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1. Full Text Large‐Scale Ex Vivo Generation of Human Red Blood Cells from Cord Blood CD34+ Cells
by Zhang, Yu and Wang, Chen and Wang, Lan and Shen, Bin and Guan, Xin and Tian, Jing and Ren, Zhihua and Ding, Xinxin and Ma, Yupo and Dai, Wei and Jiang, Yongping
STEM CELLS Translational Medicine, ISSN 2157-6564, 08/2017, Volume 6, Issue 8, pp. 1698 - 1709
The ex vivo generation of human red blood cells on a large scale from hematopoietic stem and progenitor cells has been considered as a potential method to... 
Expansion and differentiation | Transplantation | Human cord blood | Hematopoietic stem cells | Erythrocytes | Nonhuman primates | PROGENITOR CELLS | PRECURSOR EXPANSION | POPULATION | ERYTHROPOIESIS | MECHANISMS | FLT-3 LIGAND | CELL & TISSUE ENGINEERING | IN-VITRO | TRANSFUSION | HEMATOPOIETIC STEM-CELLS | DIFFERENTIATION | Antigens, CD34 - metabolism | Primary Cell Culture - methods | Humans | Cells, Cultured | Macaca fascicularis | Male | Fetal Blood - cytology | Mice, SCID | Primary Cell Culture - instrumentation | Animals | Erythrocytes - metabolism | Erythrocytes - cytology | Mice, Inbred NOD | Mice | Antigens, CD34 - genetics | Blood transfusions | CD34 antigen | Cell culture | Data analysis | Blood & organ donations | Laboratories | Research & development--R&D | Anemia | Blood cells | Stem cell transplantation | Administrative support | Blood transfusion | Progenitor cells | Hemorrhage | Hemopoiesis | Studies | Researchers | Allografts | Cord blood | Xenografts | Hemoglobin | Hypoxia
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2. Full Text Regional brain blood flow in man during acute changes in arterial blood gases
by Willie, C. K and Macleod, D. B and Shaw, A. D and Smith, K. J and Tzeng, Y. C and Eves, N. D and Ikeda, K and Graham, J and Lewis, N. C and Day, T. A and Ainslie, P. N
The Journal of Physiology, ISSN 0022-3751, 07/2012, Volume 590, Issue 14, pp. 3261 - 3275
Key points •  The partial pressures of arterial carbon dioxide () and oxygen () has a marked influence on brain blood flow. •  It is unclear if the larger... 
CO2 REACTIVITY | VELOCITY | VERTEBRAL ARTERIES | PHYSIOLOGY | CARBON DIOXIDE TENSION | CEREBROVASCULAR RESPONSE | HUMANS | ACUTE-HYPOXIA | DOPPLER ULTRASOUND | NEUROSCIENCES | EXERCISE | DYNAMIC CEREBRAL AUTOREGULATION | Hypocapnia - blood | Hypercapnia - diagnostic imaging | Cerebral Arteries - diagnostic imaging | Humans | Blood Gas Analysis | Male | Vertebral Artery - diagnostic imaging | Brain - blood supply | Vasoconstriction - physiology | Hypoxia - blood | Hypocapnia - diagnostic imaging | Ultrasonography, Doppler, Transcranial | Carotid Artery, Internal - diagnostic imaging | Adult | Female | Vasodilation - physiology | Hypoxia - diagnostic imaging | Regional Blood Flow - physiology | Blood Flow Velocity - physiology | Hypercapnia - blood | Brain | Cardiovascular
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3. Full Text The blood–brain barrier
by Daneman, Richard and Prat, Alexandre
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 01/2015, Volume 7, Issue 1, p. a020412
Blood vessels are critical to deliver oxygen and nutrients to all of the tissues and organs throughout the body. The blood vessels that vascularize the central... 
TIGHT JUNCTION STRANDS | MATRIX METALLOPROTEINASES | MULTIPLE-SCLEROSIS | MDR1A P-GLYCOPROTEIN | FOCAL CEREBRAL-ISCHEMIA | RETINAL VASCULAR DEVELOPMENT | CENTRAL-NERVOUS-SYSTEM | CAPILLARY ENDOTHELIAL-CELLS | HYPOXIA-INDUCED HYPERPERMEABILITY | AUTOIMMUNE ENCEPHALOMYELITIS | CELL BIOLOGY | Tight Junctions - metabolism | Astrocytes - physiology | Blood-Brain Barrier - cytology | Homeostasis - physiology | Humans | Blood-Brain Barrier - physiology | Basement Membrane - physiology | Muscle, Smooth, Vascular - cytology | Central Nervous System Diseases - physiopathology | Endothelial Cells - physiology | Muscle, Smooth, Vascular - physiology | 087
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4. Full Text Cerebral Blood Flow and Blood Pressure: Dependent or Codependent?
