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The Journal of clinical investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3660 - 3663
in this issue of the JCI, two reports provide intriguing new information on the role of the inflammatory cytokine IL-6 in breast and lung cancer. The study by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | PATHWAY | STAT3 | NOTCH | STEM/PROGENITOR CELLS | GROWTH-FACTOR | INTERLEUKIN-6 | IDENTIFICATION | TUMORIGENESIS | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Carbonic Anhydrases - biosynthesis | Cytokine Receptor gp130 - genetics | Receptors, Notch - metabolism | Humans | Lung Neoplasms - metabolism | Antigens, Neoplasm - biosynthesis | Spheroids, Cellular - pathology | Neoplasm Proteins - pharmacology | Receptors, Notch - genetics | Janus Kinases - metabolism | RNA, Messenger - metabolism | Serrate-Jagged Proteins | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Interleukin-6 - metabolism | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Membrane Proteins - genetics | Spheroids, Cellular - metabolism | Enzyme Inhibitors - pharmacology | Mammary Glands, Human - pathology | Lung Neoplasms - therapy | Signal Transduction - genetics | Autocrine Communication - genetics | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | RNA, Neoplasm - genetics | Stem Cells - pathology | Carcinoma - genetics | Mice | Mutation | Transcription, Genetic - genetics | Cell Hypoxia - genetics | Calcium-Binding Proteins - genetics | Neoplasm Transplantation | Carbonic Anhydrases - genetics | Lung Neoplasms - pathology | Autocrine Communication - drug effects | Mammary Glands, Human - metabolism | Neoplasm Proteins - metabolism | Stem Cells - metabolism | Breast Neoplasms - metabolism | Breast Neoplasms - therapy | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Female | Membrane Proteins - metabolism | Gene Expression Regulation, Neoplastic - drug effects | Carcinoma - pathology | STAT3 Transcription Factor - metabolism | Carbonic Anhydrase IX | Calcium-Binding Proteins - metabolism | Lung Neoplasms - genetics | Antigens, Neoplasm - genetics | Cell Hypoxia - drug effects | Janus Kinases - genetics | Neoplasm Invasiveness | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Up-Regulation - genetics | Up-Regulation - drug effects | Animals | Interleukin-6 - pharmacology | Breast Neoplasms - pathology | Interleukin-6 - biosynthesis | Carcinoma - therapy | Receptor, Notch3 | Carcinoma - metabolism | Antagonists (Biochemistry) | Epithelial tumors | Dosage and administration | Diagnosis | Research | Drug therapy | Health aspects | Interleukin-6
Journal Article
Journal Article
PLoS biology, ISSN 1545-7885, 2011, Volume 9, Issue 2, p. e1000595
Journal Article
Carcinogenesis (New York), ISSN 1460-2180, 2013, Volume 34, Issue 5, pp. 962 - 973
Journal Article
PloS one, ISSN 1932-6203, 2009, Volume 4, Issue 6, pp. e5767 - e5767
... contributions to exercise-related traits. Employing a population genetics-based hitchhiking mapping approach we performed a genome scan using 394 autosomal and X chromosome microsatellite loci and identified positively selected loci... 
STANDARD-BRED TROTTERS | DIABETES-MELLITUS | POPULATION DIFFERENTIATION | P85-ALPHA REGULATORY SUBUNIT | INSULIN-RESISTANCE | PHOSPHATIDYLINOSITOL 3-KINASE | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | BROWN ADIPOSE-TISSUE | GAMMA-HYDROXYBUTYRATE | HUMAN SKELETAL-MUSCLE | Genomics | Horses - genetics | Selection, Genetic | Genetic Variation | Chromosomes - ultrastructure | Phenotype | Animals | Alleles | Heterozygote | Hypoxia | Genome | Muscles - metabolism | Microsatellite Repeats | Type 2 diabetes | Genes | Muscles | Genomes | Muscle proteins | Fatty acids | Population genetics | Natural selection | Tenascin | Adaptations | Actinin | Racing performance | Animal populations | Food science | Dehydrogenase | Veterinary medicine | Signal transduction | Mitochondria | Exercise | Genetics | Physiology | Life sciences | Racing | Medical research | Microsatellites | Tenascin C | Metabolism | Insulin | Heterozygosity | Physical fitness | Structure-function relationships | Enrichment | Laboratories | Positive selection | Pyruvic acid | Iron | Alcohol dehydrogenase | Actin | Population | Oxidation | Muscular strength | Alpha iron | Diabetes mellitus | Cloning | Statistics | Loci | Skeletal muscle | Musculoskeletal system | Signaling | Horses | Alcoholic beverages | In vivo methods and tests | Gene mapping
Journal Article
Human molecular genetics, ISSN 0964-6906, 08/2010, Volume 19, Issue 15, pp. 3011 - 3020
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 51, pp. 42695 - 42707
Development of metastatic disease accounts for the vast majority of cancer-related deaths. Nevertheless, few treatments exist that are designed to specifically... 
