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index medicus (205) 205
humans (164) 164
animals (119) 119
hypoxia-inducible factor-proline dioxygenases - antagonists & inhibitors (91) 91
hypoxia (83) 83
hypoxia-inducible factor-proline dioxygenases (81) 81
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hypoxia-inducible factor-proline dioxygenases - metabolism (74) 74
hypoxia-inducible factor 1, alpha subunit - metabolism (65) 65
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hypoxia-inducible factor (52) 52
procollagen-proline dioxygenase - antagonists & inhibitors (47) 47
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hypoxia-inducible factor-proline dioxygenases - genetics (44) 44
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procollagen-proline dioxygenase - metabolism (40) 40
cell biology (37) 37
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enzyme inhibitors - pharmacology (35) 35
procollagen-proline dioxygenase - genetics (35) 35
hif-1-alpha (34) 34
hif (32) 32
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anemia - drug therapy (28) 28
mice, inbred c57bl (28) 28
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hypoxia-inducible factor 1, alpha subunit - genetics (26) 26
anemia (25) 25
oncology (25) 25
proteins (25) 25
disease models, animal (24) 24
prolyl hydroxylase (24) 24
hif-alpha (23) 23
hydroxylation (23) 23
rats (23) 23
cells, cultured (22) 22
erythropoietin (22) 22
oxygen (22) 22
signal transduction (22) 22
multidisciplinary sciences (21) 21
factor-i (20) 20
gene expression (20) 20
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glycine - analogs & derivatives (19) 19
hydroxylases (19) 19
inhibition (19) 19
rna, small interfering - genetics (19) 19
rodents (19) 19
anemia - etiology (18) 18
protein binding (18) 18
urology & nephrology (18) 18
vascular endothelial growth factor (18) 18
apoptosis (17) 17
cell hypoxia (17) 17
chemistry, medicinal (17) 17
dose-response relationship, drug (17) 17
gene-expression (17) 17
hydroxylase (17) 17
hypoxia-inducible factor 1, alpha subunit - antagonists & inhibitors (17) 17
pathway (17) 17
phd2 (17) 17
dioxygenases - antagonists & inhibitors (16) 16
dioxygenases - metabolism (16) 16
mice, knockout (16) 16
oxygen - metabolism (16) 16
tumors (16) 16
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hela cells (15) 15
hypoxia inducible factor (15) 15
renal insufficiency, chronic - complications (15) 15
structure-activity relationship (15) 15
basic helix-loop-helix transcription factors - metabolism (14) 14
chronic kidney-disease (14) 14
enzyme inhibitors - chemistry (14) 14
middle aged (14) 14
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glycine - therapeutic use (13) 13
hek293 cells (13) 13
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Journal Article
Journal Article
EMBO reports, ISSN 1469-221X, 10/2015, Volume 16, Issue 10, pp. 1394 - 1408
Journal Article
American Journal of Kidney Diseases, ISSN 0272-6386, 2016, Volume 67, Issue 6, pp. 861 - 871
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 652 - 664
Vascular endothelial barrier dysfunction underlies diseases such as acute respiratory distress syndrome (ARDS), characterized by edema and inflammatory cell... 
MEDICINE, RESEARCH & EXPERIMENTAL | HYPOXIA-INDUCIBLE FACTOR | ALVEOLAR HYPOXIA | FACTOR 1-ALPHA | ENDOTHELIAL-CELLS | IN-VIVO | LEUKOCYTE EXTRAVASATION | BARRIER FUNCTION | VE-CADHERIN | VASCULAR-PERMEABILITY | RESPIRATORY-DISTRESS-SYNDROME | Respiratory Distress Syndrome, Adult - pathology | Cadherins - metabolism | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics | Respiratory Distress Syndrome, Adult - metabolism | Antigens, CD - genetics | Adherens Junctions - metabolism | Antigens, CD - metabolism | Phosphorylation - genetics | Respiratory Distress Syndrome, Adult - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acute Lung Injury - metabolism | Cadherins - genetics | Adherens Junctions - genetics | Cell Line | Basic Helix-Loop-Helix Transcription Factors - genetics | Receptor-Like Protein Tyrosine Phosphatases, Class 3 - biosynthesis | Signal Transduction | Endothelial Cells - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Acute Lung Injury - pathology | Adherens Junctions - pathology | Mice, Knockout | Animals | Gene Expression Regulation, Enzymologic - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Mice | Endothelial Cells - pathology | Index Medicus | Abridged Index Medicus
Journal Article
Clinical Journal of the American Society of Nephrology, ISSN 1555-9041, 06/2016, Volume 11, Issue 6, pp. 982 - 991
Journal Article
Journal Article
Kidney International, ISSN 0085-2538, 12/2017, Volume 92, Issue 6, pp. 1370 - 1383
Hypoxia in the embryo is a frequent cause of intra-uterine growth retardation, low birth weight, and multiple organ defects. In the kidney, this can lead to... 
