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Gastroenterology, ISSN 0016-5085, 2017, Volume 152, Issue 6, pp. 1521 - 1535.e8
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 2012, Volume 209, Issue 13, pp. 2441 - 2453
... (hypoxia-inducible factor 1) transcription factor complex. This mTORC1-HIF1 pathway is required to sustain glucose metabolism and glycolysis... 
MAMMALIAN TARGET | RAPAMYCIN | SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | EFFECTOR FUNCTIONS | L-SELECTIN | ACTIVATION | KINASE | RECEPTOR | DIFFERENTIATION | IMMUNOLOGY | LYMPHOCYTES | CD8-Positive T-Lymphocytes - cytology | TOR Serine-Threonine Kinases - metabolism | Multiprotein Complexes | Phosphatidylinositol 3-Kinases - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Cell Movement - physiology | Hypoxia-Inducible Factor 1 - genetics | Mechanistic Target of Rapamycin Complex 1 | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice, Mutant Strains | CD8-Positive T-Lymphocytes - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Receptors, Antigen, T-Cell - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Receptors, Chemokine - metabolism | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Phosphatidylinositol 3-Kinases - genetics | Animals | Proteins - metabolism | Glucose - metabolism | Glycolysis | Interleukin-2 - pharmacology | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Chemokines - metabolism | Mice | CD8-Positive T-Lymphocytes - immunology
Journal Article
Stem cells (Dayton, Ohio), ISSN 1066-5099, 2014, Volume 32, Issue 2, pp. 364 - 376
Journal Article
Journal Article
Nutrition, ISSN 0899-9007, 2016, Volume 32, Issue 2, pp. 174 - 178
Abstract Flavonoid resveratrol modulates the transcription factor NF-κB; inhibits the cytochrome P450 isoenzyme CYP1 A1... 
Gastroenterology and Hepatology | Obesity | Flavonoids | Microbiota | Type 2 diabetes mellitus | Alzheimer's disease | Resveratrol | CELLS | OXIDATIVE STRESS | RISK-FACTORS | MITOCHONDRIAL-FUNCTION | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | AUTOPHAGY | SIRT1 | NUTRITION & DIETETICS | INSULIN-RESISTANCE | MOUSE MODEL | Autistic Disorder - chemically induced | Tumor Necrosis Factor-alpha - metabolism | Brain-Derived Neurotrophic Factor - genetics | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Cytochrome P-450 CYP1A1 - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Lipoxins - pharmacology | NF-kappa B - metabolism | Vascular Endothelial Growth Factor A - metabolism | Stilbenes - pharmacology | Metabolic Syndrome - chemically induced | Vascular Endothelial Growth Factor A - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Diabetes Mellitus, Type 2 - prevention & control | Gastrointestinal Tract - microbiology | Interleukin-17 - genetics | Gastrointestinal Tract - drug effects | Antioxidants - pharmacology | Autistic Disorder - prevention & control | Transcription Factors - genetics | Cytochrome P-450 CYP1A1 - metabolism | Transcription Factors - metabolism | Interleukin-17 - metabolism | Gastrointestinal Microbiome - drug effects | Interleukin-17 - antagonists & inhibitors | NF-kappa B - genetics | Cell Differentiation - drug effects | Metabolic Syndrome - prevention & control | Cell Proliferation - drug effects | Diabetes Mellitus, Type 2 - chemically induced | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Type 2 diabetes | COX-2 inhibitors | Bisphenol-A | Endothelial growth factors | Microbiota (Symbiotic organisms) | Cytochrome P-450 | Schizophrenia | Bipolar disorder | T cells | Cell differentiation | Fatty acids | Autism | Stem cells | Tumor proteins | Pathogenesis | p53 Protein | Lipids | Proteins | Antioxidants | Signal transduction | Lymphocytes | Rodents | Oxidation | Growth factors | Cytochromes P450 | Diabetes mellitus | Rapamycin | Metabolism | Bisphenol A | Alloxan | Brain-derived neurotrophic factor | Insulin resistance | Hypoxia | Diabetes | Alzheimers disease | Autoimmune diseases | Metabolic disorders | Dementia | Apoptosis | Tumors
Journal Article
Biochemical journal, ISSN 1470-8728, 2013, Volume 451, Issue 3, pp. 427 - 437
The compound BAY 11-7082 inhibits IκBα [inhibitor of NF-κB (nuclear factor κB)α] phosphorylation in cells and has been used to implicate the canonical IKKs (IκB kinases) and NF-κB in >350 publications... 
