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BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2016, Volume 1861, Issue 6, pp. 491 - 500
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2009, Volume 284, Issue 52, pp. 36213 - 36222
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2017, Volume 543, Issue 7645, pp. 385 - 390
Journal Article
Cell, ISSN 0092-8674, 08/2016, Volume 166, Issue 4, pp. 867 - 880
Journal Article
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, ISSN 0363-6119, 04/2008, Volume 294, Issue 4, pp. 1185 - 1196
Two recent, large whole-genome association studies (GWAS) in European populations have associated a ∼47-kb region that contains part of the FTO gene with high... 
Obesity | Adipose tissue | Hypothalamus | CUTL1 | CCAAT DISPLACEMENT PROTEIN | DNA-BINDING | PHYSIOLOGY | DROSOPHILA-MELANOGASTER | CUT REPEATS | adipose tissue | FUSED-TOES FT | ADULT OBESITY | BARDET-BIEDL-SYNDROME | TRANSCRIPTION FACTOR | WING MARGIN | obesity | hypothalamus | GENOME-WIDE ASSOCIATION | Bardet-Biedl Syndrome - metabolism | Homeodomain Proteins - metabolism | Humans | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | RNA, Messenger - metabolism | Obesity - genetics | Embryo, Mammalian - metabolism | Mixed Function Oxygenases | Adipose Tissue - metabolism | Transfection | Gene Expression Regulation, Developmental | Oxo-Acid-Lyases - genetics | Bardet-Biedl Syndrome - genetics | Fasting - metabolism | Oxo-Acid-Lyases - metabolism | Energy Metabolism - genetics | Nuclear Proteins - genetics | Repressor Proteins - metabolism | Disease Models, Animal | Eating | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Cultured | Gene Expression Regulation | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Leptin - genetics | Adiposity - genetics | Homeodomain Proteins - genetics | Obesity - metabolism | Proteins - genetics | Animals | Hypothalamus - metabolism | Proteins - metabolism | Adipocytes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Hypothermia, Induced | Mice, Obese | Mice | Polymorphism, Single Nucleotide | Adaptor Proteins, Signal Transducing - metabolism | Proteins | Tissue | Genomics | Rodents | Mutation | Gene expression | Binding sites | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 02/2013, Volume 17, Issue 2, pp. 236 - 248
Neuropepetide Y (NPY) is best known for its powerful stimulation of food intake and its effects on reducing energy expenditure. However, the pathways involved... 
ENERGY-BALANCE | BODY-WEIGHT | MESSENGER-RNA | ADAPTIVE THERMOGENESIS | FOOD-INTAKE | ENDOCRINOLOGY & METABOLISM | BROWN ADIPOSE-TISSUE | NORMAL RATS | NEUROPEPTIDE-Y INFUSION | DIET-INDUCED OBESITY | VENTROMEDIAL HYPOTHALAMUS | CELL BIOLOGY | Thermogenesis - genetics | Tyrosine 3-Monooxygenase - metabolism | Temperature | Receptors, Neuropeptide Y - metabolism | Arcuate Nucleus of Hypothalamus - cytology | Male | Neurons - cytology | Neuropeptide Y - genetics | Paraventricular Hypothalamic Nucleus - enzymology | RNA, Messenger - metabolism | Sympathetic Nervous System - metabolism | Neuropeptide Y - metabolism | Paraventricular Hypothalamic Nucleus - cytology | Mitochondrial Proteins - metabolism | Diet, High-Fat | Models, Animal | Energy Metabolism - genetics | Pro-Opiomelanocortin - genetics | Arcuate Nucleus of Hypothalamus - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Gene Expression Regulation | Feeding Behavior | Signal Transduction - genetics | Agouti-Related Protein - metabolism | Pro-Opiomelanocortin - metabolism | Tyrosine 3-Monooxygenase - genetics | Animals | Ion Channels - metabolism | Oxygen Consumption - genetics | Neurons - enzymology | Glutamate Decarboxylase - metabolism | Adipose Tissue, Brown - metabolism | Mice | Uncoupling Protein 1 | Neuropeptide Y | Tyrosine | Neurosciences | Neurons | Eating disorders | Phenols | Universities and colleges | Hydroxylases | Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 2007, Volume 5, Issue 6, pp. 438 - 449
Journal Article
Diabetes, ISSN 0012-1797, 05/2017, Volume 66, Issue 5, pp. 1146 - 1158
Although many biological functions of activating transcription factor 4 (ATF4) have been identified, a role of hypothalamic ATF4 in the regulation of energy... 
