Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (34938) 34938
Publication (3831) 3831
Newspaper Article (2105) 2105
Book Review (393) 393
Newsletter (327) 327
Book Chapter (230) 230
Conference Proceeding (68) 68
Dissertation (46) 46
Trade Publication Article (39) 39
Book / eBook (38) 38
Magazine Article (27) 27
Data Set (10) 10
Government Document (8) 8
Web Resource (4) 4
Paper (3) 3
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
hypoxia (21738) 21738
humans (19403) 19403
index medicus (18270) 18270
animals (15974) 15974
male (9681) 9681
female (8002) 8002
oncology (6571) 6571
cancer (6557) 6557
mice (6302) 6302
rats (5560) 5560
apoptosis (5162) 5162
tumors (4467) 4467
angiogenesis (4398) 4398
expression (4339) 4339
research (3746) 3746
cell line, tumor (3724) 3724
cell biology (3691) 3691
proteins (3650) 3650
gene expression (3169) 3169
middle aged (3084) 3084
analysis (2946) 2946
adult (2942) 2942
medicine (2874) 2874
neurosciences (2860) 2860
care and treatment (2859) 2859
health aspects (2838) 2838
ischemia (2810) 2810
rodents (2779) 2779
biochemistry & molecular biology (2769) 2769
hypoxia-inducible factor 1, alpha subunit - metabolism (2744) 2744
disease models, animal (2738) 2738
cell hypoxia (2667) 2667
oxidative stress (2657) 2657
article (2550) 2550
research article (2479) 2479
pharmacology & pharmacy (2476) 2476
metastasis (2470) 2470
vascular endothelial growth factor (2415) 2415
signal transduction (2374) 2374
kinases (2373) 2373
metabolism (2336) 2336
chemotherapy (2282) 2282
physiology (2273) 2273
cancer therapies (2269) 2269
aged (2225) 2225
physiological aspects (2211) 2211
rats, sprague-dawley (2208) 2208
multidisciplinary sciences (2185) 2185
endothelial growth-factor (2167) 2167
cells (2145) 2145
medicine, research & experimental (2122) 2122
activation (2102) 2102
hypoxia - drug therapy (2100) 2100
inflammation (2078) 2078
studies (2041) 2041
cells, cultured (1974) 1974
therapy (1956) 1956
stem cells (1946) 1946
apoptosis - drug effects (1937) 1937
science (1890) 1890
hypoxia - physiopathology (1854) 1854
biology (1806) 1806
oxygen (1792) 1792
time factors (1784) 1784
brain (1778) 1778
inhibition (1763) 1763
hypoxia - metabolism (1758) 1758
gene-expression (1649) 1649
growth (1620) 1620
in-vitro (1553) 1553
cell hypoxia - drug effects (1550) 1550
development and progression (1505) 1505
cell proliferation (1499) 1499
cell proliferation - drug effects (1493) 1493
treatment outcome (1461) 1461
dose-response relationship, drug (1458) 1458
medical research (1457) 1457
cell survival - drug effects (1443) 1443
hypoxia-inducible factor 1, alpha subunit - genetics (1443) 1443
signal transduction - drug effects (1440) 1440
genetic aspects (1436) 1436
antineoplastic agents - pharmacology (1428) 1428
in-vivo (1422) 1422
immunohistochemistry (1417) 1417
phosphorylation (1408) 1408
prognosis (1365) 1365
breast cancer (1338) 1338
surgery (1331) 1331
pediatrics (1329) 1329
oxygen - metabolism (1323) 1323
respiratory system (1305) 1305
risk factors (1298) 1298
rats, wistar (1295) 1295
review (1287) 1287
animals, newborn (1285) 1285
infant, newborn (1269) 1269
vascular endothelial growth factor a - metabolism (1261) 1261
drug therapy (1252) 1252
hypoxia - complications (1232) 1232
survival (1232) 1232
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (22) 22
Online Resources - Online (3) 3
UofT at Mississauga - Stacks (3) 3
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
Robarts - Stacks (1) 1
Scarborough Hospital - General (1) 1
UTL at Downsview - May be requested (1) 1
West Park Healthcare Centre - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (36156) 36156
Russian (494) 494
Chinese (225) 225
French (212) 212
German (208) 208
Japanese (96) 96
Spanish (86) 86
Italian (43) 43
Polish (40) 40
Ukrainian (25) 25
Hungarian (13) 13
Czech (11) 11
Danish (10) 10
Bulgarian (8) 8
Portuguese (7) 7
Dutch (4) 4
Korean (4) 4
Norwegian (3) 3
Romanian (3) 3
Turkish (3) 3
Hebrew (2) 2
Serbian (2) 2
Swedish (2) 2
Finnish (1) 1
Slovak (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Hypoxia, drug therapy and toxicity
by Lee, KangAe and Roth, Robert A and LaPres, John J
Pharmacology and Therapeutics, ISSN 0163-7258, 2007, Volume 113, Issue 2, pp. 229 - 246
Hypoxia is defined as a decrease in available oxygen reaching the tissues of the body. It is linked to the pathology of cancer, cardiovascular disease, and... 
