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Stem cells (Dayton, Ohio), ISSN 1066-5099, 2014, Volume 32, Issue 2, pp. 364 - 376
Journal Article
Gastroenterology (New York, N.Y. 1943), ISSN 0016-5085, 2017, Volume 152, Issue 6, pp. 1521 - 1535.e8
Journal Article
Oncogene, ISSN 1476-5594, 2014, Volume 34, Issue 17, pp. 2239 - 2250
.... By blocking mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signalling, rapalogue efficacy is likely to occur, in part, through suppression of hypoxia-inducible factors (HIFs... 
MAMMALIAN TARGET | RAPAMYCIN | MESSENGER-RNA TRANSLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERINE PHOSPHORYLATION | CANCER-THERAPY | CELL BIOLOGY | ONCOLOGY | GENETICS & HEREDITY | MAXIMAL ACTIVATION | TUBEROUS SCLEROSIS | TUMOR-GROWTH | HYPOXIA-INDUCIBLE FACTOR-1 | ENDOTHELIAL GROWTH-FACTOR | Kidney Neoplasms - genetics | TOR Serine-Threonine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Multiprotein Complexes - genetics | Kidney Neoplasms - metabolism | Vascular Endothelial Growth Factor A - metabolism | Neoplasm Proteins - metabolism | Phosphoproteins - metabolism | Vascular Endothelial Growth Factor A - genetics | Mechanistic Target of Rapamycin Complex 1 | Cystadenocarcinoma - metabolism | Multiprotein Complexes - metabolism | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | TOR Serine-Threonine Kinases - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | HEK293 Cells | Neoplasm Proteins - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Phosphoproteins - genetics | Mice, Knockout | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cystadenocarcinoma - pathology | Cystadenocarcinoma - genetics | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Kidney Neoplasms - pathology | Mice | Cell Hypoxia - genetics | Hypoxia-inducible factors | TOR protein | Tuberous Sclerosis Complex 2 | Stat3 protein | Clinical trials | Tuberous sclerosis | Rapamycin | Ribosomal protein S6 | Kinases | Ribosomal protein S6 kinase | Proteins | Angiogenesis | Transcription activation | Hypoxia | Initiation factor eIF-4E | Growth factors | Vascular endothelial growth factor | Clear cell-type renal cell carcinoma | Tumors | translation | HIF-1α | VEGF-A | TSC | mTORC1 | STAT3
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2016, Volume 113, Issue 3, pp. E338 - E347
... (Activin type 1 receptor). Extraskeletal bone forms through an endochondral process with a cartilage intermediary prompting the hypothesis that hypoxic signaling present during cartilage formation drives HO development... 
Cartilage | Heterotopic ossification | Mesenchymal condensation | HIF1α | Prx | HYPOXIA-INDUCIBLE FACTOR | PX-478 | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | cartilage | heterotopic ossification | RECEPTOR | mesenchymal condensation | CANCER | HUMAN SKELETAL-MUSCLE | BONE-FORMATION | IN-VIVO | HIF1 alpha | GROWTH-FACTOR | HIF-1-ALPHA | Ossification, Heterotopic - drug therapy | Chondrogenesis - drug effects | Mustard Compounds - pharmacology | Chondrogenesis - genetics | Tendons - drug effects | Humans | Tenotomy | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Luminescent Measurements | Gene Regulatory Networks - drug effects | RNA, Messenger - metabolism | X-Ray Microtomography | Adipose Tissue - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tendons - surgery | Integrases - metabolism | Burns - complications | Wound Healing - drug effects | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Mesenchymal Stromal Cells - drug effects | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Wounds and Injuries - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Messenger - genetics | Wounds and Injuries - complications | Ossification, Heterotopic - diagnostic imaging | Activin Receptors, Type I - metabolism | Sirolimus - pharmacology | Mice, Knockout | Up-Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Tendons - pathology | Ossification, Heterotopic - prevention & control | Ossification, Heterotopic - genetics | Adipose Tissue - drug effects | Burns - genetics | Biological Sciences | PNAS Plus
Journal Article
Nutrition (Burbank, Los Angeles County, Calif.), ISSN 0899-9007, 2016, Volume 32, Issue 2, pp. 174 - 178
Abstract Flavonoid resveratrol modulates the transcription factor NF-κB; inhibits the cytochrome P450 isoenzyme CYP1 A1... 
Gastroenterology and Hepatology | Obesity | Flavonoids | Microbiota | Type 2 diabetes mellitus | Alzheimer's disease | Resveratrol | CELLS | OXIDATIVE STRESS | RISK-FACTORS | MITOCHONDRIAL-FUNCTION | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | AUTOPHAGY | SIRT1 | NUTRITION & DIETETICS | INSULIN-RESISTANCE | MOUSE MODEL | Autistic Disorder - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Brain-Derived Neurotrophic Factor - genetics | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Lipoxins - pharmacology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Stilbenes - pharmacology | Metabolic Syndrome - chemically induced | Vascular Endothelial Growth Factor A - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetes Mellitus, Type 2 - prevention & control | Gastrointestinal Tract - microbiology | Interleukin-17 - genetics | Gastrointestinal Tract - drug effects | Antioxidants - pharmacology | Autistic Disorder - prevention & control | Transcription Factors - genetics | Cytochrome P-450 CYP1A1 - metabolism | Transcription Factors - metabolism | Interleukin-17 - metabolism | Gastrointestinal Microbiome - drug effects | Interleukin-17 - antagonists & inhibitors | NF-kappa B - genetics | Cell Differentiation - drug effects | Metabolic Syndrome - prevention & control | Cell Proliferation - drug effects | Diabetes Mellitus, Type 2 - chemically induced | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Type 2 diabetes | COX-2 inhibitors | Bisphenol-A | Endothelial growth factors | Microbiota (Symbiotic organisms) | Cytochrome P-450 | Schizophrenia | Bipolar disorder | T cells | Cell differentiation | Fatty acids | Autism | Stem cells | Tumor proteins | Pathogenesis | p53 Protein | Lipids | Proteins | Antioxidants | Signal transduction | Lymphocytes | Rodents | Oxidation | Growth factors | Cytochromes P450 | Diabetes mellitus | Rapamycin | Metabolism | Bisphenol A | Alloxan | Brain-derived neurotrophic factor | Insulin resistance | Hypoxia | Diabetes | Alzheimers disease | Autoimmune diseases | Metabolic disorders | Dementia | Apoptosis | Tumors
Journal Article
The FASEB journal, ISSN 1530-6860, 2014, Volume 29, Issue 4, pp. 1467 - 1479
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 2012, Volume 209, Issue 13, pp. 2441 - 2453
... (hypoxia-inducible factor 1) transcription factor complex. This mTORC1-HIF1 pathway is required to sustain glucose metabolism and glycolysis... 
MAMMALIAN TARGET | RAPAMYCIN | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | L-SELECTIN | ACTIVATION | KINASE | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Phosphatidylinositol 3-Kinases - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Cell Movement - physiology | Hypoxia-Inducible Factor 1 - genetics | Mechanistic Target of Rapamycin Complex 1 | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Receptors, Antigen, T-Cell - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphatidylinositol 3-Kinases - genetics | Animals | Proteins - metabolism | Glucose - metabolism | Glycolysis | Interleukin-2 - pharmacology | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Chemokines - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43543 - 43556