by DeWitt, Douglas S and Prough, Donald S
Critical Care Medicine, ISSN 0090-3493, 07/2019, Volume 47, Issue 7, pp. 1007 - 1009
blood pressure | ARTERIES | mean arterial pressure | CEREBROVASCULAR AUTOREGULATION | cerebral blood flow | autoregulation | PERFUSION-PRESSURE | brain hypoxia | ischemic brain injury | CRITICAL CARE MEDICINE
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5. Clinical blood gases
: assessment and intervention
by Malley, William J. 1949- (William Joseph)
2005, 2nd ed., ISBN 072168422X, xv, 523
Anoxemia | Acid-Base Imbalance | methods | Blood Gas Analysis
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6. Full Text Integrative regulation of human brain blood flow
by Willie, Christopher K and Tzeng, Yu‐Chieh and Fisher, Joseph A and Ainslie, Philip N
The Journal of Physiology, ISSN 0022-3751, 03/2014, Volume 592, Issue 5, pp. 841 - 859
Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature and... 
PHYSIOLOGY | POSITRON-EMISSION-TOMOGRAPHY | CARBON DIOXIDE TENSION | CEREBROVASCULAR CO2 REACTIVITY | HYPOXIA-INDUCED ACTIVATION | SYMPATHETIC-NERVE ACTIVITY | NITRIC-OXIDE | AUTONOMIC NEURAL-CONTROL | NEUROSCIENCES | STELLATE GANGLION BLOCK | ARTERIAL MUSCLE-CELLS | DYNAMIC CEREBRAL AUTOREGULATION | Pulmonary Gas Exchange - physiology | Cerebrovascular Circulation - physiology | Models, Cardiovascular | Humans | Autonomic Nervous System - physiology | Neurons - physiology | Blood Pressure - physiology | Feedback, Physiological - physiology | Blood Flow Velocity - physiology | Brain - physiology | Brain | Laws, regulations and rules | Blood flow | Topical Reviews
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7. Full Text Prognostic value of tumour blood flow, [18F]EF5 and [18F]FDG PET/CT imaging in patients with head and neck cancer treated with radiochemotherapy
by Komar, Gaber and Lehtiö, Kaisa and Seppänen, Marko and Eskola, Olli and Levola, Helena and Lindholm, Paula and Sipilä, Hannu and Seppälä, Jan and Grénman, Reidar and Solin, Olof and Minn, Heikki
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 11/2014, Volume 41, Issue 11, pp. 2042 - 2050
In order to improve the treatment of squamous cell carcinoma of the head and neck, precise information on the treated tumour’s biology is required and the... 
Prognosis | Oncology | [ 18 F]EF5 | Radiotherapy | Blood flow | Medicine & Public Health | Orthopedics | Hypoxia | Head and neck cancer | Nuclear Medicine | Imaging / Radiology | Cardiology | [ 18 F]FDG | PET | SURVIVAL | DISPERSION | [F-18]FDG | FLUORODEOXYGLUCOSE UPTAKE | TRACER | SQUAMOUS-CELL CARCINOMA | STANDARDIZED UPTAKE VALUE | [F-18]EF5 | DELAY | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Etanidazole - analogs & derivatives | Humans | Middle Aged | Head and Neck Neoplasms - therapy | Male | Tomography, X-Ray Computed | Positron-Emission Tomography | Hydrocarbons, Fluorinated | Chemoradiotherapy | Young Adult | Head and Neck Neoplasms - blood supply | Multimodal Imaging | Survival Analysis | Adult | Female | Fluorodeoxyglucose F18 | Head and Neck Neoplasms - diagnosis | Aged | Care and treatment | Squamous cell carcinoma | PET imaging | Tracers (Biology) | Tomography | Nuclear medicine | Chemotherapy | Radiation therapy | Head & neck cancer | Medical prognosis
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8. Full Text Evaluation of tumour hypoxia during radiotherapy using [F-18]HX4 PET imaging and blood biomarkers in patients with head and neck cancer
by Zegers, Karen and Hoebers, Frank J. P and van Elmpt, Wouter and Bons, Judith A and Öllers, Michel and Troost, Esther G. C and Eekers, Danielle and Balmaekers, Leo and Arts-Pechtold, Marlies and Mottaghy, Felix M and Lambin, Philippe
European Journal of Nuclear Medicine and Molecular Imaging, ISSN 1619-7070, 11/2016, Volume 43, Issue 12, pp. 2139 - 2146
Increased tumour hypoxia is associated with a worse overall survival in patients with head and neck squamous cell carcinoma (HNSCC). The aims of this study... 
CAIX | Medicine & Public Health | Orthopedics | VEGF | Osteopontin | Oncology | Hypoxia | Nuclear Medicine | Imaging / Radiology | Cardiology | PET | F-18 FMISO | PARAMETERS | PROGNOSTIC VALUE | RADIATION-THERAPY | TRIAL | LUNG-CANCER | PLASMA | SQUAMOUS-CELL CARCINOMA | F-18-FLUOROMISONIDAZOLE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Reproducibility of Results | Humans | Middle Aged | Male | Treatment Outcome | Positron-Emission Tomography - methods | Tumor Hypoxia - radiation effects | Biomarkers, Tumor - blood | Head and Neck Neoplasms - radiotherapy | Imidazoles | Head and Neck Neoplasms - blood | Triazoles | Sensitivity and Specificity | Female | Head and Neck Neoplasms - diagnosis | Aged | Radiopharmaceuticals | Biomarkers | Head & neck cancer | Drug therapy | Blood | Tumors | Original
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9. Full Text Serum tight-junction proteins predict hemorrhagic transformation in ischemic stroke patients
by Kazmierski, Radoslaw and Michalak, Slawomir and Wencel-Warot, Agnieszka and Nowinski, Wieslaw L
Neurology, ISSN 0028-3878, 10/2012, Volume 79, Issue 16, pp. 1677 - 1685
Objective: To evaluate the significance of circulating tight-junction (TJ) proteins as predictors of hemorrhagic transformation (HT) in ischemic stroke... 
HYPOXIA-REOXYGENATION | TISSUE-PLASMINOGEN ACTIVATOR | PERMEABILITY | FOCAL CEREBRAL-ISCHEMIA | MEDIATED DISRUPTION | ECASS II | THROMBOLYTIC THERAPY | ASSOCIATION | BRAIN | CLINICAL NEUROLOGY | ENDOTHELIAL GROWTH-FACTOR | Predictive Value of Tests | Humans | Middle Aged | Stroke - complications | Male | Tomography, X-Ray Computed | Blood Proteins - metabolism | Claudin-5 - blood | Cerebral Hemorrhage - blood | Brain Ischemia - blood | Phosphopyruvate Hydratase - blood | S100 Proteins - blood | Blood-Brain Barrier - physiology | Female | Nerve Growth Factors - blood | Zonula Occludens-1 Protein - blood | Cerebral Hemorrhage - etiology | Matrix Metalloproteinase 9 - blood | Brain Ischemia - complications | Tight Junctions - metabolism | S100 Calcium Binding Protein beta Subunit | Risk Factors | Vascular Endothelial Growth Factor A - blood | Biomarkers - blood | Stroke - blood | Nervous System Diseases - etiology | ROC Curve | Aged | Occludin - blood
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10. Full Text Hypoxic Vasodilation by Red Blood Cells: Evidence for an S-Nitrosothiol–Based Signal
by Diesen, Diana L and Hess, Douglas T and Stamler, Jonathan S
Circulation Research, ISSN 0009-7330, 08/2008, Volume 103, Issue 5, pp. 545 - 553
Red blood cells (RBCs) have been ascribed an essential role in matching blood flow to local metabolic demand during hypoxic vasodilation. The vasodilatory... 
Hemoglobin | Hypoxic vasodilation | Red blood cell | Nitric oxide | nitric oxide | CARDIAC & CARDIOVASCULAR SYSTEMS | SNO-HEMOGLOBIN | DEPENDENT VASODILATION | hypoxic vasodilation | DEOXYHEMOGLOBIN | NITRIC-OXIDE SYNTHASE | OXYGEN DELIVERY | MUSCLE | hemoglobin | FLOW | red blood cell | VASCULAR-TONE | NITROSOHEMOGLOBIN | PERIPHERAL VASCULAR DISEASE | ERYTHROCYTE | HEMATOLOGY | Humans | Endothelium, Vascular - drug effects | omega-N-Methylarginine - pharmacology | Hypoxia - metabolism | Vasoconstriction - physiology | Mice, Mutant Strains | Vasodilation - physiology | NG-Nitroarginine Methyl Ester - pharmacology | Rabbits | Nitrogen - metabolism | Oxyhemoglobins - metabolism | Mice, Inbred C57BL | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Hemoglobins - metabolism | Nitrites - pharmacology | Vasoconstriction - drug effects | Animals | Endothelium, Vascular - metabolism | Erythrocytes - metabolism | Hypoxia - physiopathology | Signal Transduction - physiology | Amidines - pharmacology | Mice | Vasodilation - drug effects | In Vitro Techniques | Regional Blood Flow - physiology | Aorta - physiology | Benzylamines - pharmacology | Nitric Oxide Synthase Type II - metabolism
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