Drug design and toxicity | Prolyl hydroxylase domain containing proteins | Hypoxia | Hypoxia inducible factor 1 | Factor inhibiting HIF | RAT-LIVER | hypoxia | OXIDATIVE STRESS | INDUCIBLE FACTOR 1-ALPHA | BLOOD-FLOW | hypoxia inducible factor 1 | factor inhibiting HIF | SMALL-MOLECULE INHIBITOR | prolyl hydroxylase domain containing proteins | MOUSE EMBRYONIC FIBROBLASTS | drug design and toxicity | IN-VIVO | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | MITOCHONDRIAL COMPLEX-III | ENDOTHELIAL GROWTH-FACTOR | Cell Hypoxia | Neurons - pathology | Animals | Signal Transduction | Drug-Related Side Effects and Adverse Reactions | Humans | Cell Death | Drug Therapy | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Mechanisms and Drug Therapy of Pulmonary Hypertension at High Altitude
by Scherrer, Urs and Allemann, Yves and Rexhaj, Emrush and Rimoldi, Stefano F and Sartori, Claudio
High Altitude Medicine & Biology, ISSN 1527-0297, 06/2013, Volume 14, Issue 2, pp. 126 - 133
Scherrer, Urs, Yves Allemann, Emrush Rexhaj, Stefano F. Rimoldi, and Claudio Sartori. Mechanisms and drug therapy of pulmonary hypertension at high altitude.... 
Special Topic on Pulmonary Hypertension at High Altitude | Chronic mountain sickness | Fetal growth | High altitude pulmonary edema | Free radicals | SPORT SCIENCES | free radicals | OXIDATIVE STRESS | PATENT FORAMEN OVALE | CHRONIC MOUNTAIN-SICKNESS | HYPOBARIC HYPOXIA | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | SYMPATHETIC ACTIVATION | BIOPHYSICS | high altitude pulmonary edema | chronic mountain sickness | ARTERY PRESSURE | DOWN-SYNDROME | CARDIOVASCULAR-DISEASE | VASCULAR-RESISTANCE | fetal growth | EXHALED NITRIC-OXIDE | Adaptation, Physiological | Oxidative Stress | Vasodilator Agents - therapeutic use | Humans | Hypertension, Pulmonary - physiopathology | Sympathetic Nervous System - physiopathology | Pre-Eclampsia - physiopathology | Pulmonary Edema - etiology | Pulmonary Edema - physiopathology | Foramen Ovale, Patent - physiopathology | Altitude Sickness - etiology | Altitude Sickness - physiopathology | Anti-Inflammatory Agents - therapeutic use | Female | Hypertension, Pulmonary - drug therapy | Biomarkers - metabolism | Altitude Sickness - drug therapy | Acute Disease | Endothelin-1 - metabolism | Risk Factors | Fetal Development | Antihypertensive Agents - therapeutic use | Pulmonary Edema - drug therapy | Pregnancy | Nitric Oxide - metabolism | Chronic Disease | Hypertension, Pulmonary - etiology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Targeting metabolic transformation for cancer therapy
by Tennant, Daniel A and Durán, Raúl V and Gottlieb, Eyal
Nature Reviews Cancer, ISSN 1474-175X, 04/2010, Volume 10, Issue 4, pp. 267 - 277
Cancer therapy has long relied on the rapid proliferation of tumour cells for effective treatment. However, the lack of specificity in this approach often... 
TUMOR-CELL GROWTH | PHASE-II TRIAL | PYRUVATE-KINASE | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | TEMSIROLIMUS CCI-779 | FATTY-ACID SYNTHASE | RECURRENT GLIOBLASTOMA-MULTIFORME | BREAST-CARCINOMA CELLS | KETOGENIC DIET | CARBONIC-ANHYDRASE INHIBITORS | Neoplasms - metabolism | Cell Hypoxia - drug effects | DNA Replication - drug effects | Humans | Survivors | DNA, Neoplasm - drug effects | Glycolysis - drug effects | Cell Division - drug effects | Drug Delivery Systems | Neoplasms - drug therapy | Neoplasms - genetics | Sensitivity and Specificity | Drug Design | Neoplasms - pathology | Care and treatment | Cancer cells | Physiological aspects | Cell metabolism | Research | Health aspects | Methods | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Adaptive therapy
by Gatenby, Robert A and Silva, Ariosto S and Gillies, Robert J and Frieden, B. Roy
Cancer Research, ISSN 0008-5472, 06/2009, Volume 69, Issue 11, pp. 4894 - 4903
A number of successful systemic therapies are available for treatment of disseminated cancers. However, tumor response is often transient, and therapy... 