Linear ubiquitin assembly complex (LUBAC) | Myeloid differentiation factor 88 (MyD88) | Nuclear factor κB (NF-κB) | Lymphoma | Ubiquitin conjugating 13 (Ubc13) | Proteasome | nuclear factor kappa B (NF-kappa B) | proteasome | ACTIVATION | CELL LYMPHOMA-CELLS | LINEAR POLYUBIQUITIN CHAINS | linear ubiquitin assembly complex (LUBAC) | BIOCHEMISTRY & MOLECULAR BIOLOGY | lymphoma | KINASE | IKK | myeloid differentiation factor 88 (MyD88) | CROSS-TALK | IN-VIVO | CONJUGATING ENZYMES | NF-KAPPA-B | NEMO | ubiquitin conjugating 13 (Ubc13) | Nitriles - pharmacology | Humans | Receptors, Interleukin-1 - genetics | Ubiquitin - metabolism | Molecular Sequence Data | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | I-kappa B Proteins - metabolism | Sulfones - pharmacology | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Amino Acid Sequence | NF-KappaB Inhibitor alpha | Ubiquitin - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Conjugating Enzymes - genetics | Macrophages - cytology | Interleukin-1 - pharmacology | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Myeloid Differentiation Factor 88 - metabolism | TRAF, tumour-necrosis-factor-receptor-associated factor | HRMS, high-resolution mass spectra | K48-pUb, Lys48-linked polyubiquitin | UBE, ubiquitin-activating enzyme | IKK, IκB kinase | NEMO, NF-κB essential modifier | HEK, human embryonic kidney | TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1 | JNK, c-Jun N-terminal kinase | HOIP, haem-oxidized IRP2 ligase-1-interacting protein | LUBAC, linear ubiquitin assembly complex | ERK, extracellular-signal-regulated kinase | HTLV-1, human T-cell lymphotropic virus 1 | K63-pUb, Lys63-linked polyubiquitin | IRAK, IL-receptor-associated kinase | pUb, polyubiquitin | IκB, inhibitor of NF-κB | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | MyD88, myeloid differentiation factor 88 | DLBCL, diffuse large B-cell lymphoma | GFP, green fluorescent protein | NF-κB, nuclear factor κB | MS, tandem MS | Ubc, ubiquitin conjugating | TAK1, transforming growth factor β-activated kinase 1 | DAPI, 4′,6-diamidino-2-phenylindole | IL-1R, IL-1 receptor | DMEM, Dulbecco’s modified Eagle’s medium | HIF1α, hypoxia-inducible factor 1α | IL, interleukin | NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8 | RBR, RING-between-RING, TAB, TAK1-binding protein | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase | PAMP, pathogen-associated molecular pattern
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2016, Volume 36, Issue 1, pp. 134 - 144
.... We have shown that in rodents, hypoxia-induced mitogenic factor (HIMF; also known as FIZZ1 or resistin-like molecule-β... 
hypoxia-inducible factor 1 | pulmonary | macrophages | resistin-like molecule | hypertension | interleukins | ACTIVATION | MUSCLE-CELL PROLIFERATION | VEGF RECEPTOR-2 | INTERLEUKIN-6 | INDUCED LUNG FIBROSIS | INFLAMMATION | ARTERIAL-HYPERTENSION | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Vascular Remodeling | Epithelial Cells - metabolism | Humans | Hypertension, Pulmonary - physiopathology | Male | Vascular Endothelial Growth Factor A - metabolism | Hypertension, Pulmonary - chemically induced | Hypertension, Pulmonary - prevention & control | Hypoxia-Inducible Factor 1, alpha Subunit - deficiency | Intercellular Signaling Peptides and Proteins - metabolism | Pulmonary Artery - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Bone Marrow Transplantation | Inflammation Mediators - metabolism | Female | Interleukin-6 - metabolism | Organ Culture Techniques | Disease Models, Animal | Fibroblasts - metabolism | Macrophages - pathology | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Epithelial Cells - pathology | Genotype | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Pulmonary Artery - physiopathology | Mice, Knockout | Macrophages - metabolism | Phenotype | Animals | Hemodynamics | In Vitro Techniques | Pulmonary Artery - pathology | Apoptosis | Cell Movement | hypoxia-inducible factor 1α | hypoxia-induced mitogenic factor | FIZZ1 | RELMα | macrophage | Pulmonary hypertension | interleukin-6
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2016, Volume 113, Issue 3, pp. E338 - E347
... (Activin type 1 receptor). Extraskeletal bone forms through an endochondral process with a cartilage intermediary prompting the hypothesis that hypoxic signaling present during cartilage formation drives HO development... 
