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Amino Acids, ISSN 0939-4451, 5/2015, Volume 47, Issue 5, pp. 1053 - 1063
TFF3 is a member of the trefoil factor family (TFF) predominantly secreted by mucous epithelia. Minute amounts are also expressed in the immune system and the... 
Life Sciences | Biochemistry, general | Immunohistochemistry | Brain | Analytical Chemistry | Neuron | Life Sciences, general | Trefoil factor | Biochemical Engineering | Proteomics | Neurobiology | TFF3 | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FACTOR FAMILY PEPTIDES | HUMAN HYPOTHALAMUS | INTESTINAL TREFOIL FACTOR | COLOCALIZATION | GENE-EXPRESSION | OXYTOCIN | NEURONS | PITUITARY | NEUROPEPTIDE | Oligodendroglia - metabolism | Abortion, Spontaneous | Amygdala - chemistry | Pituitary Gland - metabolism | White Matter - metabolism | Hippocampus - chemistry | Mesencephalon - metabolism | Choroid Plexus - chemistry | Humans | Middle Aged | Choroid Plexus - metabolism | Peptides - genetics | Male | Pituitary Gland - chemistry | Cerebral Cortex - metabolism | Peptides - metabolism | Trefoil Factor-3 | Adult | Female | Fetus | Neurons - metabolism | White Matter - chemistry | Hypothalamus - chemistry | Oligodendroglia - chemistry | Cerebral Cortex - chemistry | Gene Expression | Neurons - chemistry | Cerebellum - metabolism | Pituitary Gland, Posterior - chemistry | Amygdala - metabolism | Mesencephalon - chemistry | Organ Specificity | Hippocampus - metabolism | Hypothalamus - metabolism | Brain Mapping | Pituitary Gland, Posterior - metabolism | Cerebellum - chemistry | Nervous system diseases | Peptides | Alcoholism | Schizophrenia | Alzheimer's disease | Human | Enrichment | Cellular | Amino acids | Object recognition
Journal Article
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 2868 - 2873
A central challenge to the development of protein-based therapeutics is the inefficiency of delivery of protein cargo across the mammalian cell membrane,... 
Protein delivery | Genome editing | CRISPR/Cas9 | Cre recombinase | Lipid nanoparticle | THERAPEUTICS | genome editing | COMBINATORIAL LIBRARY | VIVO | RNA | CELLS IN-VITRO | CAS9 PROTEIN | TRANSFECTION | MULTIDISCIPLINARY SCIENCES | CANCER-THERAPY | lipid nanoparticle | protein delivery | INTRACELLULAR DELIVERY | Endonucleases - genetics | Thalamus - metabolism | Nanoparticles - chemistry | Humans | Green Fluorescent Proteins - genetics | Structure-Activity Relationship | Recombinant Proteins - biosynthesis | Endosomes - metabolism | Drug Carriers | Luminescent Proteins - biosynthesis | RNA - genetics | Cholesterol - chemistry | Endocytosis | Lipids - chemistry | Integrases - administration & dosage | Endonucleases - administration & dosage | Recombination, Genetic | Nanoparticles - metabolism | Molecular Structure | Genes, Reporter | Genetic Engineering - methods | Bacterial Proteins - genetics | Genes, Synthetic | Ceramides - chemistry | Lipids - administration & dosage | Gene Knockout Techniques | Static Electricity | Nanoparticles - toxicity | Bacterial Proteins - administration & dosage | Animals | Hypothalamus - metabolism | Lipids - chemical synthesis | Green Fluorescent Proteins - biosynthesis | CRISPR-Cas Systems | Luminescent Proteins - genetics | Mice | Nanoparticles - administration & dosage | HeLa Cells | Integrases - genetics | Phosphatidylethanolamines - chemistry | Nanoparticles | Genetic aspects | Nucleotide sequencing | Lipid metabolism | Health aspects | Methods | DNA sequencing | CRISPR | Physical Sciences | Cas9
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2003, Volume 100, Issue 25, pp. 15247 - 15252
A neuropeptide was isolated from a frog brain extract by HPLC purification and characterized by mass spectrometry. This 26-aa neuropeptide, which belongs to... 