BREAST-CANCER | SOLID TUMORS | ONCOLOGY | GROWTH | SIZE | OVARIAN-CANCER | DRUG-RESISTANCE | HYPOXIA | COMBINATION | CELL-LINE | CHEMOTHERAPY | Models, Theoretical | Humans | Antineoplastic Protocols | Antineoplastic Agents - administration & dosage | Tumor Burden | Mice, SCID | Adaptation, Biological - physiology | Feasibility Studies | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Drug Dosage Calculations | Maximum Tolerated Dose | Animals | Computer Simulation | Female | Cell Proliferation - drug effects | Mice | Neoplasms - pathology | Drug Resistance, Neoplasm - physiology | Index Medicus
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Clinical development of new drug-radiotherapy combinations
by Sharma, Ricky A and Plummer, Ruth and Stock, Julie K and Greenhalgh, Tessa A and Ataman, Ozlem and Kelly, Stephen and Clay, Robert and Adams, Richard A and Baird, Richard D and Billingham, Lucinda and Brown, Sarah R and Buckland, Sean and Bulbeck, Helen and Chalmers, Anthony J and Clack, Glen and Cranston, Aaron N and Damstrup, Lars and Ferraldeschi, Roberta and Forster, Martin D and Golec, Julian and Hagan, Russell M and Hall, Emma and Hanauske, Axel-R and Harrington, Kevin J and Haswell, Tom and Hawkins, Maria A and Illidge, Tim and Jones, Hazel and Kennedy, Andrew S and Mcdonald, Fiona and Melcher, Thorsten and O'Connor, James P. B and Pollard, John R and Saunders, Mark P and Sebag-Montefiore, David and Smitt, Melanie and Staffurth, John and Stratford, Ian J and Wedge, Stephen R and NCRI CTRad Acad-Pharma Joint Worki and NCRI CTRad Academia-Pharma Joint Working Group and on behalf of the NCRI CTRad Academia-Pharma Joint Working Group
Nature Reviews Clinical Oncology, ISSN 1759-4774, 10/2016, Volume 13, Issue 10, pp. 627 - 642
In countries with the best cancer outcomes, approximately 60% of patients receive radiotherapy as part of their treatment, which is one of the most... 
CELL LUNG-CANCER | MOLECULARLY TARGETED AGENTS | NORMAL-TISSUE | SURROGATE END-POINTS | PHASE-II TRIAL | POSITRON-EMISSION-TOMOGRAPHY | ONCOLOGY | PROSTATE-CANCER | EARLY BREAST-CANCER | ADVANCED RECTAL-CANCER | RADIATION-THERAPY | Cell Hypoxia - radiation effects | Humans | Patient Participation | Treatment Outcome | Combined Modality Therapy | Drug Approval | Radiation Dosage | Quality Assurance, Health Care | Neoplasms - drug therapy | Radiation Tolerance - radiation effects | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Neoplasms - radiotherapy | Clinical Trials as Topic - methods | Quality of Health Care | Patient Education as Topic | Evaluation | Chemotherapy | Care and treatment | Innovations | Drug therapy, Combination | Radiotherapy | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Targeting hypoxia in cancer therapy
by Hay, Michael P and Wilson, William R
Nature Reviews Cancer, ISSN 1474-175X, 06/2011, Volume 11, Issue 6, pp. 393 - 410
Hypoxia is a feature of most tumours, albeit with variable incidence and severity within a given patient population. It is a negative prognostic and predictive... 
CARBONIC-ANHYDRASE-IX | UNFOLDED PROTEIN RESPONSE | SELECTIVE ANTITUMOR AGENTS | TUMOR HYPOXIA | ONCOLOGY | HAMSTER OVARY CELLS | NITRIC-OXIDE SYNTHASE | DINITROBENZAMIDE MUSTARD PR-104A | METABOLIC-ACTIVATION | BIOREDUCTIVE DRUGS | RADIATION ONCOLOGY GROUP | Neoplasms - metabolism | Cell Hypoxia - drug effects | Prognosis | Reactive Oxygen Species - metabolism | Humans | Neoplasms - blood supply | Antineoplastic Agents - therapeutic use | Prodrugs - therapeutic use | Molecular Targeted Therapy | Biomarkers, Tumor | Neoplasms - drug therapy | Care and treatment | Development and progression | Cellular signal transduction | Metastasis | Research | Health aspects | Methods | Cancer
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights