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Thorax, ISSN 0040-6376, 12/2017, Volume 72, Issue Suppl 3, p. A160
IntroductionHypoxic challenge test consisting of breathing 15% FiO2 for 20 min with blood gas measurements is recommended by BTS guidelines for the assessment... 
Hypoxia
Journal Article
Circulation research, ISSN 1524-4571, 2015, Volume 117, Issue 1, pp. 65 - 79
Hypoxia inducible factors (HIFs) are α/β heterodimeric transcription factors that direct multiple cellular and systemic responses in response to changes in... 
hypoxia | dioxygenases | prolyl hydroxylases | hypoxia inducible factor | CARDIAC & CARDIOVASCULAR SYSTEMS | INDUCIBLE FACTOR-I | PULMONARY-HYPERTENSION | MYOCARDIAL-INFARCTION | HIGH-ALTITUDE | HETEROZYGOUS DEFICIENCY | GENE-ENVIRONMENT INTERACTION | INTERMITTENT HYPOXIA | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | CAROTID-BODY | PROLYL 4-HYDROXYLASES | HEMATOLOGY | Adaptation, Physiological | Polycythemia - genetics | Heart Defects, Congenital - embryology | Cardiovascular Diseases - drug therapy | Heart - embryology | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Cardiovascular Diseases - enzymology | Oxygen - metabolism | Hypoxia - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Hypoxia-Inducible Factor-Proline Dioxygenases - deficiency | Cell Hypoxia | Repressor Proteins - physiology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Heart Defects, Congenital - enzymology | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mixed Function Oxygenases - physiology | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - deficiency | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - physiology | Cardiovascular Diseases - metabolism | Hydroxylation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Hypertension, Pulmonary - metabolism | Cardiovascular System - enzymology | Animals | Iron - physiology | Polycythemia - enzymology | Cardiovascular System - metabolism | Ischemic Preconditioning, Myocardial | Protein Isoforms | Mice | Protein Processing, Post-Translational | Altitude | Hypoxia | oxygen sensing | HIF | 2-oxoglutarate oxygenase | hydroxylase
Journal Article
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, pp. 517 - 12
Journal Article
Journal of molecular medicine (Berlin, Germany), ISSN 1432-1440, 2007, Volume 85, Issue 12, pp. 1301 - 1307
A major feature of solid tumours is hypoxia, decreased availability of oxygen, which increases patient treatment resistance and favours tumour progression. How... 
Internal Medicine | Tumour metabolism | pH regulation | Autophagy | Angiogenesis | Biomedicine | Carbonic anhydrase | Oxygen-sensor | Bcl-2/adenovirus EIB 19 kDa-interacting protein 3 | Hypoxia-inducible factor | Hypoxia | Molecular Medicine | Cancer | Bcl-2/adenovirus EIB 19 kDa-interacting protein 3 | MEDICINE, RESEARCH & EXPERIMENTAL | hypoxia | CARBONIC-ANHYDRASE-IX | autophagy | INDUCIBLE FACTOR-I | HIF HYDROXYLASES | angiogenesis | tumour metabolism | C-MYC | TUMOR | hypoxia-inducible factor | BICARBONATE TRANSPORTERS | BREAST-CANCER | oxygen-sensor | GLUCOSE-METABOLISM | GENETICS & HEREDITY | carbonic anhydrase | cancer | GROWTH-FACTOR | EXPRESSION | Neoplasms - metabolism | Hypoxia - drug therapy | Cell Proliferation | Prognosis | Humans | Angiogenesis Inhibitors - pharmacology | Neoplasms - blood supply | Antineoplastic Agents - therapeutic use | Hypoxia-Inducible Factor 1 - metabolism | Oxygen - metabolism | Hypoxia - metabolism | Neoplasms - drug therapy | Cell Hypoxia | Neoplasm Metastasis | Phenotype | Animals | Signal Transduction - drug effects | Hypoxia - pathology | Cell Death | Angiogenesis Inhibitors - therapeutic use | Antineoplastic Agents - pharmacology | Neovascularization, Pathologic - metabolism | Neoplasms - pathology | Hydrogen-Ion Concentration | Development and progression | Research | DNA binding proteins | Health aspects | Risk factors | Oxygen | Anoxia | Signal Transduction | Hypoxia-Inducible Factor 1 | Biochemistry, Molecular Biology | Neovascularization, Pathologic | Antineoplastic Agents | Angiogenesis Inhibitors | Neoplasms | Life Sciences
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2012, Volume 87, Issue 6, p. 134
ABSTRACT Preeclampsia affects 5%–8% of pregnancies and is the leading worldwide cause of maternal and fetal morbidity and mortality. Preeclampsia is associated... 