ACTIVATION | ZEB1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENES | ATM | REGULATORS | HYPOXIA | MIR-200 FAMILY | CANCER | EXPRESSION | Carcinoma, Ductal, Breast - genetics | Cell Proliferation | Epithelial Cells - metabolism | Cadherins - metabolism | Polycomb Repressive Complex 1 - metabolism | Humans | Gene Expression Regulation, Neoplastic | Genetic Loci - genetics | Molecular Sequence Data | MicroRNAs - metabolism | Cell Shape - genetics | Epithelial-Mesenchymal Transition - genetics | Breast - metabolism | DNA-Binding Proteins - metabolism | Base Sequence | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Carcinoma, Ductal, Breast - pathology | Female | Cadherins - genetics | Nuclear Proteins - genetics | Breast - pathology | Protein-Serine-Threonine Kinases - metabolism | Multigene Family - genetics | Tumor Suppressor Proteins - metabolism | Neoplasm Invasiveness | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Genomic Imprinting - genetics | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Models, Biological | Twist-Related Protein 1 - genetics | Cell Line, Tumor | MicroRNAs - genetics | Twist-Related Protein 1 - metabolism | Molecular Bases of Disease | MicroRNA | Ataxia Telangiectasia Mutated | DLKI-DIO3 | Tumor Metastases | Epithelial to Mesenchymal Transition | Breast Cancer | EMT | TWIST
Journal Article
International journal of cancer, ISSN 1097-0215, 2019, Volume 145, Issue 4, pp. 1068 - 1082
The P2X7 receptor, an ATP‐gated ion channel, is critical for cancer cell growth, invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates... 
epithelial to mesenchymal transition | PI3K/Akt signaling pathway | P2X7 receptor | angiogenesis | osteosarcoma | CANCER-CELLS | ACTIVATION | INCREASES CELLULAR ATP | TUMOR | PROLIFERATION | PI3K | METABOLISM | ONCOLOGY | P2X RECEPTOR | Akt signaling pathway | PURINERGIC RECEPTORS | CHANNELS | Humans | Middle Aged | Glycogen Synthase Kinase 3 beta - genetics | Apoptosis - genetics | Male | Epithelial-Mesenchymal Transition - genetics | Vascular Endothelial Growth Factor A - genetics | Bone Neoplasms - pathology | Cell Movement - genetics | Proto-Oncogene Proteins c-akt - genetics | Receptors, Purinergic P2X7 - genetics | Young Adult | TOR Serine-Threonine Kinases - genetics | Adult | Female | Bone Neoplasms - genetics | Child | Gene Expression Regulation, Neoplastic - genetics | Cell Proliferation - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Signal Transduction - genetics | beta Catenin - genetics | Phosphatidylinositol 3-Kinases - genetics | Neoplasm Metastasis - genetics | Animals | Mice, Nude | Adolescent | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Osteosarcoma - genetics | Osteosarcoma - pathology | TOR protein | Cell proliferation | Leukocyte migration | Mesenchyme | AKT protein | Metastasis | Metastases | Angiogenesis | Biomedical materials | Cell growth | Osteosarcoma | Biocompatibility | Ion channels | Vascular endothelial growth factor | Catenin | Therapeutic applications | Glycogen | Invasiveness | Osteosarcoma cells | 1-Phosphatidylinositol 3-kinase | Signaling | Bone cancer | Molecular modelling | Cell migration | Tumors | Molecular Cancer Biology
Journal Article
Journal Article