy | Glucose | T cells | Glucose tolerance tests | Dextrose | Transplants & implants | Cell survival | Syngeneic grafts | Carbodiimide | Pancreatic islet transplantation | Thymoglobulin | Rapamycin | Lymphocytes T | Immunosuppression | Allografts | Islet cells | Alloantibodies | Pancreas | Index Medicus
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8. Full Text Contribution of IL-17 in Steroid Hyporesponsiveness in Obese Asthmatics Through Dysregulation of Glucocorticoid Receptors alpha and beta
by Al Heialy, Saba and Gaudet, Mellissa and Ramakrishnan, Rakhee K and Mogas, Andrea and Salameh, Laila and Mahboub, Bassam and Hamid, Qutayba
Frontiers in immunology, ISSN 1664-3224, 08/2020, Volume 11, pp. 1724 - 1724
Life Sciences & Biomedicine | Immunology | Science & Technology | Index Medicus | asthma | glucocorticoid receptors | steroid hyporesponsiveness | inflammation | obesity | IL-17
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9. Full Text Erythropoietic Response and Outcomes in Kidney Disease and Type 2 Diabetes
by Solomon, Scott D and Uno, Hajime and Lewis, Eldrin F and Eckardt, Kai-Uwe and Lin, Julie and Burdmann, Emmanuel A and de Zeeuw, Dick and Ivanovich, Peter and Levey, Andrew S and Parfrey, Patrick and Remuzzi, Giuseppe and Singh, Ajay K and Toto, Robert and Huang, Fannie and Rossert, Jerome and McMurray, John J.V and Pfeffer, Marc A and Trial Reduce Cardiovasc Events Ara and Trial to Reduce Cardiovascular Events with Aranesp Therapy (TREAT) Investigators
The New England journal of medicine, ISSN 0028-4793, 09/2010, Volume 363, Issue 12, pp. 1146 - 1155
HEMOGLOBIN | MORTALITY | TRIAL | HYPORESPONSIVENESS | MANAGEMENT | HEMODIALYSIS-PATIENTS | SECONDARY ANALYSIS | RISK | ANEMIC PATIENTS | EPOETIN-ALPHA | UMCG Approved | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | General aspects | Diabetes. Impaired glucose tolerance | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Kidney Failure, Chronic - mortality | Erythropoietin - therapeutic use | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Risk | Erythropoietin - analogs & derivatives | Anemia - drug therapy | Injections, Subcutaneous | Cardiovascular Diseases - epidemiology | Female | Stroke - epidemiology | Anemia - etiology | Diabetes Mellitus, Type 2 - complications | Double-Blind Method | Hematinics - therapeutic use | Proportional Hazards Models | Hemoglobins - metabolism | Chi-Square Distribution | Diabetes Mellitus, Type 2 - blood | Kidney Failure, Chronic - blood | Diabetes Mellitus, Type 2 - mortality | Kidney Failure, Chronic - complications | Aged | Darbepoetin alfa | Type 2 diabetes | Erythropoietin | Patient outcomes | Kidney diseases | Drug therapy | Cardiovascular diseases | Health aspects | Risk factors | Anemia | Index Medicus | Abridged Index Medicus
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10. Full Text T cells and reactive oxygen species
by Belikov, Aleksey V and Schraven, Burkhart and Simeoni, Luca
Journal of biomedical science, ISSN 1021-7770, 10/2015, Volume 22, Issue 1, pp. 85 - 85
T lymphocytes | Hyporesponsiveness | Oxidative stress | Signaling | TCR | AICD | ROS | Activation | Differentiation | Apoptosis | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | T-Lymphocytes - immunology | Animals | Lymphocyte Activation | Reactive Oxygen Species - immunology | Humans | Oxidative Stress - immunology | Physiological aspects | Cellular proteins | Immune response | Nucleic acids | T cells | Enzymes | Flow cytometry | Oxygen | Senescence | Kinases | Metabolism | Proteins | Antioxidants | Mitochondria | Microscopy | Lymphocytes | Oxidation | Index Medicus
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11.