Cartilage | Heterotopic ossification | Mesenchymal condensation | HIF1α | Prx | HYPOXIA-INDUCIBLE FACTOR | PX-478 | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | cartilage | heterotopic ossification | RECEPTOR | mesenchymal condensation | CANCER | HUMAN SKELETAL-MUSCLE | BONE-FORMATION | IN-VIVO | HIF1 alpha | GROWTH-FACTOR | HIF-1-ALPHA | Ossification, Heterotopic - drug therapy | Chondrogenesis - drug effects | Mustard Compounds - pharmacology | Chondrogenesis - genetics | Tendons - drug effects | Humans | Tenotomy | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Luminescent Measurements | Gene Regulatory Networks - drug effects | RNA, Messenger - metabolism | X-Ray Microtomography | Adipose Tissue - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tendons - surgery | Integrases - metabolism | Burns - complications | Wound Healing - drug effects | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Mesenchymal Stromal Cells - drug effects | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Wounds and Injuries - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Messenger - genetics | Wounds and Injuries - complications | Ossification, Heterotopic - diagnostic imaging | Activin Receptors, Type I - metabolism | Sirolimus - pharmacology | Mice, Knockout | Up-Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Tendons - pathology | Ossification, Heterotopic - prevention & control | Ossification, Heterotopic - genetics | Adipose Tissue - drug effects | Burns - genetics | Biological Sciences | PNAS Plus
Journal Article
Arteriosclerosis, thrombosis, and vascular biology, ISSN 1524-4636, 2017, Volume 37, Issue 11, pp. 2087 - 2101
.... The transcription factor HIF1α (hypoxia-inducible factor 1α) is canonically activated by hypoxia and has a role in plaque neovascularization... 
atherosclerosis | endothelial cells | glycolysis | MOUSE AORTAS | DEFICIENT MICE | CELL METABOLISM | DISTURBED FLOW | apolipoproteins E | hypoxia-inducible factor 1 | LAMINAR SHEAR-STRESS | PERIPHERAL VASCULAR DISEASE | HIF-1-ALPHA | HEMATOLOGY | NF-KAPPA-B | TRANSCRIPTIONAL REGULATION | HIF-ALPHA | Inflammation - pathology | Up-Regulation | Cell Proliferation | Apolipoproteins E - deficiency | Human Umbilical Vein Endothelial Cells - metabolism | Atherosclerosis - genetics | Humans | Stress, Mechanical | NF-kappa B - metabolism | Oxygen - metabolism | Inflammation - metabolism | Ubiquitination | Transfection | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Proteolysis | Inflammation Mediators - metabolism | Female | Protein Stability | Disease Models, Animal | Endopeptidases - metabolism | Atherosclerosis - pathology | Genetic Predisposition to Disease | Endothelial Cells - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Enzyme Induction | Plaque, Atherosclerotic | Regional Blood Flow | Atherosclerosis - metabolism | Mice, Knockout | Mechanotransduction, Cellular | Phenotype | Animals | Apolipoproteins E - genetics | Glycolysis | Inflammation - genetics | Human Umbilical Vein Endothelial Cells - pathology | Endothelial Cells - pathology | Sus scrofa | 10018 | 10054 | 10024 | 10188 | 10014 | Basic Sciences
Journal Article
Cancer Research, ISSN 0008-5472, 10/2010, Volume 70, Issue 19, pp. 7465 - 7475
Journal Article