AMINO-ACID | LIPID-METABOLISM | LEPTIN ACTION | ENDOCRINOLOGY & METABOLISM | CONNECTS ER STRESS | MICE | AGRP NEURONS | AUTOPHAGY | DIET-INDUCED OBESITY | LIVER STEATOSIS | BALANCE | Leptin - metabolism | Adipose Tissue, White - metabolism | Autophagy-Related Protein 5 - genetics | Adipose Tissue - metabolism | Neurons - metabolism | Energy Metabolism - genetics | Real-Time Polymerase Chain Reaction | Adipose Tissue, White - pathology | Glucose Tolerance Test | Signal Transduction | Growth Hormone - metabolism | Adipose Tissue - pathology | Insulin Resistance | Activating Transcription Factor 4 - genetics | Organ Size | Adipose Tissue, Brown - pathology | Blotting, Western | Mice, Knockout | Pro-Opiomelanocortin - metabolism | Insulin - metabolism | Animals | Hypothalamus - metabolism | Norepinephrine - metabolism | Activating Transcription Factor 4 - metabolism | Hypothalamus - cytology | Fluorescent Antibody Technique | Autophagy-Related Protein 5 - metabolism | Adipose Tissue, Brown - metabolism | Corticosterone - metabolism | Mice | Blood Glucose - metabolism | Homeostasis | Obesity | Transcription factors | Care and treatment | Research | Melanocyte-stimulating hormone | Body fat | Neurons | Activating transcription factor 4 | Energy expenditure | Proopiomelanocortin | Hypothalamus | High fat diet | Glucose tolerance | Signal transduction | Energy balance | Intolerance | Energy | Clonal deletion | Leptin | Oils & fats | Phagocytosis | Metabolic disorders | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 11/2008, Volume 28, Issue 46, pp. 12107 - 12119
Recent studies in adult and weanling rats show that dietary fat, in close association with circulating lipids, can stimulate expression of hypothalamic... 
Lipids | Maternal high-fat diet | Hypothalamus | Food intake | Orexigenic peptides | Neurogenesis | orexigenic peptides | lipids | EMBRYONIC-DEVELOPMENT | LEPTIN RECEPTOR ISOFORMS | CELL GENERATION | DOPAMINERGIC-NEURONS | DIABETIC MOTHER RATS | NEUROSCIENCES | NEUROPEPTIDE-Y | CIRCULATING TRIGLYCERIDES | PARAVENTRICULAR NUCLEUS | MESSENGER-RNA | maternal high-fat diet | neurogenesis | hypothalamus | food intake | Dietary Fats - metabolism | Hypothalamus - secretion | Opioid Peptides - secretion | Cell Proliferation | Fetal Nutrition Disorders - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Galanin - secretion | Melanins - metabolism | Galanin - metabolism | Melanins - secretion | Pituitary Hormones - metabolism | Female | Intracellular Signaling Peptides and Proteins - secretion | Obesity - etiology | Neurons - metabolism | Neuropeptides - secretion | Animals, Newborn | Dietary Fats - adverse effects | Hyperphagia - etiology | Orexins | Pituitary Hormones - secretion | Rats | Neuropeptides - metabolism | Obesity - physiopathology | Prenatal Exposure Delayed Effects - physiopathology | Hyperphagia - metabolism | Hypothalamus - physiopathology | Opioid Peptides - metabolism | Rats, Sprague-Dawley | Prenatal Exposure Delayed Effects - metabolism | Obesity - metabolism | Pregnancy | Hypothalamic Hormones - secretion | Animals | Hypothalamus - metabolism | Hypothalamic Hormones - metabolism | Neurogenesis - physiology | Hyperphagia - physiopathology | Appetite Regulation - physiology | Body Weight - physiology | Fetal Nutrition Disorders - physiopathology | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2016, Volume 22, Issue 7, pp. 800 - 806
Type 2 diabetes (T2D) is among the most common and costly disorders worldwide(1). The goal of current medical management for T2D is to transiently ameliorate... 
MEDICINE, RESEARCH & EXPERIMENTAL | HOMEOSTASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MODEL | SUPPRESSION | ASTROCYTES | BALANCE | CELL BIOLOGY | INSULIN | TANYCYTES | METABOLISM | INTRAVENOUS GLUCOSE-TOLERANCE | IN-VIVO | Body Composition | Ependymoglial Cells - metabolism | Injections, Intraventricular | Male | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Neoplasm Proteins - metabolism | Deoxyglucose | Neoplasm Proteins - drug effects | Brain - metabolism | Adipose Tissue - metabolism | Receptor, Insulin - genetics | Diet, High-Fat | Muscle, Skeletal - drug effects | Myocardium - metabolism | Hypothalamus - drug effects | Diabetes Mellitus, Experimental - metabolism | Real-Time Polymerase Chain Reaction | Disease Models, Animal | Glucose Tolerance Test | Heat-Shock Proteins - drug effects | Heat-Shock Proteins - metabolism | Liver - metabolism | Proto-Oncogene Proteins c-fos - metabolism | Rats | Ependymoglial Cells - drug effects | Receptor, Insulin - antagonists & inhibitors | Remission Induction | Blotting, Western | Proto-Oncogene Proteins c-fos - drug effects | Mice, Knockout | Blood Glucose - drug effects | Brain - drug effects | Hyperglycemia - metabolism | Rats, Zucker | Animals | Hypothalamus - metabolism | Hypothalamus - cytology | Fibroblast Growth Factor 1 - pharmacology | Heart - drug effects | Mice, Obese | Mice | Blood Glucose - metabolism | Adipose Tissue - drug effects | Forkhead Box Protein O1 - genetics | Carbon Radioisotopes | Type 2 diabetes | Molecular targeted therapy | Care and treatment | Innovations | Development and progression | Genetic aspects | Fibroblast growth factors | Health aspects | Fibroblasts | Diabetes | Drug therapy | Rodents | Index Medicus | brain | diabetes | fibroblast growth factor
Journal Article