hypoxia | chronic kidney disease | hypoxia-inducible factor | pericytes | renal development | prolyl-4-hydroxylase | NEPHROGENESIS | NEPHRON NUMBER | ORGANOGENESIS | RESPONSES | HIF-2 | DISEASE | GENE-EXPRESSION | UROLOGY & NEPHROLOGY | INTRAUTERINE GROWTH RESTRICTION | DIFFERENTIATION | ANEMIA | Cell Hypoxia - physiology | Anemia - blood | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Clinical Trials, Phase III as Topic | Kidney - metabolism | Anemia - drug therapy | Basic Helix-Loop-Helix Transcription Factors - metabolism | Forkhead Transcription Factors - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Procollagen-Proline Dioxygenase - physiology | Kidney Diseases - complications | Anemia - etiology | Molecular Targeted Therapy - methods | Disease Models, Animal | Renal Insufficiency - genetics | Hypoxia-Inducible Factor-Proline Dioxygenases - physiology | Stromal Cells - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Kidney - growth & development | Kidney Diseases - drug therapy | Organ Size - physiology | Kidney - cytology | Hydroxylation - physiology | Forkhead Transcription Factors - genetics | Enzyme Inhibitors - therapeutic use | Renal Insufficiency - mortality | Animals | Procollagen-Proline Dioxygenase - genetics | Renal Insufficiency - pathology | Mice | Mutation | Index Medicus | Hypoxia
Journal Article
Kidney International, ISSN 0085-2538, 11/2016, Volume 90, Issue 5, pp. 923 - 925
The treatment of anemia with erythropoiesis-stimulating agents and iron supplementation has become the standard of care in patients with chronic kidney... 
UROLOGY & NEPHROLOGY | EPOETIN-ALPHA | ROXADUSTAT FG-4592 | CKD | Anemia - drug therapy | Hematinics - pharmacology | Hematinics - therapeutic use | Humans | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Renal Insufficiency, Chronic - complications | Anemia - etiology | Index Medicus
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 1760, Volume 459, Issue 3, pp. 505 - 512
The tandem PHD (plant homeodomain) fingers of the CHD4 (chromodomain helicase DNA-binding protein 4) ATPase are epigenetic readers that bind either unmodified... 
Chromodomain helicase DNA-binding protein 4 (CHD4) | Plant homeodomain (PHD) | Inhibitor | Calixarene | Histone | Methylation | COMPLEX | PROTEIN | DEACETYLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HP1 CHROMO DOMAIN | SELECTIVE RECOGNITION | METHYLATED LYSINE | chromodomain helicase DNA-binding protein 4 (CHD4) | plant homeodomain (PHD) | DISCOVERY | FLUORESCENT | inhibitor | methylation | HETEROCHROMATIN | histone | calixarene | Indicators and Reagents - chemical synthesis | Hypoxia-Inducible Factor-Proline Dioxygenases - chemistry | Autoantigens - metabolism | Homeodomain Proteins - metabolism | Humans | Mi-2 Nucleosome Remodeling and Deacetylase Complex - genetics | Mi-2 Nucleosome Remodeling and Deacetylase Complex - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases - antagonists & inhibitors | Autoantigens - genetics | Chromatin Assembly and Disassembly - drug effects | Protein Subunits - metabolism | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | Mi-2 Nucleosome Remodeling and Deacetylase Complex - antagonists & inhibitors | Calixarenes - chemistry | Drug Design | HEK293 Cells | Indicators and Reagents - pharmacology | Epigenesis, Genetic - drug effects | Lysine - metabolism | Indicators and Reagents - chemistry | Histones - antagonists & inhibitors | Peptide Fragments - genetics | Protein Subunits - genetics | Recombinant Proteins - metabolism | Lysine - analogs & derivatives | Peptide Fragments - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Protein Interaction Domains and Motifs - drug effects | Calixarenes - pharmacology | Hypoxia-Inducible Factor-Proline Dioxygenases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Calixarenes - chemical synthesis | Autoantigens - chemistry | Homeodomain Proteins - chemistry | Homeodomain Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Peptide Fragments - chemistry | Hypoxia-Inducible Factor-Proline Dioxygenases - metabolism | Peptide Fragments - antagonists & inhibitors | Homeodomain Proteins - antagonists & inhibitors | Mi-2 Nucleosome Remodeling and Deacetylase Complex - chemistry | Protein Processing, Post-Translational | Protein Subunits - antagonists & inhibitors | Protein Subunits - chemistry | Histones - metabolism | Chromosomal Proteins, Non-Histone - chemistry | Index Medicus
Journal Article