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World Neurosurgery, ISSN 1878-8750, 12/2018, Volume 120, pp. e380 - e391
Glioblastoma (GBM) is the most common and fatal human brain tumor, with the worst prognosis. The aberrant microenvironment, enhanced by the activation of... 
Angiogenesis | Aspirin | HIF-1α | VEGF | Endothelial cells | Glioblastoma | GLIOMA-CELLS | SURGERY | APOPTOSIS | HIF-1 alpha | ACTIVATED PROTEIN-KINASE | RISK | PROLIFERATION | INTRACRANIAL HEMORRHAGE | CLINICAL NEUROLOGY | BREAST-CANCER | VENOUS THROMBOEMBOLISM | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | EXPRESSION | Humans | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor Receptor-2 - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | Glioblastoma - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Glioblastoma - metabolism | Aspirin - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Cell Survival - drug effects | Vascular Endothelial Growth Factor Receptor-2 - drug effects | Signal Transduction | Endothelial Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | bcl-2-Associated X Protein - metabolism | Angiogenesis Inhibitors - pharmacology | Brain Neoplasms - genetics | bcl-2-Associated X Protein - drug effects | Blotting, Western | Antineoplastic Agents, Immunological - pharmacology | Drug Synergism | Vascular Endothelial Growth Factor Receptor-1 - drug effects | Mitogen-Activated Protein Kinase Kinases - drug effects | Proto-Oncogene Proteins c-bcl-2 - drug effects | Glioblastoma - blood supply | Hypoxia-Inducible Factor 1, alpha Subunit - drug effects | Sunitinib - pharmacology | ras Proteins - genetics | Bevacizumab - pharmacology | Mitogen-Activated Protein Kinase Kinases - genetics | ras Proteins - metabolism | Antineoplastic Agents, Alkylating - pharmacology | Brain Neoplasms - blood supply | Temozolomide - pharmacology | Brain Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Antineoplastic Agents - pharmacology | ras Proteins - drug effects | Vascular Endothelial Growth Factor A - drug effects | bcl-2-Associated X Protein - genetics | RNA, Messenger - drug effects | Vascular Endothelial Growth Factor Receptor-1 - genetics | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Proto-Oncogene Proteins c-bcl-2 - genetics | Endothelial Cells - drug effects | Proto-Oncogene Proteins c-akt - drug effects | Evaluation | Oncology, Experimental | Brain tumors | Development and progression | Research | Antineoplastic agents | Glioblastoma multiforme | Cells | Antimitotic agents | Prevention | Chemotherapy | Analysis | Lymphomas | Temozolomide | Angiogenesis inhibitors | Vascular endothelial growth factor | Mitogens | Protein kinases | Cancer
Journal Article
Journal Article
Life Sciences, ISSN 0024-3205, 11/2018, Volume 213, pp. 126 - 133
This study investigated the effects of atorvastatin (ATS) on the paraquat (PQ)-induced epithelial-mesenchymal transition (EMT) and the potential mechanism... 
Atorvastatin | Hypoxia-inducible factor | Epithelial-mesenchymal transition | Paraquat | Pulmonary fibrosis | MEDICINE, RESEARCH & EXPERIMENTAL | B16.F10 MELANOMA-CELLS | STATIN USE | ACUTE LUNG INJURY | PPAR-GAMMA RECEPTORS | INDUCED PULMONARY-FIBROSIS | INFLAMMATION | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | HIF-1-ALPHA | SIMVASTATIN | EXPRESSION | Hypoxia-Inducible Factor 1, alpha Subunit - drug effects | A549 Cells | Cell Line | Cadherins - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Atorvastatin - metabolism | Humans | Rats | Epithelial-Mesenchymal Transition - drug effects | Male | Atorvastatin - pharmacology | Hypoxia-Inducible Factor 1 - metabolism | Rats, Sprague-Dawley | Paraquat - adverse effects | Animals | Signal Transduction - drug effects | Lung Injury - metabolism | Hypoxia | Hypoxia-Inducible Factor 1 - drug effects | Lung - metabolism | Pulmonary Fibrosis - metabolism | Lung Injury - drug therapy | Pulmonary Fibrosis - drug therapy | Zonula Occludens-1 Protein - metabolism | Herbicides | Medical colleges | Respiratory tract diseases | Poisoning | Stem cells | Antilipemic agents | Vimentin | Cell culture | Hypoxia-inducible factor 1 | Mesenchyme | Toxicity | E-cadherin | Hypoxia-inducible factor 1a | Attenuation | Catenin | Statins | Hypoxia-inducible factors | Lung diseases | Markers | Pharmacology | Gene expression | Chemical compounds | Zonula occludens-1 protein | Cell lines | Fibrosis | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, p. 10539
In soft tissue sarcomas (STS), low intratumoural O-2 (hypoxia) is a poor prognostic indicator. HIF-1 alpha mediates key transcriptional responses to hypoxia,... 