Frogs | Polymerase chain reaction | Biological Sciences | Messenger RNA | Databases | Complementary DNA | Food intake | Rats | Neuropeptides | Mice | Food consumption | GONADOTROPIN-RELEASE | FROG BRAIN | PROLACTIN-RELEASING PEPTIDE | FOOD-INTAKE | MULTIDISCIPLINARY SCIENCES | BIOLOGICAL-ACTIVITY | SPINAL-CORD | GENE FAMILY | SECRETOGRANIN-II | AMIDE PEPTIDE | UROTENSIN-II | Rats, Wistar | Humans | Molecular Sequence Data | Male | Chromatography, High Pressure Liquid | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Nerve Tissue Proteins - chemistry | Cell Nucleus - metabolism | In Situ Hybridization | Peptide Biosynthesis | Time Factors | Mass Spectrometry | Cloning, Molecular | Nerve Tissue Proteins - biosynthesis | Cyclic AMP - metabolism | Expressed Sequence Tags | Amino Acid Sequence | Peptides - chemistry | Databases as Topic | Sequence Homology, Amino Acid | Animals | Hypothalamus - metabolism | Ranidae | Genome, Human | DNA, Complementary - metabolism | Neuropeptides - chemistry | Research | arginylphenylalaninamide | orexin | Peptides | Neurons and Cognition | Neurobiology | Hypothalamus | Cellular Biology | Chemical Sciences | Life Sciences | Pharmaceutical sciences | Cell Behavior | Cyclic AMP | Nerve Tissue Proteins | Pharmacology | Medicinal Chemistry | RNA, Messenger | Cell Nucleus | DNA, Complementary
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e44331
Objective: The aim is to characterize subgroups or phenotypes of rheumatoid arthritis (RA) patients using a systems biology approach. The discovery of subtypes... 
METABONOMICS | LIQUID-CHROMATOGRAPHY | PRINCIPAL-COMPONENTS-ANALYSIS | STRATEGY | MULTIDISCIPLINARY SCIENCES | ACYLCARNITINES | TRADITIONAL CHINESE MEDICINE | SYSTEMS | CLASSIFICATION | MASS-SPECTROMETRY | DISEASE-ACTIVITY | Multivariate Analysis | Rheumatoid Factor - blood | Cold Temperature | Pituitary-Adrenal System - physiopathology | Rheumatology - methods | Medicine, Chinese Traditional | Humans | Middle Aged | Hot Temperature | Metabolomics - methods | Arthritis, Rheumatoid - metabolism | Chemistry, Clinical - methods | Phenotype | Adult | Female | Surveys and Questionnaires | Aged | Arthritis, Rheumatoid - classification | C-Reactive Protein - biosynthesis | Arthritis, Rheumatoid - diagnosis | Hypothalamo-Hypophyseal System - physiopathology | Precision Medicine - methods | Medical research | Rheumatoid factor | Dehydroepiandrosterone | C-reactive protein | Medicine, Experimental | Hormones, Sex | Arthritis | Information management | Plasma | Metabolomics | Laboratories | Science | Hypothalamus | Multivariate analysis | Subgroups | Cell adhesion & migration | Chinese medicine | Metabolites | Precision medicine | Breakdown | Urine | Analytical chemistry | Data analysis | Immune response | Muscles | Data processing | Hypothalamic-pituitary-adrenal axis | Metabolism | Gene expression | Joint diseases | Patients | Disease control | Fatty acids | Chronic fatigue syndrome | Physics | Disease prevention | Medicine | Heat | Dehydroepiandrosterone sulfate | Rheumatoid arthritis | Pituitary | Clinical medicine | Sulfate | Apoptosis
Journal Article
Journal of Comparative Neurology, ISSN 0021-9967, 06/2001, Volume 435, Issue 1, pp. 6 - 25
Journal Article
Brain Research, ISSN 0006-8993, 1999, Volume 827, Issue 1, pp. 243 - 260
Orexin (ORX)-A and -B are recently identified neuropeptides, which are specifically localized in neurons within and around the lateral hypothalamic area (LHA)... 
Immunohistochemistry | Feeding behavior | Hypothalamus | Orexin | SYSTEM | feeding behavior | IBOTENIC ACID LESIONS | POSTERIOR REGIONS | NEUROSCIENCES | LATERAL HYPOTHALAMIC AREA | OBESITY | INGESTIVE BEHAVIOR | MICE | orexin | immunohistochemistry | LEPTIN RECEPTOR | PROJECTIONS | EXPRESSION | hypothalamus | Antibody Specificity | Age Factors | Rats, Wistar | Hippocampus - chemistry | Dorsomedial Hypothalamic Nucleus - physiology | Septal Nuclei - physiology | Male | Neurons - cytology | Cerebellum - physiology | Brain Stem - cytology | Brain Stem - physiology | Basal Ganglia - cytology | Olfactory Pathways - physiology | Neurons - ultrastructure | Hypothalamic Area, Lateral - physiology | Dorsomedial Hypothalamic Nucleus - chemistry | Carrier Proteins - analysis | Carrier Proteins - immunology | Neuropeptides - analysis | Neurons - chemistry | Orexins | Presynaptic Terminals - chemistry | Septal Nuclei - chemistry | Intracellular Signaling Peptides and Proteins | Rats | Amygdala - cytology | Cell Size - physiology | Basal Ganglia - physiology | Feeding Behavior - physiology | Brain Chemistry - physiology | Olfactory Pathways - chemistry | Animals | Cerebellum - cytology | Neuropeptides - immunology | Hippocampus - physiology | Pituitary Gland - cytology | Amygdala - physiology | Hypothalamic Area, Lateral - chemistry | Pituitary Gland - physiology
Journal Article