angiogenesis | hypoxia-inducible factor-1 (HIF1A | soluble Fms-like tyrosine kinase-1 (sFLT-1) | endothelin-,1 hypoxia | HIF-1α | preeclampsia | angiotensin II receptor type I autoimmune antibody | soluble endoglin | Angiotensin II receptor type I autoimmune antibody | Solublefms-like tyrosine kinase-1 (sFLT-1) | Angiogenesis | Soluble endoglin | Endothelin-,1 hypoxia, hypoxia-inducible factor-1 (HIF1A; HIF-1a) | Preeclampsia | hypoxia-inducible factor-1 (HIF1A; HIF-1 alpha) | ENDOTHELIAL-GROWTH-FACTOR | HUMAN PLACENTAL HYPOXIA | NECROSIS-FACTOR-ALPHA | ANGIOTENSIN-II | CATECHOL-O-METHYLTRANSFERASE | REPRODUCTIVE BIOLOGY | RECEPTOR AGONISTIC AUTOANTIBODY | TYROSINE KINASE-1 | PREGNANT RATS | UTERINE PERFUSION-PRESSURE | Humans | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Receptor, Angiotensin, Type 1 - chemistry | Antigens, CD - metabolism | Cell Hypoxia | Endoglin | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Autoantibodies - analysis | Female | Receptors, Cell Surface - chemistry | Antigens, CD - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Pre-Eclampsia - metabolism | Endothelin-1 - chemistry | Placenta - immunology | Endothelin-1 - metabolism | Solubility | Receptors, Cell Surface - metabolism | Receptors, Cell Surface - blood | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Pre-Eclampsia - etiology | Endothelin-1 - blood | Placenta - metabolism | Pregnancy | Antigens, CD - blood | Animals | Pre-Eclampsia - blood | Vascular Endothelial Growth Factor Receptor-1 - blood | Pre-Eclampsia - immunology
Journal Article
Physiological reviews, ISSN 1522-1210, 2012, Volume 92, Issue 3, pp. 967 - 1003
Hypoxia is a fundamental stimulus that impacts cells, tissues, organs, and physiological systems. The discovery of hypoxia-inducible factor-1 (HIF-1) and... 
RAT CAROTID-BODY | IMPAIRED VENTILATORY RESPONSES | VON-HIPPEL-LINDAU | OBSTRUCTIVE SLEEP-APNEA | PHYSIOLOGY | HUMAN ERYTHROPOIETIN GENE | ARTERY SMOOTH-MUSCLE | HIF-1 TRANSCRIPTIONAL ACTIVITY | NF-KAPPA-B | ENDOTHELIAL GROWTH-FACTOR | PAS DOMAIN PROTEIN | Adaptation, Physiological | Erythropoiesis | Respiration Disorders - etiology | Oxidative Stress | Pulmonary Ventilation | Blood Vessels - metabolism | Cardiovascular Diseases - prevention & control | Humans | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Cardiovascular Diseases - genetics | Hypoxia-Inducible Factor 1 - metabolism | Carotid Body - metabolism | Hypoxia - metabolism | Hypoxia-Inducible Factor 1 - genetics | Blood Vessels - physiopathology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cardiovascular Diseases - etiology | Cardiovascular Diseases - physiopathology | Basic Helix-Loop-Helix Transcription Factors - genetics | Cardiovascular Diseases - metabolism | Signal Transduction | Gene Expression Regulation | Respiration Disorders - physiopathology | Hypoxia - complications | Respiration Disorders - metabolism | Oxygen - blood | Respiration Disorders - genetics | Hypoxia - genetics | Animals | Ischemic Preconditioning, Myocardial | Hypoxia - physiopathology | Oxidative stress | Respiratory organs | Causes of | Homeostasis | Physiological aspects | Hypoxia | Sleep apnea syndromes | Research | Respiratory physiology | Cardiopulmonary system
Journal Article
Journal of cellular and molecular medicine, ISSN 1582-1838, 2013, Volume 17, Issue 1, pp. 30 - 54
Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors, HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐... 
Hypoxia‐inducible factors | Targeted therapies | Cancer‐initiating cells | Hypoxia | Cancer progression | Metabolic pathways | Cancer stem/progenitor cells | Metastasis‐initiating cells | Metastases | Hypoxia-inducible factors | Cancer-initiating cells | Metastasis-initiating cells | MEDICINE, RESEARCH & EXPERIMENTAL | CLINICALLY RELEVANT SUBTYPES | PANCREATIC-CANCER | Cancer stem | progenitor cells | CHRONIC MYELOID-LEUKEMIA | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | PROSTATE-CANCER | GENE-EXPRESSION | FATTY-ACID SYNTHASE | ENDOTHELIAL GROWTH-FACTOR | Neoplasms - metabolism | Hypoxia - drug therapy | Neoplastic Stem Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | Molecular Targeted Therapy | Hypoxia - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasm Metastasis | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplasms - genetics | Neoplastic Stem Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Intercellular Signaling Peptides and Proteins - genetics | Transcription Factors - genetics | Neoplasms - drug therapy | Transcription Factors - metabolism | Hypoxia - genetics | Hypoxia - pathology | Cell Transformation, Neoplastic - drug effects | Neoplasms - pathology | Apoptosis | Prevention | Glucose metabolism | Physiological aspects | Development and progression | Genetic transcription | Metastasis | Transforming growth factors | Vascular endothelial growth factor | Cancer | Energy metabolism | Transcription factors | Mesenchyme | AKT protein | Insulin-like growth factors | Kinases | Autophagy | Cancer therapies | Neoplasms | Proteins | Homing | Angiogenesis | Signal transduction | Receptors | Epidermal growth factor | Bone marrow | Tumor necrosis factor-TNF | miRNA | Growth factors | Deprivation | Cell survival | Cytokines | Epidermal growth factor receptors | Breast cancer | Rapamycin | Metabolism | Gene expression | Cell differentiation | Insulin | CXCR4 protein | 1-Phosphatidylinositol 3-kinase | Signaling | Pancreatic cancer | Stem cells | Glycolysis | Regulation | Prostate | Cell migration | Tumors | Reviews
Journal Article