HYPOXIA INDUCIBLE FACTOR-2 | HEPATOCELLULAR-CARCINOMA | INHIBITION | ARYL-HYDROCARBON RECEPTOR | PATHWAY | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | CANCER | EXPRESSION | CELL CARCINOMA | MTOR | Hypoxia-Inducible Factor 1, alpha Subunit - drug effects | Immunohistochemistry | Neoplasm Transplantation | Hindlimb | TOR Serine-Threonine Kinases - metabolism | Epigenesis, Genetic | Humans | Gene Expression Regulation, Neoplastic | Immunoblotting | Tomography, X-Ray Computed | Hypoxia - metabolism | Mechanistic Target of Rapamycin Complex 1 | Liposarcoma - metabolism | Multiprotein Complexes - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | HEK293 Cells | Sarcoma - genetics | Basic Helix-Loop-Helix Transcription Factors - drug effects | Hydroxamic Acids - pharmacology | Liposarcoma - diagnostic imaging | Cell Proliferation - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Liposarcoma - genetics | Signal Transduction - genetics | Reverse Transcriptase Polymerase Chain Reaction | Sarcoma - metabolism | Hypoxia - genetics | Animals | Fluorescent Antibody Technique | Cell Line, Tumor | Histone Deacetylase Inhibitors - pharmacology | Sarcoma - diagnostic imaging | Calcium Signaling - genetics | In Vitro Techniques
Journal Article
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 06/2008, Volume 14, Issue 11, pp. 3589 - 3597
Journal Article
Digestive Diseases and Sciences, ISSN 0163-2116, 11/2016, Volume 61, Issue 11, pp. 3176 - 3189
Alendronate is an inhibitor of osteoclast-mediated bone resorption, but its clinical utility is limited due to gastrointestinal complications including... 
Biochemistry, general | Hydrogen sulfide | Gastroprotection | Hypoxia-inducible factor-1α | Medicine & Public Health | Alendronate | Hepatology | Gastroenterology | Oncology | Gastric blood flow | Carbon monoxide | Transplant Surgery | PHYSIOLOGY | NITROGEN-CONTAINING BISPHOSPHONATE | INDUCIBLE FACTOR-I | LIPID-PEROXIDATION | MECHANISM | RAT | Hypoxia-inducible factor-1 alpha | NITRIC-OXIDE SYNTHASE | HYPOXIA | DAMAGE | ISCHEMIA-REPERFUSION INJURY | GASTROENTEROLOGY & HEPATOLOGY | Hypoxia-Inducible Factor 1, alpha Subunit - drug effects | Interleukin-1beta - drug effects | Superoxide Dismutase - genetics | Rats, Wistar | Gastric Mucosa - pathology | Male | Interleukin-1beta - genetics | Gastric Mucosa - metabolism | RNA, Messenger - metabolism | Gasotransmitters - pharmacology | Carbon Monoxide - pharmacology | Cyclooxygenase 2 - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protective Agents - pharmacology | Gastric Mucosa - drug effects | Glutathione Peroxidase - drug effects | Heme Oxygenase (Decyclizing) - drug effects | Heme Oxygenase (Decyclizing) - genetics | Real-Time Polymerase Chain Reaction | RNA, Messenger - drug effects | Sulfides - pharmacology | Hydrogen Sulfide - pharmacology | Vasodilator Agents - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Nitric Oxide Synthase Type II - drug effects | Rats | Cyclooxygenase 2 - drug effects | Superoxide Dismutase - drug effects | Blotting, Western | Glutathione Peroxidase - genetics | Bone Density Conservation Agents - pharmacology | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Alendronate - pharmacology | Stress, Psychological | Organometallic Compounds - pharmacology | NF-kappa B - drug effects | Vasodilators | Analysis | Gastrointestinal diseases
Journal Article
American Journal of Physiology - Renal Physiology, ISSN 0363-6127, 2014, Volume 306, Issue 10, pp. F1236 - F1242
Journal Article